JP2015501845A5 - - Google Patents
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- Publication number
- JP2015501845A5 JP2015501845A5 JP2014547462A JP2014547462A JP2015501845A5 JP 2015501845 A5 JP2015501845 A5 JP 2015501845A5 JP 2014547462 A JP2014547462 A JP 2014547462A JP 2014547462 A JP2014547462 A JP 2014547462A JP 2015501845 A5 JP2015501845 A5 JP 2015501845A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- independently
- compound
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161576448P | 2011-12-16 | 2011-12-16 | |
| US61/576,448 | 2011-12-16 | ||
| PCT/US2012/069637 WO2013090664A1 (en) | 2011-12-16 | 2012-12-14 | Derivatives of betulin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018000027A Division JP2018065867A (ja) | 2011-12-16 | 2018-01-04 | ベツリンの誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015501845A JP2015501845A (ja) | 2015-01-19 |
| JP2015501845A5 true JP2015501845A5 (cg-RX-API-DMAC7.html) | 2016-01-28 |
| JP6300730B2 JP6300730B2 (ja) | 2018-03-28 |
Family
ID=48613199
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547462A Expired - Fee Related JP6300730B2 (ja) | 2011-12-16 | 2012-12-14 | ベツリンの誘導体 |
| JP2018000027A Withdrawn JP2018065867A (ja) | 2011-12-16 | 2018-01-04 | ベツリンの誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018000027A Withdrawn JP2018065867A (ja) | 2011-12-16 | 2018-01-04 | ベツリンの誘導体 |
Country Status (38)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3387B1 (ar) | 2011-12-16 | 2019-03-13 | Glaxosmithkline Llc | مشتقات بيتولين |
| CN103242413B (zh) * | 2012-02-08 | 2015-08-26 | 江西青峰药业有限公司 | Lupane三萜系衍生物及其药学用途 |
| KR20150093819A (ko) * | 2012-12-14 | 2015-08-18 | 글락소스미스클라인 엘엘씨 | 약제 조성물 |
| US9637516B2 (en) | 2012-12-31 | 2017-05-02 | Hetero Research Foundation | Betulinic acid proline derivatives as HIV inhibitors |
| US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
| CR20170113A (es) | 2014-09-26 | 2017-05-26 | Glaxosmilthkline Intellectual Property (No 2) Ltd | Composiciones farmacéuticas de acción prolongada |
| JP6620149B2 (ja) * | 2014-11-14 | 2019-12-11 | ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド | 拡張ベツリン酸類似体 |
| CN107250153A (zh) * | 2014-11-14 | 2017-10-13 | Viiv保健英国第五有限公司 | 氧代羽扇豆烯衍生物 |
| MA40886B1 (fr) | 2015-02-09 | 2020-03-31 | Hetero Research Foundation | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih |
| WO2016147099A2 (en) | 2015-03-16 | 2016-09-22 | Hetero Research Foundation | C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors |
| CN108026140A (zh) * | 2015-07-28 | 2018-05-11 | 葛兰素史克知识产权第二有限公司 | 用于预防或治疗hiv感染的白桦脂醇衍生物 |
| AU2016298667A1 (en) | 2015-07-28 | 2018-02-22 | Glaxosmithkline Intellectual Property (No.2) Limited | Betuin derivatives for preventing or treating HIV infections |
| CN108368071A (zh) | 2015-09-24 | 2018-08-03 | 葛兰素史克知识产权第二有限公司 | 具有hiv成熟抑制活性的化合物 |
| BR112018014622A2 (pt) | 2016-01-20 | 2018-12-11 | Glaxosmithkline Ip No 2 Ltd | ?composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para tratar uma infecção por hiv e para prevenir uma infecção por hiv, e, uso de um composto ou sal? |
| WO2018044838A1 (en) * | 2016-08-31 | 2018-03-08 | Viiv Healthcare Company | Combinations and uses and treatments thereof |
| WO2018042331A1 (en) | 2016-08-31 | 2018-03-08 | Glaxosmithkline Intellectual Property (No.2) Limited | Combinations and uses and treatments thereof |
