JP2014501250A5 - - Google Patents
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- JP2014501250A5 JP2014501250A5 JP2013544872A JP2013544872A JP2014501250A5 JP 2014501250 A5 JP2014501250 A5 JP 2014501250A5 JP 2013544872 A JP2013544872 A JP 2013544872A JP 2013544872 A JP2013544872 A JP 2013544872A JP 2014501250 A5 JP2014501250 A5 JP 2014501250A5
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- compound
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- Prior art date
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- BVSUIGWVDIZNCW-PZPSAWLHSA-N CC(C)(C1[C@](C)(CC2(C)C#N)c3nc(-c4cccnc4)ncc3CC1)C2=O Chemical compound CC(C)(C1[C@](C)(CC2(C)C#N)c3nc(-c4cccnc4)ncc3CC1)C2=O BVSUIGWVDIZNCW-PZPSAWLHSA-N 0.000 description 2
- HXPDCERWPYPLDF-MBSDFSHPSA-N CC(C)([C@H]1[C@](C)(C=C2C#N)c3nc(-c(cc4)ccc4OC)ncc3CC1)C2=O Chemical compound CC(C)([C@H]1[C@](C)(C=C2C#N)c3nc(-c(cc4)ccc4OC)ncc3CC1)C2=O HXPDCERWPYPLDF-MBSDFSHPSA-N 0.000 description 2
- AWNKVNUSWYTISD-KKSFZXQISA-N CC(C)([C@H]1[C@](C)(C=C2C#N)c3nc(-c4ccccn4)ncc3CC1)C2=O Chemical compound CC(C)([C@H]1[C@](C)(C=C2C#N)c3nc(-c4ccccn4)ncc3CC1)C2=O AWNKVNUSWYTISD-KKSFZXQISA-N 0.000 description 2
- VGKMSBIMGMCNCK-YHDJDMAPSA-N CCCC1C([C@](C)(CC(C)(C)C2=O)C=C2C#N)=NC(C)=NC1(C)OC Chemical compound CCCC1C([C@](C)(CC(C)(C)C2=O)C=C2C#N)=NC(C)=NC1(C)OC VGKMSBIMGMCNCK-YHDJDMAPSA-N 0.000 description 2
- JEPVKNXVHTYEGJ-OXOIEEGHSA-N CCOC(c1nc(OC)c(CC[C@@H]([C@H](C)C2O)[C@]3(C)C=C2C#N)c3n1)=O Chemical compound CCOC(c1nc(OC)c(CC[C@@H]([C@H](C)C2O)[C@]3(C)C=C2C#N)c3n1)=O JEPVKNXVHTYEGJ-OXOIEEGHSA-N 0.000 description 2
- NAIZMISNLZATQF-HQMMJMAESA-N CCOc1c(CC[C@@H]([C@H](C)C2=O)C3(C)C=C2C#N)c3nc(-c2ccccc2)n1 Chemical compound CCOc1c(CC[C@@H]([C@H](C)C2=O)C3(C)C=C2C#N)c3nc(-c2ccccc2)n1 NAIZMISNLZATQF-HQMMJMAESA-N 0.000 description 2
- UGFLIRGABUGULC-KLRAXDNASA-N CCOc1c(CC[C@@H]([C@H](C)C2=O)[C@]3(C)C=C2C#N)c3nc(OCC)n1 Chemical compound CCOc1c(CC[C@@H]([C@H](C)C2=O)[C@]3(C)C=C2C#N)c3nc(OCC)n1 UGFLIRGABUGULC-KLRAXDNASA-N 0.000 description 2
- GZYXTYURMDJKEM-DYALPIRYSA-N C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(-c(cccc4)c4OC)nc(OC)c3CC1)C2=O Chemical compound C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(-c(cccc4)c4OC)nc(OC)c3CC1)C2=O GZYXTYURMDJKEM-DYALPIRYSA-N 0.000 description 2
- XGEGUFBFJQYKOH-GTXQTCRKSA-N C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(-c4ccccc4)ncc3CC1)C2=O Chemical compound C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(-c4ccccc4)ncc3CC1)C2=O XGEGUFBFJQYKOH-GTXQTCRKSA-N 0.000 description 2
- KSQTVKKTLNTPHO-YHYSRRTLSA-N C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(C)nc(OC)c3CC1)C2=O Chemical compound C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(C)nc(OC)c3CC1)C2=O KSQTVKKTLNTPHO-YHYSRRTLSA-N 0.000 description 2
- UBSFPQASQDJAJC-OVSFNBESSA-N C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(OC)nc(OC)c3CC1)C2=O Chemical compound C[C@@H]([C@H]1[C@](C)(C=C2C#N)c3nc(OC)nc(OC)c3CC1)C2=O UBSFPQASQDJAJC-OVSFNBESSA-N 0.000 description 2
