JP2014501250A5 - - Google Patents
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- JP2014501250A5 JP2014501250A5 JP2013544872A JP2013544872A JP2014501250A5 JP 2014501250 A5 JP2014501250 A5 JP 2014501250A5 JP 2013544872 A JP2013544872 A JP 2013544872A JP 2013544872 A JP2013544872 A JP 2013544872A JP 2014501250 A5 JP2014501250 A5 JP 2014501250A5
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- Japan
- Prior art keywords
- compound
- alkyl
- aryl
- groups
- acyl
- Prior art date
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- BVSUIGWVDIZNCW-PZPSAWLHSA-N CC(C)(C1[C@](C)(CC2(C)C#N)c3nc(-c4cccnc4)ncc3CC1)C2=O Chemical compound CC(C)(C1[C@](C)(CC2(C)C#N)c3nc(-c4cccnc4)ncc3CC1)C2=O BVSUIGWVDIZNCW-PZPSAWLHSA-N 0.000 description 2
- HXPDCERWPYPLDF-MBSDFSHPSA-N CC(C)([C@H]1[C@](C)(C=C2C#N)c3nc(-c(cc4)ccc4OC)ncc3CC1)C2=O Chemical compound CC(C)([C@H]1[C@](C)(C=C2C#N)c3nc(-c(cc4)ccc4OC)ncc3CC1)C2=O HXPDCERWPYPLDF-MBSDFSHPSA-N 0.000 description 2
- AWNKVNUSWYTISD-KKSFZXQISA-N CC(C)([C@H]1[C@](C)(C=C2C#N)c3nc(-c4ccccn4)ncc3CC1)C2=O Chemical compound CC(C)([C@H]1[C@](C)(C=C2C#N)c3nc(-c4ccccn4)ncc3CC1)C2=O AWNKVNUSWYTISD-KKSFZXQISA-N 0.000 description 2
- VGKMSBIMGMCNCK-YHDJDMAPSA-N CCCC1C([C@](C)(CC(C)(C)C2=O)C=C2C#N)=NC(C)=NC1(C)OC Chemical compound CCCC1C([C@](C)(CC(C)(C)C2=O)C=C2C#N)=NC(C)=NC1(C)OC VGKMSBIMGMCNCK-YHDJDMAPSA-N 0.000 description 2
- JEPVKNXVHTYEGJ-OXOIEEGHSA-N CCOC(c1nc(OC)c(CC[C@@H]([C@H](C)C2O)[C@]3(C)C=C2C#N)c3n1)=O Chemical compound CCOC(c1nc(OC)c(CC[C@@H]([C@H](C)C2O)[C@]3(C)C=C2C#N)c3n1)=O JEPVKNXVHTYEGJ-OXOIEEGHSA-N 0.000 description 2
- NAIZMISNLZATQF-HQMMJMAESA-N CCOc1c(CC[C@@H]([C@H](C)C2=O)C3(C)C=C2C#N)c3nc(-c2ccccc2)n1 Chemical compound CCOc1c(CC[C@@H]([C@H](C)C2=O)C3(C)C=C2C#N)c3nc(-c2ccccc2)n1 NAIZMISNLZATQF-HQMMJMAESA-N 0.000 description 2
- UGFLIRGABUGULC-KLRAXDNASA-N CCOc1c(CC[C@@H]([C@H](C)C2=O)[C@]3(C)C=C2C#N)c3nc(OCC)n1 Chemical compound CCOc1c(CC[C@@H]([C@H](C)C2=O)[C@]3(C)C=C2C#N)c3nc(OCC)n1 UGFLIRGABUGULC-KLRAXDNASA-N 0.000 description 2
- GZYXTYURMDJKEM-DYALPIRYSA-N C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(-c(cccc4)c4OC)nc(OC)c3CC1)C2=O Chemical compound C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(-c(cccc4)c4OC)nc(OC)c3CC1)C2=O GZYXTYURMDJKEM-DYALPIRYSA-N 0.000 description 2
- XGEGUFBFJQYKOH-GTXQTCRKSA-N C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(-c4ccccc4)ncc3CC1)C2=O Chemical compound C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(-c4ccccc4)ncc3CC1)C2=O XGEGUFBFJQYKOH-GTXQTCRKSA-N 0.000 description 2
- KSQTVKKTLNTPHO-YHYSRRTLSA-N C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(C)nc(OC)c3CC1)C2=O Chemical compound C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(C)nc(OC)c3CC1)C2=O KSQTVKKTLNTPHO-YHYSRRTLSA-N 0.000 description 2
- UBSFPQASQDJAJC-OVSFNBESSA-N C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(OC)nc(OC)c3CC1)C2=O Chemical compound C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(OC)nc(OC)c3CC1)C2=O UBSFPQASQDJAJC-OVSFNBESSA-N 0.000 description 2
