|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4866132A
(en)
|
1986-04-17 |
1989-09-12 |
The Research Foundation Of State University Of New York |
Novel radiopaque barium polymer complexes, compositions of matter and articles prepared therefrom
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5811310A
(en)
|
1986-09-30 |
1998-09-22 |
Albert Einstein College Of Medicine Of Yeshiva Univ. |
The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease
|
|
ATE243754T1
(de)
|
1987-05-21 |
2003-07-15 |
Micromet Ag |
Multifunktionelle proteine mit vorbestimmter zielsetzung
|
|
US5256334A
(en)
|
1988-09-08 |
1993-10-26 |
The Research Foundation Of The State University Of New York |
Homogeneous radiopaque polymer-organobismuth composites
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5585362A
(en)
|
1989-08-22 |
1996-12-17 |
The Regents Of The University Of Michigan |
Adenovirus vectors for gene therapy
|
|
US5595732A
(en)
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
EP0600951A4
(en)
|
1991-08-01 |
1996-10-30 |
Paul H Voorheis |
Diagnostic method for alzheimer's disease.
|
|
US5733734A
(en)
|
1991-08-14 |
1998-03-31 |
The Trustees Of The University Of Pennsylvania |
Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
|
|
DE69233013T2
(de)
|
1991-08-20 |
2004-03-04 |
The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer |
Adenovirus vermittelter gentransfer in den gastrointestinaltrakt
|
|
EP0605522B1
(en)
|
1991-09-23 |
1999-06-23 |
Medical Research Council |
Methods for the production of humanized antibodies
|
|
DE69220503T2
(de)
|
1991-10-25 |
1998-02-05 |
Innogenetics Nv |
Monoklonale Antikörper gegen das mikrotubulusassoziierte Protein Tau.
|
|
US5252479A
(en)
|
1991-11-08 |
1993-10-12 |
Research Corporation Technologies, Inc. |
Safe vector for gene therapy
|
|
ATE207080T1
(de)
|
1991-11-25 |
2001-11-15 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
FR2688514A1
(fr)
|
1992-03-16 |
1993-09-17 |
Centre Nat Rech Scient |
Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
|
|
JP2579202Y2
(ja)
|
1992-04-10 |
1998-08-20 |
株式会社小松製作所 |
圧力補償弁を備えた操作弁
|
|
US5600392A
(en)
|
1992-11-25 |
1997-02-04 |
Copal Company Limited |
Position sensor
|
|
EP1024198A3
(en)
|
1992-12-03 |
2002-05-29 |
Genzyme Corporation |
Pseudo-adenoviral vectors for the gene therapy of haemophiliae
|
|
US6010913A
(en)
|
1992-12-14 |
2000-01-04 |
N.V. Innogenetics S.A. |
Isolated human tau peptide
|
|
WO1994013795A1
(en)
|
1992-12-14 |
1994-06-23 |
N.V. Innogenetics S.A. |
Monoclonal antibodies directed against the microtubule-associated protein tau, hybridomas secreting these antibodies, antigen recognition by these monoclonal antibodies and their applications
|
|
US5346981A
(en)
|
1993-01-13 |
1994-09-13 |
Miles Inc. |
Radiopaque polyurethanes
|
|
CA2115811A1
(en)
|
1993-02-17 |
1994-08-18 |
Claus Krebber |
A method for in vivo selection of ligand-binding proteins
|
|
EP0705344B8
(en)
|
1993-06-24 |
2006-05-10 |
Advec Inc. |
Adenovirus vectors for gene therapy
|
|
AU687117B2
(en)
|
1993-10-25 |
1998-02-19 |
Canji, Inc. |
Recombinant adenoviral vector and methods of use
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
ES2270421T3
(es)
|
1993-12-21 |
2007-04-01 |
Innogenetics N.V. |
Anticuerpos monoclonales especificos para phf-tau, hibridomas que secretan los mismos, reconocimiento de antigeno por estos anticuerpos y sus aplicaciones.
