JP2015504871A5 - - Google Patents
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- Publication number
- JP2015504871A5 JP2015504871A5 JP2014547838A JP2014547838A JP2015504871A5 JP 2015504871 A5 JP2015504871 A5 JP 2015504871A5 JP 2014547838 A JP2014547838 A JP 2014547838A JP 2014547838 A JP2014547838 A JP 2014547838A JP 2015504871 A5 JP2015504871 A5 JP 2015504871A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- nrf2 activator
- ppar gamma
- gamma agonist
- dimethyl fumarate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000588302 Homo sapiens Nuclear factor erythroid 2-related factor 2 Proteins 0.000 claims description 16
- 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 claims description 16
- 229940080774 Peroxisome proliferator-activated receptor gamma agonist Drugs 0.000 claims description 10
- 239000012190 activator Substances 0.000 claims description 10
- 208000023275 Autoimmune disease Diseases 0.000 claims description 5
- 208000027866 inflammatory disease Diseases 0.000 claims description 5
- 108010016731 PPAR gamma Proteins 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 102000000536 PPAR gamma Human genes 0.000 claims description 3
- 239000000556 agonist Substances 0.000 claims description 3
- 238000011282 treatment Methods 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims 8
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims 6
- LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical group COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 claims 5
- 229960004419 dimethyl fumarate Drugs 0.000 claims 5
- 206010071068 Clinically isolated syndrome Diseases 0.000 claims 4
- 230000001363 autoimmune Effects 0.000 claims 4
- 229960005095 pioglitazone Drugs 0.000 claims 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Natural products OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 3
- 229960004586 rosiglitazone Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000001530 fumaric acid Substances 0.000 claims 2
- -1 fumaric acid ester Chemical class 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229960002598 fumaric acid Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 description 8
- 230000004913 activation Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000011284 combination treatment Methods 0.000 description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 2
- 229960003957 dexamethasone Drugs 0.000 description 2
- 238000009097 single-agent therapy Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11194292 | 2011-12-19 | ||
| EP11194292.6 | 2011-12-19 | ||
| EP12004652 | 2012-06-21 | ||
| EP12004652.9 | 2012-06-21 | ||
| US201261663761P | 2012-06-25 | 2012-06-25 | |
| US61/663,761 | 2012-06-25 | ||
| US13/654,632 | 2012-10-18 | ||
| US13/654,632 US20130158077A1 (en) | 2011-12-19 | 2012-10-18 | Pharmaceutical compositions |
| PCT/EP2012/074915 WO2013092269A1 (en) | 2011-12-19 | 2012-12-10 | Pharmaceutical compositions comprising glitazones and nrf2 activators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504871A JP2015504871A (ja) | 2015-02-16 |
| JP2015504871A5 true JP2015504871A5 (OSRAM) | 2017-04-13 |
| JP6132850B2 JP6132850B2 (ja) | 2017-05-24 |
Family
ID=48610741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547838A Active JP6132850B2 (ja) | 2011-12-19 | 2012-12-10 | グリタゾンおよびｎｒｆ２アクチベーターを含む医薬組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US20130158077A1 (OSRAM) |
| EP (1) | EP2793876B1 (OSRAM) |
| JP (1) | JP6132850B2 (OSRAM) |
| KR (2) | KR102188487B1 (OSRAM) |
| CN (1) | CN103998035B (OSRAM) |
| AR (1) | AR089301A1 (OSRAM) |
| AU (4) | AU2012358420B9 (OSRAM) |
| BR (1) | BR112014014809A8 (OSRAM) |
| CA (1) | CA2859635C (OSRAM) |
| CL (1) | CL2014001639A1 (OSRAM) |
| EA (1) | EA201400729A1 (OSRAM) |
| ES (1) | ES2959111T3 (OSRAM) |
| HK (1) | HK1200711A1 (OSRAM) |