- WJOCCFDDZXJRGR-NRBRWOBXSA-N C[C@@]12c3nc(-c4ccncc4)ncc3CC[C@H]1C(C)(C)C1OC1C(C#N)=C2 Chemical compound C[C@@]12c3nc(-c4ccncc4)ncc3CC[C@H]1C(C)(C)C1OC1C(C#N)=C2 WJOCCFDDZXJRGR-NRBRWOBXSA-N 0.000 description 2
- 0 C[C@]([C@@](CCC1=C2c3nc(C)n[o]3)[C@](*)(CC3C#N)C1=N[N+]2[I-])C3=O Chemical compound C[C@]([C@@](CCC1=C2c3nc(C)n[o]3)[C@](*)(CC3C#N)C1=N[N+]2[I-])C3=O 0.000 description 2
- CPMUWNGCVAODOK-DGCLKSJQSA-N CC(C)([C@H](CC1)[C@@H](CCC=C2C#N)C(NN3C)=C1C3=O)C2=O Chemical compound CC(C)([C@H](CC1)[C@@H](CCC=C2C#N)C(NN3C)=C1C3=O)C2=O CPMUWNGCVAODOK-DGCLKSJQSA-N 0.000 description 1
- WDVOGUBCDZCVAD-BTYIYWSLSA-N CC(C)[n]1nc(-c2c(CC[C@@H](C(C)(C)C3=O)[C@]4(C)C=C3C#N)c4n[n]2C)nc1 Chemical compound CC(C)[n]1nc(-c2c(CC[C@@H](C(C)(C)C3=O)[C@]4(C)C=C3C#N)c4n[n]2C)nc1 WDVOGUBCDZCVAD-BTYIYWSLSA-N 0.000 description 1
- CTBROMATMYJRQN-QDRROVJBSA-N CCOC([n]1nc([C@](C)(C(CC2)[C@H](C)C3C)C=C3C#N)c2c1-c1ccccc1)=O Chemical compound CCOC([n]1nc([C@](C)(C(CC2)[C@H](C)C3C)C=C3C#N)c2c1-c1ccccc1)=O CTBROMATMYJRQN-QDRROVJBSA-N 0.000 description 1
- IPBMOJBHCRZDAL-CHHXXQPCSA-N C[C@@H](C1[C@](C)(C=C2C#N)c3n[n](C)c(C4=NC=CCC4)c3CC1)C2=O Chemical compound C[C@@H](C1[C@](C)(C=C2C#N)c3n[n](C)c(C4=NC=CCC4)c3CC1)C2=O IPBMOJBHCRZDAL-CHHXXQPCSA-N 0.000 description 1
- ZXGBKEALIWVHML-DBSYTXKESA-N C[C@@H]([C@H]1C(C)(C=C2C#N)c3n[n](C)c(-c4nnc(C)[o]4)c3CC1)C2=O Chemical compound C[C@@H]([C@H]1C(C)(C=C2C#N)c3n[n](C)c(-c4nnc(C)[o]4)c3CC1)C2=O ZXGBKEALIWVHML-DBSYTXKESA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424601P | 2010-12-17 | 2010-12-17 | |
| US61/424,601 | 2010-12-17 | ||
| PCT/US2011/065897 WO2012083306A2 (en) | 2010-12-17 | 2011-12-19 | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501250A JP2014501250A (ja) | 2014-01-20 |
| JP2014501250A5 true JP2014501250A5 (https=) | 2015-01-29 |
| JP5857068B2 JP5857068B2 (ja) | 2016-02-10 |
Family
ID=45470714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013544872A Active JP5857068B2 (ja) | 2010-12-17 | 2011-12-19 | 抗酸化炎症モジュレーターとしてのピラゾリルおよびピリミジニル三環式エノン |
Country Status (32)
| Country | Link |
|---|---|
| US (6) | US8513436B2 (https=) |
| EP (1) | EP2651902B1 (https=) |
| JP (1) | JP5857068B2 (https=) |
| KR (1) | KR102000301B1 (https=) |
| CN (1) | CN103596929B (https=) |
| AR (1) | AR084353A1 (https=) |
| AU (1) | AU2011343466B2 (https=) |
| BR (1) | BR112013015241B1 (https=) |
| CA (1) | CA2822071C (https=) |
| CL (1) | CL2013001754A1 (https=) |
| CO (1) | CO6910185A2 (https=) |
| CY (1) | CY1120032T1 (https=) |
| DK (1) | DK2651902T3 (https=) |
| EA (1) | EA025568B1 (https=) |
| ES (1) | ES2653717T3 (https=) |
| HR (1) | HRP20171859T1 (https=) |
| HU (1) | HUE038046T2 (https=) |
| IL (1) | IL226923A (https=) |
| LT (1) | LT2651902T (https=) |
| ME (1) | ME02973B (https=) |
| MX (1) | MX2013006902A (https=) |
| NO (1) | NO2651902T3 (https=) |
| NZ (1) | NZ612788A (https=) |
| PL (1) | PL2651902T3 (https=) |
| PT (1) | PT2651902T (https=) |
| RS (1) | RS56795B1 (https=) |