- WJOCCFDDZXJRGR-NRBRWOBXSA-N C[C@@]12c3nc(-c4ccncc4)ncc3CC[C@H]1C(C)(C)C1OC1C(C#N)=C2 Chemical compound C[C@@]12c3nc(-c4ccncc4)ncc3CC[C@H]1C(C)(C)C1OC1C(C#N)=C2 WJOCCFDDZXJRGR-NRBRWOBXSA-N 0.000 description 2
- 0 C[C@]([C@@](CCC1=C2c3nc(C)n[o]3)[C@](*)(CC3C#N)C1=N[N+]2[I-])C3=O Chemical compound C[C@]([C@@](CCC1=C2c3nc(C)n[o]3)[C@](*)(CC3C#N)C1=N[N+]2[I-])C3=O 0.000 description 2
- CPMUWNGCVAODOK-DGCLKSJQSA-N CC(C)([C@H](CC1)[C@@H](CCC=C2C#N)C(NN3C)=C1C3=O)C2=O Chemical compound CC(C)([C@H](CC1)[C@@H](CCC=C2C#N)C(NN3C)=C1C3=O)C2=O CPMUWNGCVAODOK-DGCLKSJQSA-N 0.000 description 1
- WDVOGUBCDZCVAD-BTYIYWSLSA-N CC(C)[n]1nc(-c2c(CC[C@@H](C(C)(C)C3=O)[C@]4(C)C=C3C#N)c4n[n]2C)nc1 Chemical compound CC(C)[n]1nc(-c2c(CC[C@@H](C(C)(C)C3=O)[C@]4(C)C=C3C#N)c4n[n]2C)nc1 WDVOGUBCDZCVAD-BTYIYWSLSA-N 0.000 description 1
- CTBROMATMYJRQN-QDRROVJBSA-N CCOC([n]1nc([C@](C)(C(CC2)[C@H](C)C3C)C=C3C#N)c2c1-c1ccccc1)=O Chemical compound CCOC([n]1nc([C@](C)(C(CC2)[C@H](C)C3C)C=C3C#N)c2c1-c1ccccc1)=O CTBROMATMYJRQN-QDRROVJBSA-N 0.000 description 1
- IPBMOJBHCRZDAL-CHHXXQPCSA-N C[C@@H](C1[C@](C)(C=C2C#N)c3n[n](C)c(C4=NC=CCC4)c3CC1)C2=O Chemical compound C[C@@H](C1[C@](C)(C=C2C#N)c3n[n](C)c(C4=NC=CCC4)c3CC1)C2=O IPBMOJBHCRZDAL-CHHXXQPCSA-N 0.000 description 1
- ZXGBKEALIWVHML-DBSYTXKESA-N C[C@@H]([C@H]1C(C)(C=C2C#N)c3n[n](C)c(-c4nnc(C)[o]4)c3CC1)C2=O Chemical compound C[C@@H]([C@H]1C(C)(C=C2C#N)c3n[n](C)c(-c4nnc(C)[o]4)c3CC1)C2=O ZXGBKEALIWVHML-DBSYTXKESA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424601P | 2010-12-17 | 2010-12-17 | |
| US61/424,601 | 2010-12-17 | ||
| PCT/US2011/065897 WO2012083306A2 (en) | 2010-12-17 | 2011-12-19 | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501250A JP2014501250A (ja) | 2014-01-20 |
| JP2014501250A5 true JP2014501250A5 (https=) | 2015-01-29 |
| JP5857068B2 JP5857068B2 (ja) | 2016-02-10 |
Family
ID=45470714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013544872A Active JP5857068B2 (ja) | 2010-12-17 | 2011-12-19 | 抗酸化炎症モジュレーターとしてのピラゾリルおよびピリミジニル三環式エノン |
Country Status (32)
| Country | Link |
|---|---|
| US (6) | US8513436B2 (https=) |
| EP (1) | EP2651902B1 (https=) |
| JP (1) | JP5857068B2 (https=) |
| KR (1) | KR102000301B1 (https=) |
| CN (1) | CN103596929B (https=) |
| AR (1) | AR084353A1 (https=) |
| AU (1) | AU2011343466B2 (https=) |
| BR (1) | BR112013015241B1 (https=) |
| CA (1) | CA2822071C (https=) |
| CL (1) | CL2013001754A1 (https=) |
| CO (1) | CO6910185A2 (https=) |
| CY (1) | CY1120032T1 (https=) |
| DK (1) | DK2651902T3 (https=) |
| EA (1) | EA025568B1 (https=) |
| ES (1) | ES2653717T3 (https=) |
| HR (1) | HRP20171859T1 (https=) |
| HU (1) | HUE038046T2 (https=) |
| IL (1) | IL226923A (https=) |
| LT (1) | LT2651902T (https=) |
| ME (1) | ME02973B (https=) |
| MX (1) | MX2013006902A (https=) |
| NO (1) | NO2651902T3 (https=) |
| NZ (1) | NZ612788A (https=) |
| PL (1) | PL2651902T3 (https=) |