| WO2018044853A1 (en) * | 2016-08-31 | 2018-03-08 | Viiv Healthcare Conpany | Combinations and uses and treatments thereof |
| WO2018042332A1 (en) | 2016-08-31 | 2018-03-08 | Glaxosmithkline Intellectual Property (No.2) Limited | Combinations and uses and treatments thereof |
| WO2019150300A1 (en) | 2018-02-02 | 2019-08-08 | Glaxosmithkline Intellectual Property (No.2) Limited | Crystalline forms of 4-(((3ar,5ar,5br,7ar,9s,11ar,11br,13as)-3a-((r)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2h-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid |
| WO2019186342A1 (en) | 2018-03-27 | 2019-10-03 | Glaxosmithkline Intellectual Property (No.2) Limited | Ionic liquid salts of 4-(((3ar,5ar,5br,7ar,9s,11ar,11br,13as)-3a-((r)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2h-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid |
| EP4321164A3 (en) | 2018-04-24 | 2024-04-17 | ViiV Healthcare UK (No.5) Limited | Compounds with hiv maturation inhibitory activity |
| KR101909885B1 (ko) * | 2018-05-25 | 2018-10-19 | 김예원 | 살리드로사이드 또는 베툴린을 이용한 뇌수막종 개선용 조성물 |
| PL237998B1 (pl) | 2018-05-28 | 2021-06-28 | Narodowy Inst Lekow | Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB427857A (en) | 1934-08-02 | 1935-05-01 | Newsum Sons & Company Ltd H | A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames |
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| GB8815265D0 (en) | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5358721A (en) | 1992-12-04 | 1994-10-25 | Alza Corporation | Antiviral therapy |
| WO2001090046A1 (en) | 2000-05-23 | 2001-11-29 | Univerzita Palackeho V Olomouci | Triterpenoid derivatives |
| CZ20032532A3 (en) | 2001-03-19 | 2004-03-17 | Ono Pharmaceutical Co., Ltd. | Drugs containing triazaspiro 5.5 undecane derivatives as the active ingredient |
| WO2003011254A1 (en) | 2001-07-31 | 2003-02-13 | Capricorn Pharma Inc. | Amorphous drug beads |
| US20080206161A1 (en) | 2002-10-25 | 2008-08-28 | Dov Tamarkin | Quiescent foamable compositions, steroids, kits and uses thereof |
| AU2003300911A1 (en) | 2002-12-13 | 2004-07-09 | Smithkline Beecham Corporation | Heterocyclic compounds as ccr5 antagonists |
| US7589207B2 (en) | 2002-12-13 | 2009-09-15 | Smithkline Beecham Corporation | Cyclohexyl compounds as CCR5 antagonists |
| BR0317230A (pt) | 2002-12-13 | 2005-10-25 | Smithkline Beecham Corp | Composto, composição, métodos de antagonizar uma atividade do receptor de quimiocina ccr-5, e de tratar uma infecção viral em um paciente, e, uso de um composto |
| WO2004055012A1 (en) | 2002-12-13 | 2004-07-01 | Smithkline Beecham Corporation | Indane compounds as ccr5 antagonists |
| AU2003296992A1 (en) | 2002-12-13 | 2004-07-09 | Smithkline Beecham Corporation | Pyrrolidine and azetidine compounds as ccr5 antagonists |
| JP2006514950A (ja) | 2002-12-13 | 2006-05-18 | スミスクライン ビーチャム コーポレーション | Ｃｃｒ５拮抗薬としてのシクロプロピル化合物 |
| US20050142205A1 (en) | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for encapsulating small spherical particles prepared by controlled phase separation |
| WO2005112929A2 (en) | 2004-05-20 | 2005-12-01 | Cornell Research Foundation, Inc. | Anti-hiv-1 activity of betulinol derivatives |
| CN101142227A (zh) * | 2004-11-12 | 2008-03-12 | 帕纳克斯医药公司 | 新颖的桦木醇衍生物、其制备和其用途 |
| TW200628161A (en) | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| US20090023698A1 (en) | 2005-03-29 | 2009-01-22 | Krasutsky Pavel A | Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid |
