JP2015500342A5 - - Google Patents
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- JP2015500342A5 JP2015500342A5 JP2014547445A JP2014547445A JP2015500342A5 JP 2015500342 A5 JP2015500342 A5 JP 2015500342A5 JP 2014547445 A JP2014547445 A JP 2014547445A JP 2014547445 A JP2014547445 A JP 2014547445A JP 2015500342 A5 JP2015500342 A5 JP 2015500342A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pva
- particle
- composition
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002245 particle Substances 0.000 claims description 86
- 239000008194 pharmaceutical composition Substances 0.000 claims description 55
- 238000000034 method Methods 0.000 claims description 50
- 239000000203 mixture Substances 0.000 claims description 46
- 229940079593 drug Drugs 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 238000007710 freezing Methods 0.000 claims description 10
- 230000008014 freezing Effects 0.000 claims description 10
- 229930006000 Sucrose Natural products 0.000 claims description 8
- 238000004108 freeze drying Methods 0.000 claims description 8
- 239000005720 sucrose Substances 0.000 claims description 8
- 229930012538 Paclitaxel Natural products 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 239000007900 aqueous suspension Substances 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 230000002209 hydrophobic effect Effects 0.000 claims description 4
- 230000003993 interaction Effects 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 4
- 229960001592 paclitaxel Drugs 0.000 claims description 4
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 125000000185 sucrose group Chemical group 0.000 claims description 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 4
- 238000010257 thawing Methods 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 230000002776 aggregation Effects 0.000 claims description 2
- 238000004220 aggregation Methods 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161570735P | 2011-12-14 | 2011-12-14 | |
| US61/570,735 | 2011-12-14 | ||
| PCT/US2012/069585 WO2013090634A1 (en) | 2011-12-14 | 2012-12-13 | Use of polymeric excipients for lyophilization or freezing of particles |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017183764A Division JP2017218462A (ja) | 2011-12-14 | 2017-09-25 | 粒子を凍結乾燥または凍結するためのポリマー賦形剤の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500342A JP2015500342A (ja) | 2015-01-05 |
| JP2015500342A5 true JP2015500342A5 (https=) | 2016-01-28 |
| JP6216721B2 JP6216721B2 (ja) | 2017-10-18 |
Family
ID=48613191
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547445A Active JP6216721B2 (ja) | 2011-12-14 | 2012-12-13 | 粒子を凍結乾燥または凍結するためのポリマー賦形剤の使用 |
| JP2017183764A Pending JP2017218462A (ja) | 2011-12-14 | 2017-09-25 | 粒子を凍結乾燥または凍結するためのポリマー賦形剤の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017183764A Pending JP2017218462A (ja) | 2011-12-14 | 2017-09-25 | 粒子を凍結乾燥または凍結するためのポリマー賦形剤の使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US9585960B2 (https=) |
| EP (2) | EP3560486A1 (https=) |
| JP (2) | JP6216721B2 (https=) |
| KR (2) | KR102203555B1 (https=) |
| CN (2) | CN104114159B (https=) |
| AU (2) | AU2012352167B2 (https=) |
| BR (1) | BR112014014323A2 (https=) |
| CA (1) | CA2858593C (https=) |
| CY (1) | CY1122105T1 (https=) |
| DK (1) | DK2790675T3 (https=) |
| ES (1) | ES2746057T3 (https=) |
| HR (1) | HRP20191567T1 (https=) |
| HU (1) | HUE045661T2 (https=) |
| IL (1) | IL233000B (https=) |
| LT (1) | LT2790675T (https=) |
| ME (1) | ME03532B (https=) |
| MX (2) | MX354859B (https=) |
| PL (1) | PL2790675T3 (https=) |
| PT (1) | PT2790675T (https=) |
| RS (1) | RS59322B1 (https=) |
| RU (2) | RU2705998C2 (https=) |
| SI (1) | SI2790675T1 (https=) |
| SM (1) | SMT201900502T1 (https=) |
| WO (1) | WO2013090634A1 (https=) |
