JP2019534897A5 - - Google Patents
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- JP2019534897A5 JP2019534897A5 JP2019541672A JP2019541672A JP2019534897A5 JP 2019534897 A5 JP2019534897 A5 JP 2019534897A5 JP 2019541672 A JP2019541672 A JP 2019541672A JP 2019541672 A JP2019541672 A JP 2019541672A JP 2019534897 A5 JP2019534897 A5 JP 2019534897A5
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- JP
- Japan
- Prior art keywords
- therapeutic agent
- sensitive polymer
- nanoparticles
- preparation
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 claims 20
- 229940124597 therapeutic agent Drugs 0.000 claims 20
- 238000002360 preparation method Methods 0.000 claims 13
- 239000002105 nanoparticle Substances 0.000 claims 12
- 229920000642 polymer Polymers 0.000 claims 12
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 102000004877 Insulin Human genes 0.000 claims 3
- 108090001061 Insulin Proteins 0.000 claims 3
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 3
- 230000002378 acidificating effect Effects 0.000 claims 3
- 239000012736 aqueous medium Substances 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 3
- 229940125396 insulin Drugs 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- 230000007935 neutral effect Effects 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- 229920002807 Thiomer Polymers 0.000 claims 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 208000001380 Diabetic Ketoacidosis Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 229960002964 adalimumab Drugs 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 229940126586 small molecule drug Drugs 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 229960003989 tocilizumab Drugs 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/291,480 | 2016-10-12 | ||
| US15/291,480 US11491114B2 (en) | 2016-10-12 | 2016-10-12 | Formulations for enteric delivery of therapeutic agents |
| PCT/US2017/056320 WO2018071655A1 (en) | 2016-10-12 | 2017-10-12 | Formulations for enteric delivery of therapeutic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019534897A JP2019534897A (ja) | 2019-12-05 |
| JP2019534897A5 true JP2019534897A5 (https=) | 2020-11-19 |
| JP7046081B2 JP7046081B2 (ja) | 2022-04-01 |
Family
ID=61830540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019541672A Active JP7046081B2 (ja) | 2016-10-12 | 2017-10-12 | 治療薬の腸内送達のための製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11491114B2 (https=) |
| EP (1) | EP3525772A4 (https=) |
| JP (1) | JP7046081B2 (https=) |
| KR (2) | KR102580705B1 (https=) |
| CN (1) | CN110049759A (https=) |
| AU (2) | AU2017341753B2 (https=) |
| CA (1) | CA3078570A1 (https=) |
| WO (1) | WO2018071655A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019097251A1 (en) * | 2017-11-17 | 2019-05-23 | Intract Pharma Limited | Novel compositions |
| BR112021019612A2 (pt) * | 2019-04-01 | 2021-11-30 | Genentech Inc | Formulações, recipiente, artigo de fabricação, método para produzir a formulação e método para inibir a agregação de uma proteína presente em uma solução aquosa |
| CN111743880B (zh) * | 2020-06-05 | 2022-03-08 | 浙江大学医学院附属第一医院 | 一种单抗类药物口服纳米-微球制剂及其制备方法 |
| US11365248B2 (en) | 2020-06-29 | 2022-06-21 | Anovent Pharmaceutical (U.S.), Llc | Formulation of tocilizumab and method for treating COVID-19 by inhalation |
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| IL68769A (en) | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
| JPS6051106A (ja) * | 1983-08-31 | 1985-03-22 | Yamanouchi Pharmaceut Co Ltd | 塩酸アモスラロ−ル持続性製剤 |
