JP2014531904A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014531904A5 JP2014531904A5 JP2014534810A JP2014534810A JP2014531904A5 JP 2014531904 A5 JP2014531904 A5 JP 2014531904A5 JP 2014534810 A JP2014534810 A JP 2014534810A JP 2014534810 A JP2014534810 A JP 2014534810A JP 2014531904 A5 JP2014531904 A5 JP 2014531904A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- polypeptide
- cell according
- isoprenoid
- nucleic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 48
- 229920001184 polypeptide Polymers 0.000 claims 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims 22
- 108020004707 nucleic acids Proteins 0.000 claims 20
- 102000039446 nucleic acids Human genes 0.000 claims 20
- 150000007523 nucleic acids Chemical class 0.000 claims 20
- 150000003505 terpenes Chemical class 0.000 claims 15
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 12
- 230000000694 effects Effects 0.000 claims 11
- 108010004621 phosphoketolase Proteins 0.000 claims 10
- KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 claims 7
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims 7
- 108090000790 Enzymes Proteins 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 6
- 239000002243 precursor Substances 0.000 claims 6
- 108010075483 isoprene synthase Proteins 0.000 claims 5
- 230000037361 pathway Effects 0.000 claims 5
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 4
- 241000186012 Bifidobacterium breve Species 0.000 claims 3
- JSNRRGGBADWTMC-UHFFFAOYSA-N alpha-farnesene Natural products CC(C)=CCCC(C)=CCCC(=C)C=C JSNRRGGBADWTMC-UHFFFAOYSA-N 0.000 claims 3
- SIGQQUBJQXSAMW-ZCFIWIBFSA-N (R)-5-diphosphomevalonic acid Chemical compound OC(=O)C[C@@](O)(C)CCOP(O)(=O)OP(O)(O)=O SIGQQUBJQXSAMW-ZCFIWIBFSA-N 0.000 claims 2
- AJPADPZSRRUGHI-RFZPGFLSSA-N 1-deoxy-D-xylulose 5-phosphate Chemical compound CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O AJPADPZSRRUGHI-RFZPGFLSSA-N 0.000 claims 2
- 108010092060 Acetate kinase Proteins 0.000 claims 2
- 241000228245 Aspergillus niger Species 0.000 claims 2
- 240000006439 Aspergillus oryzae Species 0.000 claims 2
- 235000002247 Aspergillus oryzae Nutrition 0.000 claims 2
- 241001608472 Bifidobacterium longum Species 0.000 claims 2
- 241000193403 Clostridium Species 0.000 claims 2
- 241000194033 Enterococcus Species 0.000 claims 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims 2
- 240000006024 Lactobacillus plantarum Species 0.000 claims 2
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims 2
- 241000186604 Lactobacillus reuteri Species 0.000 claims 2
- 241000520244 Tatumella citrea Species 0.000 claims 2
- 241000499912 Trichoderma reesei Species 0.000 claims 2
- 241000235015 Yarrowia lipolytica Species 0.000 claims 2
- OJFDKHTZOUZBOS-CITAKDKDSA-N acetoacetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OJFDKHTZOUZBOS-CITAKDKDSA-N 0.000 claims 2
- LIPOUNRJVLNBCD-UHFFFAOYSA-N acetyl dihydrogen phosphate Chemical compound CC(=O)OP(O)(O)=O LIPOUNRJVLNBCD-UHFFFAOYSA-N 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- UAHWPYUMFXYFJY-UHFFFAOYSA-N beta-myrcene Chemical compound CC(C)=CCCC(=C)C=C UAHWPYUMFXYFJY-UHFFFAOYSA-N 0.000 claims 2
- 229940009291 bifidobacterium longum Drugs 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- 229940072205 lactobacillus plantarum Drugs 0.000 claims 2
- 229940001882 lactobacillus reuteri Drugs 0.000 claims 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- NDVASEGYNIMXJL-UHFFFAOYSA-N sabinene Chemical compound C=C1CCC2(C(C)C)C1C2 NDVASEGYNIMXJL-UHFFFAOYSA-N 0.000 claims 2
