CN115605510A - B7h3抗体-依喜替康类似物偶联物及其医药用途 - Google Patents
B7h3抗体-依喜替康类似物偶联物及其医药用途 Download PDFInfo
- Publication number
- CN115605510A CN115605510A CN202180021525.1A CN202180021525A CN115605510A CN 115605510 A CN115605510 A CN 115605510A CN 202180021525 A CN202180021525 A CN 202180021525A CN 115605510 A CN115605510 A CN 115605510A
- Authority
- CN
- China
- Prior art keywords
- antibody
- seq
- group
- amino acid
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
提供了B7H3抗体‑依喜替康类似物偶联物及其医药用途。具体而言，提供了B7H3抗体‑药物偶联物或其药学上可接受的盐，以及其在制备用于治疗B7H3介导的疾病或病症的药物中的用途；尤其在制备抗癌药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (30)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020102181007 | 2020-03-25 | ||
| CN202010218100 | 2020-03-25 | ||
| PCT/CN2021/082929 WO2021190586A1 (zh) | 2020-03-25 | 2021-03-25 | B7h3抗体-依喜替康类似物偶联物及其医药用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115605510A true CN115605510A (zh) | 2023-01-13 |
Family
ID=77890934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180021525.1A Pending CN115605510A (zh) | 2020-03-25 | 2021-03-25 | B7h3抗体-依喜替康类似物偶联物及其医药用途 |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN115605510A (zh) |
| TW (1) | TW202144015A (zh) |
| WO (1) | WO2021190586A1 (zh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
| TW202400248A (zh) * | 2022-06-07 | 2024-01-01 | 中國大陸商映恩生物製藥（蘇州）有限公司 | 抗b7h3抗體-藥物結合物及其用途 |
| WO2023237050A1 (en) * | 2022-06-09 | 2023-12-14 | Beigene, Ltd. | Antibody drug conjugates |
| WO2023241663A1 (zh) * | 2022-06-15 | 2023-12-21 | 上海翰森生物医药科技有限公司 | 一种含抗体药物偶联物的药物组合物及其用途 |
| CN116789733A (zh) * | 2022-07-05 | 2023-09-22 | 上海药明合联生物技术有限公司 | 偶联连接子 |
| WO2024022372A1 (zh) * | 2022-07-27 | 2024-02-01 | 明慧医药（杭州）有限公司 | 抗体药物偶联物及其应用 |
| WO2024109840A1 (zh) * | 2022-11-22 | 2024-05-30 | 康诺亚生物医药科技（成都）有限公司 | 稠环类化合物及其偶联物和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019526529A (ja) * | 2016-06-08 | 2019-09-19 | アッヴィ・インコーポレイテッド | 抗ｂ７−ｈ３抗体及び抗体薬物コンジュゲート |
| CN110799542A (zh) * | 2017-05-12 | 2020-02-14 | 纪念斯隆-凯特琳癌症中心 | 抗-b7h3抗体用于治疗中枢神经系统癌症的用途 |
| TW201909926A (zh) * | 2017-08-04 | 2019-03-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | Ｂ７ｈ３抗體－藥物偶聯物及其醫藥用途 |
-
2021
- 2021-03-25 CN CN202180021525.1A patent/CN115605510A/zh active Pending
- 2021-03-25 WO PCT/CN2021/082929 patent/WO2021190586A1/zh active Application Filing
- 2021-03-25 TW TW110110880A patent/TW202144015A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW202144015A (zh) | 2021-12-01 |
| WO2021190586A1 (zh) | 2021-09-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112543771B (zh) | 抗b7h3抗体-依喜替康类似物偶联物及其医药用途 | |
| CN112351797B (zh) | 抗b7-h4抗体-药物偶联物及其医药用途 | |
| CN115605510A (zh) | B7h3抗体-依喜替康类似物偶联物及其医药用途 | |
| CN114846021A (zh) | 抗trop-2抗体-依喜替康类似物偶联物及其医药用途 | |
| EP4074345A1 (en) | Anti-claudin antibody-drug conjugate and pharmaceutical use thereof | |
| TW202144012A (zh) | 抗體－藥物偶聯物及其醫藥用途 | |
| WO2021190564A1 (zh) | 抗体药物偶联物及其医药用途 | |
| EP4374879A1 (en) | Drug conjugate of eribulin derivative | |
| CN114729035B (zh) | 抗cea抗体-依喜替康类似物偶联物及其医药用途 | |
| CN115298186A (zh) | 抗psma抗体-依喜替康类似物偶联物及其医药用途 | |
| RU2785664C2 (ru) | Конъюгат антитело к b7h3-аналог экзатекана и его применение в медицине | |
| TWI846736B (zh) | 抗ｂ７ｈ３抗體-依喜替康類似物偶聯物及其醫藥用途 | |
| CA3232425A1 (en) | Antibody-drug conjugate, preparation method therefor, and pharmaceutical use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |