JP2014510746A5 - - Google Patents
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- JP2014510746A5 JP2014510746A5 JP2014501719A JP2014501719A JP2014510746A5 JP 2014510746 A5 JP2014510746 A5 JP 2014510746A5 JP 2014501719 A JP2014501719 A JP 2014501719A JP 2014501719 A JP2014501719 A JP 2014501719A JP 2014510746 A5 JP2014510746 A5 JP 2014510746A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- compound according
- pharmaceutical composition
- hcv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LBKDOKHAKPIWCL-NSVPLCITSA-N CC(C)[C@@H](C(N[C@](C1)(C1C(CC(O)=C1)C=C1F)C(N(CCC1)N[C@@H]1C(O[C@@H](C/C=C/C=C/[C@@H]([C@H](C)[C@H]([C@H]1CCC(C)=O)O)O)/C(/C)=C/C=O)=O)=O)=O)NC1=O Chemical compound CC(C)[C@@H](C(N[C@](C1)(C1C(CC(O)=C1)C=C1F)C(N(CCC1)N[C@@H]1C(O[C@@H](C/C=C/C=C/[C@@H]([C@H](C)[C@H]([C@H]1CCC(C)=O)O)O)/C(/C)=C/C=O)=O)=O)=O)NC1=O LBKDOKHAKPIWCL-NSVPLCITSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1105293.3A GB201105293D0 (en) | 2011-03-29 | 2011-03-29 | Novel compounds and methods for their production |
| GB1105293.3 | 2011-03-29 | ||
| GB1113629.8 | 2011-08-08 | ||
| GBGB1113629.8A GB201113629D0 (en) | 2011-08-08 | 2011-08-08 | Novel compounds and methods for their production |
| GBGB1202060.8A GB201202060D0 (en) | 2012-02-07 | 2012-02-07 | Novel compounds and methods for their production |
| GB1202060.8 | 2012-02-07 | ||
| PCT/GB2012/050700 WO2012131371A1 (en) | 2011-03-29 | 2012-03-29 | Macrocyclic compound and methods for its production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014510746A JP2014510746A (ja) | 2014-05-01 |
| JP2014510746A5 true JP2014510746A5 (https=) | 2015-05-14 |
| JP6118792B2 JP6118792B2 (ja) | 2017-04-26 |
Family
ID=46001313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014501720A Active JP6118793B2 (ja) | 2011-03-29 | 2012-03-29 | マクロ環状化合物及びそれらの製造方法 |
| JP2014501719A Expired - Fee Related JP6118792B2 (ja) | 2011-03-29 | 2012-03-29 | マクロ環状化合物及びその製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014501720A Active JP6118793B2 (ja) | 2011-03-29 | 2012-03-29 | マクロ環状化合物及びそれらの製造方法 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US9139613B2 (https=) |
| EP (2) | EP2691413B1 (https=) |
| JP (2) | JP6118793B2 (https=) |
| KR (2) | KR101868084B1 (https=) |
| CN (3) | CN107417766A (https=) |
| AR (1) | AR085724A1 (https=) |
| AU (2) | AU2012235961B2 (https=) |
| BR (2) | BR112013024974A2 (https=) |
| CA (2) | CA2830827C (https=) |
| CL (2) | CL2013002739A1 (https=) |
| CY (2) | CY1116318T1 (https=) |
| DK (2) | DK2691413T3 (https=) |
| EA (2) | EA023848B1 (https=) |
| ES (2) | ES2533438T3 (https=) |
| HR (2) | HRP20150187T1 (https=) |
| IL (2) | IL228509B (https=) |
| JO (1) | JO3063B1 (https=) |
| MX (2) | MX345351B (https=) |
| MY (2) | MY170618A (https=) |
| PH (2) | PH12013502000B1 (https=) |
| PL (2) | PL2691413T3 (https=) |
| PT (2) | PT2691412E (https=) |
| RS (2) | RS53963B1 (https=) |
| SG (2) | SG193569A1 (https=) |
| SI (2) | SI2691413T1 (https=) |
| TW (1) | TWI525098B (https=) |
| UY (1) | UY33993A (https=) |
| WO (2) | WO2012131377A1 (https=) |
| ZA (2) | ZA201307149B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011214135B2 (en) | 2010-02-09 | 2014-07-31 | Neurovive Pharmaceutical Ab | Sanglifehrin based compounds |
| JO3063B1 (ar) * | 2011-03-29 | 2017-03-15 | Neurovive Pharmaceutical Ab | مركب مبتكر وطرق لانتاجه |
| CN103130734A (zh) * | 2011-12-01 | 2013-06-05 | 上海药明康德新药开发有限公司 | 一种合成1,2-吗啉盐酸盐的方法 |
| CN105695541B (zh) * | 2016-03-10 | 2019-03-15 | 苏州华赛生物工程技术有限公司 | 一种抗生素nvp018中间体的分离纯化方法 |
| KR20180036522A (ko) * | 2016-09-30 | 2018-04-09 | (주)나노믹스 | 스틸벤 유도체 및 그 제조 방법 |
| WO2018091634A1 (en) | 2016-11-18 | 2018-05-24 | Neurovive Pharmaceutical Ab | Use of sanglifehrin macrocyclic analogues as anticancer compounds |
| CN112410353B (zh) * | 2019-08-23 | 2023-01-24 | 上海医药工业研究院 | 一种fkbS基因、含其的基因工程菌及其制备方法和用途 |
| MX2022005359A (es) | 2019-11-04 | 2022-06-02 | Revolution Medicines Inc | Inhibidores de ras. |
| MX2023003060A (es) | 2020-09-15 | 2023-04-05 | Revolution Medicines Inc | Derivados indolicos como inhibidores de ras en el tratamiento del cancer. |
| AU2022268962A1 (en) | 2021-05-05 | 2023-12-14 | Revolution Medicines, Inc. | Ras inhibitors for the treatment of cancer |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| CN115028681B (zh) * | 2022-08-11 | 2022-11-15 | 中国科学院微生物研究所 | 一种降解亲环素a的嵌合体化合物及其制备方法与应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR006514A1 (es) | 1995-07-04 | 1999-09-08 | Sandoz Ag | Un macrolido, sus usos, un proceso para producirlo, un aislado biologicamente puro capaz de producirlo, y una composicion farmaceutica quelo comprende |
| US6124453A (en) | 1995-07-04 | 2000-09-26 | Novartis Ag | Macrolides |
| US20090221598A1 (en) * | 2005-06-17 | 2009-09-03 | Kai Lin | Use of Sanglifehrin in HCV |
| CA2674296C (en) | 2007-01-04 | 2015-11-24 | Debiopharm Sa | Non-immunosuppressive cyclosporin for treatment of ullrich congenital muscular dystrophy |
| CN101691575B (zh) * | 2008-09-24 | 2013-06-05 | 中国科学院上海有机化学研究所 | 一种萨菲菌素的生物合成基因簇 |
| EP2342335B1 (en) | 2008-09-24 | 2015-09-16 | Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences | Novel gene cluster |
| WO2011098805A1 (en) * | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
| WO2011098808A1 (en) * | 2010-02-09 | 2011-08-18 | Biotica Technology Limited | Sanglifehrin based compounds |
| AU2011214135B2 (en) | 2010-02-09 | 2014-07-31 | Neurovive Pharmaceutical Ab | Sanglifehrin based compounds |
| BR112013015501A2 (pt) * | 2010-12-20 | 2017-05-16 | Neurovive Pharmaceutical Ab | composto, composição farmacêutica, métodos para tratamento de infecções virais e de distúrbios inflamatórios, e, processo para produzir uma sangliferrina mutassintética |
| JO3063B1 (ar) * | 2011-03-29 | 2017-03-15 | Neurovive Pharmaceutical Ab | مركب مبتكر وطرق لانتاجه |
-
2012
- 2012-03-12 JO JOP/2012/0053A patent/JO3063B1/ar active
- 2012-03-28 AR ARP120101043A patent/AR085724A1/es unknown
- 2012-03-28 TW TW101110673A patent/TWI525098B/zh not_active IP Right Cessation
- 2012-03-29 SI SI201230146T patent/SI2691413T1/sl unknown
- 2012-03-29 CN CN201611126823.4A patent/CN107417766A/zh active Pending
- 2012-03-29 ES ES12716539.7T patent/ES2533438T3/es active Active
- 2012-03-29 EP EP12716539.7A patent/EP2691413B1/en active Active
- 2012-03-29 EP EP12716538.9A patent/EP2691412B1/en active Active
- 2012-03-29 SG SG2013070974A patent/SG193569A1/en unknown
- 2012-03-29 MX MX2013011043A patent/MX345351B/es active IP Right Grant