- CXENHBSYCFFKJS-UHFFFAOYSA-N α-farnesene Chemical compound CC(C)=CCCC(C)=CCC=C(C)C=C CXENHBSYCFFKJS-UHFFFAOYSA-N 0.000 claims 2
- FQTLCLSUCSAZDY-UHFFFAOYSA-N (+) E(S) nerolidol Natural products CC(C)=CCCC(C)=CCCC(C)(O)C=C FQTLCLSUCSAZDY-UHFFFAOYSA-N 0.000 claims 1
- NDVASEGYNIMXJL-NXEZZACHSA-N (+)-sabinene Natural products C=C1CC[C@@]2(C(C)C)[C@@H]1C2 NDVASEGYNIMXJL-NXEZZACHSA-N 0.000 claims 1
- QEBNYNLSCGVZOH-NFAWXSAZSA-N (+)-valencene Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CCC=C21 QEBNYNLSCGVZOH-NFAWXSAZSA-N 0.000 claims 1
- WTARULDDTDQWMU-RKDXNWHRSA-N (+)-β-pinene Chemical compound C1[C@H]2C(C)(C)[C@@H]1CCC2=C WTARULDDTDQWMU-RKDXNWHRSA-N 0.000 claims 1
- BBPXZLJCPUPNGH-CMKODMSKSA-N (-)-Abietadiene Chemical compound CC1(C)CCC[C@]2(C)[C@@H](CCC(C(C)C)=C3)C3=CC[C@H]21 BBPXZLJCPUPNGH-CMKODMSKSA-N 0.000 claims 1
- WTARULDDTDQWMU-IUCAKERBSA-N (-)-Nopinene Natural products C1[C@@H]2C(C)(C)[C@H]1CCC2=C WTARULDDTDQWMU-IUCAKERBSA-N 0.000 claims 1
- CRDAMVZIKSXKFV-FBXUGWQNSA-N (2-cis,6-cis)-farnesol Chemical compound CC(C)=CCC\C(C)=C/CC\C(C)=C/CO CRDAMVZIKSXKFV-FBXUGWQNSA-N 0.000 claims 1
- 239000000260 (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol Substances 0.000 claims 1
- 239000001890 (2R)-8,8,8a-trimethyl-2-prop-1-en-2-yl-1,2,3,4,6,7-hexahydronaphthalene Substances 0.000 claims 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims 1
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 claims 1
- JSNRRGGBADWTMC-QINSGFPZSA-N (E)-beta-Farnesene Natural products CC(C)=CCC\C(C)=C/CCC(=C)C=C JSNRRGGBADWTMC-QINSGFPZSA-N 0.000 claims 1
- OJISWRZIEWCUBN-QIRCYJPOSA-N (E,E,E)-geranylgeraniol Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CO OJISWRZIEWCUBN-QIRCYJPOSA-N 0.000 claims 1
- LXJXRIRHZLFYRP-VKHMYHEASA-L (R)-2-Hydroxy-3-(phosphonooxy)-propanal Natural products O=C[C@H](O)COP([O-])([O-])=O LXJXRIRHZLFYRP-VKHMYHEASA-L 0.000 claims 1
- OKZYCXHTTZZYSK-ZCFIWIBFSA-N (R)-5-phosphomevalonic acid Chemical compound OC(=O)C[C@@](O)(C)CCOP(O)(O)=O OKZYCXHTTZZYSK-ZCFIWIBFSA-N 0.000 claims 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims 1
- JXBSHSBNOVLGHF-UHFFFAOYSA-N 10-cis-Dihydrofarnesen Natural products CC=C(C)CCC=C(C)CCC=C(C)C JXBSHSBNOVLGHF-UHFFFAOYSA-N 0.000 claims 1
- BBPXZLJCPUPNGH-UHFFFAOYSA-N Abietadien Natural products CC1(C)CCCC2(C)C(CCC(C(C)C)=C3)C3=CCC21 BBPXZLJCPUPNGH-UHFFFAOYSA-N 0.000 claims 1
- 244000063299 Bacillus subtilis Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 101001074421 Bacillus subtilis (strain 168) Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG Proteins 0.000 claims 1
- 241001134770 Bifidobacterium animalis Species 0.000 claims 1
- GSXOAOHZAIYLCY-UHFFFAOYSA-N D-F6P Natural products OCC(=O)C(O)C(O)C(O)COP(O)(O)=O GSXOAOHZAIYLCY-UHFFFAOYSA-N 0.000 claims 1
- NGHMDNPXVRFFGS-IUYQGCFVSA-N D-erythrose 4-phosphate Chemical compound O=C[C@H](O)[C@H](O)COP(O)(O)=O NGHMDNPXVRFFGS-IUYQGCFVSA-N 0.000 claims 1
- LXJXRIRHZLFYRP-VKHMYHEASA-N D-glyceraldehyde 3-phosphate Chemical compound O=C[C@H](O)COP(O)(O)=O LXJXRIRHZLFYRP-VKHMYHEASA-N 0.000 claims 1
- FNZLKVNUWIIPSJ-RFZPGFLSSA-N D-xylulose 5-phosphate Chemical compound OCC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O FNZLKVNUWIIPSJ-RFZPGFLSSA-N 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000207201 Gardnerella vaginalis Species 0.000 claims 1