| TW201414495A (zh) | 2005-04-04 | 2014-04-16 | Tibotec Pharm Ltd | Ｈｉｖ-感染之預防 |
| WO2006117666A2 (en) | 2005-04-29 | 2006-11-09 | Pfizer Inc. | Dosage forms, pharmaceutical compositions and methods for sub-tenon delivery |
| US20070197646A1 (en) | 2006-02-21 | 2007-08-23 | Achillion Pharmaceuticals, Inc. | Substituted taraxastanes useful for treating viral infections |
| FI121468B (fi) | 2006-06-07 | 2010-11-30 | Valtion Teknillinen | Betuliiniperäiset yhdisteet antimikrobisina aineina |
| SI3366278T1 (sl) | 2006-06-23 | 2024-12-31 | Janssen Sciences Ireland Unlimited Company | Vodne suspenzije tmc278 |
| WO2008127364A2 (en) | 2006-10-13 | 2008-10-23 | Myriad Genetics, Inc. | Antiviral compounds and use thereof |
| AR063546A1 (es) | 2006-11-03 | 2009-01-28 | Panacos Pharmaceuticals Inc | DERIVADOS DE TRITERPENO, METODOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIoN POR EL VIRUS VIH. |
| MX2010007375A (es) | 2008-01-03 | 2010-09-30 | Virochem Pharma Inc | Nuevos derivados de lupano. |
| AU2008342536A1 (en) * | 2008-01-03 | 2009-07-09 | Virochem Pharma Inc. | Novel C-21-keto lupane derivatives preparation and use thereof |
| DE102008037025C5 (de) | 2008-08-08 | 2016-07-07 | Jesalis Pharma Gmbh | Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform |
| WO2010053817A1 (en) * | 2008-11-04 | 2010-05-14 | Trustees Of Dartmouth College | Betulinic acid derivatives and methods of use thereof |
| CZ2008723A3 (cs) | 2008-11-13 | 2010-01-13 | Univerzita Palackého v Olomouci | 2-Deoxyglykosidy triterpenoidu, zpusob jejich prípravy a jejich použití jako lécivo |
| CA2744019C (en) | 2008-12-11 | 2017-03-14 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates |
| US9067966B2 (en) * | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| US8802727B2 (en) | 2009-07-14 | 2014-08-12 | Hetero Research Foundation, Hetero Drugs Limited | Pharmaceutically acceptable salts of betulinic acid derivatives |
| FR2948132B1 (fr) | 2009-07-20 | 2011-08-26 | Inst Francais Textile & Habillement | Association de produits cationiques et anioniques naturels comme liant pour support textile |
| BR112012019762A2 (pt) * | 2010-02-11 | 2016-02-23 | Glaxosmithkline Llc | composto, composição, e, método para tratar uma doença. |
| TWI577377B (zh) | 2010-09-16 | 2017-04-11 | Ｖｉｉｖ醫療保健公司 | 醫藥組合物 |
| WO2013020246A1 (en) | 2011-08-08 | 2013-02-14 | Glaxosmithkline Llc | Methylene derivatives of betulin |
| WO2013020245A1 (en) * | 2011-08-08 | 2013-02-14 | Glaxosmithkline Llc | Carbonyl derivatives of betulin |
| WO2013090683A1 (en) | 2011-12-14 | 2013-06-20 | Glaxosmithkline Llc | Propenoate derivatives of betulin |
| WO2013091144A1 (en) | 2011-12-21 | 2013-06-27 | Glaxosmithkline Llc | Propenoate derivatives of betulin |
| JO3387B1 (ar) | 2011-12-16 | 2019-03-13 | Glaxosmithkline Llc | مشتقات بيتولين |
| CN104844679B (zh) * | 2011-12-16 | 2017-03-01 | 葛兰素史克有限责任公司 | 白桦脂醇的衍生物 |
| US20150209273A1 (en) | 2012-08-28 | 2015-07-30 | Glaxosmithkline Llc | Pharmaceutical Compositions |
| KR20150093819A (ko) | 2012-12-14 | 2015-08-18 | 글락소스미스클라인 엘엘씨 | 약제 조성물 |
| CR20170113A (es) | 2014-09-26 | 2017-05-26 | Glaxosmilthkline Intellectual Property (No 2) Ltd | Composiciones farmacéuticas de acción prolongada |
-
2012
- 2012-12-13 JO JOP/2012/0378A patent/JO3387B1/ar active
- 2012-12-14 SI SI201231079T patent/SI2791103T1/sl unknown
