CA2851265A1 - Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene - Google Patents

Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene Download PDF

Info

Publication number
CA2851265A1
CA2851265A1 CA2851265A CA2851265A CA2851265A1 CA 2851265 A1 CA2851265 A1 CA 2851265A1 CA 2851265 A CA2851265 A CA 2851265A CA 2851265 A CA2851265 A CA 2851265A CA 2851265 A1 CA2851265 A1 CA 2851265A1
Authority
CA
Canada
Prior art keywords
cells
polypeptide
phosphoketolase
phosphate
mevalonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2851265A
Other languages
English (en)
French (fr)
Inventor
Zachary Q. Beck
Andrew C. Eliot
Caroline M. Peres
Dmitrii V. Vaviline
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goodyear Tire and Rubber Co
Danisco US Inc
Original Assignee
Goodyear Tire and Rubber Co
Danisco US Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47046886&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2851265(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Goodyear Tire and Rubber Co, Danisco US Inc filed Critical Goodyear Tire and Rubber Co
Publication of CA2851265A1 publication Critical patent/CA2851265A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01008—Phosphate acetyltransferase (2.3.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02009—Phosphoketolase (4.1.2.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03027—Isoprene synthase (4.2.3.27)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/03—Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
    • C12Y503/03002—Isopentenyl-diphosphate DELTA-isomerase (5.3.3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CA2851265A 2011-10-07 2012-10-05 Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene Abandoned CA2851265A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161545083P 2011-10-07 2011-10-07
US61/545,083 2011-10-07
PCT/US2012/059136 WO2013066568A1 (en) 2011-10-07 2012-10-05 Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene

Publications (1)

Publication Number Publication Date
CA2851265A1 true CA2851265A1 (en) 2013-05-10

Family

ID=47046886

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2851265A Abandoned CA2851265A1 (en) 2011-10-07 2012-10-05 Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene

Country Status (12)

