JP2014514336A5 - - Google Patents

Download PDF

Info

Publication number
JP2014514336A5
JP2014514336A5 JP2014508611A JP2014508611A JP2014514336A5 JP 2014514336 A5 JP2014514336 A5 JP 2014514336A5 JP 2014508611 A JP2014508611 A JP 2014508611A JP 2014508611 A JP2014508611 A JP 2014508611A JP 2014514336 A5 JP2014514336 A5 JP 2014514336A5
Authority
JP
Japan
Prior art keywords
polymer
hydrogel
gel
alginate
compression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014508611A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014514336A (ja
JP6359966B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/035505 external-priority patent/WO2012149358A1/en
Publication of JP2014514336A publication Critical patent/JP2014514336A/ja
Publication of JP2014514336A5 publication Critical patent/JP2014514336A5/ja
Application granted granted Critical
Publication of JP6359966B2 publication Critical patent/JP6359966B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014508611A 2011-04-28 2012-04-27 最小侵襲投与のための注射可能な予成形される肉眼的三次元スキャフォールド Active JP6359966B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161480237P 2011-04-28 2011-04-28
US61/480,237 2011-04-28
PCT/US2012/035505 WO2012149358A1 (en) 2011-04-28 2012-04-27 Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018117680A Division JP6741723B2 (ja) 2011-04-28 2018-06-21 最小侵襲投与のための注射可能な予成形される肉眼的三次元スキャフォールド

Publications (3)

Publication Number Publication Date
JP2014514336A JP2014514336A (ja) 2014-06-19
JP2014514336A5 true JP2014514336A5 (enExample) 2016-10-06
JP6359966B2 JP6359966B2 (ja) 2018-07-18

Family

ID=47072783

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2014508611A Active JP6359966B2 (ja) 2011-04-28 2012-04-27 最小侵襲投与のための注射可能な予成形される肉眼的三次元スキャフォールド
JP2018117680A Active JP6741723B2 (ja) 2011-04-28 2018-06-21 最小侵襲投与のための注射可能な予成形される肉眼的三次元スキャフォールド
JP2020095862A Active JP7097629B2 (ja) 2011-04-28 2020-06-02 最小侵襲投与のための注射可能な予成形される肉眼的三次元スキャフォールド
JP2022065630A Pending JP2022092026A (ja) 2011-04-28 2022-04-12 最小侵襲投与のための注射可能な予成形される肉眼的三次元スキャフォールド

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2018117680A Active JP6741723B2 (ja) 2011-04-28 2018-06-21 最小侵襲投与のための注射可能な予成形される肉眼的三次元スキャフォールド
JP2020095862A Active JP7097629B2 (ja) 2011-04-28 2020-06-02 最小侵襲投与のための注射可能な予成形される肉眼的三次元スキャフォールド
JP2022065630A Pending JP2022092026A (ja) 2011-04-28 2022-04-12 最小侵襲投与のための注射可能な予成形される肉眼的三次元スキャフォールド

Country Status (7)

Country Link
US (3) US10045947B2 (enExample)
EP (2) EP2701745B1 (enExample)
JP (4) JP6359966B2 (enExample)
AU (3) AU2012249456A1 (enExample)
CA (1) CA2833385C (enExample)
ES (2) ES2685327T3 (enExample)
WO (1) WO2012149358A1 (enExample)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007070660A2 (en) 2005-12-13 2007-06-21 President And Fellows Of Harvard College Scaffolds for cell transplantation
US9770535B2 (en) * 2007-06-21 2017-09-26 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
CA2715460C (en) 2008-02-13 2020-02-18 President And Fellows Of Harvard College Continuous cell programming devices
US9012399B2 (en) * 2008-05-30 2015-04-21 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
US9297005B2 (en) 2009-04-13 2016-03-29 President And Fellows Of Harvard College Harnessing cell dynamics to engineer materials
AU2010278702C1 (en) 2009-07-31 2016-07-14 Forsyth Dental Infirmary For Children Programming of cells for tolerogenic therapies
WO2011109834A2 (en) 2010-03-05 2011-09-09 President And Fellows Of Harvard College Enhancement of skeletal muscle stem cell engrafment by dual delivery of vegf and igf-1
US9693954B2 (en) 2010-06-25 2017-07-04 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
