JP2011523411A5 - - Google Patents
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- Publication number
- JP2011523411A5 JP2011523411A5 JP2011509462A JP2011509462A JP2011523411A5 JP 2011523411 A5 JP2011523411 A5 JP 2011523411A5 JP 2011509462 A JP2011509462 A JP 2011509462A JP 2011509462 A JP2011509462 A JP 2011509462A JP 2011523411 A5 JP2011523411 A5 JP 2011523411A5
- Authority
- JP
- Japan
- Prior art keywords
- cycloalkyl
- alkyl
- aryl
- heteroaryl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- BGZNZZFWVYRVQV-KXZWEURJSA-O CCCC/C=C\[C@H](C1)[C@]1(C(NS(C1CC1)(=O)=O)=O)NC([C@H](C[C@H](C1)OC(CC(c2nc(CCC3)c3[s]2)=N/C2=C/COC)/C2=C/C)N1C([C@H](CC)NC(OC(C)(C)C)=O)=[OH+])=O Chemical compound CCCC/C=C\[C@H](C1)[C@]1(C(NS(C1CC1)(=O)=O)=O)NC([C@H](C[C@H](C1)OC(CC(c2nc(CCC3)c3[s]2)=N/C2=C/COC)/C2=C/C)N1C([C@H](CC)NC(OC(C)(C)C)=O)=[OH+])=O BGZNZZFWVYRVQV-KXZWEURJSA-O 0.000 description 1
- 0 CCc(c(*=C)c(*)c1c2C)c(*)c1nc1c2[o]c2c(*C)c(*)c(*)c(C)c12 Chemical compound CCc(c(*=C)c(*)c1c2C)c(*)c1nc1c2[o]c2c(*C)c(*)c(*)c(C)c12 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5385708P | 2008-05-16 | 2008-05-16 | |
| US61/053,857 | 2008-05-16 | ||
| PCT/US2008/082329 WO2009139792A1 (en) | 2008-05-16 | 2008-11-04 | Hcv protease inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011523411A JP2011523411A (ja) | 2011-08-11 |
| JP2011523411A5 true JP2011523411A5 (https=) | 2011-12-22 |
| JP5586588B2 JP5586588B2 (ja) | 2014-09-10 |
Family
ID=41316739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509462A Expired - Fee Related JP5586588B2 (ja) | 2008-05-16 | 2008-11-04 | Ｈｃｖプロテアーゼ阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090286814A1 (https=) |
| EP (1) | EP2274281B1 (https=) |
| JP (1) | JP5586588B2 (https=) |
| KR (2) | KR20140048308A (https=) |
| CN (1) | CN101580535B (https=) |
| AU (1) | AU2008356226B2 (https=) |
| CA (1) | CA2722056A1 (https=) |
| DK (1) | DK2274281T3 (https=) |
| EA (1) | EA020235B1 (https=) |
| ES (1) | ES2542880T3 (https=) |
| NZ (1) | NZ588189A (https=) |
| TW (1) | TWI414306B (https=) |
| WO (1) | WO2009139792A1 (https=) |
| ZA (1) | ZA201008988B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201071034A1 (ru) | 2008-04-15 | 2011-06-30 | Интермьюн, Инк. | Новые макроциклические ингибиторы репликаций вируса гепатита с |
| UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
| AR075584A1 (es) | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| US8232246B2 (en) | 2009-06-30 | 2012-07-31 | Abbott Laboratories | Anti-viral compounds |
| US20110178107A1 (en) * | 2010-01-20 | 2011-07-21 | Taigen Biotechnology Co., Ltd. | Hcv protease inhibitors |
| CA2822556A1 (en) | 2010-12-30 | 2012-07-05 | Enanta Pharmaceuticals, Inc | Macrocyclic hepatitis c serine protease inhibitors |
| EA201390988A1 (ru) | 2010-12-30 | 2014-04-30 | Энанта Фармасьютикалз, Инк. | Фенантридиновые макроциклические ингибиторы сериновой протеазы вируса гепатита c |
| US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| CN102911254A (zh) * | 2011-08-02 | 2013-02-06 | 上海唐润医药科技有限公司 | Hcv蛋白酶抑制剂 |
| WO2013106631A1 (en) | 2012-01-11 | 2013-07-18 | Abbvie Inc. | Processes for making hcv protease inhibitors |
| US20140100364A1 (en) | 2012-10-08 | 2014-04-10 | Abbvie Inc. | Compounds Useful For Making HCV Protease Inhibitors |
| EA025560B1 (ru) | 2012-10-19 | 2017-01-30 | Бристол-Майерс Сквибб Компани | Ингибиторы вируса гепатита с |
| US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2914613B1 (en) | 2012-11-02 | 2017-11-22 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US9334279B2 (en) | 2012-11-02 | 2016-05-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9409943B2 (en) | 2012-11-05 | 2016-08-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JP6342922B2 (ja) | 2013-03-07 | 2018-06-13 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｃ型肝炎ウイルス阻害剤 |
| CN104557954A (zh) * | 2013-10-16 | 2015-04-29 | 上海唐润医药科技有限公司 | 抗hcv的大环化合物 |
| WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
| CN104447952A (zh) * | 2014-12-11 | 2015-03-25 | 上海唐润医药科技有限公司 | 丙肝病毒蛋白酶抑制剂及其合成方法 |
| CN108727417B (zh) * | 2015-02-05 | 2021-10-08 | 爱博新药研发(上海)有限公司 | 多环化合物钠盐及其多晶型、制备方法及应用 |
| WO2016127859A1 (en) * | 2015-02-13 | 2016-08-18 | Sunshine Lake Pharma Co., Ltd. | Compounds as hepatitis c inhibitors and uses thereof in medicine |
| CN107074876B (zh) * | 2016-04-08 | 2019-12-20 | 上海长森药业有限公司 | 一类抑制丙肝病毒的大环状杂环化合物及其制备和用途 |
| CN107722109B (zh) * | 2016-08-11 | 2020-12-18 | 广东东阳光药业有限公司 | 作为丙型肝炎病毒抑制剂的晶型 |
| TW201805289A (zh) * | 2016-08-11 | 2018-02-16 | 廣東東陽光藥業有限公司 | 作為丙型肝炎病毒抑制劑的鹽 |
| CN110958880B (zh) * | 2017-05-30 | 2023-08-08 | 东莞东阳光太景医药研发有限责任公司 | 固体分散制剂 |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
| CN113337624A (zh) * | 2021-05-24 | 2021-09-03 | 温州医科大学 | 同时检测沙眼衣原体、淋病奈瑟氏球菌和解脲支原体的组合物及方法 |
| CN114773302B (zh) * | 2022-04-29 | 2024-04-02 | 中国药科大学 | 一种苯并呋喃衍生物及其医药用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4555508A (en) * | 1984-03-02 | 1985-11-26 | Usv Pharmaceutical Corp. | Antihypertensive spiro-cyclic compounds |
| US5876984A (en) * | 1996-09-25 | 1999-03-02 | Shionogi & Co., Ltd | Sequiterpene derivatives having antiviral activity |
| TW426516B (en) * | 1996-12-06 | 2001-03-21 | Fujisawa Pharmaceutical Co | An oral pharmaceutical composition in solid dispersion containing water-insoluble tricyclic compounds |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| CA2449504A1 (en) * | 2001-07-11 | 2003-01-23 | Vertex Pharmaceuticals Incorporated | Bridged bicyclic serine protease inhibitors |
| US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| US6894072B2 (en) * | 2002-01-23 | 2005-05-17 | Schering Corporation | Compounds as NS3-serine protease inhibitors of hepatitis C virus |
| US7119072B2 (en) * | 2002-01-30 | 2006-10-10 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis C virus |
| JP4271148B2 (ja) * | 2002-05-20 | 2009-06-03 | ブリストル−マイヤーズ スクイブ カンパニー | 置換シクロアルキルｐ１’ｃ型肝炎ウイルスインヒビター |
| MY140680A (en) * | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| JP4733023B2 (ja) * | 2003-04-16 | 2011-07-27 | ブリストル−マイヤーズ スクイブ カンパニー | Ｃ型肝炎ウイルスの大環状イソキノリンペプチド阻害剤 |
| US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