- 239000005792 Geraniol Substances 0.000 claims 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 claims 1
- 241001340632 Mucilaginibacter paludis Species 0.000 claims 1
- FQTLCLSUCSAZDY-ATGUSINASA-N Nerolidol Chemical compound CC(C)=CCC\C(C)=C\CC[C@](C)(O)C=C FQTLCLSUCSAZDY-ATGUSINASA-N 0.000 claims 1
- 241000424623 Nostoc punctiforme Species 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 241000520272 Pantoea Species 0.000 claims 1
- 108700023175 Phosphate acetyltransferases Proteins 0.000 claims 1
- 241000219000 Populus Species 0.000 claims 1
- 241000168036 Populus alba Species 0.000 claims 1
- 241000218982 Populus nigra Species 0.000 claims 1
- 241001600128 Populus tremula x Populus alba Species 0.000 claims 1
- 240000004923 Populus tremuloides Species 0.000 claims 1
- 235000011263 Populus tremuloides Nutrition 0.000 claims 1
- 241000218976 Populus trichocarpa Species 0.000 claims 1
- WTARULDDTDQWMU-UHFFFAOYSA-N Pseudopinene Natural products C1C2C(C)(C)C1CCC2=C WTARULDDTDQWMU-UHFFFAOYSA-N 0.000 claims 1
- 241000219780 Pueraria Species 0.000 claims 1
- 235000010575 Pueraria lobata Nutrition 0.000 claims 1
- 241000913776 Pueraria montana Species 0.000 claims 1
- 241000219781 Pueraria montana var. lobata Species 0.000 claims 1
- 241001478271 Rahnella aquatilis Species 0.000 claims 1
- 241000190950 Rhodopseudomonas palustris Species 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 241000124033 Salix Species 0.000 claims 1
- 241000899950 Salix glauca Species 0.000 claims 1
- 241000187747 Streptomyces Species 0.000 claims 1
- 241001468227 Streptomyces avermitilis Species 0.000 claims 1
- 241000187432 Streptomyces coelicolor Species 0.000 claims 1
- 241000187392 Streptomyces griseus Species 0.000 claims 1
- 241000187398 Streptomyces lividans Species 0.000 claims 1
- 241000203780 Thermobifida fusca Species 0.000 claims 1
- 229930014549 abietadiene Natural products 0.000 claims 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 claims 1
- VYBREYKSZAROCT-UHFFFAOYSA-N alpha-myrcene Natural products CC(=C)CCCC(=C)C=C VYBREYKSZAROCT-UHFFFAOYSA-N 0.000 claims 1
- KQAZVFVOEIRWHN-UHFFFAOYSA-N alpha-thujene Natural products CC1=CCC2(C(C)C)C1C2 KQAZVFVOEIRWHN-UHFFFAOYSA-N 0.000 claims 1
- HMTAHNDPLDKYJT-CBBWQLFWSA-N amorpha-4,11-diene Chemical compound C1=C(C)CC[C@H]2[C@H](C)CC[C@@H](C(C)=C)[C@H]21 HMTAHNDPLDKYJT-CBBWQLFWSA-N 0.000 claims 1
- HMTAHNDPLDKYJT-UHFFFAOYSA-N amorphadiene Natural products C1=C(C)CCC2C(C)CCC(C(C)=C)C21 HMTAHNDPLDKYJT-UHFFFAOYSA-N 0.000 claims 1
- BGWGXPAPYGQALX-ARQDHWQXSA-N beta-D-fructofuranose 6-phosphate Chemical compound OC[C@@]1(O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O BGWGXPAPYGQALX-ARQDHWQXSA-N 0.000 claims 1
- YSNRTFFURISHOU-UHFFFAOYSA-N beta-farnesene Natural products C=CC(C)CCC=C(C)CCC=C(C)C YSNRTFFURISHOU-UHFFFAOYSA-N 0.000 claims 1
- 229930006722 beta-pinene Natural products 0.000 claims 1
- 229940118852 bifidobacterium animalis Drugs 0.000 claims 1
- 229930006737 car-3-ene Natural products 0.000 claims 1
- 229930007796 carene Natural products 0.000 claims 1
- BQOFWKZOCNGFEC-UHFFFAOYSA-N carene Chemical compound C1C(C)=CCC2C(C)(C)C12 BQOFWKZOCNGFEC-UHFFFAOYSA-N 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 229930004069 diterpene Natural products 0.000 claims 1
- 125000000567 diterpene group Chemical group 0.000 claims 1
- 229930002886 farnesol Natural products 0.000 claims 1
- 229940043259 farnesol Drugs 0.000 claims 1