Country Link
US (3) US8993305B2 (https=)
EP (2) EP2764084B2 (https=)
JP (2) JP6420147B2 (https=)
CN (1) CN104053765A (https=)
AU (1) AU2012332996A1 (https=)
BR (1) BR112014008278A2 (https=)
CA (1) CA2851265A1 (https=)
DK (2) DK3339426T3 (https=)
HK (1) HK1201071A1 (https=)
MX (1) MX2014004209A (https=)
SG (1) SG11201401249PA (https=)
WO (1) WO2013066568A1 (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
CN103328631B (zh) * 2011-01-20 2017-04-26 丰田自动车株式会社 重组酵母和使用该重组酵母的物质生产方法
PE20141519A1 (es) 2011-07-12 2014-10-17 Scientist Of Fortune Sa Microorganismo recombinante para la produccion de metabolitos utiles
BR112014008278A2 (pt) 2011-10-07 2017-04-18 Danisco Us Inc utilização de fosfocetolase na produção de mevalonato, precursores isoprenoides e isopreno
US20140128645A1 (en) * 2011-12-23 2014-05-08 The Goodyear Tire & Rubber Company Enhanced production of isoprene using marine bacterial cells
US20130323820A1 (en) 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
WO2013181647A2 (en) 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
US20160002672A1 (en) 2012-12-21 2016-01-07 Danisco Us Inc. Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway
US9518278B2 (en) 2013-03-14 2016-12-13 The Regents Of The University Of California Recombinant microorganisms having a methanol elongation cycle (MEC)
SG11201508186XA (en) * 2013-04-10 2015-11-27 Danisco Us Inc Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids
WO2015002977A1 (en) * 2013-07-01 2015-01-08 Braskem S/A Ap 09 Modified microorganisms and methods of using same for anaerobic coproduction of isoprene and acetic acid
CN105636661B (zh) 2013-09-12 2018-02-23 格雷迪安特公司 包括诸如泡罩塔冷凝器的冷凝装置的系统
US20160376600A1 (en) 2013-11-25 2016-12-29 Genomatica, Inc. Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol
EP4296364B1 (en) 2013-12-03 2025-12-03 Genomatica, Inc. Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis
US10648004B2 (en) 2014-02-20 2020-05-12 Danisco Us Inc. Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-CoA-derived products
US20170130210A1 (en) * 2014-06-09 2017-05-11 Massachusetts Institute Of Technology Dynamic knockdown of central metabolism for redirecting glucose-6-phosphate fluxes
US10760105B2 (en) * 2014-12-30 2020-09-01 Novogy, Inc. Enhanced production of core lipids in oleaginous yeasts
WO2016134381A1 (en) 2015-02-20 2016-08-25 The Regents Of The University Of California Novel host cells and methods for producing isopentenol from mevalonate
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2017132924A1 (zh) * 2016-02-04 2017-08-10 中国科学院微生物研究所 一种用于生物合成异戊二烯和异戊烯的酶及其突变体
CN107815424B (zh) * 2016-09-12 2021-03-05 华东理工大学 一种产柠檬烯的解脂耶氏酵母基因工程菌及其应用
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
BR112019012306A2 (pt) * 2016-12-16 2019-11-12 Danisco Us Inc polipeptídeos de fusão de fosfocetolase-fosfotransacetilase bifuncionais
CN109234216B (zh) * 2017-07-10 2022-05-20 上海医药工业研究院 一种生产鲨烯的基因工程菌及其方法
CN108179114B (zh) * 2017-11-27 2021-08-20 南京晓庄学院 产抗厌氧菌化合物的菌株和发酵方法、抗厌氧菌化合物提取及制备方法和使用方法
WO2019113387A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
JP2021506316A (ja) 2017-12-21 2021-02-22 ザイマージェン インコーポレイテッド ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物
CA3090055A1 (en) * 2018-03-01 2019-09-06 Total Raffinage Chimie Metabolic pathways with increased carbon yield
CN109486720B (zh) * 2018-12-18 2020-08-04 江南大学 一种产l-木酮糖的枯草芽孢杆菌及其应用
EP3908663A1 (en) 2019-02-20 2021-11-17 Braskem S.A. Microorganisms and methods for the production of oxygenated compounds from hexoses
JP7463388B2 (ja) * 2019-02-20 2024-04-08 ブラスケム エス．エー． ペントース糖およびヘキソース糖のための分解経路
CN109929883A (zh) * 2019-04-02 2019-06-25 烟台华康荣赞生物科技有限公司 重组酵母、构建方法和其在制备酪醇及衍生物中的应用
KR102229379B1 (ko) * 2019-06-11 2021-03-19 주식회사 제노포커스 파이토플루엔 고생산성 재조합 미생물 및 이를 이용한 파이토플루엔의 제조방법
US20230272364A1 (en) * 2019-07-11 2023-08-31 Bp Corporation North America Inc. Gluconate dehydratase enzymes and recombinant cells
JP6917434B2 (ja) * 2019-10-25 2021-08-11 長瀬産業株式会社 好気性菌の代謝酵素破壊株およびその培養法
CN112300952B (zh) * 2020-11-27 2023-05-09 华东理工大学 一种产α-蒎烯的解脂耶氏酵母基因工程菌及其应用
WO2022232444A1 (en) * 2021-04-29 2022-11-03 Ginkgo Bioworks, Inc. Genetically modified yeast cells and methods of use for increased lipid yield
CN113549562B (zh) * 2021-07-14 2023-10-24 南京师范大学 一种高效生产广藿香醇的工程菌及其构建方法和应用
WO2023028459A1 (en) * 2021-08-24 2023-03-02 Lanzatech, Inc. Microbial fermentation for the production of isoprenoid alcohols and derivatives
CN115948456B (zh) * 2022-10-18 2024-09-17 重庆大学 一种可提升广藿香醇合成量的融合基因及方法