| IL (1) | IL233134A0 (OSRAM) |
| MX (2) | MX394473B (OSRAM) |
| PH (1) | PH12014501029A1 (OSRAM) |
| SG (1) | SG11201403241XA (OSRAM) |
| WO (1) | WO2013092269A1 (OSRAM) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2554347C2 (ru) | 2008-08-19 | 2015-06-27 | Ксенопорт, Инк. | Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения |
| US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
| US9962361B2 (en) | 2011-01-03 | 2018-05-08 | The William M. Yarbrough Foundation | Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use |
| MX339243B (es) | 2011-02-03 | 2016-05-18 | Vtv Therapeutics Llc | Derivados fusionados sustituidos de imidazol, composiciones farmaceuticas y metodos de uso de los mismos. |
| US9532969B2 (en) | 2011-02-08 | 2017-01-03 | The William M. Yarbrough Foundation | Method for treating psoriasis |
| US9504679B2 (en) | 2011-12-19 | 2016-11-29 | Bjoern Colin Kahrs | Pharmaceutical compositions comprising glitazones and Nrf2 activators |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| US10434082B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms |
| US10434081B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Inhibitors of macrophage migration inhibitory factor |
| US10441561B2 (en) | 2012-07-26 | 2019-10-15 | The William M. Yanbrough Foundation | Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer |
| US10335387B2 (en) | 2012-07-26 | 2019-07-02 | The William M. Yarbrough Foundation | Method for treating infectious diseases with isothiocyanate functional compounds |
| EP2887934A1 (en) | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| AU2013305684B2 (en) | 2012-08-22 | 2016-11-24 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| MX2015007479A (es) * | 2012-12-11 | 2015-09-04 | Metabolic Solutions Dev Co Llc | Tiazolidindionas ahorradoras de receptores activados proliferadores de peroxisoma (ppar) y combinaciones para el tratamiento de enfermedades neurodegenerativas. |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| UA116648C2 (uk) | 2013-03-14 | 2018-04-25 | Алкермес Фарма Айерленд Лімітед | Фумарати як проліки та їх застосування при лікуванні різних захворювань |
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| US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
| WO2014205392A1 (en) | 2013-06-21 | 2014-12-24 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
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| EP3501510B1 (en) | 2014-02-28 | 2020-07-01 | Banner Life Sciences LLC | Controlled release enteric soft capsules of fumarate esters |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| WO2016071727A1 (en) | 2014-11-04 | 2016-05-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the prevention and the treatment of rapidly progressive glomerulonephritis |
| WO2016074684A1 (en) * | 2014-11-11 | 2016-05-19 | Syddansk Universitet | Fumaric acid derivatives for medical use |
| MA40990A (fr) * | 2014-11-19 | 2017-09-26 | Biogen Ma Inc | Formulations de matrice pharmaceutique comprenant du fumarate de diméthyle |
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| MA41785A (fr) | 2015-03-20 | 2018-01-23 | Biogen Ma Inc | Procédés et compositions pour l'administration intraveineuse de fumarates pour le traitement de maladies neurologiques |
| KR101704410B1 (ko) | 2015-07-22 | 2017-02-22 | 대구가톨릭대학교산학협력단 | 사파논 a를 함유하는 심혈관질환의 예방 및 치료용 조성물 |
| WO2017072699A1 (en) * | 2015-10-28 | 2017-05-04 | Sun Pharmaceutical Industries Limited | Pharmaceutical compositions of dimethyl fumarate |
| CN108699011B (zh) * | 2016-02-03 | 2022-05-06 | 参宿七制药股份有限公司 | Nrf2活化性化合物及其用途 |
| CN106389457A (zh) * | 2016-11-30 | 2017-02-15 | 胡立志 | PPAR‑γ激动剂在制备治疗脱发药物中的应用及治疗脱发的药物 |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| US12274703B2 (en) | 2017-12-21 | 2025-04-15 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising a dementia |