|
|
WO1996004309A1
(en)
|
1994-07-29 |
1996-02-15 |
Innogenetics N.V. |
Monoclonal antibodies specific for an epitope of a particular subclass or form of phosphorylated tau, hybridomas secreting them, antigen recognition of these antibodies and their applications
|
|
US5625048A
(en)
|
1994-11-10 |
1997-04-29 |
The Regents Of The University Of California |
Modified green fluorescent proteins
|
|
US7427392B1
(en)
|
1994-11-14 |
2008-09-23 |
Elan Pharmaceuticals, Inc. |
Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau
|
|
KR100551104B1
(ko)
|
1994-12-09 |
2006-02-09 |
임페리얼 컬리지 이노베이션스 리미티드 |
유전자의 동정
|
|
WO1996019487A1
(en)
|
1994-12-22 |
1996-06-27 |
Nissan Chemical Industries, Ltd. |
Organobismuth derivatives and process for producing the same
|
|
US5958713A
(en)
|
1995-01-31 |
1999-09-28 |
Novo Nordisk A/S |
Method of detecting biologically active substances by using green fluorescent protein
|
|
US5670477A
(en)
|
1995-04-20 |
1997-09-23 |
Joseph F. Poduslo |
Method to enhance permeability of the blood/brain blood/nerve bariers to therapeutic agents
|
|
US5968738A
(en)
|
1995-12-06 |
1999-10-19 |
The Board Of Trustees Of The Leland Stanford Junior University |
Two-reporter FACS analysis of mammalian cells using green fluorescent proteins
|
|
US5874304A
(en)
|
1996-01-18 |
1999-02-23 |
University Of Florida Research Foundation, Inc. |
Humanized green fluorescent protein genes and methods
|
|
US6020192A
(en)
|
1996-01-18 |
2000-02-01 |
University Of Florida |
Humanized green fluorescent protein genes and methods
|
|
ES2166097T5
(es)
|
1996-08-27 |
2007-03-16 |
Novartis Vaccines And Diagnostics, Inc. |
Glicoconjugados de neisseria meningitidis de serogrupo b y procedimientos para usarlos.
|
|
US5976796A
(en)
|
1996-10-04 |
1999-11-02 |
Loma Linda University |
Construction and expression of renilla luciferase and green fluorescent protein fusion genes
|
|
TW371617B
(en)
|
1996-10-09 |
1999-10-11 |
Of Animal And Plant Health Inspection And Quarantine Council Of Agriculture Executive Yuan Bureau |
Method to transplant GFP into autographa californica multiple nuclear polyhedrosis virus for inflicting pest in an attempt to detect and flow up it existence and to improve life span against UV
|
|
AU5508798A
(en)
|
1996-11-19 |
1998-06-10 |
Trustees Of The University Of Pennsylvania, The |
Diagnostic and therapeutic reagents for alzheimer's disease
|
|
US6080849A
(en)
|
1997-09-10 |
2000-06-27 |
Vion Pharmaceuticals, Inc. |
Genetically modified tumor-targeted bacteria with reduced virulence
|
|
KR20010015856A
(ko)
|
1997-12-12 |
2001-02-26 |
마크로메드 인코퍼레이션 |
단백질 변성용으로 헤테로 작용기를 가진 별 모양의폴리(에틸렌글리콜)
|
|
US20040014142A1
(en)
|
1998-07-03 |
2004-01-22 |
Innogenetics N.V. |
Differential diagnosis of neurodegeneration
|
|
US5985577A
(en)
|
1998-10-14 |
1999-11-16 |
The Trustees Of Columbia University In The City Of New York |
Protein conjugates containing multimers of green fluorescent protein
|
|
EP1204674A4
(en)
|