HRP20200310T1 (hr) 2010-10-06 2020-08-21 President And Fellows Of Harvard College Hidrogelovi koji stvaraju pore pogodni za injekcije, namijenjeni staničnim terapijama na bazi materijala
WO2012064697A2 (en) 2010-11-08 2012-05-18 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
EP2701753B1 (en) 2011-04-27 2018-12-26 President and Fellows of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
ES2685327T3 (es) 2011-04-28 2018-10-08 President And Fellows Of Harvard College Armazones tridimensionales macroscópicos preformados inyectables para administración mínimamente invasiva
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
US9486512B2 (en) 2011-06-03 2016-11-08 President And Fellows Of Harvard College In situ antigen-generating cancer vaccine
US8753309B2 (en) 2011-06-24 2014-06-17 The Invention Science Fund I, Llc Device, system, and method including micro-patterned cell treatment array
ES2773895T3 (es) 2012-04-16 2020-07-15 Harvard College Composiciones de sílice mesoporosa para modular las respuestas inmunitarias
EP2983718A4 (en) * 2013-04-11 2016-12-07 Univ Of Vermont And State Agricultural College Decellularization and recellularization of whole organs
JP6787789B2 (ja) 2014-04-04 2020-11-18 プレジデント アンド フェローズ オブ ハーバード カレッジ 詰め替え可能な薬物送達デバイスおよびその使用方法
CN107073090A (zh) 2014-04-30 2017-08-18 哈佛学院董事会 结合的疫苗装置和杀死癌细胞的方法
WO2016013594A1 (ja) * 2014-07-24 2016-01-28 国立研究開発法人物質・材料研究機構 医療用生体吸収性部材及びその製造方法
KR20170070008A (ko) * 2014-08-15 2017-06-21 더 존스 홉킨스 유니버시티 조직 복원용 복합 재료
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
SG11201702401RA (en) 2014-10-14 2017-04-27 Novartis Ag Antibody molecules to pd-l1 and uses thereof
WO2016123573A1 (en) 2015-01-30 2016-08-04 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
US11150242B2 (en) 2015-04-10 2021-10-19 President And Fellows Of Harvard College Immune cell trapping devices and methods for making and using the same
US20180207273A1 (en) 2015-07-29 2018-07-26 Novartis Ag Combination therapies comprising antibody molecules to tim-3
US20180340025A1 (en) 2015-07-29 2018-11-29 Novartis Ag Combination therapies comprising antibody molecules to lag-3
EP3328418A1 (en) 2015-07-29 2018-06-06 Novartis AG Combination therapies comprising antibody molecules to pd-1
DE102016203287A1 (de) * 2015-08-07 2017-02-09 Aesculap Ag Mechanophores Medizinprodukt
CN108289734B (zh) * 2015-08-17 2024-06-18 约翰·霍普金斯大学 用于组织恢复的间充质细胞结合复合材料
GB201521784D0 (en) 2015-12-10 2016-01-27 Univ Birmingham Cell purification
CN108495651A (zh) 2015-12-17 2018-09-04 诺华股份有限公司 抗pd-1的抗体分子及其用途
WO2017136837A1 (en) 2016-02-06 2017-08-10 President And Fellows Of Harvard College Recapitulating the hematopoietic niche to reconstitute immunity
CN117244049A (zh) 2016-02-16 2023-12-19 哈佛学院院长等 病原体疫苗及其生产和使用方法
AU2017295704B2 (en) 2016-07-13 2023-07-13 President And Fellows Of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
CN110418651A (zh) 2016-08-02 2019-11-05 哈佛学院院长等 用于调节免疫应答的生物材料
JP7216006B2 (ja) 2017-03-22 2023-01-31 ジェネンテック， インコーポレイテッド ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法
ES3060255T3 (en) 2018-05-09 2026-03-25 Univ Johns Hopkins Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
EP3790602A1 (en) 2018-05-09 2021-03-17 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
US12303618B2 (en) 2018-08-08 2025-05-20 Northeastern University Oxygen-generating cryogels
WO2020061129A1 (en) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions and methods for labeling and modulation of cells in vitro and in vivo
WO2020116989A1 (ko) * 2018-12-07 2020-06-11 한국생명공학연구원 생체내 세포 투입칩을 포함하는 항암용 조성물
