JP2014533659A - スクレロスチンに対するイムノバインダー - Google Patents

スクレロスチンに対するイムノバインダー Download PDF

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Publication number
JP2014533659A
JP2014533659A JP2014538922A JP2014538922A JP2014533659A JP 2014533659 A JP2014533659 A JP 2014533659A JP 2014538922 A JP2014538922 A JP 2014538922A JP 2014538922 A JP2014538922 A JP 2014538922A JP 2014533659 A JP2014533659 A JP 2014533659A
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Japan
Prior art keywords
seq
residues
binding protein
sclerostin
antibody
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JP2014538922A
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Japanese (ja)
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JP2014533659A5 (enExample
Inventor
シェ，チュン−ミン
イワノフ，アレクサンダー
ウェイゲル，ウェンディ
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AbbVie Inc
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AbbVie Inc
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Publication of JP2014533659A publication Critical patent/JP2014533659A/ja
Publication of JP2014533659A5 publication Critical patent/JP2014533659A5/ja
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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