1999-07-27 |
2005-06-01 |
Abgenix Inc |
METHODS AND COMPOUNDS FOR PREVENTING POLYPEPTIDE COLLECTIONS ASSOCIATED WITH NEUROLOGICAL DISORDERS
|
|
ATE342509T1
(de)
|
2000-01-24 |
2006-11-15 |
Innogenetics Nv |
Diagnose von tauopathien durch bestimmung des verhältnisses von tau/phospho-tau
|
|
DE60141752D1
(de)
|
2000-06-30 |
2010-05-20 |
Innogenetics Nv |
Differentielle diagnose von neurologischen krankheiten
|
|
JP2004503747A
(ja)
|
2000-07-11 |
2004-02-05 |
モレキュラー ジェリアトリクス コーポレイション |
結合物質の同定するための試薬と方法
|
|
AU2002222139A1
(en)
*
|
2000-12-09 |
2002-06-18 |
Cambridge University Technical Services Limited |
Hcv vaccines
|
|
US7466180B2
(en)
|
2000-12-12 |
2008-12-16 |
Intel Corporation |
Clock network
|
|
GB0101049D0
(en)
|
2001-01-15 |
2001-02-28 |
Univ Aberdeen |
Materials and methods relating to protein aggregation in neurodegenerative disease
|
|
AT500379B8
(de)
|
2001-02-02 |
2009-08-15 |
Axon Neuroscience |
Tau-proteine
|
|
GB0105924D0
(en)
|
2001-03-09 |
2001-04-25 |
Microscience Ltd |
Promoter
|
|
WO2002094191A2
(en)
|
2001-05-23 |
2002-11-28 |
New York University |
Detection of alzheimer's amyloid by magnetic resonance imaging
|
|
GB0117326D0
(en)
|
2001-07-16 |
2001-09-05 |
Univ Aberdeen |
Napthoquinone-type inhibitors of protein aggregation
|
|
AU2002355477B2
(en)
|
2001-08-03 |
2008-09-25 |
Medical Research Council |
Method of identifying a consensus sequence for intracellular antibodies
|
|
IL160701A0
(en)
|
2001-09-21 |
2004-08-31 |
Mitsubishi Pharma Corp |
3-substituted-4-pyrimidone derivatives
|
|
WO2004001421A2
(en)
|
2002-06-21 |
2003-12-31 |
Innogenetics N.V. |
Method for the diagnosis and differential diagnosis of neurological diseases
|
|
US20060167227A1
(en)
|
2002-07-12 |
2006-07-27 |
Axon Neuroscience Forschungs-Und Entwicklungs Gmbh |
Truncated tau proteins
|
|
US7250551B2
(en)
|
2002-07-24 |
2007-07-31 |
President And Fellows Of Harvard College |
Transgenic mice expressing inducible human p25
|
|
JP4393382B2
(ja)
|
2002-08-14 |
2010-01-06 |
三菱化学株式会社 |
中枢性タウ蛋白質特異的抗体
|
|
EP1480041A1
(en)
|
2003-05-22 |
2004-11-24 |
Innogenetics N.V. |
Method for the prediction, diagnosis and differential diagnosis of Alzheimer's disease
|
|
EP2784084B2
(en)
|
2003-07-08 |
2023-10-04 |
Novartis Pharma AG |
Antagonist antibodies to IL-17A/F heterologous polypeptides
|
|
US20050261475A1
(en)
|
2004-02-13 |
2005-11-24 |
Harvard Medical School |
Solid-phase capture-release-tag methods for phosphoproteomic analyses
|
|
US7238788B2
(en)
|
2004-02-18 |
2007-07-03 |
University Of Iowa Foundation |
Antibodies to phosphorylated tau, methods of making and methods of use
|
|
CA2555989A1
(en)
|
2004-02-24 |
2005-09-01 |
Innogenetics N.V. |
Method for determining the risk of developing a neurological disease
|
|
ES2367311T3
(es)
|
2004-04-15 |
2011-11-02 |
University Of Florida Research Foundation, Inc. |
Productos de degradación proteolítica de map-2 como biomarcadores de diagnóstico para las lesiones neurales.
