JP2014502141A5 - - Google Patents
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- JP2014502141A5 JP2014502141A5 JP2013532226A JP2013532226A JP2014502141A5 JP 2014502141 A5 JP2014502141 A5 JP 2014502141A5 JP 2013532226 A JP2013532226 A JP 2013532226A JP 2013532226 A JP2013532226 A JP 2013532226A JP 2014502141 A5 JP2014502141 A5 JP 2014502141A5
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 30
- 102000013498 tau Proteins Human genes 0.000 claims description 22
- 108010026424 tau Proteins Proteins 0.000 claims description 22
- 201000010099 disease Diseases 0.000 claims description 20
- 206010012289 Dementia Diseases 0.000 claims description 12
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 11
- 210000002682 neurofibrillary tangle Anatomy 0.000 claims description 11
- 208000035475 disorder Diseases 0.000 claims description 10
- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 8
- 230000007170 pathology Effects 0.000 claims description 7
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- 238000003745 diagnosis Methods 0.000 claims description 6
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- 208000024827 Alzheimer disease Diseases 0.000 claims description 4
- 208000011990 Corticobasal Degeneration Diseases 0.000 claims description 4
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims description 4
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims description 4
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims description 4
- 201000010374 Down Syndrome Diseases 0.000 claims description 4
- 208000026072 Motor neurone disease Diseases 0.000 claims description 4
- 208000001089 Multiple system atrophy Diseases 0.000 claims description 4
- 206010068871 Myotonic dystrophy Diseases 0.000 claims description 4
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 4
- 208000036757 Postencephalitic parkinsonism Diseases 0.000 claims description 4
- 108091000054 Prion Proteins 0.000 claims description 4
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 claims description 4
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 claims description 4
- 208000034799 Tauopathies Diseases 0.000 claims description 4
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 4
- 206010044688 Trisomy 21 Diseases 0.000 claims description 4
- 208000007930 Type C Niemann-Pick Disease Diseases 0.000 claims description 4
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- 230000002739 subcortical effect Effects 0.000 claims description 4
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- 208000033556 type C1 Niemann-Pick disease Diseases 0.000 claims description 4
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- 102000040430 polynucleotide Human genes 0.000 claims description 3
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- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 206010033799 Paralysis Diseases 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 41
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 10
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 10
- 210000004408 hybridoma Anatomy 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 102000057063 human MAPT Human genes 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102100034452 Alternative prion protein Human genes 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
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- 230000000875 corresponding effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
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- 238000011065 in-situ storage Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000001898 pallidal effect Effects 0.000 claims 1
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
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- 210000004556 brain Anatomy 0.000 description 5
- 208000004434 Calcinosis Diseases 0.000 description 3
- 102000029797 Prion Human genes 0.000 description 3
- 206010059245 Angiopathy Diseases 0.000 description 2
- 208000037765 diseases and disorders Diseases 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 201000002212 progressive supranuclear palsy Diseases 0.000 description 2
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000024571 Pick disease Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10186810.7 | 2010-10-07 | ||
| EP10186810 | 2010-10-07 | ||
| EP11174248 | 2011-07-15 | ||
| EP11174248.2 | 2011-07-15 | ||
| PCT/EP2011/067604 WO2012045882A2 (en) | 2010-10-07 | 2011-10-07 | Pharmaceutical composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017008740A Division JP2017113004A (ja) | 2010-10-07 | 2017-01-20 | 薬学的組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014502141A JP2014502141A (ja) | 2014-01-30 |
| JP2014502141A5 true JP2014502141A5 (https=) | 2016-06-23 |
| JP6371526B2 JP6371526B2 (ja) | 2018-08-08 |
Family
ID=44947048
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532226A Active JP6371526B2 (ja) | 2010-10-07 | 2011-10-07 | タウを認識するリン酸化部位特異的抗体 |
| JP2017008740A Pending JP2017113004A (ja) | 2010-10-07 | 2017-01-20 | 薬学的組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017008740A Pending JP2017113004A (ja) | 2010-10-07 | 2017-01-20 | 薬学的組成物 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US9304138B2 (https=) |
| EP (2) | EP2987807A3 (https=) |
| JP (2) | JP6371526B2 (https=) |
| KR (1) | KR101988672B1 (https=) |
| CN (1) | CN103502272B (https=) |
| AR (1) | AR085198A1 (https=) |
| AU (1) | AU2011311516B2 (https=) |
| BR (1) | BR112013008333B1 (https=) |
| CA (1) | CA2812865C (https=) |
| CL (1) | CL2013000951A1 (https=) |
| CO (1) | CO6710903A2 (https=) |
| CR (1) | CR20130160A (https=) |
| DK (1) | DK2625198T3 (https=) |
| EC (1) | ECSP13012609A (https=) |
| ES (1) | ES2548686T3 (https=) |
| HK (1) | HK1216897A1 (https=) |
| HU (1) | HUE027649T2 (https=) |
| IL (1) | IL225568A (https=) |
| MX (1) | MX338421B (https=) |
| MY (1) | MY164376A (https=) |
| PE (1) | PE20140218A1 (https=) |
| PH (1) | PH12013500615A1 (https=) |
| PL (1) | PL2625198T3 (https=) |
| RU (1) | RU2603078C2 (https=) |
| SG (1) | SG189136A1 (https=) |
| SI (1) | SI2625198T1 (https=) |
| TW (1) | TW201216985A (https=) |
| WO (1) | WO2012045882A2 (https=) |
| ZA (1) | ZA201302432B (https=) |
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| US10266585B2 (en) * | 2009-08-28 | 2019-04-23 | The Board Of Regents Of The Univerity Of Texas System | Methods of treating brain injury |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| ES2548686T3 (es) * | 2010-10-07 | 2015-10-20 | Ac Immune S.A. | Anticuerpos que reconocen fosfo-Tau |
| BR112013008765B8 (pt) | 2010-10-11 | 2023-05-02 | Biogen Idec Int Neuroscience Gmbh | Anticorpos monoclonais anti-tau humano isolados ou um fragmento de ligação à tau dos mesmos, métodos de preparação dos mesmos, polinucleotídeo ou polinucleotídeos, vetor ou vetores, composição, método in vitro de diagnóstico ou monitoramento da progressão de uma tauopatia neurodegenerativa em um indivíduo humano, método in vitro para diagnosticar uma tauopatia neurodegenerativa em um indivíduo humano, e kit útil para o diagnóstico de uma tauopatia neurodegenerativa |
| US8703137B2 (en) | 2011-01-31 | 2014-04-22 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
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| US12024568B2 (en) | 2012-09-13 | 2024-07-02 | Cornell University | Treatment of brain cancers using central nervous system mediated gene transfer of monoclonal antibodies |
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