|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
HRP20050089B1
(hr)
|
2002-07-29 |
2015-06-19 |
Rigel Pharmaceuticals |
Upotreba 2,4 pirimidindiaminskog spoja za proizvodnju lijeka za lijeäśenje ili sprjeäśavanje autoimunosne bolesti
|
|
WO2005012294A1
(en)
*
|
2003-07-30 |
2005-02-10 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
|
|
SI1814878T1
(sl)
|
2004-11-24 |
2012-06-29 |
Rigel Pharmaceuticals Inc |
Spojine spiro-2,4-pirimidindiamina in njihova uporaba
|
|
AU2006206458B2
(en)
|
2005-01-19 |
2012-10-25 |
Rigel Pharmaceuticals, Inc. |
Prodrugs of 2,4-pyrimidinediamine compounds and their uses
|
|
BRPI0610876B8
(pt)
|
2005-06-08 |
2021-05-25 |
Rigel Pharmaceuticals Inc |
composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel
|
|
US20070203161A1
(en)
*
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
JP2008543855A
(ja)
|
2005-06-13 |
2008-12-04 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
変形性骨疾患を処置するための方法および組成物
|
|
ATE352714T1
(de)
*
|
2005-06-17 |
2007-02-15 |
Magneti Marelli Powertrain Spa |
Brennstoffeinspritzventil
|
|
US7713987B2
(en)
*
|
2005-12-06 |
2010-05-11 |
Rigel Pharmaceuticals, Inc. |
Pyrimidine-2,4-diamines and their uses
|
|
ES2622493T3
(es)
*
|
2006-02-24 |
2017-07-06 |
Rigel Pharmaceuticals, Inc. |
Composiciones y métodos para la inhibición de la ruta de JAK
|
|
JP5161233B2
(ja)
|
2006-10-19 |
2013-03-13 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
自己免疫疾患の処置のためのjakキナーゼの阻害剤としての2,4−ピリミジンアミン誘導体
|
|
ATE540041T1
(de)
|
2006-11-21 |
2012-01-15 |
Rigel Pharmaceuticals Inc |
Prodrug-salze von 2,4-pyrimidindiaminverbindungen und anwendungen davon
|
|
WO2008118822A1
(en)
|
2007-03-23 |
2008-10-02 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
US7834024B2
(en)
*
|
2007-03-26 |
2010-11-16 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the JAK pathway
|
|
CN101903357A
(zh)
|
2007-07-17 |
2010-12-01 |
里格尔药品股份有限公司 |
作为pkc抑制剂的环状胺取代的嘧啶二胺
|
|
US20090088371A1
(en)
*
|
2007-08-28 |
2009-04-02 |
Rigel Pharmaceuticals, Inc. |
Combination therapy with syk kinase inhibitor
|
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
NZ603525A
(en)
|
2008-06-27 |
2015-02-27 |
Celgene Avilomics Res Inc |
Pyrimidine based compound and uses thereof
|
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
|
US8809343B2
(en)
*
|
2008-12-26 |
2014-08-19 |
Fudan University |
Pyrimidine derivative, preparation method and use thereof
|
|
CN106420756A
(zh)
*
|
2009-07-28 |
2017-02-22 |
里格尔药品股份有限公司 |
抑制jak途径的组合物和方法
|
|
ES2689103T3
(es)
*
|
2010-06-30 |
2018-11-08 |
Fujifilm Corporation |
Nuevo derivado de nicotinamida o sal del mismo
|
|
MX336875B
(es)
|
2010-08-10 |
2016-02-04 |
Celgene Avilomics Res Inc |
Sal de besilato de un inhibidor de tirosina cinasa de bruton (btk).
