JP2015501147A5 - - Google Patents
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- JP2015501147A5 JP2015501147A5 JP2014535807A JP2014535807A JP2015501147A5 JP 2015501147 A5 JP2015501147 A5 JP 2015501147A5 JP 2014535807 A JP2014535807 A JP 2014535807A JP 2014535807 A JP2014535807 A JP 2014535807A JP 2015501147 A5 JP2015501147 A5 JP 2015501147A5
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- 108010029697 CD40 Ligand Proteins 0.000 claims description 19
- 102100032937 CD40 ligand Human genes 0.000 claims description 19
- 102000008100 Human Serum Albumin Human genes 0.000 claims 12
- 108091006905 Human Serum Albumin Proteins 0.000 claims 12
- 238000000034 method Methods 0.000 claims 7
- 239000000178 monomer Substances 0.000 claims 7
- 208000023275 Autoimmune disease Diseases 0.000 claims 5
- 101150013553 CD40 gene Proteins 0.000 claims 5
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 230000001404 mediated effect Effects 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 206010025135 lupus erythematosus Diseases 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 208000023328 Basedow disease Diseases 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 208000007465 Giant cell arteritis Diseases 0.000 claims 2
- 208000015023 Graves' disease Diseases 0.000 claims 2
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 2
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
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- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
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- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims 2
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000026872 Addison Disease Diseases 0.000 claims 1
- 208000008190 Agammaglobulinemia Diseases 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims 1
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- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 1
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- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 206010018498 Goitre Diseases 0.000 claims 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
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- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
- 241000721454 Pemphigus Species 0.000 claims 1
- 208000031845 Pernicious anaemia Diseases 0.000 claims 1
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
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- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 206010072148 Stiff-Person syndrome Diseases 0.000 claims 1
- 208000001106 Takayasu Arteritis Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 230000001919 adrenal effect Effects 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 208000004631 alopecia areata Diseases 0.000 claims 1
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- 230000002491 angiogenic effect Effects 0.000 claims 1
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- 230000001363 autoimmune Effects 0.000 claims 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 208000000594 bullous pemphigoid Diseases 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 201000003278 cryoglobulinemia Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
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- 239000013604 expression vector Substances 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 201000011066 hemangioma Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 229920000592 inorganic polymer Polymers 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 201000011486 lichen planus Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 125000003588 lysine group Chemical class [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
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- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
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- 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 206010034674 peritonitis Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 201000006292 polyarteritis nodosa Diseases 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108020001580 protein domains Proteins 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
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- 201000000306 sarcoidosis Diseases 0.000 claims 1
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- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 5
- 239000013078 crystal Substances 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161546028P | 2011-10-11 | 2011-10-11 | |
| US61/546,028 | 2011-10-11 | ||
| PCT/US2012/059477 WO2013055745A2 (en) | 2011-10-11 | 2012-10-10 | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017090963A Division JP6539300B2 (ja) | 2011-10-11 | 2017-05-01 | ＣＤ４０Ｌ特異的Ｔｎ３由来足場およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015501147A JP2015501147A (ja) | 2015-01-15 |
| JP2015501147A5 true JP2015501147A5 (enExample) | 2015-12-10 |
| JP6140712B2 JP6140712B2 (ja) | 2017-05-31 |
Family
ID=48082729
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014535807A Active JP6140712B2 (ja) | 2011-10-11 | 2012-10-10 | ＣＤ４０Ｌ特異的Ｔｎ３由来足場およびその使用方法 |
| JP2017090963A Active JP6539300B2 (ja) | 2011-10-11 | 2017-05-01 | ＣＤ４０Ｌ特異的Ｔｎ３由来足場およびその使用方法 |
