HK1213471A1 - 作為蛋白脫乙酰基酶抑制劑的嘧啶羥基酰胺化合物及其使用方法 - Google Patents

作為蛋白脫乙酰基酶抑制劑的嘧啶羥基酰胺化合物及其使用方法

Info

Publication number
HK1213471A1
HK1213471A1 HK16101257.8A HK16101257A HK1213471A1 HK 1213471 A1 HK1213471 A1 HK 1213471A1 HK 16101257 A HK16101257 A HK 16101257A HK 1213471 A1 HK1213471 A1 HK 1213471A1
Authority
HK
Hong Kong
Prior art keywords
methods
amide compounds
deacetylase inhibitors
hydroxy amide
protein deacetylase
Prior art date
Application number
HK16101257.8A
Other languages
English (en)
Inventor
Olivier Roland Berton
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of HK1213471A1 publication Critical patent/HK1213471A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK16101257.8A 2012-10-12 2016-02-03 作為蛋白脫乙酰基酶抑制劑的嘧啶羥基酰胺化合物及其使用方法 HK1213471A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261713014P 2012-10-12 2012-10-12
PCT/US2013/064593 WO2014059306A1 (en) 2012-10-12 2013-10-11 Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof

Publications (1)

Publication Number Publication Date
HK1213471A1 true HK1213471A1 (zh) 2016-07-08

Family

ID=50477933

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16101257.8A HK1213471A1 (zh) 2012-10-12 2016-02-03 作為蛋白脫乙酰基酶抑制劑的嘧啶羥基酰胺化合物及其使用方法

Country Status (5)

Country Link
US (1) US20150250786A1 (zh)
EP (1) EP2906211A4 (zh)
JP (1) JP2015533173A (zh)
HK (1) HK1213471A1 (zh)
WO (1) WO2014059306A1 (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9145412B2 (en) 2012-11-02 2015-09-29 Acetylon Pharmaceuticals, Inc. Selective HDAC1 and HDAC2 inhibitors
JP6626437B2 (ja) 2013-10-08 2019-12-25 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． ヒストンデアセチラーゼ阻害剤とＨｅｒ２阻害剤またはＰＩ３Ｋ阻害剤のいずれかの組み合わせ
ES2806258T3 (es) 2013-12-03 2021-02-17 Acetylon Pharmaceuticals Inc Combinaciones de inhibidores de histona desacetilasa y fármacos inmunomoduladores
US9464073B2 (en) 2014-02-26 2016-10-11 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
WO2016090230A1 (en) * 2014-12-05 2016-06-09 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds for treating peripheral neuropathy
US10272084B2 (en) 2015-06-01 2019-04-30 Regenacy Pharmaceuticals, Llc Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy
AR105812A1 (es) 2015-06-08 2017-11-15 Acetylon Pharmaceuticals Inc Métodos para la preparación de inhibidores de proteína deacetilasa
AR104935A1 (es) 2015-06-08 2017-08-23 Acetylon Pharmaceuticals Inc Formas cristalinas de un inhibidor de histona deacetilasa
WO2018031472A1 (en) 2016-08-08 2018-02-15 Acetylon Pharmaceuticals Inc. Pharmaceutical combinations of histone deacetylase 6 inhibitors and cd20 inhibitory antibodies and uses thereof
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
WO2018191360A1 (en) * 2017-04-11 2018-10-18 The General Hospital Corporation Hdac6 inhibitors and imaging agents
IL307883A (en) 2021-04-23 2023-12-01 Tenaya Therapeutics Inc HDAC6 inhibitors for use in the treatment of dilated myocardial disease
KR20240016950A (ko) 2021-05-04 2024-02-06 테나야 테라퓨틱스, 인코포레이티드 대사 질환 및 hfpef의 치료에 사용하기 위한 2-플루오로알킬-1,3,4-옥사디아졸-5-일-티아졸, hdac6 억제제
US20240139187A1 (en) * 2022-10-12 2024-05-02 The Children's Medical Center Corporation Selective hypothalamus permeable hdac6 inhibitors for treatment of leptin-resistant obesity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1917244A2 (de) * 2005-08-24 2008-05-07 Abbott GmbH & Co. KG Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
JP2012051851A (ja) * 2010-09-02 2012-03-15 Nagoya City Univ 抗うつ薬及びその用途
JP6041808B2 (ja) * 2010-11-16 2016-12-14 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 蛋白質脱アセチル化酵素抑制剤としてのピリミジン水酸基アミド化合物およびその利用方法

Also Published As

Publication number Publication date
WO2014059306A1 (en) 2014-04-17
US20150250786A1 (en) 2015-09-10
EP2906211A1 (en) 2015-08-19
EP2906211A4 (en) 2016-04-20
JP2015533173A (ja) 2015-11-19

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