JP2022514568A (ja) 2018-12-17 2022-02-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 免疫系のモジュレーションのための生物工学的スキャフォールドおよびその使用
JP2022549270A (ja) 2019-09-23 2022-11-24 プレジデント アンド フェローズ オブ ハーバード カレッジ バイオマテリアルベースの無抗原ワクチンおよびその使用
US12076464B2 (en) * 2019-10-17 2024-09-03 The Texas A&M University System Drug eluting shape memory foam
US11850325B2 (en) 2019-10-24 2023-12-26 Northeastern University Injectable, bioadhesive cryogel scaffolds for biomedical uses
EP4164706A1 (en) 2019-12-04 2023-04-19 Centre Hospitalier Universitaire Vaudois (CHUV) Device and process for tissue-engineering and regenerative medicine
CN112245658A (zh) * 2020-10-09 2021-01-22 北京大学 一种可注射晶胶微球细胞扩增载体及其制备方法
US20240033401A1 (en) * 2020-12-18 2024-02-01 Drexel University Injectable, cross-linkable and subcellular size microfibers for soft tissue repair
PL244645B1 (pl) 2021-02-22 2024-02-19 Inst Podstawowych Problemow Techniki Polskiej Akademii Nauk Sposób otrzymywania wstrzykiwalnego biokompatybilnego nośnika leków, komórek lub ich kombinacji, w postaci mikrorusztowań, kompozycja do podawania przez wstrzykiwanie zawierająca wspomniane nośniki oraz jej zastosowanie
EP4147730A1 (en) 2021-09-09 2023-03-15 ETH Zurich Method of preparing a functional hydrogel material that can be injected
US12201643B2 (en) 2021-10-15 2025-01-21 The Board Of Trustees Of The University Of Illinois Mechanochemical dynamic for focal cancer treatment
KR102721585B1 (ko) * 2022-04-06 2024-10-25 성균관대학교산학협력단 형상복원능을 갖는 콜라겐 기반 하이드로겔의 제조방법 및 이의 용도
CN114957810B (zh) * 2022-05-05 2023-04-18 中国科学院天津工业生物技术研究所 一种普鲁兰多糖形状记忆材料的制备方法及其4d打印方法及制品
CN115804870B (zh) * 2022-12-02 2023-12-19 浙江大学 一种微创注射生物支架及其制造方法与应用
WO2024187056A2 (en) * 2023-03-08 2024-09-12 The Trustees Of The University Of Pennsylvania Minoxidil-crosslinked injectable hydrogels for local and sustained intradermal delivery
AU2024366722A1 (en) * 2023-10-27 2026-05-14 William Marsh Rice University Photo-responsive therapeutic encapsulation compositions and devices
WO2026050387A1 (en) * 2024-08-27 2026-03-05 IVANOV, Ian Gitsov Mechanochromic shape memory polymers with simultaneous shape and color change

Family Cites Families (168)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5073627A (en) 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
GB9206504D0 (en) 1992-03-25 1992-05-06 Jevco Ltd Heteromorphic sponges as wound implants
JPH09506866A (ja) 1993-12-14 1997-07-08 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 医薬として活性のある物質の免疫療法のための放出制御
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US6251396B1 (en) 1994-11-18 2001-06-26 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
US6329499B1 (en) 1994-11-18 2001-12-11 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
IL118376A0 (en) 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
WO1997045533A1 (en) 1996-05-28 1997-12-04 The Regents Of The University Of Michigan Engineering oral tissues
US6124128A (en) 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
JP4335316B2 (ja) * 1996-09-19 2009-09-30 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン アルギネートまたは修飾アルギネートのようなポリサッカライドを含むポリマー
US5863551A (en) * 1996-10-16 1999-01-26 Organogel Canada Ltee Implantable polymer hydrogel for therapeutic uses
GB2318577B (en) 1996-10-28 2000-02-02 Johnson & Johnson Medical Solvent dried polysaccharide sponges
GB2323282B (en) 1997-03-17 2001-03-07 Bristol Myers Squibb Co Improvements relating to hygiene and medical products
DE69818052T2 (de) 1997-03-31 2004-07-08 The Regents Of The University Of Michigan, Ann Arbor Offenporige bioabbaubare matrize
EP1014897B1 (en) 1997-05-30 2008-10-29 Osteobiologics, Inc. Fiber-reinforced, porous, biodegradable implant device