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19629568C1 (de) 1996-07-15 1998-01-08 Fraunhofer Ges Forschung Verfahren zur Herstellung von Isopren
GB9614979D0 (en) 1996-07-17 1996-09-04 Newteam Ltd Aerating arrangement primarily for a shower head
US6531303B1 (en) * 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
WO2002010398A2 (en) * 2000-07-31 2002-02-07 Hahn Frederick M Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
SE0200857D0 (sv) 2002-03-19 2002-03-19 Forskarpatent I Syd Ab Metabolic engineering for improved xylose utilisation of saccharomyces cerevisiae
JPWO2003095651A1 (ja) 2002-05-10 2005-09-15 協和醗酵工業株式会社 メバロン酸の製造方法
KR101148255B1 (ko) 2002-10-04 2012-08-08 다니스코 유에스 인크. 고수율을 갖는 1,3-프로판디올의 생물학적 제조 방법
JP4168870B2 (ja) 2003-08-14 2008-10-22 トヨタ自動車株式会社 プレニルアルコールの製造方法
EP2298859A3 (en) * 2004-07-27 2011-05-25 The Regents of the University of California Genetically modified host cells and use of same for producing isoprenoid compounds
DE602005020469D1 (de) * 2004-08-10 2010-05-20 Ajinomoto Kk Verwendung von phosphoketolase zur herstellung geeigneter metabolite
RU2004124226A (ru) * 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
US20090053797A1 (en) * 2005-08-19 2009-02-26 Yoichiro Shiba Genetically modified host cells and use of same for producing isoprenoid compounds
WO2007140339A2 (en) * 2006-05-26 2007-12-06 Amyris Biotechnologies, Inc. Production of isoprenoids
US7947478B2 (en) 2006-06-29 2011-05-24 The Regents Of The University Of California Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria
JP4986547B2 (ja) 2006-09-04 2012-07-25 株式会社Ａｄｅｋａ 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法
WO2009005704A1 (en) * 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
AU2008305655B2 (en) * 2007-09-20 2013-10-31 Amyris, Inc. Production of isoprenoids
EP2062967A1 (en) * 2007-11-21 2009-05-27 Technical University of Denmark Genetically engineered aspergillus
CN105368764B (zh) 2007-12-13 2019-03-12 丹尼斯科美国公司 用于生产异戊二烯的组合物和方法
US20110045563A1 (en) 2008-02-06 2011-02-24 The Regents Of The University Of California Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi
CA2728285A1 (en) * 2008-03-03 2009-09-11 Joule Unlimited, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest
WO2009132220A2 (en) 2008-04-23 2009-10-29 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
US7632995B2 (en) 2008-05-09 2009-12-15 Monsanto Technology Llc Plants and seeds of hybrid corn variety CH852179
MX318543B (es) 2008-07-02 2014-03-18 Danisco Us Inc Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros.
HU3516U (en) 2008-07-31 2008-11-28 Zoltan Kuthi Anti-theft protection of draining for fuel tanks
WO2010031062A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
EP2340312A2 (en) † 2008-09-15 2011-07-06 Danisco US Inc. Conversion of prenyl derivatives to isoprene
EP2344629B1 (en) 2008-09-15 2018-01-24 Danisco US Inc. Systems using cell culture for production of isoprene
CA2737223A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
MY161071A (en) * 2008-12-30 2017-04-14 Danisco Us Inc Methods of producing isoprene and a co-product
US20100297749A1 (en) 2009-04-21 2010-11-25 Sapphire Energy, Inc. Methods and systems for biofuel production
AU2010238770A1 (en) 2009-04-23 2011-11-03 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
JP4760951B2 (ja) 2009-05-08 2011-08-31 トヨタ自動車株式会社 ブタノール生産能を有する組換え微生物及びブタノールの製造方法
TW201412988A (zh) * 2009-06-17 2014-04-01 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
US20120252054A1 (en) 2009-09-15 2012-10-04 Sapphire Energy Inc System for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp.
BR112012006939A2 (pt) 2009-09-29 2015-09-08 Butamax Tm Advanced Biofuels célula hospedeira de produção de levedura recombinante e método para a produção de um produto selecionado do grupo que consiste em 2,3-butanodiol, isobutanol, 2-butanol, 1-butanol, 2-butanona, valina, leucina, ácido lático, ácido málico, álcool, isoampilico e isoprenoides
CN102812129B (zh) * 2009-11-10 2015-08-26 麻省理工学院 用于从类异戊二烯途径生产化学和医药产品的微生物工程
US8569562B2 (en) 2009-12-18 2013-10-29 Danisco Us Inc. Purification of isoprene from renewable resources
SG196782A1 (en) 2009-12-23 2014-02-13 Danisco Us Inc Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (pgl)
JP2013515507A (ja) 2009-12-29 2013-05-09 ビュータマックス・アドバンスド・バイオフューエルズ・エルエルシー 組換え宿主細胞におけるヘキソースキナーゼの発現
US8871488B2 (en) * 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases
CA2816306A1 (en) 2010-10-27 2012-05-03 Danisco Us Inc. Isoprene synthase variants for improved production of isoprene
CN103328631B (zh) † 2011-01-20 2017-04-26 丰田自动车株式会社 重组酵母和使用该重组酵母的物质生产方法
SG194691A1 (en) * 2011-04-29 2013-12-30 Danisco Us Inc Production of mevalonate, isoprene, and isoprenoids using genes encodingpolypeptides having thiolase, hmg-coa synthase and hmg-coa reductase enzymatic activities
PE20141519A1 (es) † 2011-07-12 2014-10-17 Scientist Of Fortune Sa Microorganismo recombinante para la produccion de metabolitos utiles
BR112014008278A2 (pt) 2011-10-07 2017-04-18 Danisco Us Inc utilização de fosfocetolase na produção de mevalonato, precursores isoprenoides e isopreno
CN104039974B (zh) * 2011-11-09 2016-10-12 阿迈瑞斯公司 乙酰辅酶a衍生的类异戊二烯的生产
MX364748B (es) * 2013-03-15 2019-05-06 Amyris Inc Uso de fosfoquetolasa y fosfotransacetilasa para la produccion de compuestos derivados de acetil-coenzima a.

