JP2015505536A - 疾患の処置のための置換された複素環化合物 - Google Patents
疾患の処置のための置換された複素環化合物 Download PDFInfo
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- JP2015505536A JP2015505536A JP2014553488A JP2014553488A JP2015505536A JP 2015505536 A JP2015505536 A JP 2015505536A JP 2014553488 A JP2014553488 A JP 2014553488A JP 2014553488 A JP2014553488 A JP 2014553488A JP 2015505536 A JP2015505536 A JP 2015505536A
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261589108P | 2012-01-20 | 2012-01-20 | |
| US61/589,108 | 2012-01-20 | ||
| PCT/US2013/022304 WO2013109991A1 (en) | 2012-01-20 | 2013-01-18 | Substituted heterocyclic compounds for disease treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015505536A true JP2015505536A (ja) | 2015-02-23 |
| JP2015505536A5 JP2015505536A5 (enExample) | 2016-03-03 |
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| JP2014553488A Pending JP2015505536A (ja) | 2012-01-20 | 2013-01-18 | 疾患の処置のための置換された複素環化合物 |
Country Status (6)
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|---|---|
| US (1) | US9447078B2 (enExample) |
| EP (1) | EP2804605A4 (enExample) |
| JP (1) | JP2015505536A (enExample) |
| CN (1) | CN104703598A (enExample) |
| HK (2) | HK1198514A1 (enExample) |
| WO (1) | WO2013109991A1 (enExample) |
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| WO2013109991A1 (en) | 2012-01-20 | 2013-07-25 | Acucela Inc. | Substituted heterocyclic compounds for disease treatment |
| BR112015022041A2 (pt) * | 2013-03-12 | 2017-07-18 | Acucela Inc | derivados substituídos de 3-fenilpropilamina para o tratamento de doenças e distúrbios oftálmicas |
| WO2016202935A1 (en) | 2015-06-19 | 2016-12-22 | Bayer Pharma Aktiengesellschaft | Glucose transport inhibitors |
| CA3129891A1 (en) * | 2019-02-12 | 2020-08-20 | The Texas A&M University System | Anti-fibrotic neu3 inhibitor compounds and methods of use |
| KR20220004996A (ko) | 2019-04-03 | 2022-01-12 | 알리고스 테라퓨틱스 인코포레이티드 | 피롤 화합물 |
Citations (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3509153A (en) * | 1967-03-24 | 1970-04-28 | Miles Lab | 5-phenyl (or 5-phenylalkyl)-2-(omega-(4-phenyl-1-piperazinyl)alkyl)tetrazoles |
| JPS60105647A (ja) * | 1983-10-19 | 1985-06-11 | エフ・ホフマン―ラ ロシユ アーゲー | フエノキシプロパノールアミン類 |
| WO1994008943A1 (fr) * | 1992-10-21 | 1994-04-28 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose 2-amino-1,3-propanediol et immunosuppresseur |
| JPH0940646A (ja) * | 1995-07-27 | 1997-02-10 | Yamanouchi Pharmaceut Co Ltd | ベンゼン縮合環誘導体又はその塩 |
| JPH10510248A (ja) * | 1994-11-17 | 1998-10-06 | マレキュラー ジェリアトリクス コーポレイション | ある置換された1−アリール−3−ピペラジン−1’−イルプロパノン類 |
| JP2002053575A (ja) * | 2000-08-09 | 2002-02-19 | Sankyo Co Ltd | アミノアルコ−ル類 |
| JP2002167382A (ja) * | 2000-07-13 | 2002-06-11 | Sankyo Co Ltd | アミノアルコ−ル誘導体 |
| JP2003520800A (ja) * | 2000-01-20 | 2003-07-08 | メルク エンド カムパニー インコーポレーテッド | αvインテグリン受容体拮抗薬 |
| JP2003267950A (ja) * | 2002-01-11 | 2003-09-25 | Sankyo Co Ltd | アミノアルコ−ル誘導体又はホスホン酸誘導体及びそれらを含有する医薬組成物 |
| JP2005041867A (ja) * | 2003-07-08 | 2005-02-17 | Sankyo Co Ltd | アミノアルコ−ル誘導体又はホスホン酸誘導体を含有する医薬組成物 |
| JP2006519250A (ja) * | 2003-03-04 | 2006-08-24 | ファイザー・プロダクツ・インク | 医療処置におけるep2選択的受容体アゴニストの使用 |
| WO2006101102A1 (ja) * | 2005-03-22 | 2006-09-28 | Kyowa Hakko Kogyo Co., Ltd. | 固形腫瘍治療剤 |
| WO2008011484A2 (en) * | 2006-07-18 | 2008-01-24 | Bethesda Pharmacology Associates, Llc | Nicotinic desensitizers and methods of selecting, testing, and using them |