US6218371B1 (en) 1998-04-03 2001-04-17 University Of Iowa Research Foundation Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
US7427602B1 (en) 1998-05-13 2008-09-23 The Regents Of The University Of Michigan Sustained DNA delivery from structural matrices
FR2780730B1 (fr) 1998-07-01 2000-10-13 Corneal Ind Compositions biphasiques injectables, notamment utiles en chirurgies reparatrice et esthetique
EP1100529B2 (en) 1998-07-30 2010-08-25 The Government of the United States of America, as repres. by the Secretary of Health and Human Services, Nat. Inst. of Health Thymosin beta 4 promotes wound repair
EP1374908A3 (en) 1998-10-09 2004-03-24 The Regents Of The University Of Michigan Polymer-drug conjugates comprising hydrazide linkers
WO2000050006A2 (en) 1999-02-26 2000-08-31 Chiron Corporation Microemulsions with adsorbed macromoelecules and microparticles
US6541022B1 (en) 1999-03-19 2003-04-01 The Regents Of The University Of Michigan Mineral and cellular patterning on biomaterial surfaces
US6767928B1 (en) 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
DE60036863T2 (de) 1999-03-25 2008-07-31 Metabolix, Inc., Cambridge Medizinische vorrichtungen und verwendungen von polyhydroxyalkanoatpolymeren
US6511650B1 (en) 1999-04-09 2003-01-28 The Regents Of The University Of Michigan Preparing porous hydrogel products
AU782297B2 (en) 1999-06-30 2005-07-14 Ethicon Inc. Porous tissue scaffoldings for the repair or regeneration of tissue
US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
CA2379909C (en) 1999-08-06 2011-01-04 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
US7015205B1 (en) 1999-10-18 2006-03-21 St. Vincent's Hospital And Medical Center Of New York Melanoma vaccine and methods of making and using same
WO2001035932A2 (en) 1999-11-18 2001-05-25 The Regents Of The University Of Michigan Sustained drug delivery from structural matrices
US6790840B1 (en) 1999-11-26 2004-09-14 The Regents Of The University Of Michigan Reversibly cross-linked hydrogels
WO2002009650A2 (en) 2000-07-31 2002-02-07 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
JP2004507237A (ja) 2000-08-21 2004-03-11 ライスユニバーシティ マトリクスタンパク質の産生を促進する組織工学足場
US7785810B2 (en) 2000-09-09 2010-08-31 The Research Foundation Of State University Of New York Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof
US6748954B2 (en) 2000-10-27 2004-06-15 The Regents Of The University Of Michigan Drug release from polymer matrices through mechanical stimulation
WO2002040071A1 (en) 2000-11-14 2002-05-23 Osteogenesis Co., Ltd. Compositions for forming bone or periodontium and injections for forming bone or periodontium
MXPA03006587A (es) 2001-01-24 2003-09-22 Schering Corp Quimiocinas como adyuvantes de respuesta inmune.
WO2002068605A2 (en) 2001-02-26 2002-09-06 The Regents Of The University Of California Non-oligomerizing tandem fluorescent proteins
JP2002263981A (ja) 2001-03-14 2002-09-17 Murata Mach Ltd 板材吸着持ち上げ装置の吸着制御装置
US6656488B2 (en) 2001-04-11 2003-12-02 Ethicon Endo-Surgery, Inc. Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering
WO2002087627A1 (en) 2001-04-27 2002-11-07 Xcyte Therapies, Inc. Maturation of antigen-presenting cells using activated t cells
US20050079159A1 (en) 2001-06-13 2005-04-14 Massachusetts Instiute Of Technology In vivo bioreactors
US7297343B2 (en) 2001-07-31 2007-11-20 Biosurface Engineering Technologies, Inc. Bioactive medical films
US7354909B2 (en) 2001-08-14 2008-04-08 The United States Of America As Represented By Secretary Of The Department Of Health And Human Services Method for rapid generation of mature dendritic cells
SE0103404D0 (sv) * 2001-10-12 2001-10-12 Protista Internat Ab Macroporous gel, ITS preparation and its use
CA2412012C (en) 2001-11-20 2011-08-02 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage
AU2002361902A1 (en) 2001-12-31 2003-07-24 Ares Medical, Inc. Hemostatic compositions and methods for controlling bleeding
US7575759B2 (en) 2002-01-02 2009-08-18 The Regents Of The University Of Michigan Tissue engineering scaffolds
US6811777B2 (en) 2002-04-13 2004-11-02 Allan Mishra Compositions and minimally invasive methods for treating incomplete connective tissue repair
CN101160399A (zh) 2002-04-22 2008-04-09 拜奥尼茨生命科学公司 寡核苷酸组合物及其在调节免疫应答中的应用
US6960617B2 (en) 2002-04-22 2005-11-01 Purdue Research Foundation Hydrogels having enhanced elasticity and mechanical strength properties
US20040242469A1 (en) 2002-05-13 2004-12-02 Lee Richard T. Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof
AUPS312602A0 (en) 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
US7332160B2 (en) 2002-07-12 2008-02-19 Boston Scientific Scimed, Inc. Medical device and method for tissue removal and repair
US20040136968A1 (en) 2002-09-27 2004-07-15 Verigen Ag Autologous cells on a support matrix for tissue repair
US20040063206A1 (en) 2002-09-30 2004-04-01 Rowley Jon A. Programmable scaffold and method for making and using the same
AU2003272805A1 (en) 2002-10-01 2004-04-23 Peter K. Law Bioactive implants
US8940292B2 (en) 2003-01-28 2015-01-27 Wake Forest University Health Sciences Enhancement of angiogenesis to grafts using cells engineered to produce growth factors
SE0301109D0 (sv) 2003-04-14 2003-04-14 Mallen Huang Nucleotide vaccine composition
CA2524356C (en) 2003-05-05 2015-03-10 Smadar Cohen Injectable cross-linked polymeric preparations and uses thereof
EP1475434A1 (en) 2003-05-09 2004-11-10 Oncoscience AG Method for storing tumor cells
US20050053667A1 (en) 2003-07-09 2005-03-10 Darrell Irvine Programmed immune responses using a vaccination node
US20060264380A1 (en) 2003-07-21 2006-11-23 Mats Hellstrom Compounds and Methods for Promoting Angiogenesis
GB0317999D0 (en) 2003-07-31 2003-09-03 Univ Liege Improvements in or relating to drug delivery systems
US8247231B2 (en) 2003-07-31 2012-08-21 Wilson Constance N Methods and compositions for producing antigenic responses
EP1664168B1 (en) 2003-08-29 2008-12-03 Mayo Foundation for Medical Education and Research Hydrogel porogens for fabricating biodegradable scaffolds
WO2005037190A2 (en) 2003-09-03 2005-04-28 Dendritherapeutics, Inc. Multiplex vaccines
JP5021309B2 (ja) 2003-10-16 2012-09-05 ステファン ジョン ラルフ 免疫調節性組成物およびその使用方法
EP1689289B1 (en) 2003-11-07 2016-12-21 Carnegie Mellon University Robot for minimally invasive interventions
CA2448995A1 (en) 2003-11-12 2005-05-12 James Keenan Device and method for attracting diseased cells and foreign substances
JP2005160669A (ja) 2003-12-02 2005-06-23 Olympus Corp 生体組織補填体の製造方法
CA2548992A1 (en) 2003-12-11 2005-08-11 Vaxdesign Corporation Immunotherapy compositions, method of making and method of use thereof
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US7192693B2 (en) 2004-02-24 2007-03-20 University Of Washington Methods for photopatterning hydrogels
US7790699B2 (en) 2004-10-12 2010-09-07 Fmc Biopolymer As Self-gelling alginate systems and uses thereof
US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
US7999161B2 (en) 2005-01-22 2011-08-16 Alexander Oraevsky Laser-activated nanothermolysis of cells
JP5199866B2 (ja) 2005-03-23 2013-05-15 メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ 細胞及び薬物送達用の光架橋性オリゴ（ポリ（エチレングリコール）フマレート）ヒドロゲル