- LCWMKIHBLJLORW-UHFFFAOYSA-N gamma-carene Natural products C1CC(=C)CC2C(C)(C)C21 LCWMKIHBLJLORW-UHFFFAOYSA-N 0.000 claims 1
- 229940113087 geraniol Drugs 0.000 claims 1
- XWRJRXQNOHXIOX-UHFFFAOYSA-N geranylgeraniol Natural products CC(C)=CCCC(C)=CCOCC=C(C)CCC=C(C)C XWRJRXQNOHXIOX-UHFFFAOYSA-N 0.000 claims 1
- OJISWRZIEWCUBN-UHFFFAOYSA-N geranylnerol Natural products CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCO OJISWRZIEWCUBN-UHFFFAOYSA-N 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims 1
- 235000001510 limonene Nutrition 0.000 claims 1
- 229940087305 limonene Drugs 0.000 claims 1
- 229930007744 linalool Natural products 0.000 claims 1
- 229930003658 monoterpene Natural products 0.000 claims 1
- 150000002773 monoterpene derivatives Chemical class 0.000 claims 1
- 235000002577 monoterpenes Nutrition 0.000 claims 1
- WASNIKZYIWZQIP-AWEZNQCLSA-N nerolidol Natural products CC(=CCCC(=CCC[C@@H](O)C=C)C)C WASNIKZYIWZQIP-AWEZNQCLSA-N 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920001550 polyprenyl Polymers 0.000 claims 1
- 125000001185 polyprenyl group Polymers 0.000 claims 1
- 150000003097 polyterpenes Chemical class 0.000 claims 1
- 229930006696 sabinene Natural products 0.000 claims 1
- RXHIKAIVEMAPRU-JRIGQVHBSA-N sequiterpene Natural products C1=C(C)[C@@H](OC(C)=O)[C@H](O)[C@@]2(O)[C@H](C)CC[C@@H](C(C)=C)[C@H]21 RXHIKAIVEMAPRU-JRIGQVHBSA-N 0.000 claims 1
- 229930004725 sesquiterpene Natural products 0.000 claims 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 claims 1
- 229930006978 terpinene Natural products 0.000 claims 1
- 150000003507 terpinene derivatives Chemical class 0.000 claims 1
- 150000003535 tetraterpenes Chemical class 0.000 claims 1
- 235000009657 tetraterpenes Nutrition 0.000 claims 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 claims 1
- 150000003648 triterpenes Chemical class 0.000 claims 1
- WCTNXGFHEZQHDR-UHFFFAOYSA-N valencene Natural products C1CC(C)(C)C2(C)CC(C(=C)C)CCC2=C1 WCTNXGFHEZQHDR-UHFFFAOYSA-N 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161545083P | 2011-10-07 | 2011-10-07 | |
| US61/545,083 | 2011-10-07 | ||
| PCT/US2012/059136 WO2013066568A1 (en) | 2011-10-07 | 2012-10-05 | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018192631A Division JP6639606B2 (ja) | 2011-10-07 | 2018-10-11 | メバロン酸、イソプレノイド前駆体、及びイソプレンの産生におけるホスホケトラーゼの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014531904A JP2014531904A (ja) | 2014-12-04 |
| JP2014531904A5 true JP2014531904A5 (https=) | 2015-11-26 |
| JP6420147B2 JP6420147B2 (ja) | 2018-11-07 |
Family
ID=47046886
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014534810A Active JP6420147B2 (ja) | 2011-10-07 | 2012-10-05 | メバロン酸、イソプレノイド前駆体、及びイソプレンの産生におけるホスホケトラーゼの使用 |
| JP2018192631A Active JP6639606B2 (ja) | 2011-10-07 | 2018-10-11 | メバロン酸、イソプレノイド前駆体、及びイソプレンの産生におけるホスホケトラーゼの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018192631A Active JP6639606B2 (ja) | 2011-10-07 | 2018-10-11 | メバロン酸、イソプレノイド前駆体、及びイソプレンの産生におけるホスホケトラーゼの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8993305B2 (https=) |
| EP (2) | EP2764084B2 (https=) |
| JP (2) | JP6420147B2 (https=) |
| CN (1) | CN104053765A (https=) |
| AU (1) | AU2012332996A1 (https=) |
| BR (1) | BR112014008278A2 (https=) |
| CA (1) | CA2851265A1 (https=) |
| DK (2) | DK3339426T3 (https=) |
| HK (1) | HK1201071A1 (https=) |
| MX (1) | MX2014004209A (https=) |
| SG (1) | SG11201401249PA (https=) |
