MX367013B - Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo. - Google Patents

Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo.

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Publication number
MX367013B
MX367013B MX2014004065A MX2014004065A MX367013B MX 367013 B MX367013 B MX 367013B MX 2014004065 A MX2014004065 A MX 2014004065A MX 2014004065 A MX2014004065 A MX 2014004065A MX 367013 B MX367013 B MX 367013B
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MX
Mexico
Prior art keywords
cd40l
methods
specific
scaffolds
derived scaffolds
Prior art date
Application number
MX2014004065A
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English (en)
Other versions
MX2014004065A (es
Inventor
Coyle Anthony
Baca Manuel
Thisted Thomas
Drabic Stacey
Grinberg Luba
Novarra Shabazz
Oganesyan Vaheh
Kenneth Spencer David
Herbst Ronald
Original Assignee
Medimmune Llc
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Publication date
Application filed by Medimmune Llc filed Critical Medimmune Llc
Publication of MX2014004065A publication Critical patent/MX2014004065A/es
Publication of MX367013B publication Critical patent/MX367013B/es

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    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • G—PHYSICS
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Abstract

La presente invención proporciona matrices de soporte basadas en el dominio FnIII de la tenascina 3 que se unen específicamente a CD4OL. La invención proporciona además variantes modificadas con una mayor afinidad por la diana. La presente invención también se refiere a matrices de soporte diseñadas como agentes profilácticos, terapéuticos o de diagnóstico, en particular para usos terapéuticos contra el LES y otras enfermedades y afecciones autoinmunes.
MX2014004065A 2011-10-11 2012-10-10 Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo. MX367013B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161546028P 2011-10-11 2011-10-11
PCT/US2012/059477 WO2013055745A2 (en) 2011-10-11 2012-10-10 Cd40l-specific tn3-derived scaffolds and methods of use thereof

Publications (2)

Publication Number Publication Date
MX2014004065A MX2014004065A (es) 2014-08-22
MX367013B true MX367013B (es) 2019-08-02

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ID=48082729

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014004065A MX367013B (es) 2011-10-11 2012-10-10 Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo.
MX2019009104A MX2019009104A (es) 2011-10-11 2014-04-03 Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo.

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MX2019009104A MX2019009104A (es) 2011-10-11 2014-04-03 Matrices de soporte derivadas de tn3 especificas para cd40l y sus metodos de empleo.

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US (5) US10000553B2 (es)
EP (2) EP3753567A1 (es)
JP (5) JP6140712B2 (es)
KR (4) KR20240142616A (es)
CN (3) CN108948196B (es)
AU (1) AU2012323316B2 (es)
BR (1) BR112014008804A2 (es)
CA (1) CA2851667A1 (es)
CY (1) CY1123690T1 (es)
DK (1) DK2771022T3 (es)
ES (1) ES2819075T3 (es)
HR (1) HRP20201513T1 (es)
HU (1) HUE051439T2 (es)
LT (1) LT2771022T (es)
MX (2) MX367013B (es)
PT (1) PT2771022T (es)
RS (1) RS60828B1 (es)
RU (1) RU2704992C2 (es)
SG (2) SG11201400567QA (es)
SI (1) SI2771022T1 (es)
SM (1) SMT202000513T1 (es)
WO (1) WO2013055745A2 (es)

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CA2851667A1 (en) 2011-10-11 2013-04-18 Medimmune, Llc Cd40l-specific tn3-derived scaffolds and methods of use thereof
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
PT3218406T (pt) 2014-11-10 2021-06-17 Medimmune Ltd Moléculas de ligação específicas para cd73 e seus usos
KR20240093725A (ko) * 2015-03-12 2024-06-24 메디뮨 엘엘씨 알부민 융합 단백질의 정제 방법
KR101810778B1 (ko) * 2015-06-23 2017-12-20 서울대학교산학협력단 Cd154 결합 폴리펩타이드 및 그 용도
EA201890434A1 (ru) 2015-08-05 2018-10-31 Янссен Байотек, Инк. Антитела к cd154 и способы их применения
IL267886B2 (en) * 2017-01-09 2024-11-01 Biomunex Pharmaceuticals A polypeptide linker for preparing multispecific antibodies
US11905313B2 (en) * 2017-11-28 2024-02-20 The United States of America, as represented by the Secretary, Department of Health and Human Services. Recombinant RSV G proteins and their use
US20210317220A1 (en) * 2018-09-24 2021-10-14 Janssen Biotech, Inc. Method of providing safe administration of an anti-cd154 antibody
KR20210110287A (ko) * 2018-09-26 2021-09-07 비엘라 바이오, 인크. Cd40l 길항제 및 이의 용도
WO2020086885A2 (en) * 2018-10-24 2020-04-30 Brandeis University Multivalent glycopeptides that tightly bind to carbohydrate-binding monoclonal antibody family pgt128
WO2020139956A1 (en) 2018-12-28 2020-07-02 Sparx Therapeutics Inc. Binding molecules specific for claudin 18.2, compositons and methods thereof, for treatment of cancer and other diseases
CN111440253B (zh) * 2019-01-17 2021-08-27 中国科学院上海药物研究所 立方形环糊精骨架-rgd组合物及其制备方法
EP4340867A1 (en) * 2021-05-21 2024-03-27 Viela Bio, Inc. Cd40l antagonist and uses thereof in the treatment of lupus nephritis
WO2024211211A1 (en) 2023-04-03 2024-10-10 Regeneron Pharmaceuticals, Inc. Methods of improving transplant survival using il-2 receptor gamma chain antibodies
WO2024222895A1 (zh) 2023-04-28 2024-10-31 信达生物制药(苏州)有限公司 抗cd40l抗体及其在人自身免疫疾病治疗的应用

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