- 2012-03-29 PL PL12716539T patent/PL2691413T3/pl unknown
- 2012-03-29 MY MYPI2013701789A patent/MY170618A/en unknown
- 2012-03-29 HR HRP20150187TT patent/HRP20150187T1/hr unknown
- 2012-03-29 US US14/006,341 patent/US9139613B2/en active Active
- 2012-03-29 WO PCT/GB2012/050707 patent/WO2012131377A1/en not_active Ceased
- 2012-03-29 AU AU2012235961A patent/AU2012235961B2/en not_active Ceased
- 2012-03-29 KR KR1020137027773A patent/KR101868084B1/ko not_active Expired - Fee Related
- 2012-03-29 US US13/433,944 patent/US9090657B2/en active Active
- 2012-03-29 ES ES12716538.9T patent/ES2533437T3/es active Active
- 2012-03-29 DK DK12716539T patent/DK2691413T3/en active
- 2012-03-29 EA EA201391399A patent/EA023848B1/ru not_active IP Right Cessation
- 2012-03-29 CN CN201280026190.3A patent/CN103619869B/zh not_active Expired - Fee Related
- 2012-03-29 WO PCT/GB2012/050700 patent/WO2012131371A1/en not_active Ceased
- 2012-03-29 JP JP2014501720A patent/JP6118793B2/ja active Active
- 2012-03-29 PH PH1/2013/502000A patent/PH12013502000B1/en unknown
- 2012-03-29 BR BR112013024974A patent/BR112013024974A2/pt not_active Application Discontinuation
- 2012-03-29 CA CA2830827A patent/CA2830827C/en not_active Expired - Fee Related
- 2012-03-29 EA EA201391396A patent/EA023907B1/ru not_active IP Right Cessation
- 2012-03-29 RS RS20150161A patent/RS53963B1/sr unknown
- 2012-03-29 PH PH1/2013/502016A patent/PH12013502016A1/en unknown
- 2012-03-29 MX MX2013011051A patent/MX345352B/es active IP Right Grant
- 2012-03-29 DK DK12716538T patent/DK2691412T3/en active
- 2012-03-29 JP JP2014501719A patent/JP6118792B2/ja not_active Expired - Fee Related
- 2012-03-29 UY UY0001033993A patent/UY33993A/es not_active Application Discontinuation
- 2012-03-29 KR KR1020137028095A patent/KR101911484B1/ko not_active Expired - Fee Related
- 2012-03-29 AU AU2012235880A patent/AU2012235880B2/en not_active Ceased
- 2012-03-29 PT PT127165389T patent/PT2691412E/pt unknown
- 2012-03-29 RS RS20150162A patent/RS53964B1/sr unknown
- 2012-03-29 SI SI201230145T patent/SI2691412T1/sl unknown
- 2012-03-29 PL PL12716538T patent/PL2691412T3/pl unknown
- 2012-03-29 CN CN201280026793.3A patent/CN103635484B/zh not_active Expired - Fee Related
- 2012-03-29 MY MYPI2013701788A patent/MY170637A/en unknown
- 2012-03-29 HR HRP20150184TT patent/HRP20150184T1/hr unknown
- 2012-03-29 BR BR112013024965A patent/BR112013024965A2/pt not_active Application Discontinuation
- 2012-03-29 CA CA2830831A patent/CA2830831C/en not_active Expired - Fee Related
- 2012-03-29 SG SG2013070966A patent/SG193568A1/en unknown
- 2012-03-29 PT PT127165397T patent/PT2691413E/pt unknown
-
2013
- 2013-09-17 IL IL228509A patent/IL228509B/en active IP Right Grant
- 2013-09-17 IL IL228508A patent/IL228508B/en active IP Right Grant
- 2013-09-23 ZA ZA2013/07149A patent/ZA201307149B/en unknown
- 2013-09-25 CL CL2013002739A patent/CL2013002739A1/es unknown
- 2013-09-25 CL CL2013002740A patent/CL2013002740A1/es unknown
- 2013-09-26 ZA ZA2013/07231A patent/ZA201307231B/en unknown
-
2015
- 2015-02-27 CY CY20151100207T patent/CY1116318T1/el unknown
- 2015-03-06 CY CY20151100236T patent/CY1116186T1/el unknown
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