CN112351797B - 抗b7-h4抗体-药物偶联物及其医药用途 - Google Patents
抗b7-h4抗体-药物偶联物及其医药用途 Download PDFInfo
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Abstract
Description
名称 | 序列 | 编号 |
HCDR1 | GFTF SRYGMS | SEQ ID NO:3 |
HCDR2 | GINGGGSYTYYLDTVKG | SEQ ID NO:4 |
HCDR3 | QGSNYYFDY | SEQ ID NO:5 |
LCDR1 | HASQGISSNIG | SEQ ID NO:6 |
LCDR2 | HGTNLED | SEQ ID NO:7 |
LCDR3 | VQYAQFPYT | SEQ ID NO:8 |
名称 | 序列 | 编号 |
HCDR1 | GFTF SNYYMS | SEQ ID NO:9 |
HCDR2 | YVSSGGGSTYYSDSVKG | SEQ ID NO:10 |
HCDR3 | ESYSQGNYFDY | SEQ ID NO:11 |
LCDR1 | RASQSISDYLH | SEQ ID NO:12 |
LCDR2 | FASQSIS | SEQ ID NO:13 |
LCDR3 | QNGHSF SLT | SEQ ID NO:14 |
名称 | 序列 | 编号 |
HCDR1 | GYTFTNSWMN | SEQ ID NO:23 |
HCDR2 | GIYPNSGNIEYNEKFKG | SEQ ID NO:24 |
HCDR3 | DSRFSY | SEQ ID NO:25 |
LCDR1 | KASQDVRTAVA | SEQ ID NO:26 |
LCDR2 | STSYRYT | SEQ ID NO:27 |
LCDR3 | QQHYSTPLT | SEQ ID NO:28 |
抗体名称 | 与MX-1细胞的FACS Binding EC50(nM) |
hu2G6 | 14.3 |
hu2F8 | 7.26 |
hu1C9 | 7.25 |
hu2F7 | 7.32 |
抗体 | 0小时(%) | 0.5小时(%) | 2小时(%) |
IgG对照 | 0 | 0.1 | 0.9 |
hu2G6 | 0 | 18.6 | 28.7 |
hu2F7 | 0 | 13.9 | 25.9 |
给药组 | 抑瘤率 |
hu2F7-MC-MMAF(y=2)3mg/kg | 87.99% |
hu2F7-MC-MMAF(y=4)3mg/kg | 197.87% |
Claims (66)
Applications Claiming Priority (5)
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CN2019104989932 | 2019-06-06 | ||
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CN2020102153223 | 2020-03-24 | ||
PCT/CN2020/094856 WO2020244657A1 (zh) | 2019-06-06 | 2020-06-08 | 抗b7-h4抗体-药物偶联物及其医药用途 |
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CN112351797B true CN112351797B (zh) | 2023-12-22 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2021003382A (es) * | 2018-09-26 | 2021-05-27 | Jiangsu Hengrui Medicine Co | Conjugado de ligando y farmaco analogo de exatecan, metodo de preparacion del mismo y aplicacion del mismo. |
KR20220113728A (ko) * | 2019-12-12 | 2022-08-16 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 항 클라우딘 항체 약물 접합체 및 그 의약 용도 |
BR112022024930A2 (pt) | 2020-06-08 | 2022-12-27 | Baili Bio Chengdu Pharmaceutical Co Ltd | Fármaco de camptotecina possuindo unidade de conexão hidrofílica de alta estabilidade e conjugado do mesmo |
AU2020442003B2 (en) * | 2020-09-15 | 2023-09-28 | Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. | A camptothecin drug and its antibody conjugate thereof |
JP2024501894A (ja) | 2021-01-04 | 2024-01-16 | メルサナ セラピューティクス インコーポレイテッド | B7h4ターゲティング抗体-薬物コンジュゲートおよびその使用方法 |
EP4285936A1 (en) * | 2021-01-29 | 2023-12-06 | Shanghai Hansoh Biomedical Co., Ltd. | Antibody-drug conjugate and medical use thereof |
CN114409562A (zh) * | 2021-02-08 | 2022-04-29 | 四川百利药业有限责任公司 | 一种ca4衍生物及其配体-药物偶联物 |
CN116888123A (zh) * | 2021-02-09 | 2023-10-13 | 微境生物医药科技(上海)有限公司 | 用于adc制备的喜树碱衍生物 |
CN117015549A (zh) * | 2021-03-17 | 2023-11-07 | 江苏恒瑞医药股份有限公司 | 一种喜树碱衍生物的制备方法 |
WO2023178641A1 (zh) | 2022-03-25 | 2023-09-28 | 成都百利多特生物药业有限责任公司 | 一种dna毒性二聚体化合物及其偶联物 |
CN116917324A (zh) * | 2021-04-26 | 2023-10-20 | 江苏恒瑞医药股份有限公司 | 抗Nectin-4抗体和抗Nectin-4抗体-药物偶联物及其医药用途 |
CN113816969B (zh) * | 2021-04-30 | 2024-01-16 | 联宁(苏州)生物制药有限公司 | 依喜替康类化合物、其抗体药物偶联物及其应用 |
US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
TW202340255A (zh) * | 2022-03-30 | 2023-10-16 | 大陸商映恩生物製藥(蘇州)有限公司 | B7h4抗體藥物偶聯物及其用途 |
KR20240001074A (ko) * | 2022-06-24 | 2024-01-03 | 주식회사 피노바이오 | 하나의 항체에 2종의 약물-링커 접합체가 연결된 항체-약물접합체 |
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EP3981434A4 (en) | 2023-11-01 |
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