| ES2361997T3 (es) * | 2003-09-22 | 2011-06-27 | Boehringer Ingelheim International Gmbh | Péptidos macrocíclicos activos contra el virus de la hepatitis c. |
| RU2006113880A (ru) * | 2003-09-26 | 2007-11-20 | Шеринг Корпорейшн (US) | Макроциклические ингибиторы сериновой протеиназы ns3 вируса гепатита с |
| US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| MXPA06005683A (es) * | 2003-11-20 | 2006-12-14 | Schering Corp | Inhibidores despeptidizados de la proteasa ns3 del virus de la hepatitis c. |
| WO2005058821A1 (en) * | 2003-12-11 | 2005-06-30 | Schering Corporation | Inhibitors of hepatitis c virus ns3/ns4a serine protease |
| ATE495185T1 (de) * | 2004-01-21 | 2011-01-15 | Boehringer Ingelheim Int | Makrocyclische peptide mit wirkung gegen das hepatitis-c-virus |
| WO2006033878A1 (en) * | 2004-09-17 | 2006-03-30 | Boehringer Ingelheim International, Gmbh | Process for preparing macrocyclic hcv protease inhibitors |
| US20070207949A1 (en) * | 2005-06-02 | 2007-09-06 | Anima Ghosal | Medicaments and methods combining a HCV protease inhibitor and an AKR competitor |
| US20070237818A1 (en) * | 2005-06-02 | 2007-10-11 | Malcolm Bruce A | Controlled-release formulation of HCV protease inhibitor and methods using the same |
| TWI393723B (zh) * | 2005-07-29 | 2013-04-21 | Tibotec Pharm Ltd | Ｃ型肝炎病毒之大環抑制劑（九） |
| US7605126B2 (en) * | 2006-08-11 | 2009-10-20 | Enanta Pharmaceuticals, Inc. | Acylaminoheteroaryl hepatitis C virus protease inhibitors |
| WO2008022006A2 (en) * | 2006-08-11 | 2008-02-21 | Enanta Pharmaceuticals, Inc. | Arylalkoxyl hepatitis c virus protease inhibitors |
| US20080267917A1 (en) * | 2007-04-26 | 2008-10-30 | Deqiang Niu | N-functionalized amides as hepatitis c serine protease inhibitors |
| US20090005387A1 (en) * | 2007-06-26 | 2009-01-01 | Deqiang Niu | Quinoxalinyl macrocyclic hepatitis c virus serine protease inhibitors |
| US20090111757A1 (en) * | 2007-10-25 | 2009-04-30 | Taigen Biotechnology Co., Ltd. | Hcv protease inhibitors |
-
2008
- 2008-10-28 CN CN2008101743025A patent/CN101580535B/zh active Active
- 2008-11-04 EP EP08874317.4A patent/EP2274281B1/en not_active Not-in-force
- 2008-11-04 WO PCT/US2008/082329 patent/WO2009139792A1/en not_active Ceased
- 2008-11-04 EA EA201071315A patent/EA020235B1/ru not_active IP Right Cessation
- 2008-11-04 KR KR1020147005119A patent/KR20140048308A/ko not_active Withdrawn
- 2008-11-04 NZ NZ588189A patent/NZ588189A/xx not_active IP Right Cessation
- 2008-11-04 AU AU2008356226A patent/AU2008356226B2/en not_active Ceased
- 2008-11-04 CA CA2722056A patent/CA2722056A1/en not_active Abandoned
- 2008-11-04 US US12/264,508 patent/US20090286814A1/en not_active Abandoned
- 2008-11-04 DK DK08874317.4T patent/DK2274281T3/en active
- 2008-11-04 KR KR1020107027553A patent/KR20110011663A/ko not_active Ceased
- 2008-11-04 ES ES08874317.4T patent/ES2542880T3/es active Active
- 2008-11-04 JP JP2011509462A patent/JP5586588B2/ja not_active Expired - Fee Related
- 2008-11-06 TW TW097142922A patent/TWI414306B/zh not_active IP Right Cessation
-
2010
- 2010-12-14 ZA ZA2010/08988A patent/ZA201008988B/en unknown
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