|
|
WO2012061303A1
(en)
|
2010-11-01 |
2012-05-10 |
Avila Therapeutics, Inc. |
Heteroaryl compounds and uses thereof
|
|
EP2635284B1
(en)
|
2010-11-01 |
2019-12-18 |
Celgene CAR LLC |
Heterocyclic compounds and uses thereof
|
|
WO2012064706A1
(en)
|
2010-11-10 |
2012-05-18 |
Avila Therapeutics, Inc. |
Mutant-selective egfr inhibitors and uses thereof
|
|
US9145391B2
(en)
|
2011-05-10 |
2015-09-29 |
Merck Sharp & Dohme Corp. |
Bipyridylaminopyridines as Syk inhibitors
|
|
EP2706853B1
(en)
|
2011-05-10 |
2017-06-14 |
Merck Sharp & Dohme Corp. |
Aminopyrimidines as syk inhibitors
|
|
CA2834062A1
(en)
|
2011-05-10 |
2012-11-15 |
Merck Sharp & Dohme Corp. |
Pyridyl aminopyridines as syk inhibitors
|
|
HRP20190186T4
(hr)
*
|
2011-07-28 |
2024-12-20 |
Rigel Pharmaceuticals, Inc. |
Nove formulacije (trimetoksifenilamino)pirimidinila
|
|
WO2013052391A1
(en)
|
2011-10-05 |
2013-04-11 |
Merck Sharp & Dohme Corp. |
PHENYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS
|
|
US9216173B2
(en)
|
2011-10-05 |
2015-12-22 |
Merck Sharp & Dohme Corp. |
2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
|
|
EP2763975B1
(en)
|
2011-10-05 |
2016-04-06 |
Merck Sharp & Dohme Corp. |
3-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
|
|
US9364476B2
(en)
|
2011-10-28 |
2016-06-14 |
Celgene Avilomics Research, Inc. |
Methods of treating a Bruton's Tyrosine Kinase disease or disorder
|
|
EP2799431B1
(en)
|
2011-12-28 |
2018-01-24 |
FUJIFILM Corporation |
Novel nicotinamide derivative or salt thereof
|
|
US9073944B2
(en)
*
|
2012-02-21 |
2015-07-07 |
Merck Patent Gmbh |
Cyclic diaminopyrimidine derivatives
|
|
CA2866852C
(en)
|
2012-03-15 |
2020-12-29 |
Celgene Avilomics Research, Inc. |
Solid forms of an epidermal growth factor receptor kinase inhibitor
|
|
BR112014022790B1
(pt)
|
2012-03-15 |
2022-04-19 |
Celgene Car Llc |
Sais de um inibidor de quinase de receptor de fator do crescimento epidermal, composição farmacêutica e usos do mesmo
|
|
WO2013169704A2
(en)
|
2012-05-08 |
2013-11-14 |
Merck Sharp & Dohme Corp. |
TETRAHYDRONAPHTHYRIDINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
|
|
JP6242868B2
(ja)
|
2012-05-08 |
2017-12-06 |
リセラ・コーポレイションLycera Corporation |
RORγのアゴニストとしての使用のためおよび疾患の処置のためのテトラヒドロ[1,8]ナフチリジンスルホンアミドおよび関連化合物
|
|
CN103958526B
(zh)
*
|
2012-06-20 |
2015-09-09 |
上海恒瑞医药有限公司 |
嘧啶二胺类衍生物、其制备方法及其在医药上的应用
|
|
EP2863913B1
(en)
|
2012-06-20 |
2018-09-12 |
Merck Sharp & Dohme Corp. |
Imidazolyl analogs as syk inhibitors
|
|
EP2863914B1
(en)
|
2012-06-20 |
2018-10-03 |
Merck Sharp & Dohme Corp. |
Pyrazolyl derivatives as syk inhibitors
|
|
EP2863915B1
(en)
|
2012-06-22 |
2017-12-06 |
Merck Sharp & Dohme Corp. |
SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS
|
|
EP2863916B1
(en)
|
2012-06-22 |
2018-07-18 |
Merck Sharp & Dohme Corp. |
Substituted pyridine spleen tyrosine kinase (syk) inhibitors
|
|
KR101446742B1
(ko)
*
|
2012-08-10 |
2014-10-01 |
한국화학연구원 |
N2,n4-비스(4-(피페라진-1-일)페닐)피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
|
|
US9353066B2
(en)
|
2012-08-20 |
2016-05-31 |
Merck Sharp & Dohme Corp. |
Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors
|
|
WO2014048065A1
(en)
|
2012-09-28 |
2014-04-03 |
Merck Sharp & Dohme Corp. |
Triazolyl derivatives as syk inhibitors
|
|
EP2931281B1
(en)
|
2012-12-12 |
2018-01-17 |
Merck Sharp & Dohme Corp. |
Amino-pyrimidine-containing spleen tyrosine kinase inhibitors
|
|
US9126950B2
(en)
|
2012-12-21 |
2015-09-08 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
EP2934525B1
(en)
|
2012-12-21 |
2019-05-08 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
|
|
MX2015009952A
(es)
|
2013-02-08 |
2015-10-05 |
Celgene Avilomics Res Inc |
Inhibidores de cinasas reguladas por señales extracelulares (erk) y sus usos.