| JP2008510790A (ja) * | 2004-08-26 | 2008-04-10 | ファイザー・インク | プロテインキナーゼ阻害薬としてのエナンチオピュアなアミノヘテロアリール化合物 |
| WO2008146691A1 (ja) * | 2007-05-25 | 2008-12-04 | Daiichi Sankyo Company, Limited | 肝炎の予防又は治療のための医薬組成物 |
| JP2009513700A (ja) * | 2005-11-01 | 2009-04-02 | アレイ バイオファーマ、インコーポレイテッド | グルコキナーゼ活性化因子 |
| JP2009521467A (ja) * | 2005-12-23 | 2009-06-04 | ジーランド ファーマ アクティーゼルスカブ | 修飾リジン模倣化合物 |
| WO2009113637A1 (ja) * | 2008-03-12 | 2009-09-17 | 東ソー株式会社 | 新規なチアゾール誘導体、チアゾール誘導体固定化マトリックス、及びそれらの製造方法 |
| JP2009536615A (ja) * | 2006-04-07 | 2009-10-15 | メシルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
| JP2009538326A (ja) * | 2006-05-23 | 2009-11-05 | アイアールエム・リミテッド・ライアビリティ・カンパニー | チャネル活性化プロテアーゼ阻害剤としての化合物および組成物 |
| JP2009544751A (ja) * | 2006-07-28 | 2009-12-17 | ファイザー・プロダクツ・インク | Ep2作動薬 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB884663A (en) | 1958-11-06 | 1961-12-13 | Ciba Ltd | New amines and processes for their manufacture |
| CH396941A (de) | 1959-08-10 | 1965-08-15 | Ciba Geigy | Verfahren zur Herstellung neuer sekundärer Amine |
| GB1200886A (en) | 1966-09-23 | 1970-08-05 | Allen & Hanburys Ltd | Phenylaminoethanol derivatives |
| DE2710997C3 (de) | 1977-03-14 | 1980-08-14 | Dr. Karl Thomae Gmbh, 7950 Biberach | 4-Alkoxy carbonylamino-phenyläthanolamine, deren Herstellung und deren Verwendung als Arzneimittel |
| US4569354A (en) | 1982-03-22 | 1986-02-11 | Boston University | Method and apparatus for measuring natural retinal fluorescence |
| JPH0228112A (ja) | 1988-04-21 | 1990-01-30 | Kaken Pharmaceut Co Ltd | 点眼用眼圧調整剤 |
| US5135955A (en) | 1988-04-25 | 1992-08-04 | Eli Lilly And Company | Propanamine derivatives |
| IT1240427B (it) | 1990-03-02 | 1993-12-15 | Ministero Dall Uni E Della Ric | Arilpropilammine ad azione antifungina |
| DE69224861T2 (de) | 1991-07-30 | 1998-08-06 | Korea Res Inst Chem Tech | Neue Phenylacetamidderivate und Verfahren zu ihrer Herstellung |
| AU3481593A (en) | 1992-01-29 | 1993-09-01 | Smithkline Beecham Corporation | N-(3-phenylpropyl)oxamic acid, oxamate, and oxamide derivatives |
| US5958973A (en) * | 1993-09-03 | 1999-09-28 | Gilead Sciences, Inc. | Polyhydroxy benzoic acid derivatives and their use as neuraminidase inhibitors |
| KR970700646A (ko) | 1994-01-19 | 1997-02-12 | 헤르베르트 루프·울리히 볼프 | 니트록시기를 포함한 벤질아민 유도체, 및 심장 혈관 질환과 안압 상승의 치료를 위한 이의 용도(nitroxy group-containing benzylamine derivatives and their use for treating cardiovascular diseases, as well as increased intra-ocular pressure) |
| US5541228A (en) | 1994-10-14 | 1996-07-30 | Bristol-Myers Squibb Co. | Melatonergic agents |
| US5641750A (en) | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
| US6090624A (en) | 1996-04-19 | 2000-07-18 | Brown University Research Foundation | Immortalized retinal cell lines and their applications |
| US6878544B2 (en) | 1996-04-19 | 2005-04-12 | Neurotech Sa | Retinal cell lines with extended life-span and their applications |
| FR2747690B1 (fr) | 1996-04-19 | 1998-06-12 | Neurotech Sa | Lignees immortalisees de cellules retiniennes et leurs applications au traitement de differents troubles primaires ou secondaires ophtalmologiques ou neurologiques |
| AUPO235996A0 (en) | 1996-09-16 | 1996-10-10 | Garvan Institute Of Medical Research | Method of cell culture |