EP1869169A4 (en) 2005-03-29 2015-11-04 Univ California REGULATION OF THE DESTINATION OF STEM CELLS WITH TUNABLE NETS
US20070003595A1 (en) 2005-04-19 2007-01-04 Shaopeng Wang Three dimensional micro-environments and methods of making and using same
US8828433B2 (en) 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
CN101355928B (zh) 2005-04-26 2013-05-22 卫材R&D管理株式会社 用于癌症免疫疗法的组合物和方法
WO2006119619A1 (en) 2005-05-06 2006-11-16 Replicor Inc. Oligonucleotides inhibiting cell proliferation
ITPI20050071A1 (it) 2005-06-20 2006-12-21 Giuseppe Calvosa Composizione biocompatibile per la sostituzione/rigenerazione di tessuti
US7645742B2 (en) 2005-06-22 2010-01-12 Advocare International, L.P. Composition for enhancing cellular energy
CN1302050C (zh) 2005-07-07 2007-02-28 复旦大学 一种互穿网络聚合物超多孔水凝胶及其制备方法和应用
US20090017096A1 (en) 2005-08-15 2009-01-15 Anthony Lowman Porous non-biodegradable hydrogel admixed with a chemoattractant for tissue replacement
BRPI0503817A (pt) 2005-09-12 2007-05-15 Cristalia Prod Quimicos Farm complexo imunogênico formado por antìgenos vacinais encapsulados por sìlica mesoporosa nanoestruturada
US20070081972A1 (en) 2005-09-30 2007-04-12 The University Of Iowa Research Foundation Polymer-based delivery system for immunotherapy of cancer
US20070116680A1 (en) 2005-11-18 2007-05-24 Rensselaer Polytechnic Institute Stem cells within gel microenvironments
DK2119450T3 (da) 2005-11-29 2013-05-06 Actogenix Nv Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener
KR100687281B1 (ko) 2005-11-30 2007-02-27 한국과학기술연구원 생리 활성 물질이 결합된 조직 재생용 주입형 온도 감응성플루로닉 유도체 하이드로겔 및 이의 제조 방법
WO2007070660A2 (en) 2005-12-13 2007-06-21 President And Fellows Of Harvard College Scaffolds for cell transplantation
EP1806395A1 (en) 2006-01-06 2007-07-11 Stichting Sanquin Bloedvoorziening Maturation of dendritic cells
US20070178159A1 (en) 2006-01-30 2007-08-02 Alza Corporation In-Situ Forming Porous Scaffold
US20070190646A1 (en) 2006-02-10 2007-08-16 The Trustees Of The University Of Pennsylvania Regulating stem cell differentiation by controlling matrix elasticity
US20100015709A1 (en) 2006-02-10 2010-01-21 Trustees Of The University Of Pennsylvania Regulating Stem Cell Differentiation By Controlling 2D and 3D Matrix Elasticity
US20090169532A1 (en) 2006-02-27 2009-07-02 Ying Jackie Y Curable bone cement
US9456860B2 (en) 2006-03-14 2016-10-04 Kci Licensing, Inc. Bioresorbable foaming tissue dressing
GB0605521D0 (en) 2006-03-18 2006-04-26 Isis Innovation Adjuvant
WO2008127256A1 (en) 2006-06-01 2008-10-23 Massachusetts Institute Of Technology Control of cells and cell multipotentiality in three dimensional matrices
EP2032149A4 (en) 2006-06-13 2010-09-01 Fmc Biopolymer As METHOD AND SYSTEMS FOR THE USE OF BIOPOLYMER-BASED BEADS AND HYDROGELS
US20070298067A1 (en) 2006-06-22 2007-12-27 Boston Scientific Scimed, Inc. Control release drug coating for medical devices
WO2007150020A1 (en) 2006-06-23 2007-12-27 Simon Paul M Targeted immune conjugates
US7993918B2 (en) 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
KR100802139B1 (ko) 2006-08-08 2008-02-11 한국생명공학연구원 자성 나노입자를 함유하는 골드 나노케이지
KR100818708B1 (ko) 2006-08-18 2008-04-01 주식회사 하이닉스반도체 표면 세정을 포함하는 반도체소자 제조방법
ITMI20061726A1 (it) 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
CA2663722C (en) 2006-09-21 2014-12-09 Purdue Research Foundation Collagen preparation and method of isolation
US20080114277A1 (en) 2006-11-09 2008-05-15 Archel Ambrosio Porous bioresorbable dressing conformable to a wound and methods of making same
WO2008086486A1 (en) 2007-01-10 2008-07-17 The Regents Of The University Of Michigan Porous objects having immobilized encapsulated biomolecules
