CN112351797A - 抗b7-h4抗体-药物偶联物及其医药用途 - Google Patents

抗b7-h4抗体-药物偶联物及其医药用途 Download PDF

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CN112351797A
CN112351797A CN202080003353.0A CN202080003353A CN112351797A CN 112351797 A CN112351797 A CN 112351797A CN 202080003353 A CN202080003353 A CN 202080003353A CN 112351797 A CN112351797 A CN 112351797A
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antibody
drug conjugate
pharmaceutically acceptable
acceptable salt
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CN112351797B (zh
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花海清
刘素霞
包如迪
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Changzhou Hengbang Pharmaceutical Co ltd
Jiangsu Hansoh Pharmaceutical Group Co Ltd
Shanghai Hansoh Biomedical Co Ltd
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Jiangsu Hansoh Pharmaceutical Group Co Ltd
Shanghai Hansoh Biomedical Co Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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Abstract

一种抗B7‑H4抗体‑药物偶联物及其医药用途。具体地，一种抗B7‑H4抗体或其抗原结合片段，包含所述抗B7‑H4抗体的CDR区的人源化抗体，及其抗体‑药物偶联物或其可药用盐或溶剂化合物，以及前述抗体‑药物偶联物或其可药用盐或溶剂化合物的药物组合物，以及其作为抗癌药物的用途，尤其在制备用于治疗B7‑H4高表达的疾病或病症的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (41)

  1. PCT国内申请，权利要求书已公开。
CN202080003353.0A 2019-06-06 2020-06-08 抗b7-h4抗体-药物偶联物及其医药用途 Active CN112351797B (zh)

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CN2019104989932 2019-06-06
CN201910498993 2019-06-06
CN2020102153223 2020-03-24
CN202010215322 2020-03-24
PCT/CN2020/094856 WO2020244657A1 (zh) 2019-06-06 2020-06-08 抗b7-h4抗体-药物偶联物及其医药用途

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US (1) US20230072897A1 (zh)
EP (1) EP3981434A4 (zh)
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CN (1) CN112351797B (zh)
AU (1) AU2020288275A1 (zh)
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WO2023186015A1 (zh) * 2022-03-30 2023-10-05 映恩生物制药（苏州）有限公司 B7h4抗体药物偶联物及其用途

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WO2022171115A1 (zh) * 2021-02-09 2022-08-18 微境生物医药科技(上海)有限公司 用于adc制备的喜树碱衍生物
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BR112023022098A2 (pt) * 2021-04-26 2023-12-19 Jiangsu Hengrui Pharmaceuticals Co Ltd Anticorpo anti-nectina-4 e conjugado anticorpo-fármaco anti-nectina-4 e uso medicinal dos mesmos
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