DK2119450T3 - Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener - Google Patents
Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigenerInfo
- Publication number
- DK2119450T3 DK2119450T3 DK09169276.4T DK09169276T DK2119450T3 DK 2119450 T3 DK2119450 T3 DK 2119450T3 DK 09169276 T DK09169276 T DK 09169276T DK 2119450 T3 DK2119450 T3 DK 2119450T3
- Authority
- DK
- Denmark
- Prior art keywords
- induction
- pancreatic islet
- beta cell
- islet beta
- mucosal tolerance
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/20—Feeding-stuffs specially adapted for particular animals for horses
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/50—Feeding-stuffs specially adapted for particular animals for rodents
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A61K35/66—Microorganisms or materials therefrom
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- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
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- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
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- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
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- A61K2039/542—Mucosal route oral/gastrointestinal
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- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A61K2039/544—Mucosal route to the airways
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- A61K2039/552—Veterinary vaccine
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
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- Epidemiology (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05111467 | 2005-11-29 | ||
EP06830192.8A EP1957100B1 (en) | 2005-11-29 | 2006-11-29 | Induction of mucosal tolerance to antigens |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2119450T3 true DK2119450T3 (da) | 2013-05-06 |
Family
ID=37889980
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09169276.4T DK2119450T3 (da) | 2005-11-29 | 2006-11-29 | Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener |
Country Status (13)
Country | Link |
---|---|
US (5) | US8748126B2 (da) |
EP (3) | EP3097924B1 (da) |
JP (2) | JP5410759B2 (da) |
CN (1) | CN101316611B (da) |
AU (1) | AU2006319216B2 (da) |
BR (1) | BRPI0619206A2 (da) |
CA (1) | CA2631598C (da) |
DK (1) | DK2119450T3 (da) |
ES (2) | ES2596855T3 (da) |
HK (1) | HK1231371A1 (da) |
PT (1) | PT2119450E (da) |
RU (1) | RU2420569C2 (da) |
WO (1) | WO2007063075A1 (da) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
DK2119450T3 (da) | 2005-11-29 | 2013-05-06 | Actogenix Nv | Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener |
AU2006326405B2 (en) | 2005-12-13 | 2013-10-31 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
JP2010513245A (ja) * | 2006-12-14 | 2010-04-30 | アクトジェニックス・エヌブイ | 免疫調節を誘起するための結合分子の送達 |
ES2492468T3 (es) | 2007-01-25 | 2014-09-09 | Actogenix N.V. | Tratamiento de enfermedad inmunitaria por administración a través de la mucosa de antígenos usando Lactobacillus genéticamente modificado |
US9770535B2 (en) | 2007-06-21 | 2017-09-26 | President And Fellows Of Harvard College | Scaffolds for cell collection or elimination |
FI20075539L (fi) * | 2007-07-12 | 2009-01-13 | Valio Oy | Maitohappobakteerit, joilla on proinflammatorisia ominaisuuksia |
US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
CA2715460C (en) | 2008-02-13 | 2020-02-18 | President And Fellows Of Harvard College | Continuous cell programming devices |
EP2331124A1 (en) | 2008-08-15 | 2011-06-15 | Circassia Limited | T-cell antigen peptide from allergen for stimulation of il-10 production |