| WO1993000077A1 (en) | 1991-06-21 | 1993-01-07 | University Of Cincinnati | Orally administrable therapeutic proteins and method of making |
| ATE167396T1 (de) | 1993-02-22 | 1998-07-15 | Alza Corp | Mittel zur oralen gabe von wirkstoffen |
| AU698393B2 (en) | 1994-06-24 | 1998-10-29 | Immunex Corporation | Controlled release polypeptide compositions and methods of treating inflammatory bowel disease |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US5916595A (en) * | 1997-12-12 | 1999-06-29 | Andrx Pharmaceutials, Inc. | HMG co-reductase inhibitor |
| FR2775435B1 (fr) | 1998-02-27 | 2000-05-26 | Bioalliance Pharma | Nanoparticules comprenant au moins un polymere et au moins un compose apte a complexer un ou plusieurs principes actifs |
| FR2786098B1 (fr) * | 1998-11-20 | 2003-05-30 | Flamel Tech Sa | Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication |
| EP1429731B1 (en) | 2001-09-19 | 2007-01-03 | Elan Pharma International Limited | Nanoparticulate insulin formulations |
| US20040234602A1 (en) | 2001-09-21 | 2004-11-25 | Gina Fischer | Polymer release system |
| US20040038303A1 (en) * | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
| AU2004277419B2 (en) * | 2003-09-30 | 2007-10-11 | Brown University Research Foundation | Nanoparticulate therapeutic biologically active agents |
| US20050170004A1 (en) | 2003-10-31 | 2005-08-04 | Vered Rosenberger | Nanoparticles for drug delivery |
| KR100638041B1 (ko) * | 2003-12-24 | 2006-10-23 | 주식회사 삼양사 | 수용성 약물의 경구투여용 나노입자 조성물 및 그의제조방법 |
| US20040224019A1 (en) | 2004-03-03 | 2004-11-11 | Adi Shefer | Oral controlled release system for targeted drug delivery into the cell and its nucleus for gene therapy, DNA vaccination, and administration of gene based drugs |
| US7282194B2 (en) | 2004-10-05 | 2007-10-16 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US7541028B2 (en) | 2005-01-04 | 2009-06-02 | Gp Medical, Inc. | Nanoparticles for monoclonal antibody delivery |
| US7291598B2 (en) | 2005-01-04 | 2007-11-06 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| EP1933862B1 (en) | 2005-09-06 | 2014-03-26 | Oramed Pharmaceuticals Inc. | Methods and compositions for oral administration of proteins |
| WO2007032018A1 (en) * | 2005-09-15 | 2007-03-22 | Council Of Scientific And Industrial Research | pH SENSITIVE NANOPARTICLE FORMULATION FOR ORAL DELIVERY OF PROTEINS/PEPTIDES |
| US20080241260A1 (en) * | 2005-09-28 | 2008-10-02 | Padma Venkitachalam Devarajan | Compositions for Enhanced Absorption of Biologically Active Agents |
| WO2008031770A2 (en) | 2006-09-12 | 2008-03-20 | Cosmo Technologies Ltd | Pharmaceutical compositions for the oral or rectal administration of protein substances |
| WO2008073558A2 (en) | 2006-10-05 | 2008-06-19 | The Johns Hopkins University | Water-dispersible oral, parenteral, and topical formulations for poorly water soluble drugs using smart polymeric nanoparticles |
| WO2008065502A1 (en) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | Pharmaceutical compositions based on a) nanoparticles comprising enteric polymers and b) casein |
| US20100215747A1 (en) * | 2007-07-13 | 2010-08-26 | Corey Jay Bloom | Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers |
| US9233078B2 (en) * | 2007-12-06 | 2016-01-12 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer |
| CN102083423A (zh) * | 2008-05-06 | 2011-06-01 | 葛兰素集团有限公司 | 生物活性剂的囊封方法 |
| JP5841708B2 (ja) * | 2008-07-01 | 2016-01-13 | 日東電工株式会社 | 表面被覆微粒子の医薬組成物 |
| US20100021549A1 (en) | 2008-07-28 | 2010-01-28 | Flamel Technologies, S.A. | Microparticle oral form useful for the modified release of nanoparticles |
