CN104053765A - 利用磷酸酮醇酶产生甲羟戊酸、类异戊二烯前体和异戊二烯 - Google Patents

利用磷酸酮醇酶产生甲羟戊酸、类异戊二烯前体和异戊二烯 Download PDF

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Publication number
CN104053765A
CN104053765A CN201280059852.7A CN201280059852A CN104053765A CN 104053765 A CN104053765 A CN 104053765A CN 201280059852 A CN201280059852 A CN 201280059852A CN 104053765 A CN104053765 A CN 104053765A
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polypeptide
phosphoketolase
nucleic acid
heterologous nucleic
cell
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CN201280059852.7A
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English (en)
Chinese (zh)
Inventor
Z·Q·贝克
A·C·埃利奥特
C·M·派瑞斯
D·V·瓦维林
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Goodyear Tire and Rubber Co
Danisco USA Inc
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Goodyear Tire and Rubber Co
Danisco USA Inc
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Application filed by Goodyear Tire and Rubber Co, Danisco USA Inc filed Critical Goodyear Tire and Rubber Co
Publication of CN104053765A publication Critical patent/CN104053765A/zh
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    • C—CHEMISTRY; METALLURGY
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    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
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    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01008—Phosphate acetyltransferase (2.3.1.8)
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    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02009—Phosphoketolase (4.1.2.9)
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    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03027—Isoprene synthase (4.2.3.27)
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    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/03—Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
    • C12Y503/03002—Isopentenyl-diphosphate DELTA-isomerase (5.3.3.2)
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    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
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    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Biophysics (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201280059852.7A 2011-10-07 2012-10-05 利用磷酸酮醇酶产生甲羟戊酸、类异戊二烯前体和异戊二烯 Pending CN104053765A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161545083P 2011-10-07 2011-10-07
US61/545,083 2011-10-07
PCT/US2012/059136 WO2013066568A1 (en) 2011-10-07 2012-10-05 Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene

Publications (1)

Publication Number Publication Date
CN104053765A true CN104053765A (zh) 2014-09-17

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CN201280059852.7A Pending CN104053765A (zh) 2011-10-07 2012-10-05 利用磷酸酮醇酶产生甲羟戊酸、类异戊二烯前体和异戊二烯

Country Status (12)

Country Link
US (3) US8993305B2 (https=)
EP (2) EP2764084B2 (https=)
JP (2) JP6420147B2 (https=)
CN (1) CN104053765A (https=)
AU (1) AU2012332996A1 (https=)
BR (1) BR112014008278A2 (https=)
CA (1) CA2851265A1 (https=)
DK (2) DK3339426T3 (https=)
HK (1) HK1201071A1 (https=)
MX (1) MX2014004209A (https=)
SG (1) SG11201401249PA (https=)
WO (1) WO2013066568A1 (https=)

Cited By (7)

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WO2017132924A1 (zh) * 2016-02-04 2017-08-10 中国科学院微生物研究所 一种用于生物合成异戊二烯和异戊烯的酶及其突变体
CN107815424A (zh) * 2016-09-12 2018-03-20 华东理工大学 一种产柠檬烯的解脂耶氏酵母基因工程菌及其应用
CN108179114A (zh) * 2017-11-27 2018-06-19 南京晓庄学院 产抗厌氧菌化合物的菌株和发酵方法、抗厌氧菌化合物提取及制备方法和使用方法
CN109234216A (zh) * 2017-07-10 2019-01-18 上海医药工业研究院 一种生产鲨烯的基因工程菌及其方法
CN109486720A (zh) * 2018-12-18 2019-03-19 江南大学 一种产l-木酮糖的枯草芽孢杆菌及其应用
CN113549562A (zh) * 2021-07-14 2021-10-26 南京师范大学 一种高效生产广藿香醇的工程菌及其构建方法和应用
CN115948456A (zh) * 2022-10-18 2023-04-11 重庆大学 一种可提升广藿香醇合成量的融合基因及方法

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CN110366594B (zh) * 2016-12-16 2023-12-15 丹尼斯科美国公司 双功能磷酸转酮酶-磷酸转乙酰酶融合多肽
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CN109929883A (zh) * 2019-04-02 2019-06-25 烟台华康荣赞生物科技有限公司 重组酵母、构建方法和其在制备酪醇及衍生物中的应用
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JP6917434B2 (ja) * 2019-10-25 2021-08-11 長瀬産業株式会社 好気性菌の代謝酵素破壊株およびその培養法
CN112300952B (zh) * 2020-11-27 2023-05-09 华东理工大学 一种产α-蒎烯的解脂耶氏酵母基因工程菌及其应用
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