| SG (1) | SG191181A1 (https=) |
| SI (1) | SI2651902T1 (https=) |
| SM (1) | SMT201800069T1 (https=) |
| TW (1) | TWI527788B (https=) |
| WO (1) | WO2012083306A2 (https=) |
| ZA (1) | ZA201305060B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0907423A2 (pt) | 2008-01-11 | 2020-10-27 | Reata Pharmaceuticals, Inc. | composto triterpenoide sintético para uso em um método de melhoria da função renal em um indivíduo, e uso do referido composto |
| WO2009146218A2 (en) | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
| JP5529851B2 (ja) | 2008-04-18 | 2014-06-25 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体 |
| CN103596929B (zh) | 2010-12-17 | 2016-10-19 | 里亚塔医药公司 | 作为抗氧化发炎调节剂的吡唑及嘧啶三环烯酮 |
| BR112013015000A2 (pt) | 2010-12-17 | 2016-08-09 | Novartis Ag | formas cristalinas de 5-cloron2-(2-isopropóxi-5-metil-4-piperidin-4-il-fenil)-n4-[2-(propano-2-sulfonil)-fenil]-pirimidina-2,4-diamina |
| TWI623548B (zh) | 2012-04-27 | 2018-05-11 | 瑞塔醫藥有限責任公司 | 齊墩果酸（ｂａｒｄｏｘｏｌｏｎｅ ｍｅｔｈｙｌ）之２，２-二氟基丙醯胺衍生物、多晶型及其使用方法 |
| WO2013188818A1 (en) | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| JP6243428B2 (ja) | 2012-09-10 | 2017-12-06 | リアタ ファーマシューティカルズ インコーポレイテッド | オレアノール酸のｃ１７−アルカンジイルおよびアルケンジイル誘導体ならびにその使用方法 |
| WO2014040073A1 (en) | 2012-09-10 | 2014-03-13 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| AR096046A1 (es) | 2013-04-24 | 2015-12-02 | Abbvie Inc | Derivados de 2,2-difluoropropanamida de metil bardoxolona, formas polimórficas y métodos de uso |
| WO2015112792A1 (en) * | 2014-01-24 | 2015-07-30 | Abbvie Inc. | Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
| EP3256451B1 (en) * | 2015-02-12 | 2021-10-20 | Reata Pharmaceuticals, Inc. | Imidazolyl tricyclic enones as antioxidant inflammation modulators |
| CN110198718B (zh) | 2016-11-08 | 2023-01-10 | 里亚塔医药控股有限责任公司 | 使用甲基巴多索隆或其类似物治疗阿尔波特综合征的方法 |
| TWI831738B (zh) * | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| US11286226B2 (en) | 2017-09-21 | 2022-03-29 | Northwestern University | Polycyclic carbogenic molecules and uses thereof as anti-cancer agents |
| US11465963B2 (en) * | 2017-11-21 | 2022-10-11 | Biogen Ma Inc. | Tetrahydronaphthalene derivatives useful as Nrf2 activators |
| US11993574B2 (en) * | 2018-06-15 | 2024-05-28 | Reata Pharmaceuticals, Inc | Pyrazole and imidazole compounds for inhibition of IL-17 and RORgamma |
| US12060340B2 (en) | 2018-06-20 | 2024-08-13 | Reata Pharmaceuticals, Inc | Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith |
| US12509438B2 (en) | 2020-01-13 | 2025-12-30 | Aptabio Therapeutics Inc. | Pyrazole derivative |
| WO2023092034A1 (en) * | 2021-11-17 | 2023-05-25 | Northwestern University | Wt-idh1 inhibition using a covalent and brain-penetrant small molecular inhibitor for ferroptosis induction in high-grade glioma |
| WO2024255851A1 (en) * | 2023-06-16 | 2024-12-19 | Nanjing Curegene Technology Co., Ltd. | Tumor-specific expression cassette and uses thereof |
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