JP2014517842A5 - - Google Patents

Download PDF

Info

Publication number
JP2014517842A5
JP2014517842A5 JP2014512101A JP2014512101A JP2014517842A5 JP 2014517842 A5 JP2014517842 A5 JP 2014517842A5 JP 2014512101 A JP2014512101 A JP 2014512101A JP 2014512101 A JP2014512101 A JP 2014512101A JP 2014517842 A5 JP2014517842 A5 JP 2014517842A5
Authority
JP
Japan
Prior art keywords
cancer
group
pharmaceutically acceptable
acceptable salt
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014512101A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014517842A (ja
JP6105566B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/039312 external-priority patent/WO2012162482A1/en
Publication of JP2014517842A publication Critical patent/JP2014517842A/ja
Publication of JP2014517842A5 publication Critical patent/JP2014517842A5/ja
Application granted granted Critical
Publication of JP6105566B2 publication Critical patent/JP6105566B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014512101A 2011-05-26 2012-05-24 免疫コンジュゲート、それらを含有する組成物、ならびに製造方法および使用方法 Expired - Fee Related JP6105566B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161490117P 2011-05-26 2011-05-26
US61/490,117 2011-05-26
PCT/US2012/039312 WO2012162482A1 (en) 2011-05-26 2012-05-24 Immunoconjugates, compositions containing them, and methods of making and use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017017666A Division JP6359133B2 (ja) 2011-05-26 2017-02-02 免疫コンジュゲート、それらを含有する組成物、ならびに製造方法および使用方法

Publications (3)

Publication Number Publication Date
JP2014517842A JP2014517842A (ja) 2014-07-24
JP2014517842A5 true JP2014517842A5 (cg-RX-API-DMAC7.html) 2015-05-21
JP6105566B2 JP6105566B2 (ja) 2017-03-29

Family

ID=46172969

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014512101A Expired - Fee Related JP6105566B2 (ja) 2011-05-26 2012-05-24 免疫コンジュゲート、それらを含有する組成物、ならびに製造方法および使用方法
JP2017017666A Expired - Fee Related JP6359133B2 (ja) 2011-05-26 2017-02-02 免疫コンジュゲート、それらを含有する組成物、ならびに製造方法および使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017017666A Expired - Fee Related JP6359133B2 (ja) 2011-05-26 2017-02-02 免疫コンジュゲート、それらを含有する組成物、ならびに製造方法および使用方法

Country Status (23)