| ZA (1) | ZA201404262B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| SI1853250T1 (sl) | 2005-02-18 | 2012-01-31 | Abraxis Bioscience Llc | Kombinacije in reĹľimi dajanja terapevtskih sredstev in kombinirana terapija |
| EP3470071A1 (en) | 2006-12-14 | 2019-04-17 | Abraxis BioScience, LLC | Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane |
| HRP20192259T1 (hr) | 2009-04-15 | 2020-03-06 | Abraxis Bioscience, Llc | Pripravci nanočestica bez priona i metode njihove proizvodnje |
| CA3051495A1 (en) | 2010-03-26 | 2011-09-29 | Abraxis Bioscience, Llc | Use of nanoparticles comprising a taxane and albumin in the treatment of hepatocellular carcinoma |
| KR20130028727A (ko) | 2010-03-29 | 2013-03-19 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 약물 전달 및 유효성 향상 방법 |
| NZ717490A (en) | 2010-03-29 | 2017-12-22 | Abraxis Bioscience Llc | Methods of treating cancer |
| BR112012030909A2 (pt) | 2010-06-04 | 2020-08-18 | Abraxis Bioscience, Llc | métodos de tratamento de câncer pancreático |
| JP6038123B2 (ja) | 2011-04-28 | 2016-12-07 | アブラクシス バイオサイエンス， エルエルシー | ナノ粒子組成物の脈管内送達およびそれらの使用 |
| JP6216721B2 (ja) * | 2011-12-14 | 2017-10-18 | アブラクシス バイオサイエンス， エルエルシー | 粒子を凍結乾燥または凍結するためのポリマー賦形剤の使用 |
| US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
| US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
| EP3698784A1 (en) | 2013-03-12 | 2020-08-26 | Abraxis BioScience, LLC | Methods of treating lung cancer |
| EP2968191B1 (en) | 2013-03-14 | 2021-06-16 | Abraxis BioScience, LLC | Methods of treating bladder cancer |
| US10705070B1 (en) | 2015-03-05 | 2020-07-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug |
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| PL3998069T3 (pl) | 2015-06-29 | 2025-03-31 | Abraxis Bioscience, Llc | Nanocząsteczki zawierające syrolimus i albuminę do zastosowania w leczeniu nowotworów z komórek nabłonkowatych |
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| RU2681933C1 (ru) * | 2018-11-28 | 2019-03-14 | Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" | Способ получения полимерных противоопухолевых частиц в проточном микрореакторе и лиофилизата на их основе |
| JP7832108B2 (ja) | 2019-10-28 | 2026-03-17 | アブラクシス バイオサイエンス， エルエルシー | アルブミンおよびラパマイシンの医薬組成物 |
| US12178921B2 (en) | 2020-08-14 | 2024-12-31 | Arcturus Therapeutics, Inc. | Method of lyophilizing lipid nanoparticles |
| WO2024046448A1 (en) * | 2022-09-02 | 2024-03-07 | Suzhou Abogen Biosciences Co., Ltd. | Lyophilized formulations and liquid formulations of lipid nanoparticles |
| WO2024077054A1 (en) * | 2022-10-05 | 2024-04-11 | Purdue Research Foundation | Excipient-free lyophilization of polymer lung surfactants |
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| PL3998069T3 (pl) | 2015-06-29 | 2025-03-31 | Abraxis Bioscience, Llc | Nanocząsteczki zawierające syrolimus i albuminę do zastosowania w leczeniu nowotworów z komórek nabłonkowatych |
| HK1247093A1 (zh) | 2015-06-29 | 2018-09-21 | 阿布拉科斯生物科学有限公司 | 使用纳米颗粒mtor抑制剂联合疗法治疗实体瘤的方法 |
| US20180256551A1 (en) | 2015-06-29 | 2018-09-13 | Abraxis Bioscience, Llc | Methods of treating hematological malignancy using nanoparticle mtor inhibitor combination therapy |
| US20170181988A1 (en) | 2015-12-23 | 2017-06-29 | Cipla Limited | Methods for the treatment of bladder cancer |
| WO2017201189A1 (en) | 2016-05-17 | 2017-11-23 | Abraxis Bioscience, Llc | Methods for assessing neoadjuvant therapies |
| US20190247357A1 (en) | 2016-10-10 | 2019-08-15 | Abraxis Bioscience, Llc | Nanoparticle formulations and methods of making and using thereof |
| US20180374583A1 (en) | 2017-05-16 | 2018-12-27 | Abraxis Bioscience, Llc | Nomogram and survival predictions for pancreatic cancer |
| EA202091514A1 (ru) | 2017-12-19 | 2020-09-15 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | СПОСОБЫ ЛЕЧЕНИЯ РАКА ТОЛСТОЙ КИШКИ С ИСПОЛЬЗОВАНИЕМ КОМБИНИРОВАННОЙ ТЕРАПИИ НАНОЧАСТИЦАМИ С ИНГИБИТОРОМ mTOR |
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