JP2014521725A - ＪＡＫＰＩ３Ｋ／ｍＴＯＲ併用療法 - Google Patents

ＪＡＫＰＩ３Ｋ／ｍＴＯＲ併用療法 Download PDF

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Publication number
JP2014521725A
JP2014521725A JP2014525162A JP2014525162A JP2014521725A JP 2014521725 A JP2014521725 A JP 2014521725A JP 2014525162 A JP2014525162 A JP 2014525162A JP 2014525162 A JP2014525162 A JP 2014525162A JP 2014521725 A JP2014521725 A JP 2014521725A
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JP
Japan
Prior art keywords
compound
formula
pharmaceutically acceptable
methyl
alkyl
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JP2014525162A
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English (en)
Japanese (ja)
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JP2014521725A5 (enExample
Inventor
アレッサンドロ・エンメ・ヴァンヌッキ
コスタンツァ・ボガーニ
ニッコロ・ヴァルタルッチ
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Novartis Pharma AG
Incyte Corp
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Novartis Pharma AG
Incyte Corp
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Publication of JP2014521725A publication Critical patent/JP2014521725A/ja
Publication of JP2014521725A5 publication Critical patent/JP2014521725A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014525162A 2011-08-10 2012-08-10 ＪＡＫＰＩ３Ｋ／ｍＴＯＲ併用療法 Pending JP2014521725A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161522001P 2011-08-10 2011-08-10
US61/522,001 2011-08-10
PCT/US2012/050252 WO2013023119A1 (en) 2011-08-10 2012-08-10 JAK P13K/mTOR COMBINATION THERAPY

Publications (2)

Publication Number Publication Date
JP2014521725A true JP2014521725A (ja) 2014-08-28
JP2014521725A5 JP2014521725A5 (enExample) 2015-09-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014525162A Pending JP2014521725A (ja) 2011-08-10 2012-08-10 ＪＡＫＰＩ３Ｋ／ｍＴＯＲ併用療法

Country Status (6)

Country Link
US (1) US9358229B2 (enExample)
EP (1) EP2741747A1 (enExample)
JP (1) JP2014521725A (enExample)
CA (1) CA2844507A1 (enExample)
HK (1) HK1198579A1 (enExample)
WO (1) WO2013023119A1 (enExample)

Cited By (1)

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JP2014533294A (ja) * 2011-11-15 2014-12-11 ノバルティス アーゲー ホスホイノシチド３−キナーゼ阻害剤およびヤヌスキナーゼ２−シグナル伝達兼転写活性化因子５経路の調節剤の組合せ

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