|
|
CA2570458C
(en)
*
|
2004-06-09 |
2014-05-20 |
Technion Research & Development Foundation Ltd. |
Antibodies for selective apoptosis of cells
|
|
US7632924B2
(en)
|
2004-06-18 |
2009-12-15 |
Ambrx, Inc. |
Antigen-binding polypeptides and their uses
|
|
CN1721437A
(zh)
*
|
2004-07-13 |
2006-01-18 |
中南大学 |
一种与Tau蛋白相关的多肽抗原及抗体
|
|
JP4730584B2
(ja)
|
2004-12-06 |
2011-07-20 |
東亞合成株式会社 |
抗菌ペプチド及びその利用
|
|
US20090016959A1
(en)
|
2005-02-18 |
2009-01-15 |
Richard Beliveau |
Delivery of antibodies to the central nervous system
|
|
EP1772732A1
(en)
|
2005-10-07 |
2007-04-11 |
Innogenetics N.V. |
Polymer replicated interdigitated electrode arrays for (bio)sensing applications
|
|
US8741260B2
(en)
|
2005-10-07 |
2014-06-03 |
Armagen Technologies, Inc. |
Fusion proteins for delivery of GDNF to the CNS
|
|
WO2007068105A1
(en)
|
2005-12-12 |
2007-06-21 |
Robarts Research Institute |
Method of diagnosing amyotrophic lateral sclerosis
|
|
US20070218491A1
(en)
|
2006-02-08 |
2007-09-20 |
Oligomerix, Inc. |
Oligomerization of amyloid proteins
|
|
US20110143380A1
(en)
|
2006-03-14 |
2011-06-16 |
The Washington University |
Alzheimer's disease biomarkers and methods of use
|
|
US8012936B2
(en)
|
2006-03-29 |
2011-09-06 |
New York University |
Tau fragments for immunotherapy
|
|
US8729225B2
(en)
|
2006-11-13 |
2014-05-20 |
Intrexon Corporation |
Glycogen synthase kinase heteropolyligand polypeptide
|
|
HRP20140049T1
(hr)
|
2007-01-05 |
2014-02-28 |
University Of Zürich |
Anti beta-amiloid antitijela i njihova upotreba
|
|
WO2008140639A2
(en)
|
2007-02-08 |
2008-11-20 |
Oligomerix, Inc. |
Biomarkers and assays for alzheimer's disease
|
|
WO2009002607A1
(en)
|
2007-05-01 |
2008-12-31 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identifying transforming and tumor suppressor genes
|
|
PE20090329A1
(es)
|
2007-05-30 |
2009-03-27 |
Abbott Lab |
Anticuerpos humanizados contra el globulomero ab(20-42) y sus usos
|
|
EP2198292A4
(en)
|
2007-08-21 |
2010-09-08 |
Univ Washington |
IMPROVED MORBUS ALZHEIMER DIAGNOSIS
|
|
WO2009027105A2
(en)
|
2007-08-31 |
2009-03-05 |
Neurimmune Therapeutics Ag |
Method of providing patient specific immune response in amyloidoses and protein aggregation disorders
|
|
WO2009033151A1
(en)
|
2007-09-07 |
2009-03-12 |
The Trustees Of Columbia University In The City Of New York |
Tau protein screening assay
|
|
US8506933B2
(en)
|
2007-11-30 |
2013-08-13 |
Msdx, Inc. |
Methods of detecting a neurological condition via analysis of circulating phagocytes
|
|
JP5781929B2
(ja)
|
2008-07-15 |
2015-09-24 |
ノバルティス アーゲー |
免疫原性の両親媒性ペプチド組成物
|
|
US20110312059A1
(en)
|
2008-08-20 |
2011-12-22 |
Oligomerix Inc. |
Tau protease compositions and methods
|
|
US9464122B2
(en)
|
2008-08-20 |
2016-10-11 |
Oligomerix, Inc. |
Methods and compositions comprising tau oligomers
|
|
CN102348723A
(zh)
|
2008-12-05 |
2012-02-08 |
安吉奥开米公司 |
肽治疗剂轭合物及其应用
|
|
US9605054B2
(en)
|
2009-02-23 |
2017-03-28 |
The Board Of Trustees Of The University Of Illinois |
Composition and method for treating a tauopathy
|
|
UA107571C2
(xx)
|
2009-04-03 |
2015-01-26 |
|