Country Link
US (2) US8852599B2 (cg-RX-API-DMAC7.html)
EP (1) EP2714092B1 (cg-RX-API-DMAC7.html)
JP (2) JP6105566B2 (cg-RX-API-DMAC7.html)
KR (1) KR102070464B1 (cg-RX-API-DMAC7.html)
CN (1) CN103561772B (cg-RX-API-DMAC7.html)
AR (1) AR086568A1 (cg-RX-API-DMAC7.html)
AU (1) AU2012258750B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013029764A2 (cg-RX-API-DMAC7.html)
CA (1) CA2837327C (cg-RX-API-DMAC7.html)
CL (1) CL2013003393A1 (cg-RX-API-DMAC7.html)
CO (1) CO6831975A2 (cg-RX-API-DMAC7.html)
EA (1) EA024844B1 (cg-RX-API-DMAC7.html)
ES (1) ES2814798T3 (cg-RX-API-DMAC7.html)
IL (1) IL229477A (cg-RX-API-DMAC7.html)
MA (1) MA35153B1 (cg-RX-API-DMAC7.html)
MX (1) MX336806B (cg-RX-API-DMAC7.html)
PE (1) PE20141480A1 (cg-RX-API-DMAC7.html)
PH (1) PH12013502189A1 (cg-RX-API-DMAC7.html)
SG (1) SG195011A1 (cg-RX-API-DMAC7.html)
TW (1) TW201300401A (cg-RX-API-DMAC7.html)
UY (1) UY34100A (cg-RX-API-DMAC7.html)
WO (1) WO2012162482A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA201309669B (cg-RX-API-DMAC7.html)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009012394A1 (en) 2007-07-17 2009-01-22 Medarex, Inc. Monoclonal antibodies against glypican-3
CA3111357A1 (en) 2011-12-23 2013-06-27 Pfizer Inc. Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
BR112015014712A2 (pt) 2012-12-21 2017-07-11 Abgenomics Int Inc ligadores de autoimolação hidrofílicos e seus conjugados
EP2976362B1 (en) 2013-03-19 2019-10-23 Beijing Shenogen Pharma Group Ltd. Antibodies and methods for treating estrogen receptor-associated diseases
WO2014177771A1 (en) 2013-05-02 2014-11-06 Glykos Finland Oy Conjugates of a glycoprotein or a glycan with a toxic payload
CN105636612B (zh) 2013-08-12 2020-01-14 基因泰克公司 抗体-药物缀合物及使用和治疗方法
CN105828840B (zh) 2013-12-16 2020-08-04 基因泰克公司 1-(氯甲基)-2,3-二氢-1H-苯并[e]吲哚二聚体抗体-药物缀合物化合物及使用和治疗方法
MY180257A (en) 2014-01-27 2020-11-26 Pfizer Bifunctional cytotoxic agents
US10450363B2 (en) 2014-03-20 2019-10-22 Bristol-Myers Squibb Company Stabilized fibronectin based scaffold molecules
MX375284B (es) * 2014-04-30 2025-03-06 Pfizer Conjugados de anticuerpo-fármaco anti-proteína tirosina quinasa 7 (anti-ptk7).
JP2017523958A (ja) * 2014-06-20 2017-08-24 バイオアライアンス コマンディテール フェンノートシャップ 抗cd22抗体−薬物コンジュゲート及びその使用方法
AU2015276821A1 (en) 2014-06-20 2017-01-12 Abgenomics International Inc. Anti-folate receptor aplha (FRA) antibody-drug conjugates and methods of using thereof
CA2954934C (en) 2014-06-30 2023-09-26 Glykos Finland Oy Drug derivative and conjugates
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
ES2807182T3 (es) 2014-11-21 2021-02-22 Bristol Myers Squibb Co Anticuerpos frente a CD73 y sus usos
WO2016081746A2 (en) 2014-11-21 2016-05-26 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
EA037590B1 (ru) 2014-11-25 2021-04-19 Бристол-Майерс Сквибб Компани Связывающиеся с pd-l1 полипептиды на основе 10fn3 домена для визуализации
WO2016144608A1 (en) 2015-03-10 2016-09-15 Bristol-Myers Squibb Company Antibodies conjugatable by transglutaminase and conjugates made therefrom
CA2923862C (en) 2015-03-20 2024-02-13 Pfizer Inc. Bifunctional cytotoxic agents containing the cti pharmacophore
RS63897B1 (sr) 2015-05-29 2023-02-28 Bristol Myers Squibb Co Antitela protiv ox40 i njihova primena
EP3319597B1 (en) 2015-07-10 2021-02-17 Byondis B.V. Compositions comprising antibody-duocarmycin drug conjugates
GB201601073D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
GB201601075D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies molecules
GB201601077D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibody molecule
WO2017040349A1 (en) 2015-08-28 2017-03-09 Ventana Medical Systems, Inc. Protein proximity assay in formalin fixed paffafin embedded tissue using caged haptens
KR102818445B1 (ko) 2015-09-23 2025-06-10 브리스톨-마이어스 스큅 컴퍼니 글리피칸-3-결합 피브로넥틴 기반 스캐폴드 분자
GEP20207174B (en) 2015-11-18 2020-11-10 Merck Sharp & Dohme Ctla4 binders
US10689458B2 (en) 2015-11-30 2020-06-23 Pfizer Inc. Site specific HER2 antibody drug conjugates
