JP2014525233A5 - - Google Patents

Info

Publication number

JP2014525233A5

JP2014525233A5 JP2014524371A JP2014524371A JP2014525233A5 JP 2014525233 A5 JP2014525233 A5 JP 2014525233A5 JP 2014524371 A JP2014524371 A JP 2014524371A JP 2014524371 A JP2014524371 A JP 2014524371A JP 2014525233 A5 JP2014525233 A5 JP 2014525233A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

antibody

acid sequence

sequence

Prior art date

2012-08-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 125000003275 alpha amino acid group Chemical group 0.000 claims 41
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 24
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 24
• YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 claims 8
• 229950004354 phosphorylcholine Drugs 0.000 claims 8
• 150000007523 nucleic acids Chemical group 0.000 claims 7
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 230000002265 prevention Effects 0.000 claims 5
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 201000001320 Atherosclerosis Diseases 0.000 claims 2
• 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 2
• 101100495352 Candida albicans CDR4 gene Proteins 0.000 claims 2
• 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 2
• 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 2
• 241000124008 Mammalia Species 0.000 claims 2
• 208000030159 metabolic disease Diseases 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 239000013612 plasmid Substances 0.000 claims 2
• 201000010065 polycystic ovary syndrome Diseases 0.000 claims 2
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 108091026890 Coding region Proteins 0.000 claims 1
• 208000032928 Dyslipidaemia Diseases 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 241000282412 Homo Species 0.000 claims 1
• 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 1
• 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
• 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
• 206010022489 Insulin Resistance Diseases 0.000 claims 1
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
• 206010036049 Polycystic ovaries Diseases 0.000 claims 1
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 239000000427 antigen Substances 0.000 claims 1
• 102000036639 antigens Human genes 0.000 claims 1
• 108091007433 antigens Proteins 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000016097 disease of metabolism Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 201000001421 hyperglycemia Diseases 0.000 claims 1
• 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
• 238000002649 immunization Methods 0.000 claims 1
• 230000003053 immunization Effects 0.000 claims 1
• 230000000302 ischemic effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000003405 preventing effect Effects 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1