|
|
WO2014176210A1
(en)
|
2013-04-26 |
2014-10-30 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
|
EP2988749B1
(en)
|
2013-04-26 |
2019-08-14 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
|
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
|
US9809561B2
(en)
|
2013-12-20 |
2017-11-07 |
Merck Sharp & Dohme Corp. |
Tetrahydronaphthyridine, benzoxazine, aza-benzoxazine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease
|
|
US9415049B2
(en)
|
2013-12-20 |
2016-08-16 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
|
WO2015094997A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
|
US9822107B2
(en)
|
2013-12-20 |
2017-11-21 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
|
WO2015095444A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
|
WO2015095788A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE
|
|
US9783511B2
(en)
|
2013-12-20 |
2017-10-10 |
Lycera Corporation |
Carbamate benzoxazine propionic acids and acid derivatives for modulation of RORgamma activity and the treatment of disease
|
|
JP2017507950A
(ja)
|
2014-02-27 |
2017-03-23 |
リセラ・コーポレイションLycera Corporation |
レチノイン酸受容体関連オーファン受容体ガンマのアゴニストを使用する養子細胞療法及び関連治療方法
|
|
WO2015138273A1
(en)
|
2014-03-13 |
2015-09-17 |
Merck Sharp & Dohme Corp. |
2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
|
|
EP3140291A4
(en)
|
2014-05-05 |
2018-01-10 |
Lycera Corporation |
Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease
|
|
JP6523337B2
(ja)
|
2014-05-05 |
2019-05-29 |
リセラ・コーポレイションLycera Corporation |
RORγのアゴニストとしての使用及び疾患治療のためのベンゼンスルホンアミド及び関連化合物
|
|
EP3179858B1
(en)
|
2014-08-13 |
2019-05-15 |
Celgene Car Llc |
Forms and compositions of an erk inhibitor
|
|
CA2975997A1
(en)
|
2015-02-11 |
2016-08-18 |
Merck Sharp & Dohme Corp. |
Substituted pyrazole compounds as rorgammat inhibitors and uses thereof
|
|
US10421751B2
(en)
|
2015-05-05 |
2019-09-24 |
Lycera Corporation |
Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
|
|
AU2016276947A1
(en)
|
2015-06-11 |
2017-12-14 |
Lycera Corporation |
Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease
|
|
JP2018535958A
(ja)
|
2015-10-27 |
2018-12-06 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
RORγT阻害薬としての置換インダゾール化合物及びその使用
|
|
EP3368535B1
(en)
|
2015-10-27 |
2020-12-02 |
Merck Sharp & Dohme Corp. |
Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof
|
|
US10344000B2
(en)
|
2015-10-27 |
2019-07-09 |
Merck Sharp & Dohme Corp. |
Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof
|
|
EP4013420B1
(en)
*
|
2019-08-14 |
2023-11-01 |
Rigel Pharmaceuticals, Inc. |
Method of blocking or ameliorating cytokine release syndrome
|