| US12310967B2 (en) | 2017-12-21 | 2025-05-27 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising motor neuron diseases |
| CN108685903B (zh) * | 2018-07-05 | 2019-10-18 | 陕西师范大学 | 鼠尾草酚在制备防治实验性自身免疫性脑脊髓炎药物的应用 |
| WO2020094767A1 (en) | 2018-11-08 | 2020-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of nrf2 activators for the treatment of staphylococcus aureus infections |
| KR20210096162A (ko) * | 2018-11-27 | 2021-08-04 | 쿄와 기린 가부시키가이샤 | 의약 조성물 |
| WO2020132378A2 (en) | 2018-12-22 | 2020-06-25 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising depression |
| CN111606828B (zh) * | 2019-02-22 | 2023-07-28 | 浙江海正药业股份有限公司 | (E)-α,β-不饱和酰胺化合物的晶型及其制备方法和用途 |
| CN109846867A (zh) * | 2019-03-29 | 2019-06-07 | 北京中医药大学 | 花姜酮用于制备抗心肌缺血的药物的用途 |
| WO2021024054A1 (en) * | 2019-08-05 | 2021-02-11 | International Business Machines Corporation | Combination therapy to achieve enhanced antimicrobial activity |
| CN110279866B (zh) * | 2019-08-12 | 2021-06-29 | 浙江养生堂天然药物研究所有限公司 | 包含柠檬苦素类化合物和噻唑烷二酮类药物的组合产品 |
| CN110613712B (zh) * | 2019-10-22 | 2021-06-29 | 上海交通大学医学院附属第九人民医院 | 中药组合物及其在治疗血管炎症和内皮损伤中的应用 |
| WO2021142062A1 (en) | 2020-01-10 | 2021-07-15 | Banner Life Sciences Llc | Fumarate ester dosage forms with enhanced gastrointestinal tolerability |
| CN113244221B (zh) * | 2020-02-12 | 2022-10-25 | 华东师范大学 | 双甲基鼠尾草酚在制备治疗恶病质疾病的药物中的应用 |
| US20250002436A1 (en) * | 2020-02-24 | 2025-01-02 | Robert F. Hofmann | Naphthoquinone-based chalcone derivatives and uses thereof |
| US20230134760A1 (en) * | 2020-03-04 | 2023-05-04 | Hongbing Wang | Car and nrf2 dual activator agents for cyclophosphamide-based and doxorubicin-based treatments of cancer |
| EP4117785A4 (en) * | 2020-03-13 | 2024-04-17 | Marc J. Simard | METHODS OF TREATMENT OF MULTIPLE SCLEROSIS |
| CN111574437A (zh) * | 2020-06-22 | 2020-08-25 | 上海长车生物科技有限公司 | (e)-3-芳杂环基丙-2-烯酸衍生物及其制备和用途 |
| CN111529514A (zh) * | 2020-06-23 | 2020-08-14 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 一种特丁基对苯二酚的应用及治疗椎间盘退变的药物 |
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| KR20230123323A (ko) | 2022-02-16 | 2023-08-23 | 대구대학교 산학협력단 | 알릴 이소티오시아네이트(Allyl isothiocyanate)를 유효성분으로 포함하는 골 대사성 질환의 예방, 개선 또는 치료용 조성물 |
| CN114414809B (zh) * | 2022-03-28 | 2022-06-21 | 中元伯瑞生物科技(珠海横琴)有限公司 | 用于诊断尘肺病的生物标志物的应用 |
| WO2024047248A1 (en) | 2022-09-02 | 2024-03-07 | Institut National de la Santé et de la Recherche Médicale | Use of nrf2 activators for the treatment of cerebral small vessel disease |
| CN117137897B (zh) * | 2023-10-31 | 2024-02-13 | 中国中医科学院中药研究所 | 索法酮在制备用于预防/治疗银屑病的药物中的应用 |
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2012
- 2012-10-18 US US13/654,632 patent/US20130158077A1/en not_active Abandoned
- 2012-12-10 CN CN201280062704.0A patent/CN103998035B/zh active Active
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- 2012-12-10 AU AU2012358420A patent/AU2012358420B9/en active Active
- 2012-12-10 WO PCT/EP2012/074915 patent/WO2013092269A1/en not_active Ceased
- 2012-12-10 EA EA201400729A patent/EA201400729A1/ru unknown
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- 2012-12-10 JP JP2014547838A patent/JP6132850B2/ja active Active
- 2012-12-10 BR BR112014014809A patent/BR112014014809A8/pt not_active Application Discontinuation
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- 2012-12-10 PH PH1/2014/501029A patent/PH12014501029A1/en unknown
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- 2012-12-10 HK HK15101190.9A patent/HK1200711A1/xx unknown
- 2012-12-10 MX MX2014007254A patent/MX2014007254A/es unknown
- 2012-12-10 KR KR1020227033805A patent/KR20220139414A/ko not_active Ceased
- 2012-12-10 EP EP12801539.3A patent/EP2793876B1/en active Active
- 2012-12-18 AR ARP120104793A patent/AR089301A1/es unknown
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