JP5650406B2 (ja) 2007-03-07 2015-01-07 ユーティーアイ リミテッド パートナーシップ 自己免疫状態の予防および治療のための組成物および方法
EP2181121A4 (en) 2007-03-21 2012-07-11 Id Biomedical Corp Quebec CHIMÄRE ANTIGENE
US8501905B2 (en) 2007-03-22 2013-08-06 The Regents Of The University Of California Synthetic cell platforms and methods of use thereof
EP1975230A1 (en) 2007-03-30 2008-10-01 Capsulution Nanoscience AG Method for forming glucose sensing micro-particles, use of micro-particles, and kit
WO2008131074A1 (en) 2007-04-19 2008-10-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4-associated disorders
AU2008258646A1 (en) 2007-06-05 2008-12-11 Fondazione Centro San Raffaele Del Monte Tabor Induction of tolerogenic phenotype in mature dendritic cells
JP2010531138A (ja) 2007-06-13 2010-09-24 ラ ホヤ インスティテュート フォア アラージー アンド イムノロジー 制御性ｔ細胞ならびに同製造および使用方法
US9770535B2 (en) 2007-06-21 2017-09-26 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
US11083190B2 (en) 2007-06-29 2021-08-10 Makoto Funaki Soft gel systems in modulating stem cell development
EP2178896A1 (en) 2007-07-31 2010-04-28 The Johns Hopkins University Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders
US20090192079A1 (en) 2007-10-09 2009-07-30 Genzyme Corporation Prolonged delivery of heparin-binding growth factors from heparin-derivatized collagen
KR100900837B1 (ko) 2007-12-07 2009-06-04 (주)두비엘 리포펩타이드와 폴리(ｉ:ｃ)를 아쥬반트로 포함하는 강력한백신 조성물
EP2072617A1 (en) 2007-12-12 2009-06-24 Trimed Biotech GmbH Method for producing dendritic cells
DE102008008522A1 (de) 2008-02-11 2009-08-13 Magforce Nanotechnologies Ag Implantierbare Nanopartikel-enthaltende Produkte
WO2011063336A2 (en) 2009-11-20 2011-05-26 President And Fellows Of Harvard College Secondary site of antigen stimulation for therapeutic vaccination
CA2715460C (en) 2008-02-13 2020-02-18 President And Fellows Of Harvard College Continuous cell programming devices
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
US20090238853A1 (en) 2008-03-21 2009-09-24 3D Biotek, Llc Hybrid Biomedical Device Fabricated From Biomaterials and Coated With a Natural Extra Cellular Matrix (ECM) Coating
US9012399B2 (en) 2008-05-30 2015-04-21 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
US20110182957A1 (en) 2008-06-19 2011-07-28 Nicoll Steven B Cellulosics for tissue replacement
CN102149735A (zh) * 2008-09-15 2011-08-10 玛丽亚·斯特罗姆 乙烯醇共聚物冷冻凝胶、乙烯醇共聚物及其制备方法和由其制得的产品
US8889124B2 (en) 2008-09-25 2014-11-18 The Board Of Trustees Of The Leland Stanford Junior University Tolerogenic populations of dendritic cells
KR101132732B1 (ko) 2008-11-26 2012-04-06 한국과학기술연구원 인 시튜 조직재생용 지능형 다공성 생분해 고분자 지지체 및 이의 제조방법
US8273373B2 (en) * 2008-12-30 2012-09-25 Case Western Reserve University Photocrosslinked biodegradable hydrogel
US9297005B2 (en) 2009-04-13 2016-03-29 President And Fellows Of Harvard College Harnessing cell dynamics to engineer materials
US8551749B2 (en) 2009-04-23 2013-10-08 The Invention Science Fund I, Llc Device including bone cage and method for treatment of disease in a subject
AU2010278702C1 (en) 2009-07-31 2016-07-14 Forsyth Dental Infirmary For Children Programming of cells for tolerogenic therapies
CN101655611B (zh) 2009-09-11 2011-06-08 中国科学院长春应用化学研究所 一种具有双层杂化结构的反蛋白石水凝胶光子晶体的制备方法
EP2514718A4 (en) 2009-12-18 2013-09-04 Kao Corp METHOD FOR PRODUCING MESOPOROUS SILICONE ARTICLES
JP5603063B2 (ja) 2009-12-21 2014-10-08 花王株式会社 複合シリカ粒子の製造方法
WO2011109834A2 (en) 2010-03-05 2011-09-09 President And Fellows Of Harvard College Enhancement of skeletal muscle stem cell engrafment by dual delivery of vegf and igf-1
CN102905732A (zh) 2010-03-15 2013-01-30 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的方法