| WO (1) | WO2013066568A1 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| CN103328631B (zh) * | 2011-01-20 | 2017-04-26 | 丰田自动车株式会社 | 重组酵母和使用该重组酵母的物质生产方法 |
| PE20141519A1 (es) | 2011-07-12 | 2014-10-17 | Scientist Of Fortune Sa | Microorganismo recombinante para la produccion de metabolitos utiles |
| BR112014008278A2 (pt) | 2011-10-07 | 2017-04-18 | Danisco Us Inc | utilização de fosfocetolase na produção de mevalonato, precursores isoprenoides e isopreno |
| US20140128645A1 (en) * | 2011-12-23 | 2014-05-08 | The Goodyear Tire & Rubber Company | Enhanced production of isoprene using marine bacterial cells |
| US20130323820A1 (en) | 2012-06-01 | 2013-12-05 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
| WO2013181647A2 (en) | 2012-06-01 | 2013-12-05 | Danisco Us Inc. | Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms |
| US20160002672A1 (en) | 2012-12-21 | 2016-01-07 | Danisco Us Inc. | Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway |
| US9518278B2 (en) | 2013-03-14 | 2016-12-13 | The Regents Of The University Of California | Recombinant microorganisms having a methanol elongation cycle (MEC) |
| SG11201508186XA (en) * | 2013-04-10 | 2015-11-27 | Danisco Us Inc | Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids |
| WO2015002977A1 (en) * | 2013-07-01 | 2015-01-08 | Braskem S/A Ap 09 | Modified microorganisms and methods of using same for anaerobic coproduction of isoprene and acetic acid |
| CN105636661B (zh) | 2013-09-12 | 2018-02-23 | 格雷迪安特公司 | 包括诸如泡罩塔冷凝器的冷凝装置的系统 |
| US20160376600A1 (en) | 2013-11-25 | 2016-12-29 | Genomatica, Inc. | Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol |
| EP4296364B1 (en) | 2013-12-03 | 2025-12-03 | Genomatica, Inc. | Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis |
| US10648004B2 (en) | 2014-02-20 | 2020-05-12 | Danisco Us Inc. | Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-CoA-derived products |
| US20170130210A1 (en) * | 2014-06-09 | 2017-05-11 | Massachusetts Institute Of Technology | Dynamic knockdown of central metabolism for redirecting glucose-6-phosphate fluxes |
| US10760105B2 (en) * | 2014-12-30 | 2020-09-01 | Novogy, Inc. | Enhanced production of core lipids in oleaginous yeasts |
| WO2016134381A1 (en) | 2015-02-20 | 2016-08-25 | The Regents Of The University Of California | Novel host cells and methods for producing isopentenol from mevalonate |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2017132924A1 (zh) * | 2016-02-04 | 2017-08-10 | 中国科学院微生物研究所 | 一种用于生物合成异戊二烯和异戊烯的酶及其突变体 |
| CN107815424B (zh) * | 2016-09-12 | 2021-03-05 | 华东理工大学 | 一种产柠檬烯的解脂耶氏酵母基因工程菌及其应用 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| BR112019012306A2 (pt) * | 2016-12-16 | 2019-11-12 | Danisco Us Inc | polipeptídeos de fusão de fosfocetolase-fosfotransacetilase bifuncionais |
| CN109234216B (zh) * | 2017-07-10 | 2022-05-20 | 上海医药工业研究院 | 一种生产鲨烯的基因工程菌及其方法 |
| CN108179114B (zh) * | 2017-11-27 | 2021-08-20 | 南京晓庄学院 | 产抗厌氧菌化合物的菌株和发酵方法、抗厌氧菌化合物提取及制备方法和使用方法 |
| WO2019113387A1 (en) | 2017-12-07 | 2019-06-13 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
| JP2021506316A (ja) | 2017-12-21 | 2021-02-22 | ザイマージェン インコーポレイテッド | ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物 |
| CA3090055A1 (en) * | 2018-03-01 | 2019-09-06 | Total Raffinage Chimie | Metabolic pathways with increased carbon yield |
| CN109486720B (zh) * | 2018-12-18 | 2020-08-04 | 江南大学 | 一种产l-木酮糖的枯草芽孢杆菌及其应用 |
| EP3908663A1 (en) | 2019-02-20 | 2021-11-17 | Braskem S.A. | Microorganisms and methods for the production of oxygenated compounds from hexoses |