JP2019505575A (ja) 2015-12-21 2019-02-28 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 部位特異的な結合のための変異型抗体
IL260289B (en) 2016-01-08 2022-08-01 Bioalliance Cv Tetravalent anti-psgl-1 antibodies and uses thereof
SG10201913033UA (en) 2016-03-04 2020-03-30 Bristol Myers Squibb Co Combination therapy with anti-cd73 antibodies
US20170326249A1 (en) 2016-05-10 2017-11-16 Bristol-Myers Squibb Company Antibody-drug conjugate of an anti-glypican-3 antibody and a tubulysin analog, preparation and uses
WO2018035391A1 (en) 2016-08-19 2018-02-22 Bristol-Myers Squibb Company Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use
HUE057289T2 (hu) 2016-08-31 2022-05-28 Jiangsu Hengrui Medicine Co Oxopikolinamid-származék, annak elõállítási módszere és gyógyszerészeti felhasználása
WO2018048975A1 (en) 2016-09-09 2018-03-15 Bristol-Myers Squibb Company Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment
WO2018064094A1 (en) 2016-09-28 2018-04-05 Bristol-Myers Squibb Company Enantioselective synthesis of pyrroloindole compounds
AU2017355446A1 (en) * 2016-11-03 2019-05-02 Bristol-Myers Squibb Company Activatable anti-CTLA-4 antibodies and uses thereof
CA3221995C (en) 2017-02-08 2024-05-28 Dragonfly Therapeutics, Inc. Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
WO2018148610A1 (en) * 2017-02-10 2018-08-16 Adimab, Llc Proteins binding psma, nkg2d and cd16
SG11201907646YA (en) 2017-02-20 2019-09-27 Dragonfly Therapeutics Inc Proteins binding her2, nkg2d and cd16
EP3630833A1 (en) 2017-05-25 2020-04-08 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
TWI870011B (zh) 2017-08-25 2025-01-11 美商戊瑞治療有限公司 B7-h4抗體及其使用方法
US11364303B2 (en) 2017-09-29 2022-06-21 Pfizer Inc. Cysteine engineered antibody drug conjugates
CN108148137B (zh) * 2017-12-29 2021-03-23 中国人民解放军第四军医大学 一种b7h4/1e10单克隆抗体及其应用
KR20200118824A (ko) 2018-02-08 2020-10-16 드래곤플라이 쎄라퓨틱스, 인크. 자연 살해 세포를 활성화시키는 다중-특이성 결합 단백질을 수반하는 암의 병용 요법
PT3749346T (pt) 2018-02-08 2024-09-05 Dragonfly Therapeutics Inc Combinações de domínios variáveis de anticorpos dirigidas ao receptor nkg2d
CA3091424A1 (en) 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
CN111741978A (zh) 2018-02-21 2020-10-02 戊瑞治疗有限公司 B7-h4抗体制剂
CA3091801A1 (en) 2018-03-02 2019-09-06 Five Prime Therapeutics, Inc. B7-h4 antibodies and methods of use thereof
AU2019318083A1 (en) 2018-08-08 2021-02-25 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind BCMA, NKG2D and CD16, and methods of use
CA3108646A1 (en) 2018-08-08 2020-02-13 Dragonfly Therapeutics, Inc. Proteins binding nkg2d, cd16 and a tumor-associated antigen
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
EP3887397A1 (en) 2018-11-28 2021-10-06 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
FI3886914T3 (fi) 2018-11-30 2023-05-26 Bristol Myers Squibb Co Glutamiinin sisältävän kevytketjun c-terminaalisen jatkeen käsittävä vasta-aine, sen konjugaatteja, ja menetelmiä ja käyttöjä
KR20210102334A (ko) 2018-12-12 2021-08-19 브리스톨-마이어스 스큅 컴퍼니 트랜스글루타미나제 접합을 위해 변형된 항체, 그의 접합체, 및 방법 및 용도
CN112351797B (zh) * 2019-06-06 2023-12-22 上海翰森生物医药科技有限公司 抗b7-h4抗体-药物偶联物及其医药用途
US20240377413A1 (en) 2019-09-16 2024-11-14 Bristol-Myers Squibb Company Dual capture method for analysis of antibody-drug conjugates
MX2022013944A (es) 2020-05-06 2022-11-30 Dragonfly Therapeutics Inc Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a).
WO2022140289A1 (en) 2020-12-21 2022-06-30 Cornell University Peptide-linked drug delivery system
TW202241954A (zh) 2021-01-04 2022-11-01 美商梅爾莎納醫療公司 靶向b7-h4之抗體-藥物共軛體和使用彼之方法
JP2024504944A (ja) * 2021-01-15 2024-02-02 ヴェンタナ メディカル システムズ, インク. 保存安定なケージドハプテン
JP2024508894A (ja) 2021-03-03 2024-02-28 ドラゴンフライ セラピューティクス, インコーポレイテッド Nkg2d、cd16、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016324A1 (en) 1990-04-25 1991-10-31 The Upjohn Company Novel cc-1065 analogs
US5686072A (en) * 1992-06-17 1997-11-11 Board Of Regents, The University Of Texas Epitope-specific monoclonal antibodies and immunotoxins and uses thereof
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US5659022A (en) 1996-01-05 1997-08-19 Epoch Pharmaceuticals, Inc. Oligonucleotide-cyclopropapyrroloindole conjugates as sequence specific hybridization and crosslinking agents for nucleic acids