| CA2216439A1 (en) | 1996-09-25 | 1998-03-25 | Derek Van Der Kooy | Pharmaceuticals containing retinal stem cells |
| DE19643592A1 (de) | 1996-10-22 | 1998-04-23 | Bayer Ag | Verfahren zur Herstellung von alpha-Alkoxy-alpha-trifluormethyl-arylessigsäureestern und -arylessigsäuren |
| US6713300B1 (en) | 1997-02-27 | 2004-03-30 | University Of Utah Research Foundation | Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter |
| TW593331B (en) | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
| US6051605A (en) | 1997-08-08 | 2000-04-18 | Warner-Lambert Company | Method of treating psychosis and schizophrenia |
| US6171837B1 (en) | 1997-09-29 | 2001-01-09 | The Trustees Of Columbia University In The City Of New York | Mouse and human 9-cis-retinol dehydrogenase |
| AU1996599A (en) | 1997-12-05 | 1999-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Long-term survival and regeneration of central nervous system neurons |
| US6331537B1 (en) | 1998-06-03 | 2001-12-18 | Gpi Nil Holdings, Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
| ATE402253T1 (de) | 1999-01-05 | 2008-08-15 | Aventis Pharma Sa | Humane adulte astrozyten, sowie deren herstellung und verwendung |
| AU6391000A (en) | 1999-07-28 | 2001-02-19 | Genentech Inc. | Method of preventing the injury or death of retinal cells and treating ocular diseases |
| EP1107003A1 (en) | 1999-12-09 | 2001-06-13 | Trophos | Methods for screening compounds active on neurons |
| US6406840B1 (en) | 1999-12-17 | 2002-06-18 | Biomosaic Systems, Inc. | Cell arrays and the uses thereof |
| MXPA02006134A (es) | 1999-12-21 | 2002-12-13 | Guilford Pharm Inc | Compuestos derivados de hidantoina, composiciones farmaceuticas y metodos de uso de los mismos. |
| WO2001083714A2 (en) | 2000-05-02 | 2001-11-08 | Central Institute For The Deaf | Composition and methods for treating photoreceptor degeneration |
| US20020009713A1 (en) | 2000-05-11 | 2002-01-24 | Miller Freda D. | Methods for identifying modulators of neuronal growth |
| BR0112484A (pt) * | 2000-07-13 | 2003-09-23 | Sankyo Co | Composto ou um seu sal, éster ou outro derivado farmacologicamente aceitável, composição farmacêutica, uso de um composto ou de um seu sal, éster ou outro derivado farmacologicamente aceitável, e, processo para a preparação do mesmo |
| US20030032078A1 (en) | 2001-01-23 | 2003-02-13 | Board Of Regents, The University Of Texas System | Methods and compositions for the treatment of macular and retinal degenerations |
| DE10141018A1 (de) | 2001-08-22 | 2003-03-13 | Eth Zuerich Eidgenoessische Te | Verwendung von negativ geladenen Phospholipiden, sowie Zusammensetzungen umfassend Phospholipide zur Behandlung des Auges |
| US7312025B2 (en) | 2002-07-12 | 2007-12-25 | University Of Washington | Methods and systems for extended in vitro culture of neuronal cells |
| DE10235312A1 (de) | 2002-08-01 | 2004-02-12 | Basf Ag | Verfahren zur Herstellung von Aminoalkoxybenzylaminen und Aminoalkoxybenzonitrilen als Zwischenprodukte |
| CN1717234A (zh) | 2002-12-06 | 2006-01-04 | 爱尔康公司 | 用于治疗眼紊乱和疾病的超氧化物岐化酶模拟物 |
| EP2327401A3 (en) | 2003-03-14 | 2011-10-19 | University of Washington | Retinoid Replacements and Opsin Agonists and Methods for the Use Thereof |
| EP1649009A2 (en) | 2003-07-30 | 2006-04-26 | Acucela, Inc. | Extended primary retinal cell culture and stress models, and methods of use |