| JP7463388B2 (ja) * | 2019-02-20 | 2024-04-08 | ブラスケム エス．エー． | ペントース糖およびヘキソース糖のための分解経路 |
| CN109929883A (zh) * | 2019-04-02 | 2019-06-25 | 烟台华康荣赞生物科技有限公司 | 重组酵母、构建方法和其在制备酪醇及衍生物中的应用 |
| KR102229379B1 (ko) * | 2019-06-11 | 2021-03-19 | 주식회사 제노포커스 | 파이토플루엔 고생산성 재조합 미생물 및 이를 이용한 파이토플루엔의 제조방법 |
| US20230272364A1 (en) * | 2019-07-11 | 2023-08-31 | Bp Corporation North America Inc. | Gluconate dehydratase enzymes and recombinant cells |
| JP6917434B2 (ja) * | 2019-10-25 | 2021-08-11 | 長瀬産業株式会社 | 好気性菌の代謝酵素破壊株およびその培養法 |
| CN112300952B (zh) * | 2020-11-27 | 2023-05-09 | 华东理工大学 | 一种产α-蒎烯的解脂耶氏酵母基因工程菌及其应用 |
| WO2022232444A1 (en) * | 2021-04-29 | 2022-11-03 | Ginkgo Bioworks, Inc. | Genetically modified yeast cells and methods of use for increased lipid yield |
| CN113549562B (zh) * | 2021-07-14 | 2023-10-24 | 南京师范大学 | 一种高效生产广藿香醇的工程菌及其构建方法和应用 |
| WO2023028459A1 (en) * | 2021-08-24 | 2023-03-02 | Lanzatech, Inc. | Microbial fermentation for the production of isoprenoid alcohols and derivatives |
| CN115948456B (zh) * | 2022-10-18 | 2024-09-17 | 重庆大学 | 一种可提升广藿香醇合成量的融合基因及方法 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19629568C1 (de) | 1996-07-15 | 1998-01-08 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Isopren |
| GB9614979D0 (en) | 1996-07-17 | 1996-09-04 | Newteam Ltd | Aerating arrangement primarily for a shower head |
| US6531303B1 (en) * | 1998-07-06 | 2003-03-11 | Arkion Life Sciences Llc | Method of producing geranylgeraniol |
| WO2002010398A2 (en) * | 2000-07-31 | 2002-02-07 | Hahn Frederick M | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| SE0200857D0 (sv) | 2002-03-19 | 2002-03-19 | Forskarpatent I Syd Ab | Metabolic engineering for improved xylose utilisation of saccharomyces cerevisiae |
| JPWO2003095651A1 (ja) | 2002-05-10 | 2005-09-15 | 協和醗酵工業株式会社 | メバロン酸の製造方法 |
| KR101148255B1 (ko) | 2002-10-04 | 2012-08-08 | 다니스코 유에스 인크. | 고수율을 갖는 1,3-프로판디올의 생물학적 제조 방법 |
| JP4168870B2 (ja) | 2003-08-14 | 2008-10-22 | トヨタ自動車株式会社 | プレニルアルコールの製造方法 |
| EP2298859A3 (en) * | 2004-07-27 | 2011-05-25 | The Regents of the University of California | Genetically modified host cells and use of same for producing isoprenoid compounds |
| DE602005020469D1 (de) * | 2004-08-10 | 2010-05-20 | Ajinomoto Kk | Verwendung von phosphoketolase zur herstellung geeigneter metabolite |
| RU2004124226A (ru) * | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| US20090053797A1 (en) * | 2005-08-19 | 2009-02-26 | Yoichiro Shiba | Genetically modified host cells and use of same for producing isoprenoid compounds |
| WO2007140339A2 (en) * | 2006-05-26 | 2007-12-06 | Amyris Biotechnologies, Inc. | Production of isoprenoids |
| US7947478B2 (en) | 2006-06-29 | 2011-05-24 | The Regents Of The University Of California | Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria |
| JP4986547B2 (ja) | 2006-09-04 | 2012-07-25 | 株式会社Ａｄｅｋａ | 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法 |
| WO2009005704A1 (en) * | 2007-07-03 | 2009-01-08 | The Regents Of The University Of California | Methods of increasing isoprenoid or isoprenoid precursor production |
| AU2008305655B2 (en) * | 2007-09-20 | 2013-10-31 | Amyris, Inc. | Production of isoprenoids |
| EP2062967A1 (en) * | 2007-11-21 | 2009-05-27 | Technical University of Denmark | Genetically engineered aspergillus |
| CN105368764B (zh) | 2007-12-13 | 2019-03-12 | 丹尼斯科美国公司 | 用于生产异戊二烯的组合物和方法 |