EP2153841B2 (en) | 2008-08-15 | 2015-11-11 | Circassia Limited | Vaccine comprising Amb a 1 peptides for use in the treatment of ragweed allergy |
WO2010056143A1 (en) * | 2008-11-13 | 2010-05-20 | Instituto De Medicina Molecular | The use of adjuvant to facilitate the induction of immune tolerance |
EP2393830B8 (en) | 2009-02-05 | 2015-03-18 | Circassia Limited | Grass peptides for vaccine |
US10617640B2 (en) | 2009-07-07 | 2020-04-14 | The Research Foundation For The State University Of New York | Phosphoserine containing compositions for immune tolerance induction |
EP3058953A1 (en) * | 2009-07-07 | 2016-08-24 | The Research Foundation Of State University Of New York | Lipidic compositions for induction of immune tolerance |
CA2768552A1 (en) * | 2009-07-31 | 2011-02-03 | President And Fellows Of Harvard College | Programming of cells for tolerogenic therapies |
US20110081320A1 (en) * | 2009-10-06 | 2011-04-07 | Nubiome, Inc. | Treatment/Cure of Autoimmune Disease |
US20130058898A1 (en) * | 2010-03-10 | 2013-03-07 | Kaneka Corporation | Lactic acid bacterium-containing preparation |
WO2011150235A1 (en) * | 2010-05-27 | 2011-12-01 | Allertein Therapeutics, Llc | Methods and reagents for treating autoimmune disorders and/or graft rejection |
US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
PT2624873T (pt) | 2010-10-06 | 2020-03-04 | Harvard College | Hidrogéis injectáveis formadores de poros para terapias celulares à base de materiais |
ES2685327T3 (es) | 2011-04-28 | 2018-10-08 | President And Fellows Of Harvard College | Armazones tridimensionales macroscópicos preformados inyectables para administración mínimamente invasiva |
US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
EP2714073B1 (en) | 2011-06-03 | 2021-03-10 | President and Fellows of Harvard College | In situ antigen-generating cancer vaccine |
EP2758512B1 (en) | 2011-09-23 | 2018-05-09 | Intrexon Actobiotics NV | Modified gram positive bacteria and uses thereof |
CN103917639B (zh) | 2011-09-23 | 2017-09-26 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 经修饰的革兰氏阳性细菌及其用途 |
EP2726089A2 (en) * | 2012-02-08 | 2014-05-07 | Premune AB | Prevention of inflammatory disorders in domestic non-human mammals |
HUE047973T2 (hu) | 2012-04-16 | 2020-05-28 | Harvard College | Mezoporózus szilíciumdioxid készítmények immunválaszok modulálására |
MX370265B (es) * | 2012-05-25 | 2019-12-09 | Cellectis | Métodos para manipular por ingeniería genética célula t alogénica y resistente a inmunosupresores para inmunoterapia. |
JP6219728B2 (ja) * | 2014-01-15 | 2017-10-25 | キッコーマン株式会社 | Foxp3陽性制御性T細胞とIFN−γ産生IL−10産生T細胞誘導を指標とした、経口免疫寛容物質スクリーニング方法及び経口免疫寛容増強組成物 |
US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
AU2015233084B2 (en) * | 2014-02-21 | 2020-12-17 | Anokion Sa | Glycotargeting therapeutics |
US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
CN107073090A (zh) | 2014-04-30 | 2017-08-18 | 哈佛学院董事会 | 结合的疫苗装置和杀死癌细胞的方法 |
EP2989904A1 (en) * | 2014-07-29 | 2016-03-02 | Heinrich-Heine-Universität | Induction of immunological tolerance using yeast |
KR101662898B1 (ko) * | 2014-09-02 | 2016-10-06 | 서울대학교산학협력단 | 점막점착성 고분자 및 이의 용도 |
JP6581208B2 (ja) | 2014-12-23 | 2019-09-25 | イリヤ ファーマ エービー | 創傷治癒の方法 |
WO2016115253A1 (en) | 2015-01-14 | 2016-07-21 | The Regents Of The University Ofcolordo, A Body Corporate | Insulin mimotopes and methods of using the same |
EP3250250A4 (en) | 2015-01-30 | 2019-05-22 | President and Fellows of Harvard College | PERITUMORAL AND INTRATUMORAL MATERIALS FOR CANCER THERAPY |
CN107708756A (zh) | 2015-04-10 | 2018-02-16 | 哈佛学院院长等 | 免疫细胞捕获装置及其制备和使用方法 |
EP3081227A1 (en) * | 2015-04-15 | 2016-10-19 | Institut National De La Recherche Agronomique | Lactococcus lactis producing tslp or il-25 and their uses as probiotics and therapeutics |