| ES2754221T3 (es) | 2003-08-29 | 2020-04-16 | Ono Pharmaceutical Co | Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo |
| US7706863B2 (en) | 2004-01-21 | 2010-04-27 | University Of Washington | Methods for assessing a physiological state of a mammalian retina |
| US7566808B2 (en) | 2004-02-17 | 2009-07-28 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
| TWI359810B (en) * | 2004-11-04 | 2012-03-11 | Mitsubishi Tanabe Pharma Corp | Carboxylic acid derivative containing thiazole rin |
| WO2006091796A2 (en) | 2005-02-22 | 2006-08-31 | Acucela, Inc. | Compositions and methods for diagnosing and treating retinal diseases |
| US8098907B2 (en) | 2005-07-01 | 2012-01-17 | Siemens Corporation | Method and system for local adaptive detection of microaneurysms in digital fundus images |
| TW200744567A (en) | 2005-09-23 | 2007-12-16 | Alcon Inc | Phenylethylamine analogs and their use for treating glaucoma |
| EP1973868B1 (en) | 2006-01-13 | 2015-09-09 | McGill University | Novel elatonin ligands having antidepressant activity as well as sleep inducing properties |
| EP2004166A2 (en) | 2006-03-31 | 2008-12-24 | La Jolla Pharmaceutical Company | Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases |
| MX2009011360A (es) | 2007-04-20 | 2010-02-12 | Acucela Inc | Compuestos derivados de estirenilo para tratar enfermedades y trastornos oftalmicos. |
| CA2690229C (en) | 2007-06-29 | 2013-10-29 | Acucela, Inc. | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders |
| US7973079B2 (en) * | 2007-09-27 | 2011-07-05 | Revision Therapeutics, Inc. | Methods and compounds for treating retinol-related diseases |
| WO2009045479A1 (en) | 2007-10-05 | 2009-04-09 | Acucela Inc. | Alkoxy compounds for disease treatment |
| WO2009055696A1 (en) * | 2007-10-25 | 2009-04-30 | Achaogen, Inc. | CARBACEPHEM β-LACTAM ANTIBIOTICS |
| JP5592265B2 (ja) | 2007-11-01 | 2014-09-17 | アキュセラ インコーポレイテッド | 眼の疾患及び障害治療用のアミン誘導体化合物 |
| BRPI0919327A2 (pt) | 2008-09-05 | 2019-09-24 | Acucela Inc | compostos ligados a enxofre para tratar doenças e distúrbios oftálmicos |
| NZ592993A (en) | 2008-10-22 | 2013-02-22 | Acucela Inc | Compounds for treating ophthalmic diseases and disorders |
| EP4000610A1 (en) * | 2009-07-02 | 2022-05-25 | Acucela Inc. | Pharmacology of visual cycle modulators |
| GB2474120B (en) | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
| WO2013109991A1 (en) | 2012-01-20 | 2013-07-25 | Acucela Inc. | Substituted heterocyclic compounds for disease treatment |
| TW201406707A (zh) | 2012-05-04 | 2014-02-16 | Acucela Inc | 用以治療糖尿病性視網膜病變及其他眼部疾病之方法 |
-
2013
- 2013-01-18 WO PCT/US2013/022304 patent/WO2013109991A1/en not_active Ceased
- 2013-01-18 US US13/745,675 patent/US9447078B2/en not_active Expired - Fee Related
- 2013-01-18 HK HK14112001.6A patent/HK1198514A1/xx unknown
- 2013-01-18 EP EP13738431.9A patent/EP2804605A4/en not_active Withdrawn
- 2013-01-18 JP JP2014553488A patent/JP2015505536A/ja active Pending
- 2013-01-18 CN CN201380015582.4A patent/CN104703598A/zh active Pending
- 2013-01-18 HK HK15111946.5A patent/HK1210969A1/xx unknown
Patent Citations (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3509153A (en) * | 1967-03-24 | 1970-04-28 | Miles Lab | 5-phenyl (or 5-phenylalkyl)-2-(omega-(4-phenyl-1-piperazinyl)alkyl)tetrazoles |
| JPS60105647A (ja) * | 1983-10-19 | 1985-06-11 | エフ・ホフマン―ラ ロシユ アーゲー | フエノキシプロパノールアミン類 |