- 2012-12-14 JP JP2014547462A patent/JP6300730B2/ja not_active Expired - Fee Related
- 2012-12-14 KR KR1020147019864A patent/KR101953869B1/ko not_active Expired - Fee Related
- 2012-12-14 ES ES12857774.9T patent/ES2644578T3/es active Active
- 2012-12-14 LT LTEP12857774.9T patent/LT2791103T/lt unknown
- 2012-12-14 US US14/365,802 patent/US20150218142A1/en not_active Abandoned
- 2012-12-14 EA EA201490919A patent/EA027363B1/ru not_active IP Right Cessation
- 2012-12-14 WO PCT/US2012/069637 patent/WO2013090664A1/en not_active Ceased
- 2012-12-14 MX MX2014007280A patent/MX360679B/es active IP Right Grant
- 2012-12-14 HU HUE12857774A patent/HUE034877T2/hu unknown
- 2012-12-14 HR HRP20171512TT patent/HRP20171512T1/hr unknown
- 2012-12-14 SM SM20170466T patent/SMT201700466T1/it unknown
- 2012-12-14 UA UAA201406100A patent/UA116978C2/uk unknown
- 2012-12-14 CN CN201710755281.5A patent/CN107501383A/zh active Pending
- 2012-12-14 TW TW106104296A patent/TW201730202A/zh unknown
- 2012-12-14 SG SG11201402707PA patent/SG11201402707PA/en unknown
- 2012-12-14 EA EA201790923A patent/EA201790923A1/ru unknown
- 2012-12-14 TW TW101147685A patent/TWI583696B/zh not_active IP Right Cessation
- 2012-12-14 AU AU2012352110A patent/AU2012352110B2/en not_active Ceased
- 2012-12-14 BR BR112014014769-8A patent/BR112014014769A2/pt active Search and Examination
- 2012-12-14 RS RS20170937A patent/RS56373B1/sr unknown
- 2012-12-14 ME MEP-2017-198A patent/ME02895B/me unknown
- 2012-12-14 CN CN201280069739.7A patent/CN105008322B/zh active Active
- 2012-12-14 PE PE2014000975A patent/PE20141788A1/es active IP Right Grant
- 2012-12-14 EP EP12857774.9A patent/EP2791103B1/en active Active
- 2012-12-14 PL PL12857774T patent/PL2791103T3/pl unknown
- 2012-12-14 DK DK12857774.9T patent/DK2791103T3/en active
- 2012-12-14 CA CA2859030A patent/CA2859030C/en active Active
- 2012-12-14 US US13/714,627 patent/US9102685B2/en active Active
- 2012-12-14 PT PT128577749T patent/PT2791103T/pt unknown
- 2012-12-14 EP EP17184312.1A patent/EP3263580A1/en not_active Withdrawn
- 2012-12-17 AR ARP120104775A patent/AR089285A1/es not_active Application Discontinuation
- 2012-12-17 UY UY0001034523A patent/UY34523A/es not_active Application Discontinuation
-
2014
- 2014-05-30 CO CO14117726A patent/CO6970600A2/es unknown
- 2014-06-05 ZA ZA2014/04135A patent/ZA201404135B/en unknown
- 2014-06-06 DO DO2014000121A patent/DOP2014000121A/es unknown
- 2014-06-12 IL IL233081A patent/IL233081A/en active IP Right Grant
- 2014-06-13 MA MA37132A patent/MA35833B1/fr unknown
- 2014-06-16 PH PH12014501362A patent/PH12014501362A1/en unknown
- 2014-06-16 CL CL2014001585A patent/CL2014001585A1/es unknown
- 2014-06-20 CR CR20140301A patent/CR20140301A/es unknown
- 2014-08-18 US US14/461,731 patent/US20140357643A1/en not_active Abandoned
-
2015
- 2015-12-23 US US14/757,754 patent/US20160120878A1/en not_active Abandoned
-
2017
- 2017-03-21 US US15/464,553 patent/US10064873B2/en active Active
- 2017-08-09 PH PH12017501429A patent/PH12017501429A1/en unknown
- 2017-08-09 PH PH12017501426A patent/PH12017501426A1/en unknown
- 2017-08-24 US US15/685,150 patent/US20170348324A1/en not_active Abandoned
- 2017-10-06 CY CY20171101043T patent/CY1119422T1/el unknown
-
2018
- 2018-01-04 JP JP2018000027A patent/JP2018065867A/ja not_active Withdrawn
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