| JP2019106642A Active JP7068231B2 (ja) | 2011-10-11 | 2019-06-07 | ＣＤ４０Ｌ特異的Ｔｎ３由来足場およびその使用方法 |
| JP2022073975A Active JP7560507B2 (ja) | 2011-10-11 | 2022-04-28 | ＣＤ４０Ｌ特異的Ｔｎ３由来足場およびその使用方法 |
| JP2024161632A Pending JP2025000710A (ja) | 2011-10-11 | 2024-09-19 | ＣＤ４０Ｌ特異的Ｔｎ３由来足場およびその使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017090963A Active JP6539300B2 (ja) | 2011-10-11 | 2017-05-01 | ＣＤ４０Ｌ特異的Ｔｎ３由来足場およびその使用方法 |
| JP2019106642A Active JP7068231B2 (ja) | 2011-10-11 | 2019-06-07 | ＣＤ４０Ｌ特異的Ｔｎ３由来足場およびその使用方法 |
| JP2022073975A Active JP7560507B2 (ja) | 2011-10-11 | 2022-04-28 | ＣＤ４０Ｌ特異的Ｔｎ３由来足場およびその使用方法 |
| JP2024161632A Pending JP2025000710A (ja) | 2011-10-11 | 2024-09-19 | ＣＤ４０Ｌ特異的Ｔｎ３由来足場およびその使用方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US10000553B2 (enExample) |
| EP (2) | EP3753567A1 (enExample) |
| JP (5) | JP6140712B2 (enExample) |
| KR (4) | KR102132997B1 (enExample) |
| CN (3) | CN116063509A (enExample) |
| AU (1) | AU2012323316B2 (enExample) |
| BR (1) | BR112014008804A2 (enExample) |
| CA (1) | CA2851667A1 (enExample) |
| CY (1) | CY1123690T1 (enExample) |
| DK (1) | DK2771022T3 (enExample) |
| ES (1) | ES2819075T3 (enExample) |
| HR (1) | HRP20201513T1 (enExample) |
| HU (1) | HUE051439T2 (enExample) |
| LT (1) | LT2771022T (enExample) |
| MX (2) | MX367013B (enExample) |
| PT (1) | PT2771022T (enExample) |
| RS (1) | RS60828B1 (enExample) |
| RU (1) | RU2704992C2 (enExample) |
| SG (2) | SG11201400567QA (enExample) |
| SI (1) | SI2771022T1 (enExample) |
| SM (1) | SMT202000513T1 (enExample) |
| WO (1) | WO2013055745A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8956849B2 (en) * | 2007-11-01 | 2015-02-17 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses to Eimeria |
| DK2771022T3 (da) | 2011-10-11 | 2020-09-28 | Viela Bio Inc | Cd40l-specifikke tn3-afledte skeletter (scaffolds) og fremgangsmåder til anvendelse deraf |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| RS62003B2 (sr) | 2014-11-10 | 2025-01-31 | Medimmune Ltd | Vezujući molekuli specifični za cd73 i njihove upotrebe |
| US10683340B2 (en) | 2015-03-12 | 2020-06-16 | Medimmune, Llc | Method of purifying albumin-fusion proteins |
| KR101810778B1 (ko) * | 2015-06-23 | 2017-12-20 | 서울대학교산학협력단 | Cd154 결합 폴리펩타이드 및 그 용도 |
| CN107921128B (zh) | 2015-08-05 | 2022-04-26 | 詹森生物科技公司 | 抗cd154抗体及其使用方法 |
| SG11201906313SA (en) * | 2017-01-09 | 2019-08-27 | Biomunex Pharmaceuticals | A polypeptide linker for preparing multispecific antibodies |
| WO2019108541A1 (en) * | 2017-11-28 | 2019-06-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant rsv g proteins and their use |
| WO2020068723A1 (en) * | 2018-09-24 | 2020-04-02 | Janssen Biotech, Inc. | Method of providing safe administration of an anti-cd154 antibody |
| BR112021005614A2 (pt) * | 2018-09-26 | 2021-06-29 | Viela Bio, Inc. | antagonista de cd40l e seus usos |
| US12247320B2 (en) | 2018-10-24 | 2025-03-11 | Brandeis University | Multivalent glycopeptides that tightly bind to carbohydrate-binding monoclonal antibody family PGT128 |
| KR102713267B1 (ko) | 2018-12-28 | 2024-10-04 | 스팍스 테라퓨틱스 인크. | 암 및 다른 질환을 치료하기 위한 클라우딘 18.2에 특이적인 결합 분자, 이의 조성물 및 방법 |
| CN111440253B (zh) * | 2019-01-17 | 2021-08-27 | 中国科学院上海药物研究所 | 立方形环糊精骨架-rgd组合物及其制备方法 |
| JP2024519904A (ja) * | 2021-05-21 | 2024-05-21 | ビエラ バイオ インコーポレイテッド | Ｃｄ４０ｌアンタゴニスト及びループス腎炎の治療におけるその使用 |
| WO2024211211A1 (en) | 2023-04-03 | 2024-10-10 | Regeneron Pharmaceuticals, Inc. | Methods of improving transplant survival using il-2 receptor gamma chain antibodies |
| AU2024262779A1 (en) | 2023-04-28 | 2025-12-11 | Fortvita Biologics Inc. | Anti-cd40l antibody and use thereof in treatment of human autoimmune diseases |
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| US4666884A (en) | 1984-04-10 | 1987-05-19 | New England Deaconess Hospital | Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls |
| DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
| JP3319594B2 (ja) | 1990-03-20 | 2002-09-03 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | 定常領域の代わりに受容体結合性リガンドを有するキメラ抗体 |
| WO1991015581A1 (en) | 1990-04-05 | 1991-10-17 | Roberto Crea | Walk-through mutagenesis |
| US7063943B1 (en) | 1990-07-10 | 2006-06-20 | Cambridge Antibody Technology | Methods for producing members of specific binding pairs |
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| US5866344A (en) | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| US5440018A (en) | 1992-05-20 | 1995-08-08 | The Green Cross Corporation | Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same |
| WO1994004670A1 (en) | 1992-08-26 | 1994-03-03 | President And Fellows Of Harvard College | Use of the cytokine ip-10 as an anti-tumor agent |
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| US5747035A (en) | 1995-04-14 | 1998-05-05 | Genentech, Inc. | Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor |
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| WO1997043316A1 (en) | 1996-05-10 | 1997-11-20 | Beth Israel Deaconess Medical Center, Inc. | Physiologically active molecules with extended half-lives and methods of using same |
| US6699658B1 (en) | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| EP2380906A2 (en) | 1997-06-12 | 2011-10-26 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
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