WO2001014424A2 (en) 1999-08-24 2001-03-01 Medarex, Inc. Human ctla-4 antibodies and their uses
US7087600B2 (en) 2001-05-31 2006-08-08 Medarex, Inc. Peptidyl prodrugs and linkers and stabilizers useful therefor
CA2451188A1 (en) 2001-06-25 2003-01-03 Drug Innovation & Design, Incorporated Exponential pattern recognition based cellular targeting, compositions, methods and anticancer applications
KR100829283B1 (ko) 2002-01-09 2008-05-13 메다렉스, 인코포레이티드 Cd30에 대한 인간 모노클로날 항체
US6756397B2 (en) 2002-04-05 2004-06-29 Immunogen, Inc. Prodrugs of CC-1065 analogs
GT200400138A (es) 2003-07-22 2005-03-22 Anticuerpos rgi y uso de los mismos.
JP4806680B2 (ja) 2004-05-19 2011-11-02 メダレックス インコーポレイテッド 自己犠牲リンカー及び薬剤複合体
RU2402548C2 (ru) 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
CA2598454C (en) 2005-02-18 2013-04-09 Medarex, Inc. Monoclonal antibodies against prostate specific membrane antigen (psma) lacking in fucosyl residues
DK1851250T3 (da) 2005-02-18 2012-07-09 Medarex Inc Humant monoklonalt antistof mod prostataspecifikt membranantigen (psma)
EP1896582A4 (en) 2005-05-09 2009-04-08 Ono Pharmaceutical Co HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED CELL DEATH 1 (PD-1) AND METHOD FOR CREATING TREATMENT WITH ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS
MX2007015944A (es) 2005-06-20 2008-03-07 Medarex Inc Anticuerpos cd19 y sus usos.
NZ566982A (en) 2005-09-26 2011-06-30 Medarex Inc Duocarmycin drug conjugates
CA2623236A1 (en) 2005-09-26 2007-04-05 Medarex, Inc. Human monoclonal antibodies to cd70
CA2627190A1 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
EA017812B1 (ru) 2005-12-08 2013-03-29 Медарекс, Инк. Выделенное моноклональное антитело или его антигенсвязывающий участок, которые связываются с протеинтирозинкиназой 7 ( ptk7) человека, и их применение
BRPI0620601A2 (pt) 2005-12-08 2011-11-16 Medarex Inc anticorpo monoclonal humano isolado ou uma porção ligante ao antìgeno do mesmo, composição, imunoconjugado, molécula de ácido nucléico isolada, vetor de expressão, célula hospedeira, método para preparar um anticorpo anti-o8e e método para tratar ou prevenir uma doença definida pelo crescimento de células tumorais expressando o8e
RU2489423C2 (ru) 2006-02-02 2013-08-10 Синтарга Б.В. Водорастворимые аналоги сс-1065 и их конъюгаты
JP2010502221A (ja) 2006-09-08 2010-01-28 アンブルックス,インコーポレイテッド 脊椎動物細胞による非天然アミノ酸の部位特異的組み込み
KR101552735B1 (ko) 2006-12-01 2015-09-14 메다렉스, 엘.엘.시. 씨디22에 결합하는 인간 항체 및 이의 용도
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
CN101605906A (zh) * 2006-12-14 2009-12-16 梅达雷克斯公司 结合cd70的人类抗体及其用途
NZ578354A (en) * 2006-12-14 2012-01-12 Medarex Inc Antibody-partner molecule conjugates that bind cd70 and uses thereof
UY30776A1 (es) 2006-12-21 2008-07-03 Medarex Inc Anticuerpos cd44
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
AU2008218766A1 (en) 2007-02-21 2008-08-28 Medarex, Inc. Chemical linkers with single amino acids and conjugates thereof
WO2009012394A1 (en) 2007-07-17 2009-01-22 Medarex, Inc. Monoclonal antibodies against glypican-3
BRPI0816014A8 (pt) * 2007-10-01 2018-06-19 Bristol Myers Squibb Co anticorpo humano monoclonal isolado, composição, conjugado anticorpo-molécula parceiro, mólecula isolada de ácido nucléico, vetor de expressão, célula hospedeira, método para preparar um anticorpo anti-mesotelina, método de inibição do crescimento de uma célula tumoral expressando a mesotelina, método de tratamento do câncer em um indivíduo, anticorpo anti-mesotelina isolado, e método de inibir o crescimento de uma célula expressando a mesotelina
TW200930407A (en) 2007-11-30 2009-07-16 Medarex Inc Conjugates of anti-RG-1 antibodies
AR069747A1 (es) * 2007-11-30 2010-02-17 Medarex Inc Conjugado anticuerpo monoclonal anti-b7h4- farmaco y metodos de utilizacion
EP2229187A2 (en) * 2007-11-30 2010-09-22 Bristol-Myers Squibb Company Monoclonal antibody partner molecule conjugates directed to protein tyrosine kinase 7 (ptk7)