WO2017062175A1 (en) * | 2015-10-06 | 2017-04-13 | Albert Einstein College Of Medicine, Inc. | Microbial hyperswarmers and uses thereof |
JP7138864B2 (ja) | 2016-02-06 | 2022-09-20 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫を再構成するための造血ニッチの再現 |
CN115404196A (zh) | 2016-07-13 | 2022-11-29 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
RU2768027C2 (ru) * | 2016-09-02 | 2022-03-23 | Интрексон Актобиотикс Н.В. | Генетически модифицированные бактерии, стабильно экспрессирующие ил-10 и инсулин |
KR102469701B1 (ko) | 2016-09-13 | 2022-11-22 | 인트랙슨 액토바이오틱스 엔.브이. | 점막부착성 미생물 |
CN108114272A (zh) * | 2016-11-28 | 2018-06-05 | 上海市第五人民医院 | 一种构建哮喘免疫耐受模型的方法 |
AU2018338786A1 (en) * | 2017-09-29 | 2020-04-16 | Nantcell, Inc. | Antigenic proteins and methods therefor |
US11052060B2 (en) | 2018-02-12 | 2021-07-06 | The Regents Of The University Of Colorado, A Body Corporate | Compounds and methods for treating autoimmunity |
US11013707B2 (en) | 2018-03-23 | 2021-05-25 | The Regents Of The University Of Colorado, A Body Corporate | Administration of oral methyldopa |
JP2020000033A (ja) * | 2018-06-26 | 2020-01-09 | 国立大学法人広島大学 | 経口免疫寛容誘導剤、これを含有する食品および医薬品、ならびに加工食品の製造方法 |
WO2020232247A1 (en) | 2019-05-14 | 2020-11-19 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
CN110408579A (zh) * | 2019-06-03 | 2019-11-05 | 东北农业大学 | 牛白细胞介素-2重组乳酸菌及其应用 |
US20220340621A1 (en) | 2019-09-27 | 2022-10-27 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Treatment of celiac disease |
BR112022025381A2 (pt) | 2020-06-11 | 2023-01-24 | Provention Bio Inc | Métodos e composições para prevenir diabetes tipo 1 |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4100495A (en) | 1975-11-27 | 1978-07-11 | Cselt - Centro Studi E Laboratori Telecomunicazioni | Adaptive method of and means for recovering digital signals |
US4190495A (en) | 1976-09-27 | 1980-02-26 | Research Corporation | Modified microorganisms and method of preparing and using same |
US4874702A (en) | 1980-09-08 | 1989-10-17 | Biogen, Inc. | Vectors and methods for making such vectors and for expressive cloned genes |
US4888170A (en) | 1981-10-22 | 1989-12-19 | Research Corporation | Vaccines obtained from antigenic gene products of recombinant genes |
US5417986A (en) | 1984-03-16 | 1995-05-23 | The United States Of America As Represented By The Secretary Of The Army | Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres |
US5032510A (en) | 1984-09-26 | 1991-07-16 | Eli Lilly And Company | Method for expression and secretion in bacillus |
IL76422A0 (en) | 1984-09-26 | 1986-01-31 | Lilly Co Eli | Method for expression and secretion in bacillus |
US5504005A (en) | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
US5591632A (en) | 1987-03-02 | 1997-01-07 | Beth Israel Hospital | Recombinant BCG |
EP0347425B1 (en) | 1987-03-02 | 1995-12-27 | Whitehead Institute For Biomedical Research | Recombinant mycobacterial vaccine |
US5330753A (en) | 1987-04-29 | 1994-07-19 | President And Fellows Of Harvard College | Cholera vaccines |
US6130082A (en) | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
US5972685A (en) | 1988-07-21 | 1999-10-26 | Iowa State University Research Foundation, Inc. | Oral administration of coprostanol producing microorganisms to humans to decrease plasma cholesterol concentration |
IE892131A1 (en) | 1989-06-30 | 1991-01-02 | Univ Cork | Marker genes for genetic manipulation |
US5149532A (en) | 1989-11-01 | 1992-09-22 | Cedars Sinai Medical Center | Method of vaccine or toxoid preparation and immunization by colonization with recombinant microorganisms |