| US20110045563A1 (en) | 2008-02-06 | 2011-02-24 | The Regents Of The University Of California | Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi |
| CA2728285A1 (en) * | 2008-03-03 | 2009-09-11 | Joule Unlimited, Inc. | Engineered co2 fixing microorganisms producing carbon-based products of interest |
| WO2009132220A2 (en) | 2008-04-23 | 2009-10-29 | Danisco Us Inc. | Isoprene synthase variants for improved microbial production of isoprene |
| US7632995B2 (en) | 2008-05-09 | 2009-12-15 | Monsanto Technology Llc | Plants and seeds of hybrid corn variety CH852179 |
| MX318543B (es) | 2008-07-02 | 2014-03-18 | Danisco Us Inc | Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros. |
| HU3516U (en) | 2008-07-31 | 2008-11-28 | Zoltan Kuthi | Anti-theft protection of draining for fuel tanks |
| WO2010031062A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using the archaeal lower mevalonate pathway |
| EP2340312A2 (en) † | 2008-09-15 | 2011-07-06 | Danisco US Inc. | Conversion of prenyl derivatives to isoprene |
| EP2344629B1 (en) | 2008-09-15 | 2018-01-24 | Danisco US Inc. | Systems using cell culture for production of isoprene |
| CA2737223A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Reduction of carbon dioxide emission during isoprene production by fermentation |
| MY161071A (en) * | 2008-12-30 | 2017-04-14 | Danisco Us Inc | Methods of producing isoprene and a co-product |
| US20100297749A1 (en) | 2009-04-21 | 2010-11-25 | Sapphire Energy, Inc. | Methods and systems for biofuel production |
| AU2010238770A1 (en) | 2009-04-23 | 2011-11-03 | Danisco Us Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| TW201412988A (zh) * | 2009-06-17 | 2014-04-01 | Danisco Us Inc | 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造 |
| TWI434921B (zh) | 2009-06-17 | 2014-04-21 | Danisco Us Inc | 從生物異戊二烯組合物製造燃料成分之方法及系統 |
| US20120252054A1 (en) | 2009-09-15 | 2012-10-04 | Sapphire Energy Inc | System for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp. |
| BR112012006939A2 (pt) | 2009-09-29 | 2015-09-08 | Butamax Tm Advanced Biofuels | célula hospedeira de produção de levedura recombinante e método para a produção de um produto selecionado do grupo que consiste em 2,3-butanodiol, isobutanol, 2-butanol, 1-butanol, 2-butanona, valina, leucina, ácido lático, ácido málico, álcool, isoampilico e isoprenoides |
| CN102812129B (zh) * | 2009-11-10 | 2015-08-26 | 麻省理工学院 | 用于从类异戊二烯途径生产化学和医药产品的微生物工程 |
| US8569562B2 (en) | 2009-12-18 | 2013-10-29 | Danisco Us Inc. | Purification of isoprene from renewable resources |
| SG196782A1 (en) | 2009-12-23 | 2014-02-13 | Danisco Us Inc | Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (pgl) |
| JP2013515507A (ja) | 2009-12-29 | 2013-05-09 | ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー | 組換え宿主細胞におけるヘキソースキナーゼの発現 |
| US8871488B2 (en) * | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| CA2816306A1 (en) | 2010-10-27 | 2012-05-03 | Danisco Us Inc. | Isoprene synthase variants for improved production of isoprene |
| CN103328631B (zh) † | 2011-01-20 | 2017-04-26 | 丰田自动车株式会社 | 重组酵母和使用该重组酵母的物质生产方法 |
| SG194691A1 (en) * | 2011-04-29 | 2013-12-30 | Danisco Us Inc | Production of mevalonate, isoprene, and isoprenoids using genes encodingpolypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities |
| PE20141519A1 (es) † | 2011-07-12 | 2014-10-17 | Scientist Of Fortune Sa | Microorganismo recombinante para la produccion de metabolitos utiles |