Similar Documents

Publication Publication Date Title
JP2014517842A5 (cg-RX-API-DMAC7.html)
JP6359133B2 (ja) 免疫コンジュゲート、それらを含有する組成物、ならびに製造方法および使用方法
JP2015508074A5 (cg-RX-API-DMAC7.html)
JP2016530254A5 (cg-RX-API-DMAC7.html)
US20200277306A1 (en) Biologically active molecules, conjugates thereof, and therapeutic uses
JP2013542958A5 (cg-RX-API-DMAC7.html)
JP2017514905A5 (cg-RX-API-DMAC7.html)
JP6302490B2 (ja) ツブリシン化合物、その製造および使用方法
JP2016508136A5 (cg-RX-API-DMAC7.html)
RU2014146951A (ru) Конъюгаты типа лиганд dr5-лекарственное средство
RU2016150377A (ru) Сайт-специфичная конъюгация линкерных лекарственных препаратов с антителами и получаемые в результате adc
JP2007527421A5 (cg-RX-API-DMAC7.html)
RU2015129800A (ru) Гидрофильные саморазрушающиеся линкеры и их конъюгаты
JP2017525755A5 (cg-RX-API-DMAC7.html)
JP2017504606A5 (cg-RX-API-DMAC7.html)
RU2017101681A (ru) Конъюгаты анти-cd22 антитело - лекарственное средство и способы их применения
JP2016521256A5 (cg-RX-API-DMAC7.html)
JP2020526584A5 (cg-RX-API-DMAC7.html)
TR201802090T4 (tr) Kanserin tedavisine yönelik monoklonal anti-GT468 antikorlar.
JP2016512832A5 (cg-RX-API-DMAC7.html)
RU2016129894A (ru) Ковалентно связанные конъюгаты хеликар-антитело против хеликара и их применения
WO2023083900A1 (en) Conjugates comprising a phosphorus (v) and a drug moiety
RU2019111303A (ru) Антитела против edb и конъюгаты антитело-лекарственное средство
RU2016130349A (ru) Способы применения антител против steap1 и иммуноконъюгатов
JPWO2019232449A5 (cg-RX-API-DMAC7.html)