Also Published As

Publication number Publication date
US20150225744A1 (en) 2015-08-13
AU2012332996A1 (en) 2014-04-24
US20130089906A1 (en) 2013-04-11
EP2764084A1 (en) 2014-08-13
US8993305B2 (en) 2015-03-31
DK2764084T4 (da) 2021-12-06
JP6420147B2 (ja) 2018-11-07
US20170198311A1 (en) 2017-07-13
US9493791B2 (en) 2016-11-15
DK3339426T3 (da) 2022-09-12
DK2764084T3 (en) 2018-04-09
SG11201401249PA (en) 2014-05-29
MX2014004209A (es) 2014-08-08
CN104053765A (zh) 2014-09-17
WO2013066568A1 (en) 2013-05-10
EP2764084B2 (en) 2021-11-03
JP2014531904A (ja) 2014-12-04
BR112014008278A2 (pt) 2017-04-18
JP2019030315A (ja) 2019-02-28
EP2764084B1 (en) 2018-02-28
JP6639606B2 (ja) 2020-02-05
EP3339426A1 (en) 2018-06-27
HK1201071A1 (en) 2015-08-21
EP3339426B1 (en) 2022-08-24
US10113185B2 (en) 2018-10-30

Similar Documents

Publication Publication Date Title
US10113185B2 (en) Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
US11371035B2 (en) Phosphoketolases for improved production of acetyl coenzyme A-derived metabolites, isoprene, isoprenoid precursors, and isoprenoid
US10364443B2 (en) Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, HMG-CoA synthase and HMG-CoA reductase enzymatic activities
US10138498B2 (en) Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids
US20160002672A1 (en) Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway
WO2013020118A1 (en) Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase
BR122023000309B1 (pt) Célula recombinante e método de produção de isopreno, de precursores de isoprenoides, de isoprenoides e/ou de metabólitos derivados de acetil coenzima a

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20181005