DE4006521A1 (de) | 1990-03-02 | 1991-09-05 | Bayer Ag | Zuckerhaltige polymere zur umhuellung und einbettung von arzneistoffen |
GB9006400D0 (en) | 1990-03-22 | 1990-05-23 | Ciba Geigy Ag | Bacterial vectors |
IL99097A0 (en) | 1990-09-05 | 1992-07-15 | Akzo Nv | Haemophilus paragallinarum vaccine |
AU664360B2 (en) | 1991-03-05 | 1995-11-16 | Wellcome Foundation Limited, The | Expression of recombinant proteins in attenuated bacteria |
DK0607278T3 (da) | 1991-10-07 | 2002-06-17 | Brigham & Womens Hospital | Fremgangsmåde til forstærkning af tarmabsorption |
IL103530A0 (en) | 1991-10-25 | 1993-03-15 | Duphar Int Res | Treponema hyodysenteriae vaccine |
US6221648B1 (en) | 1992-02-27 | 2001-04-24 | Microdial Technics Ltd. | Heterologous gene expression in lactococcus, and the expression products therefrom |
US5455034A (en) | 1992-06-26 | 1995-10-03 | Kansas State University Research Foundation | Fusobacterium necrophorum leukotoxoid vaccine |
DE4231764A1 (de) | 1992-09-23 | 1994-03-24 | Inst Pflanzengenetik & Kultur | Verfahren zur chromosomalen Integration eines Produkt-Gens |
US5830463A (en) | 1993-07-07 | 1998-11-03 | University Technology Corporation | Yeast-based delivery vehicles |
US5691185A (en) | 1993-10-08 | 1997-11-25 | Chr. Hansen A/S | Lactic acid bacterial suppressor mutants and their use as selective markers and as means of containment in lactic acid bacteria |
CA2173751A1 (en) | 1993-10-13 | 1995-04-20 | Sýren Molin | Recombinant staphylococcal nucleases and their use in limiting the survival of genetically engineered microorganisms |
IT1270123B (it) | 1994-10-05 | 1997-04-28 | Dompe Spa | Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia |
US5733540A (en) | 1995-03-08 | 1998-03-31 | Lee; Peter Poon-Hang | Protection from viral infection via colonization of mucosal membranes with genetically modified bacteria |
AU2149495A (en) | 1995-04-11 | 1996-10-30 | Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno | Method for the construction of vectors for lactic acid bacte ria like lactobacillus such that the bacteria can efficientl y express, secrete and display proteins at the surface |
US5753622A (en) | 1995-05-10 | 1998-05-19 | University Technologies International, Inc. | Use of epidermal growth factor as a gastrointestinal therapeutic agent |
ATE312934T1 (de) | 1995-06-07 | 2005-12-15 | Univ Washington | Rekombinant bakterielle system mit umweltbeschränkte lebensfähigkeit |
US5824538A (en) | 1995-09-06 | 1998-10-20 | The United States Of America As Represented By The Secretary Of The Army | Shigella vector for delivering DNA to a mammalian cell |
GB9518323D0 (en) | 1995-09-07 | 1995-11-08 | Steidler Lothar | Materials and methods relating to the attachment and display of substances on cell surfaces |
GB9521568D0 (en) | 1995-10-20 | 1995-12-20 | Lynxvale Ltd | Delivery of biologically active polypeptides |
JP2000516911A (ja) * | 1996-03-28 | 2000-12-19 | ホワイトヘッド インスティテュート フォー バイオメディカル リサーチ | オプソニン強化細胞、および抗原に対する免疫応答を調節する方法 |
JP2000508645A (ja) | 1996-04-12 | 2000-07-11 | ペプテック リミテッド | ポリ不飽和脂肪酸を使用する免疫病の治療方法 |
ATE331798T1 (de) | 1996-04-19 | 2006-07-15 | Jackson H M Found Military Med | Verfahren zur anregung einer immunantwort durch verabreichung von nutzorganismen, die intimin allein oder als fusionsprotein mit einem oder mehreren anderen antigenen exprimieren |
US5972887A (en) | 1996-09-19 | 1999-10-26 | The Nemours Foundation | Treatment of intestinal epithelial cell malfunctions with Hepatocyte Growth Factor |
US5723245A (en) | 1996-10-09 | 1998-03-03 | Xerox Corporation | Colored toner and developer compositions and process for enlarged color gamut |
US7361331B2 (en) * | 1996-10-18 | 2008-04-22 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Plant bioreactors |
