CA2851667A1 - Cd40l-specific tn3-derived scaffolds and methods of use thereof - Google Patents

Cd40l-specific tn3-derived scaffolds and methods of use thereof Download PDF

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Publication number
CA2851667A1
CA2851667A1 CA2851667A CA2851667A CA2851667A1 CA 2851667 A1 CA2851667 A1 CA 2851667A1 CA 2851667 A CA2851667 A CA 2851667A CA 2851667 A CA2851667 A CA 2851667A CA 2851667 A1 CA2851667 A1 CA 2851667A1
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sequence
scaffold
seq
comprises seq
loop comprises
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French (fr)
Inventor
Anthony Coyle
Manuel Baca
Thomas Thisted
Stacey DRABIC
Luba Grinberg
Shabazz NOVARRA
Vaheh Oganesyan
Ronald Herbst
David Kenneth Spencer
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Viela Bio Inc
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MedImmune LLC
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C07K2319/00—Fusion polypeptide
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  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
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  • Endocrinology (AREA)
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  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Computing Systems (AREA)
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  • Rheumatology (AREA)
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CA2851667A 2011-10-11 2012-10-10 Cd40l-specific tn3-derived scaffolds and methods of use thereof Pending CA2851667A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161546028P 2011-10-11 2011-10-11
US61/546,028 2011-10-11
PCT/US2012/059477 WO2013055745A2 (en) 2011-10-11 2012-10-10 Cd40l-specific tn3-derived scaffolds and methods of use thereof

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Publication Number Publication Date
CA2851667A1 true CA2851667A1 (en) 2013-04-18

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CA2851667A Pending CA2851667A1 (en) 2011-10-11 2012-10-10 Cd40l-specific tn3-derived scaffolds and methods of use thereof

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Country Link
US (5) US10000553B2 (enExample)
EP (2) EP2771022B1 (enExample)
JP (5) JP6140712B2 (enExample)
KR (4) KR20220116585A (enExample)
CN (3) CN116063509A (enExample)
AU (1) AU2012323316B2 (enExample)
BR (1) BR112014008804A2 (enExample)
CA (1) CA2851667A1 (enExample)
CY (1) CY1123690T1 (enExample)
DK (1) DK2771022T3 (enExample)
ES (1) ES2819075T3 (enExample)
HR (1) HRP20201513T1 (enExample)
HU (1) HUE051439T2 (enExample)
LT (1) LT2771022T (enExample)
MX (2) MX367013B (enExample)
PT (1) PT2771022T (enExample)
RS (1) RS60828B1 (enExample)
RU (1) RU2704992C2 (enExample)
SG (2) SG10201707813YA (enExample)
SI (1) SI2771022T1 (enExample)
SM (1) SMT202000513T1 (enExample)
WO (1) WO2013055745A2 (enExample)

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KR20220116585A (ko) 2011-10-11 2022-08-23 비엘라 바이오, 인크. Cd40l 특이적 tn3 유래 스카폴드 및 이의 사용 방법
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
KR102781223B1 (ko) 2014-11-10 2025-03-12 메디뮨 리미티드 Cd73에 특이적인 결합 분자 및 이의 용도
CN107428817B (zh) * 2015-03-12 2022-07-12 免疫医疗有限责任公司 纯化白蛋白融合蛋白的方法
KR101810778B1 (ko) * 2015-06-23 2017-12-20 서울대학교산학협력단 Cd154 결합 폴리펩타이드 및 그 용도
EA201890434A1 (ru) 2015-08-05 2018-10-31 Янссен Байотек, Инк. Антитела к cd154 и способы их применения
IL267886B2 (en) * 2017-01-09 2024-11-01 Biomunex Pharmaceuticals A polypeptide linker for preparing multispecific antibodies
US11905313B2 (en) * 2017-11-28 2024-02-20 The United States of America, as represented by the Secretary, Department of Health and Human Services. Recombinant RSV G proteins and their use
WO2020068723A1 (en) * 2018-09-24 2020-04-02 Janssen Biotech, Inc. Method of providing safe administration of an anti-cd154 antibody
JP7596261B2 (ja) * 2018-09-26 2024-12-09 ビエラ バイオ インコーポレイテッド Ｃｄ４０ｌアンタゴニスト及びその使用
WO2020086885A2 (en) * 2018-10-24 2020-04-30 Brandeis University Multivalent glycopeptides that tightly bind to carbohydrate-binding monoclonal antibody family pgt128
CN113227135B (zh) 2018-12-28 2025-03-21 斯帕克斯治疗公司 用于治疗癌症和其他疾病的对紧密连接蛋白18.2具有特异性的结合分子、其组合物和方法
CN111440253B (zh) * 2019-01-17 2021-08-27 中国科学院上海药物研究所 立方形环糊精骨架-rgd组合物及其制备方法
AU2022276507A1 (en) * 2021-05-21 2023-12-07 Viela Bio, Inc. Cd40l antagonist and uses thereof in the treatment of lupus nephritis
EP4688856A1 (en) 2023-04-03 2026-02-11 Regeneron Pharmaceuticals, Inc. Methods of improving transplant survival using il-2 receptor gamma chain antibodies
AU2024262779A1 (en) 2023-04-28 2025-12-11 Fortvita Biologics Inc. Anti-cd40l antibody and use thereof in treatment of human autoimmune diseases

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