JP2015512441A5 - - Google Patents
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- Publication number
- JP2015512441A5 JP2015512441A5 JP2015504545A JP2015504545A JP2015512441A5 JP 2015512441 A5 JP2015512441 A5 JP 2015512441A5 JP 2015504545 A JP2015504545 A JP 2015504545A JP 2015504545 A JP2015504545 A JP 2015504545A JP 2015512441 A5 JP2015512441 A5 JP 2015512441A5
- Authority
- JP
- Japan
- Prior art keywords
- acrylic resin
- eudragit
- resin polymer
- composition
- immunological composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 13
- 238000000034 method Methods 0.000 claims 12
- 229920000178 Acrylic resin Polymers 0.000 claims 8
- 239000004925 Acrylic resin Substances 0.000 claims 8
- 229920000642 polymer Polymers 0.000 claims 8
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 6
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 6
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 6
- 230000001900 immune effect Effects 0.000 claims 5
- 239000002671 adjuvant Substances 0.000 claims 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 3
- 229910052782 aluminium Inorganic materials 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- ZAFFWOKULJCCSA-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate;trimethylazanium;chloride Chemical compound [Cl-].C[NH+](C)C.CCOC(=O)C(C)=C ZAFFWOKULJCCSA-UHFFFAOYSA-N 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 102000003930 C-Type Lectins Human genes 0.000 claims 2
- 108090000342 C-Type Lectins Proteins 0.000 claims 2
- 229920003135 Eudragit® L 100-55 Polymers 0.000 claims 2
- 229920003156 Eudragit® RL PO Polymers 0.000 claims 2
- 229920003160 Eudragit® RS PO Polymers 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical group CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical group [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- FAHBNUUHRFUEAI-UHFFFAOYSA-M hydroxidooxidoaluminium Chemical group O[Al]=O FAHBNUUHRFUEAI-UHFFFAOYSA-M 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 235000017281 sodium acetate Nutrition 0.000 claims 1
- 239000001632 sodium acetate Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261686372P | 2012-04-04 | 2012-04-04 | |
| US61/686,372 | 2012-04-04 | ||
| PCT/US2013/000102 WO2013151595A1 (en) | 2012-04-04 | 2013-04-03 | Improved adjuvant system for oral vaccine adminstration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512441A JP2015512441A (ja) | 2015-04-27 |
| JP2015512441A5 true JP2015512441A5 (https=) | 2015-09-17 |
| JP6240155B2 JP6240155B2 (ja) | 2017-11-29 |
Family
ID=49300897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504545A Active JP6240155B2 (ja) | 2012-04-04 | 2013-04-03 | 経口ワクチン投与のための改善アジュバント系 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20150079130A1 (https=) |
| EP (2) | EP3549605A1 (https=) |
| JP (1) | JP6240155B2 (https=) |
| KR (1) | KR101867428B1 (https=) |
| AU (1) | AU2013243971B2 (https=) |
| CA (1) | CA2903313C (https=) |
| DK (1) | DK2833914T3 (https=) |
| IL (1) | IL234937B (https=) |
| MX (1) | MX364946B (https=) |
| WO (1) | WO2013151595A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201606814RA (en) * | 2014-02-20 | 2016-09-29 | Vaxart Inc | Formulations for small intestinal delivery |
| CA2988165C (en) * | 2014-06-20 | 2023-08-01 | University Of Saskatchewan | Exotoxin/thermolysin compositions and methods and uses for treating or preventing laminitis |
| WO2016200951A1 (en) | 2015-06-12 | 2016-12-15 | Vaxart, Inc. | Formulations for small intestinal delivery of rsv and norovirus antigens |
| JP2019513128A (ja) * | 2016-03-07 | 2019-05-23 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 薬物送達粒子 |
| EP3781192A1 (en) * | 2018-04-16 | 2021-02-24 | Merck Patent GmbH | Additives for protein formulations to improve thermal stability |
| KR102369740B1 (ko) | 2020-09-21 | 2022-03-02 | 부경대학교 산학협력단 | 자궁경부암 조기진단을 위한 모바일 질확대경 장치 |
| WO2022094816A1 (en) * | 2020-11-04 | 2022-05-12 | Janssen Pharmaceuticals, Inc. | Solid formulation |
| CN113750228B (zh) * | 2021-09-25 | 2024-02-20 | 大连理工大学 | 一种冷冻保护剂在铝佐剂中的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4133397A (en) * | 1996-10-28 | 1998-05-22 | Pfizer Inc. | Oral vaccines for young animals with an enteric coating |
| EP1017283B1 (en) * | 1997-02-14 | 2004-12-15 | Merck & Co., Inc. | Polynucleotide vaccine formulations |
| US7087235B2 (en) | 1997-06-25 | 2006-08-08 | The United States Of America As Represented By The Secretary Of The Army | Fusion protein of streptococcal pyrogenic exotoxins |
| US20030162955A1 (en) * | 1998-03-17 | 2003-08-28 | Lionel Chalus | Isolated mammalian membrane protein genes; related reagents |
| KR100606857B1 (ko) * | 1998-07-08 | 2006-08-01 | 키린-암젠 인코포레이티드 | 고분자 의약품 함유 분말상 경점막 투여 제제 |
| EP1046651A1 (en) * | 1999-04-19 | 2000-10-25 | Koninklijke Universiteit Nijmegen | Composition and method for modulating dendritic cell-T interaction |
| AU2003265523A1 (en) * | 2002-08-20 | 2004-03-11 | Genitrix, Llc | Lectin compositions and methods for modulating an immune response to an antigen |
| US20040213745A1 (en) * | 2003-02-20 | 2004-10-28 | Vincent Sullivan | Powder formulations of rSEB for improved vaccination |
| GB0505518D0 (en) * | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| AU2007300543A1 (en) * | 2006-09-26 | 2008-04-03 | Alexion Pharmaceuticals, Inc. | Compositions and methods for enhancing an adjuvant |
| CN107582526A (zh) * | 2009-08-12 | 2018-01-16 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
| GB0919690D0 (en) * | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
| GB201101665D0 (en) * | 2011-01-31 | 2011-03-16 | Novartis Ag | Immunogenic compositions |
-
2013
- 2013-04-03 KR KR1020147030919A patent/KR101867428B1/ko not_active Expired - Fee Related
- 2013-04-03 CA CA2903313A patent/CA2903313C/en active Active
- 2013-04-03 WO PCT/US2013/000102 patent/WO2013151595A1/en not_active Ceased
- 2013-04-03 JP JP2015504545A patent/JP6240155B2/ja active Active
- 2013-04-03 DK DK13772028.0T patent/DK2833914T3/en active
- 2013-04-03 EP EP19151134.4A patent/EP3549605A1/en not_active Withdrawn
- 2013-04-03 AU AU2013243971A patent/AU2013243971B2/en not_active Ceased
- 2013-04-03 MX MX2014011806A patent/MX364946B/es active IP Right Grant
- 2013-04-03 US US13/261,964 patent/US20150079130A1/en not_active Abandoned
- 2013-04-03 EP EP13772028.0A patent/EP2833914B1/en active Active
-
2014
- 2014-10-02 IL IL234937A patent/IL234937B/en unknown
-
2018
- 2018-12-06 US US16/212,088 patent/US20190105389A1/en not_active Abandoned
-
2020
- 2020-11-05 US US17/090,292 patent/US20210052725A1/en not_active Abandoned
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