Фармацевтична композиція
|
|
WO2010129674A2
(en)
|
2009-05-05 |
2010-11-11 |
New York University |
Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins
|
|
CN103154735B
(zh)
|
2009-05-11 |
2018-10-02 |
连接Dx股份有限公司 |
用于检测分析物的方法和组合物
|
|
CN106390107B
(zh)
|
2009-06-10 |
2019-12-31 |
纽约大学 |
病理tau蛋白的免疫靶向
|
|
US8609097B2
(en)
|
2009-06-10 |
2013-12-17 |
Hoffmann-La Roche Inc. |
Use of an anti-Tau pS422 antibody for the treatment of brain diseases
|
|
JP2013500326A
(ja)
|
2009-07-30 |
2013-01-07 |
ファイザー バクシーンズ エルエルシー |
抗原性タウペプチドおよびその使用
|
|
AU2010286501B2
(en)
|
2009-08-28 |
2015-06-11 |
The Board Of Regents Of The University Of Texas System |
Antibodies that bind Tau oligomers
|
|
DK2496594T3
(en)
|
2009-11-06 |
2018-03-05 |
The J David Gladstone Inst |
METHODS AND COMPOSITIONS FOR MODULATING TAU LEVELS
|
|
WO2012020124A1
(en)
|
2010-08-12 |
2012-02-16 |
Ac Immune S.A. |
Vaccine engineering
|
|
MY164376A
(en)
*
|
2010-10-07 |
2017-12-15 |
Univ Leuven Kath |
Phosphospecific antibodies recognizing tau
|
|
CA2813493C
(en)
|
2010-10-11 |
2019-07-09 |
University Of Zurich |
Human anti-tau antibodies
|
|
US20120244174A1
(en)
|
2011-01-31 |
2012-09-27 |
Intellect Neurosciences Inc. |
Treatment of tauopathies
|
|
EP2686418A4
(en)
|
2011-03-17 |
2015-04-22 |
Minerva Biotechnologies Corp |
METHOD FOR THE PRODUCTION OF PLURIPOTENTAL STEM CELLS
|
|
GB201111361D0
(en)
|
2011-07-04 |
2011-08-17 |
Nordic Bioscience As |
Biochemical markers for neurodegenerative conditions
|
|
GB201112056D0
(en)
*
|
2011-07-14 |
2011-08-31 |
Univ Leuven Kath |
Antibodies
|
|
ME03008B
(me)
|
2011-09-19 |
2018-10-20 |
Axon Neuroscience Se |
Terapija na osnovu proteina i dijagnoza patologije u којој posreduje tau u alcнajмerovoj bolesti
|
|
CA2811188C
(en)
|
2011-09-23 |
2020-04-28 |
Andrea Pfeifer |
Vaccine therapy
|
|
KR101981351B1
(ko)
|
2011-10-07 |
2019-09-02 |
에이씨 이뮨 에스.에이. |
타우를 인식하는 포스포특이적 항체
|
|
US20140294724A1
(en)
|
2011-10-24 |
2014-10-02 |
Intellect Neurosciences, Inc. |
Compositions and methods for treatment of proteinopathies
|
|
MX350311B
(es)
|
2011-12-20 |
2017-09-01 |
Janssen Biotech Inc |
Anticuerpos anti-phf-tau y sus usos.
|
|
RU2644242C2
(ru)
|
2012-04-05 |
2018-02-08 |
Ац Иммуне С.А. |
Гуманизированное тау-антитело
|
|
SG10201708959WA
(en)
*
|
2012-07-03 |
2017-11-29 |
Univ Washington |
Antibodies to tau
|
|
NZ630542A
(en)
|
2012-08-16 |
2017-06-30 |
Ipierian Inc |
Methods of treating a tauopathy
|
|
US20140056901A1
(en)
|
2012-08-21 |
2014-02-27 |
The Institute For Molecular Medicine |
Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies
|
|
US8980270B2
(en)
|
2013-01-18 |
2015-03-17 |
Ipierian, Inc. |
Methods of treating a tauopathy
|
|
BR112015030356A2
(pt)
*
|
2013-06-10 |
2017-12-05 |
Ipierian Inc |
métodos de tratamento de uma taupatia
|
|
US20160122421A1
(en)
|
2013-06-10 |
2016-05-05 |
Ipierian, Inc. |
Methods of treating a tauopathy
|
|
BR112016010454A2
(pt)
|
2013-11-27 |
2017-12-05 |
Ipierian Inc |
métodos para tratar uma taupatia
|
|
JP2017512751A
(ja)
|
2014-02-14 |
2017-05-25 |
アイピエリアン，インコーポレイティド |
タウペプチド、抗タウ抗体、およびそれらの使用方法
|