CN115279781A - 抗体药物偶联物及其医药用途 - Google Patents
抗体药物偶联物及其医药用途 Download PDFInfo
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- CN115279781A CN115279781A CN202180021537.4A CN202180021537A CN115279781A CN 115279781 A CN115279781 A CN 115279781A CN 202180021537 A CN202180021537 A CN 202180021537A CN 115279781 A CN115279781 A CN 115279781A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
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- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
提供了一种抗BCMA抗体‑药物偶联物及其医药用途。进一步地，提供了一种包含抗BCMA抗体或其抗原结合片段的抗体‑药物偶联物或其可药用盐或溶剂化合物，以及其在制备用于治疗BCMA介导的疾病或病症的药物中的用途以及用于疾病检测和诊断中的用途。
Description
PCT国内申请，说明书已公开。
Claims (23)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020102249921 | 2020-03-26 | ||
| CN202010224992 | 2020-03-26 | ||
| CN202010743217 | 2020-07-29 | ||
| CN2020107432177 | 2020-07-29 | ||
| CN202110123953 | 2021-01-29 | ||
| CN2021101239537 | 2021-01-29 | ||
| PCT/CN2021/082735 WO2021190564A1 (zh) | 2020-03-26 | 2021-03-24 | 抗体药物偶联物及其医药用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115279781A true CN115279781A (zh) | 2022-11-01 |
Family
ID=77890956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180021537.4A Pending CN115279781A (zh) | 2020-03-26 | 2021-03-24 | 抗体药物偶联物及其医药用途 |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN115279781A (zh) |
| TW (1) | TW202144017A (zh) |
| WO (1) | WO2021190564A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220251228A1 (en) * | 2019-07-30 | 2022-08-11 | Shanghai Hansoh Biomedical Co., Ltd. | Anti-bcma antibody, antigen-binding fragment thereof and medical use thereof |
| WO2023237050A1 (en) * | 2022-06-09 | 2023-12-14 | Beigene, Ltd. | Antibody drug conjugates |
| WO2024179564A1 (zh) * | 2023-03-01 | 2024-09-06 | 江苏恒瑞医药股份有限公司 | 一种茚并[1,2-b]喹啉-10,13-二酮衍生物的制备方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016165580A1 (zh) * | 2015-04-17 | 2016-10-20 | 江苏恒瑞医药股份有限公司 | 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途 |
| TW201813980A (zh) * | 2016-09-16 | 2018-04-16 | 西雅圖遺傳學公司 | Bcma抗體及其用於治療癌症及免疫病症之用途 |
| CN108778329A (zh) * | 2016-02-17 | 2018-11-09 | 西雅图基因公司 | Bcma抗体和其用以治疗癌症和免疫病症的用途 |
| US20190040152A1 (en) * | 2017-08-01 | 2019-02-07 | Medimmune, Llc | BCMA Monoclonal Antibody-Drug Conjugate |
| CN109963591A (zh) * | 2017-08-04 | 2019-07-02 | 江苏恒瑞医药股份有限公司 | B7h3抗体-药物偶联物及其医药用途 |
| WO2019241686A1 (en) * | 2018-06-14 | 2019-12-19 | Bluebird Bio, Inc. | Anti-bcma car antibodies, conjugates, and methods of use |
| US20190388555A1 (en) * | 2016-11-25 | 2019-12-26 | Mabwell (shanghai) Bioscience Co., Ltd. | Di-substituted maleic amide linker for antibody-drug conjugating and preparation method and use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL290488B2 (en) * | 2015-04-13 | 2024-07-01 | Pfizer | Therapeutic antibodies and their uses |
| WO2017083511A1 (en) * | 2015-11-13 | 2017-05-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-bcma polypeptides and proteins |
-
2021
- 2021-03-24 CN CN202180021537.4A patent/CN115279781A/zh active Pending
- 2021-03-24 WO PCT/CN2021/082735 patent/WO2021190564A1/zh active Application Filing
- 2021-03-26 TW TW110111143A patent/TW202144017A/zh unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016165580A1 (zh) * | 2015-04-17 | 2016-10-20 | 江苏恒瑞医药股份有限公司 | 抗c-Met抗体和抗c-Met抗体-细胞毒性药物偶联物及其医药用途 |
| CN108778329A (zh) * | 2016-02-17 | 2018-11-09 | 西雅图基因公司 | Bcma抗体和其用以治疗癌症和免疫病症的用途 |
| TW201813980A (zh) * | 2016-09-16 | 2018-04-16 | 西雅圖遺傳學公司 | Bcma抗體及其用於治療癌症及免疫病症之用途 |
| US20190388555A1 (en) * | 2016-11-25 | 2019-12-26 | Mabwell (shanghai) Bioscience Co., Ltd. | Di-substituted maleic amide linker for antibody-drug conjugating and preparation method and use thereof |
| US20190040152A1 (en) * | 2017-08-01 | 2019-02-07 | Medimmune, Llc | BCMA Monoclonal Antibody-Drug Conjugate |
| CN109963591A (zh) * | 2017-08-04 | 2019-07-02 | 江苏恒瑞医药股份有限公司 | B7h3抗体-药物偶联物及其医药用途 |
| WO2019241686A1 (en) * | 2018-06-14 | 2019-12-19 | Bluebird Bio, Inc. | Anti-bcma car antibodies, conjugates, and methods of use |
Non-Patent Citations (2)
| Title |
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| GENBANK: "Accession No.:ARG41595.1 anti-RON nanobody, partial [Lama glama]", 《GENBANK》, 15 April 2017 (2017-04-15) * |
| SHIH-FENG CHO: "Targeting B Cell Maturation Antigen (BCMA) in Multiple Myeloma: Potential Uses of BCMA-Based Immunotherapy", 《FRONTIERS IN IMMUNOLOGY 》, vol. 9, 10 August 2018 (2018-08-10), pages 1 - 15 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021190564A1 (zh) | 2021-09-30 |
| TW202144017A (zh) | 2021-12-01 |
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