GB9700939D0 (en) | 1997-01-17 | 1997-03-05 | Microbial Technics Limited | Therapy |
US6685943B1 (en) | 1997-01-21 | 2004-02-03 | The Texas A&M University System | Fibronectin binding protein compositions and methods of use |
DK0892054T3 (da) | 1997-06-20 | 2007-04-02 | Intervet Int Bv | Clostridium perfringens-vaccine |
US6100388A (en) | 1998-03-16 | 2000-08-08 | Biogaia Biologies Ab | Lactobacilli harboring aggregation gene as a vaccine delivery vehicle |
EP1075512B1 (en) | 1998-05-07 | 2010-04-14 | Universite Libre De Bruxelles | Cytotoxin-based biological containment |
US6190669B1 (en) | 1998-05-13 | 2001-02-20 | University Of Maryland, Baltimore | Attenuated mutants of salmonella which constitutively express the Vi antigen |
AU757343B2 (en) | 1998-09-28 | 2003-02-20 | Capsugel Belgium Nv | Enteric and colonic delivery using HPMC capsules |
AU1071200A (en) | 1998-10-19 | 2000-05-08 | Biotech Australia Pty Limited | Systems for oral delivery |
DE69914932T2 (de) | 1998-10-20 | 2004-12-09 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis |
US7220418B1 (en) | 1999-07-05 | 2007-05-22 | Vlaams Interuniversitair Instituut Voor Biotechnologie | Delivery of trefoil peptides |
ATE449861T1 (de) | 2000-10-20 | 2009-12-15 | Bioneer As | Verfahren zur fermentativen herstellung von heterologen genprodukten in milchsäurebakterien |
US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
DE60212825T2 (de) | 2001-05-03 | 2007-01-11 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Selbsterhaltender lactococcus stamm |
NO318426B1 (no) | 2001-10-02 | 2005-04-18 | Neurozym Biotech As | Et materiale for a senke konsentrasjonen av patogene tarmpeptider |
EP1319410A1 (en) | 2001-12-11 | 2003-06-18 | Société des Produits Nestlé S.A. | Use of micro-organisms for a directed delivery of substances to specific parts of the gut |
US20040043003A1 (en) | 2002-01-31 | 2004-03-04 | Wei Chen | Clinical grade vectors based on natural microflora for use in delivering therapeutic compositions |
DE10208653A1 (de) * | 2002-02-28 | 2003-09-18 | Medinnova Ges Med Innovationen | Mikroorganismus als Träger von Nukleotidsequenzen kodierend für Zellantigene zur Behandlung von Tumoren |
US7425449B2 (en) | 2002-04-30 | 2008-09-16 | The Regents Of The University Of California | Site specific Listeria integration vectors and methods for using the same |
AU2003234634A1 (en) | 2002-05-14 | 2003-12-02 | Felix Hausch | Drug therapy for celiac sprue |
EP1364586A1 (en) | 2002-05-24 | 2003-11-26 | Nestec S.A. | Probiotics and oral tolerance |
JP2005529622A (ja) | 2002-06-19 | 2005-10-06 | ヴェーイーベー・ヴェーゼットウェー | 腸吸収を促進するための方法および手段 |
AU2003298291A1 (en) | 2002-11-15 | 2004-06-15 | Universiteit Gent | Self-containing lactobacillus strain |
DK1563300T3 (da) | 2002-11-20 | 2012-07-23 | Univ Leland Stanford Junior | Diagnostisk fremgangsmåde til cøliaki |
JP4589618B2 (ja) | 2003-11-28 | 2010-12-01 | 独立行政法人農業生物資源研究所 | 免疫調節性機能を誘導する乳酸菌類とその成分 |
JP2007520566A (ja) * | 2004-02-04 | 2007-07-26 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | 自己免疫治療のための抗cd3及び抗原特異的免疫療法 |
CN1695469A (zh) | 2005-05-17 | 2005-11-16 | 田星 | 一种风味益生发酵乳及其制作方法 |
DK2119450T3 (da) * | 2005-11-29 | 2013-05-06 | Actogenix Nv | Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener |
ES2492468T3 (es) | 2007-01-25 | 2014-09-09 | Actogenix N.V. | Tratamiento de enfermedad inmunitaria por administración a través de la mucosa de antígenos usando Lactobacillus genéticamente modificado |
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- 2006-11-29 ES ES06830192.8T patent/ES2596855T3/es active Active
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