| FR2934161B1 (fr) * | 2008-07-28 | 2010-09-17 | Flamel Tech Sa | Forme orale microparticulaire utile pour la liberation modifiee de nanoparticules. |
| GB0815852D0 (en) * | 2008-09-01 | 2008-10-08 | Unilever Plc | Improvements relating to pharmaceutical compositions |
| WO2010113177A2 (en) | 2009-03-31 | 2010-10-07 | Reliance Life Sciences Pvt. Ltd. | Oral insulin delivery systems for controlling diabetes |
| US8673359B2 (en) | 2010-07-08 | 2014-03-18 | Brown University | Nanoparticle compositions and methods for improved oral delivery of active agents |
| CN102614498B (zh) * | 2011-01-28 | 2014-12-17 | 四川科伦药物研究有限公司 | 一种胰岛素纳米粒及其制备方法 |
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| EP2548571A1 (en) * | 2011-07-22 | 2013-01-23 | Institut Curie | Compositions having means for targeting at least one antigen to dendritic cells |
| US8859004B2 (en) | 2011-08-04 | 2014-10-14 | Nano And Advanced Materials Institute Limited | pH-sensitive nanoparticles for oral insulin delivery |
| CN102908332B (zh) * | 2011-08-04 | 2014-04-16 | 纳米及先进材料研发院有限公司 | 用于口服胰岛素递送的包含阳离子纳米粒子的肠溶包衣胶囊 |
| US9101547B2 (en) | 2011-08-04 | 2015-08-11 | Nano And Advanced Materials Institute Limited | Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery |
| CN104094119A (zh) | 2011-10-21 | 2014-10-08 | 斯特姆詹尼克斯公司 | 用于胞内传递生物活性分子的官能化纳米粒子 |
| EP2802314B1 (en) * | 2012-01-13 | 2020-11-25 | XSpray Microparticles AB | A method for producing stable, amorphous hybrid nanoparticles comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix- forming component. |
| EP3778696A1 (en) | 2012-04-23 | 2021-02-17 | NanoProteagen Ltd. | Polymeric nanoparticles and a process of preparation thereof |
| CN105142631A (zh) * | 2013-01-14 | 2015-12-09 | 健康诊所有限公司 | 抗癌药物和用途 |
| US9833522B2 (en) * | 2013-12-23 | 2017-12-05 | The Research Foundation For The State University Of New York | Graphene-based contrast agents for photoacoustic and thermoacoustic tomography and method of use |
| WO2015181344A1 (en) * | 2014-05-30 | 2015-12-03 | AbbVie Deutschland GmbH & Co. KG | Nanoencapsulation of antigen-binding molecules |
| US9370488B2 (en) | 2014-07-21 | 2016-06-21 | Kimia Zist Parsian | Method and system for synthesizing nanocarrier based long acting drug delivery system for insulin |
| PT107846B (pt) * | 2014-08-01 | 2019-03-22 | Hovione Farm S A | Produção de nano- partículas de dispersões sólidas amorfas por co-precipitação controlada |
| US9937256B2 (en) | 2015-01-14 | 2018-04-10 | Board Of Regents, The University Of Texas System | Hydrogels for delivery of therapeutic compounds |
| CN104739806B (zh) * | 2015-04-17 | 2018-04-03 | 黑龙江大学 | 口服胰岛素复合微囊及制备方法 |
| CN105056212B (zh) * | 2015-07-14 | 2018-06-15 | 江西省药物研究所 | 一种提高胰岛素口服结肠吸收的壳聚糖纳米粒及制备方法 |
-
2016
- 2016-10-12 US US15/291,480 patent/US11491114B2/en active Active
-
2017
- 2017-10-12 AU AU2017341753A patent/AU2017341753B2/en active Active
- 2017-10-12 KR KR1020197013487A patent/KR102580705B1/ko active Active
- 2017-10-12 CN CN201780076441.1A patent/CN110049759A/zh active Pending
- 2017-10-12 WO PCT/US2017/056320 patent/WO2018071655A1/en not_active Ceased
- 2017-10-12 CA CA3078570A patent/CA3078570A1/en active Pending
- 2017-10-12 KR KR1020237031642A patent/KR20230135694A/ko active Pending
- 2017-10-12 JP JP2019541672A patent/JP7046081B2/ja active Active
- 2017-10-12 EP EP17860772.7A patent/EP3525772A4/en active Pending
-
2022
- 2022-10-03 US US17/958,815 patent/US12594246B2/en active Active
-
2024
- 2024-03-05 AU AU2024201438A patent/AU2024201438A1/en not_active Abandoned
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