| BR112014008278A2 (pt) | 2011-10-07 | 2017-04-18 | Danisco Us Inc | utilização de fosfocetolase na produção de mevalonato, precursores isoprenoides e isopreno |
| CN104039974B (zh) * | 2011-11-09 | 2016-10-12 | 阿迈瑞斯公司 | 乙酰辅酶a衍生的类异戊二烯的生产 |
| MX364748B (es) * | 2013-03-15 | 2019-05-06 | Amyris Inc | Uso de fosfoquetolasa y fosfotransacetilasa para la produccion de compuestos derivados de acetil-coenzima a. |
-
2012
- 2012-10-05 BR BR112014008278A patent/BR112014008278A2/pt not_active Application Discontinuation
- 2012-10-05 SG SG11201401249PA patent/SG11201401249PA/en unknown
- 2012-10-05 JP JP2014534810A patent/JP6420147B2/ja active Active
- 2012-10-05 DK DK17206148.3T patent/DK3339426T3/da active
- 2012-10-05 WO PCT/US2012/059136 patent/WO2013066568A1/en not_active Ceased
- 2012-10-05 HK HK15101539.9A patent/HK1201071A1/xx unknown
- 2012-10-05 US US13/646,562 patent/US8993305B2/en active Active
- 2012-10-05 DK DK12775413.3T patent/DK2764084T4/da active
- 2012-10-05 EP EP12775413.3A patent/EP2764084B2/en active Active
- 2012-10-05 MX MX2014004209A patent/MX2014004209A/es unknown
- 2012-10-05 EP EP17206148.3A patent/EP3339426B1/en active Active
- 2012-10-05 CA CA2851265A patent/CA2851265A1/en not_active Abandoned
- 2012-10-05 AU AU2012332996A patent/AU2012332996A1/en not_active Abandoned
- 2012-10-05 CN CN201280059852.7A patent/CN104053765A/zh active Pending
-
2015
- 2015-02-18 US US14/625,487 patent/US9493791B2/en active Active
-
2016
- 2016-09-28 US US15/279,184 patent/US10113185B2/en active Active
-
2018
- 2018-10-11 JP JP2018192631A patent/JP6639606B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014531904A5 (https=) | ||
| JP2014519812A5 (https=) | ||
| JP2016512047A5 (https=) | ||
| US10113185B2 (en) | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene | |
| JP5706444B2 (ja) | ６−ホスホグルコノラクトナーゼ（ｐｇｌ）によりイソプレン及び他の産物の生産を増加させるためのｐｇｌに関する組成物及び方法 | |
| US10988750B2 (en) | Phosphoketolases for improved production of acetyl coenzyme A-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids | |
| Yang et al. | Bio-isoprene production using exogenous MVA pathway and isoprene synthase in Escherichia coli | |
| CN103764814B (zh) | 利用编码具有硫解酶、hmg-coa合酶和hmg-coa还原酶酶活性的多肽的基因产生甲羟戊酸、异戊二烯和类异戊二烯 | |
| You et al. | Utilization of biodiesel by-product as substrate for high-production of β-farnesene via relatively balanced mevalonate pathway in Escherichia coli | |
| US20140234926A1 (en) | Recombinant anaerobic acetogenic bacteria for production of isoprene and/or industrial bio-products using synthesis gas | |
| US20130122562A1 (en) | Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase | |
| JP2011518564A5 (https=) | ||
| JP2017506078A5 (https=) | ||
| JP2016508737A5 (https=) | ||
| JP2016519577A5 (https=) | ||
| US20130273625A1 (en) | Methods for increasing microbial production of isoprene, isoprenoids, and isoprenoid precursor molecules using glucose and acetate co-metabolism | |
| CN107418978A (zh) | 一种利用生物柴油副产物制备金合欢烯的方法 | |
| JPWO2018079619A1 (ja) | 組換え細胞、並びに、イソプレン又はテルペンの生産方法 | |
| Liu et al. | Combinational biosynthesis of isoprene by engineering the MEP pathway in Escherichia coli | |
| Huibin et al. | Microbial production of isoprene: opportunities and challenges | |
| JP2017512460A (ja) | イソプレンモノマーの製造方法 | |
| WO2015100168A1 (en) | Composition and methods for control of industrial scale production of bio-products | |
| Ye et al. | Efforts toward industrial biosynthesis of isoprene |