| WO1994008943A1 (fr) * | 1992-10-21 | 1994-04-28 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose 2-amino-1,3-propanediol et immunosuppresseur |
| JPH10510248A (ja) * | 1994-11-17 | 1998-10-06 | マレキュラー ジェリアトリクス コーポレイション | ある置換された1−アリール−3−ピペラジン−1’−イルプロパノン類 |
| JPH0940646A (ja) * | 1995-07-27 | 1997-02-10 | Yamanouchi Pharmaceut Co Ltd | ベンゼン縮合環誘導体又はその塩 |
| JP2003520800A (ja) * | 2000-01-20 | 2003-07-08 | メルク エンド カムパニー インコーポレーテッド | αvインテグリン受容体拮抗薬 |
| JP2002167382A (ja) * | 2000-07-13 | 2002-06-11 | Sankyo Co Ltd | アミノアルコ−ル誘導体 |
| JP2002053575A (ja) * | 2000-08-09 | 2002-02-19 | Sankyo Co Ltd | アミノアルコ−ル類 |
| JP2003267950A (ja) * | 2002-01-11 | 2003-09-25 | Sankyo Co Ltd | アミノアルコ−ル誘導体又はホスホン酸誘導体及びそれらを含有する医薬組成物 |
| JP2006519250A (ja) * | 2003-03-04 | 2006-08-24 | ファイザー・プロダクツ・インク | 医療処置におけるep2選択的受容体アゴニストの使用 |
| JP2005041867A (ja) * | 2003-07-08 | 2005-02-17 | Sankyo Co Ltd | アミノアルコ−ル誘導体又はホスホン酸誘導体を含有する医薬組成物 |
| JP2008510790A (ja) * | 2004-08-26 | 2008-04-10 | ファイザー・インク | プロテインキナーゼ阻害薬としてのエナンチオピュアなアミノヘテロアリール化合物 |
| WO2006101102A1 (ja) * | 2005-03-22 | 2006-09-28 | Kyowa Hakko Kogyo Co., Ltd. | 固形腫瘍治療剤 |
| JP2009513700A (ja) * | 2005-11-01 | 2009-04-02 | アレイ バイオファーマ、インコーポレイテッド | グルコキナーゼ活性化因子 |
| JP2009521467A (ja) * | 2005-12-23 | 2009-06-04 | ジーランド ファーマ アクティーゼルスカブ | 修飾リジン模倣化合物 |
| JP2009536615A (ja) * | 2006-04-07 | 2009-10-15 | メシルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
| JP2009538326A (ja) * | 2006-05-23 | 2009-11-05 | アイアールエム・リミテッド・ライアビリティ・カンパニー | チャネル活性化プロテアーゼ阻害剤としての化合物および組成物 |
| WO2008011484A2 (en) * | 2006-07-18 | 2008-01-24 | Bethesda Pharmacology Associates, Llc | Nicotinic desensitizers and methods of selecting, testing, and using them |
| JP2009544751A (ja) * | 2006-07-28 | 2009-12-17 | ファイザー・プロダクツ・インク | Ep2作動薬 |
| WO2008146691A1 (ja) * | 2007-05-25 | 2008-12-04 | Daiichi Sankyo Company, Limited | 肝炎の予防又は治療のための医薬組成物 |
| WO2009113637A1 (ja) * | 2008-03-12 | 2009-09-17 | 東ソー株式会社 | 新規なチアゾール誘導体、チアゾール誘導体固定化マトリックス、及びそれらの製造方法 |
Non-Patent Citations (5)
| Title |
|---|
| HOYE, THOMAS R ET AL.: "Synthesis of the C2-Symmetric, Macrocyclic Alkaloid, (+)-Xestospongin A and Its C(9)-Epimer, (-)-Xes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 118, no. 48, JPN6016031747, 1996, pages 12074 - 12081, ISSN: 0003381370 * |
| REGISTRY(STN)[ONLINE], JPN7016002427, 10 November 2011 (2011-11-10), ISSN: 0003381371 * |
| SCHIAVI, BRUNO ET AL.: "Synthesis of 5-deazathiogirollines: analogs of a natural antitumor agent", TETRAHEDRON, vol. 58, no. 21, JPN6016031745, 2002, pages 4201 - 4215, ISSN: 0003381369 * |
| SELLANES, D ET AL.: "Synthesis and evaluation of anthelmintic and cytotoxic properties of bis-1,3-azole analogs of natura", LETTERS IN DRUG DESIGN & DISCOVERY, vol. 3, JPN6016031744, 2006, pages 35 - 43, ISSN: 0003381368 * |
| ZAREEF, MUHAMMAD ET AL.: "Carbonic anhydrase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozym", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 21, no. 4, JPN7016002426, 2006, pages 351 - 359, ISSN: 0003381367 * |
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| US20130225619A1 (en) | 2013-08-29 |
| CN104703598A (zh) | 2015-06-10 |
| US9447078B2 (en) | 2016-09-20 |
| HK1210969A1 (en) | 2016-05-13 |
| WO2013109991A1 (en) | 2013-07-25 |
| EP2804605A1 (en) | 2014-11-26 |
| HK1198514A1 (en) | 2015-05-15 |
| EP2804605A4 (en) | 2015-07-08 |
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