US20110300186A1 (en) 2010-04-14 2011-12-08 Battelle Memorial Institute Functionalized Nano- and Micro-materials for Medical Therapies
CN107029223A (zh) 2010-05-26 2017-08-11 西莱克塔生物科技公司 合成纳米载体联合疫苗
GB201009273D0 (en) 2010-06-03 2010-07-21 Glaxosmithkline Biolog Sa Novel vaccine
US9693954B2 (en) 2010-06-25 2017-07-04 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
CN103118678A (zh) 2010-07-16 2013-05-22 约翰斯·霍普金斯大学 用于癌症免疫治疗的方法和组合物
AU2011285639B2 (en) 2010-08-04 2014-12-18 Georgia Tech Research Corporation Devices, systems, and methods for excavating cancer cells
HRP20200310T1 (hr) 2010-10-06 2020-08-21 President And Fellows Of Harvard College Hidrogelovi koji stvaraju pore pogodni za injekcije, namijenjeni staničnim terapijama na bazi materijala
WO2012064697A2 (en) 2010-11-08 2012-05-18 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
EP2701753B1 (en) 2011-04-27 2018-12-26 President and Fellows of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
ES2685327T3 (es) 2011-04-28 2018-10-08 President And Fellows Of Harvard College Armazones tridimensionales macroscópicos preformados inyectables para administración mínimamente invasiva
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
US9486512B2 (en) 2011-06-03 2016-11-08 President And Fellows Of Harvard College In situ antigen-generating cancer vaccine
DK2723741T3 (en) 2011-06-24 2016-06-06 Arqule Inc SUBSTITUTED imidazopyridinyl-aminopyridine compounds
CN104411331B (zh) 2012-01-13 2018-08-21 哈佛学院董事会 在结构聚合装置中tlr激动剂的控制传递
ES2773895T3 (es) 2012-04-16 2020-07-15 Harvard College Composiciones de sílice mesoporosa para modular las respuestas inmunitarias
CN107073090A (zh) 2014-04-30 2017-08-18 哈佛学院董事会 结合的疫苗装置和杀死癌细胞的方法
WO2016123573A1 (en) 2015-01-30 2016-08-04 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
WO2016161372A1 (en) 2015-04-01 2016-10-06 President And Fellows Of Harvard College Immunoconjugates for programming or reprogramming of cells

Similar Documents

Publication Publication Date Title
Ghanian et al. In situ forming, cytocompatible, and self-recoverable tough hydrogels based on dual ionic and click cross-linked alginate
Sedlacik et al. Preparation of tough double-and triple-network supermacroporous hydrogels through repeated cryogelation
AU2019201669B2 (en) Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
US7988992B2 (en) Superporous hydrogels for heavy-duty applications
CN104140630B (zh) 一种壳聚糖基双网络水凝胶及其制备方法
JP2022079725A (ja) アルギネートヒドロゲル組成物
CN107737370A (zh) 一种用于软骨修复的高强、超弹、导电水凝胶的制备方法
Xu et al. Double-cross-linked hydrogel strengthened by UV irradiation from a hyperbranched PEG-based trifunctional polymer
JP2008507302A5 (enExample)
CN105713106A (zh) 一种海藻酸钠双交联水凝胶及其制备方法与应用
CN105175756A (zh) 具有互穿网络结构的角蛋白/甲基丙烯酸-β-羟乙酯复合水凝胶的制备及应用
CN103408777A (zh) 一种有机凝胶的制备方法
CN104892864A (zh) 一种角蛋白-海藻酸钠复合微孔凝胶的制备及作为药物载体的应用
JP2011511116A5 (enExample)
Hasan et al. Recent advancements of nitric oxide-releasing hydrogels for wound dressing applications
JP2017536458A (ja) ポリリン酸ヒドロゲル並びにその製造及び使用方法
CN105131308B (zh) 一种漆酶/叔丁基过氧化氢催化制备木质素水凝胶的方法
Than‐ardna et al. Preparation, Characterization, and Properties of Chitosan‐Based Semi‐Interpenetrating Polymer Networks and Poly (2‐hydroxyethyl methacrylate) Structure
Ghanem et al. A review on recent advances in hydrogels as drug delivery system
Le et al. A study on the weldability of tough alginate–poly (acrylic acid) hydrogels
CN105017495B (zh) 一种大豆蛋白基双敏感性高分子微孔凝胶的制备及作为药物载体的应用
CN104927003A (zh) 一种具有良好生物相容性和溶胀性能的大豆蛋白基高分子凝胶的制备和应用
EP3330310A1 (en) Hydrogel composite material
TW201204745A (en) Crosslinked chitosan and preparation method thereof
CN110760069A (zh) 一种高强度的共聚物改性丝素蛋白吸水材料及其制法