| PT (1) | PT2651902T (https=) |
| RS (1) | RS56795B1 (https=) |
| SG (1) | SG191181A1 (https=) |
| SI (1) | SI2651902T1 (https=) |
| SM (1) | SMT201800069T1 (https=) |
| TW (1) | TWI527788B (https=) |
| WO (1) | WO2012083306A2 (https=) |
| ZA (1) | ZA201305060B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2252283T3 (pl) | 2008-01-11 | 2019-09-30 | Reata Pharmaceuticals, Inc. | Syntetyczne triterpenoidy i sposoby zastosowania w leczeniu choroby |
| WO2009129546A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17 |
| CA2721665C (en) | 2008-04-18 | 2017-01-24 | Reata Pharmaceuticals, Inc. | Compounds including an anti-inflammatory pharmacore and methods of use |
| PL2651902T3 (pl) | 2010-12-17 | 2018-04-30 | Reata Pharmaceuticals, Inc. | Pirazolilowe i pirymidynylowe tricykliczne enony jako modulatory zapalenia o działaniu przeciwutleniającym |
| CN103282359A (zh) | 2010-12-17 | 2013-09-04 | 诺华股份有限公司 | 5-氯-n2-(2-异丙氧基-5-甲基-4-哌啶-4-基-苯基)-n4-[2-(丙烷-2-磺酰基)-苯基]-嘧啶-2,4-二胺的结晶形式 |
| JP6410710B2 (ja) | 2012-04-27 | 2018-10-24 | リアタ ファーマシューティカルズ インコーポレイテッド | バルドキソロンメチルの２，２−ジフルオロプロピオンアミド誘導体、その多形体および使用方法 |
| WO2013188818A1 (en) | 2012-06-15 | 2013-12-19 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
| WO2014040060A1 (en) | 2012-09-10 | 2014-03-13 | Reata Pharmaceuticals, Inc. | C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof |
| US9278912B2 (en) | 2012-09-10 | 2016-03-08 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| TWI649330B (zh) | 2013-04-24 | 2019-02-01 | 艾伯維有限公司 | 甲基巴多索龍之２，２－二氟丙醯胺衍生物、其多晶形及其使用方法 |
| JP6530758B2 (ja) * | 2014-01-24 | 2019-06-12 | リアタ ファーマシューティカルズ，インク | 抗酸化性炎症調節剤としてのアリールおよびアリールアルキル置換されたピラゾリルおよびピリミジニル三環式エノン類 |
| CN107428698B (zh) * | 2015-02-12 | 2021-10-26 | 里亚塔医药公司 | 作为抗氧化炎症调节剂的咪唑基三环烯酮 |
| KR102486434B1 (ko) | 2016-11-08 | 2023-01-09 | 리아타 파마슈티컬즈 홀딩스, 엘엘씨 | 바독솔론 메틸 또는 이의 유사체를 사용하는 알포트 증후군의 치료 방법 |
| TWI831738B (zh) * | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| US11286226B2 (en) | 2017-09-21 | 2022-03-29 | Northwestern University | Polycyclic carbogenic molecules and uses thereof as anti-cancer agents |
| WO2019104030A1 (en) * | 2017-11-21 | 2019-05-31 | Biogen Ma Inc. | Tetrahydronaphthalene derivatives useful as nrf2 activators |
| IL279348B2 (en) * | 2018-06-15 | 2026-01-01 | Reata Pharmaceuticals Inc | Decahydro-2h-naphth[1,2-d]imidazole compounds for inhibition of IL-17 and ROR-gamma |
| WO2019246461A1 (en) * | 2018-06-20 | 2019-12-26 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
| JP2023511302A (ja) | 2020-01-13 | 2023-03-17 | アプタバイオ セラピューティクス インコーポレイテッド | 新規なピラゾール誘導体 |
| US20250025465A1 (en) * | 2021-11-17 | 2025-01-23 | Northwestern University | Wt-idh1 inhibition using a covalent and brain-penetrant small molecular inhibitor for ferroptosis induction in high-grade glioma |
| CN121358860A (zh) * | 2023-06-16 | 2026-01-16 | 南京科捷基因技术有限公司 | 肿瘤特异性表达盒及其用途 |
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