JP2011523411A5 - - Google Patents
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- Publication number
- JP2011523411A5 JP2011523411A5 JP2011509462A JP2011509462A JP2011523411A5 JP 2011523411 A5 JP2011523411 A5 JP 2011523411A5 JP 2011509462 A JP2011509462 A JP 2011509462A JP 2011509462 A JP2011509462 A JP 2011509462A JP 2011523411 A5 JP2011523411 A5 JP 2011523411A5
- Authority
- JP
- Japan
- Prior art keywords
- cycloalkyl
- alkyl
- aryl
- heteroaryl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- BGZNZZFWVYRVQV-KXZWEURJSA-O CCCC/C=C\[C@H](C1)[C@]1(C(NS(C1CC1)(=O)=O)=O)NC([C@H](C[C@H](C1)OC(CC(c2nc(CCC3)c3[s]2)=N/C2=C/COC)/C2=C/C)N1C([C@H](CC)NC(OC(C)(C)C)=O)=[OH+])=O Chemical compound CCCC/C=C\[C@H](C1)[C@]1(C(NS(C1CC1)(=O)=O)=O)NC([C@H](C[C@H](C1)OC(CC(c2nc(CCC3)c3[s]2)=N/C2=C/COC)/C2=C/C)N1C([C@H](CC)NC(OC(C)(C)C)=O)=[OH+])=O BGZNZZFWVYRVQV-KXZWEURJSA-O 0.000 description 1
- 0 CCc(c(*=C)c(*)c1c2C)c(*)c1nc1c2[o]c2c(*C)c(*)c(*)c(C)c12 Chemical compound CCc(c(*=C)c(*)c1c2C)c(*)c1nc1c2[o]c2c(*C)c(*)c(*)c(C)c12 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5385708P | 2008-05-16 | 2008-05-16 | |
| US61/053,857 | 2008-05-16 | ||
| PCT/US2008/082329 WO2009139792A1 (en) | 2008-05-16 | 2008-11-04 | Hcv protease inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011523411A JP2011523411A (ja) | 2011-08-11 |
| JP2011523411A5 true JP2011523411A5 (https=) | 2011-12-22 |
| JP5586588B2 JP5586588B2 (ja) | 2014-09-10 |
Family
ID=41316739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509462A Expired - Fee Related JP5586588B2 (ja) | 2008-05-16 | 2008-11-04 | Ｈｃｖプロテアーゼ阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090286814A1 (https=) |
| EP (1) | EP2274281B1 (https=) |
| JP (1) | JP5586588B2 (https=) |
| KR (2) | KR20110011663A (https=) |
| CN (1) | CN101580535B (https=) |
| AU (1) | AU2008356226B2 (https=) |
| CA (1) | CA2722056A1 (https=) |
| DK (1) | DK2274281T3 (https=) |
| EA (1) | EA020235B1 (https=) |
| ES (1) | ES2542880T3 (https=) |
| NZ (1) | NZ588189A (https=) |
| TW (1) | TWI414306B (https=) |
| WO (1) | WO2009139792A1 (https=) |
| ZA (1) | ZA201008988B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009142842A2 (en) | 2008-04-15 | 2009-11-26 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
| UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
| AR075584A1 (es) | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| US8232246B2 (en) | 2009-06-30 | 2012-07-31 | Abbott Laboratories | Anti-viral compounds |
| US20110178107A1 (en) * | 2010-01-20 | 2011-07-21 | Taigen Biotechnology Co., Ltd. | Hcv protease inhibitors |
| KR20140003521A (ko) | 2010-12-30 | 2014-01-09 | 이난타 파마슈티칼스, 인코포레이티드 | 페난트리딘 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제 |
| EP2658859A4 (en) | 2010-12-30 | 2014-07-30 | Enanta Pharm Inc | MACROCYCLIC HEPATITIS C SERIN PROTEASE INHIBITORS |
| US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| CN102911254A (zh) * | 2011-08-02 | 2013-02-06 | 上海唐润医药科技有限公司 | Hcv蛋白酶抑制剂 |
| CA2863002A1 (en) | 2012-01-11 | 2013-07-18 | Abbvie Inc. | Processes for making hcv protease inhibitors |
| EP2903988A1 (en) | 2012-10-08 | 2015-08-12 | AbbVie Inc. | Compounds useful for making hcv protease inhibitors |
| EA025560B1 (ru) | 2012-10-19 | 2017-01-30 | Бристол-Майерс Сквибб Компани | Ингибиторы вируса гепатита с |
| WO2014071007A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2014070964A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| EP2914614B1 (en) | 2012-11-05 | 2017-08-16 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| WO2014137869A1 (en) | 2013-03-07 | 2014-09-12 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| CN104557954A (zh) * | 2013-10-16 | 2015-04-29 | 上海唐润医药科技有限公司 | 抗hcv的大环化合物 |
| EP3089757A1 (en) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Solid antiviral dosage forms |
| CN104447952A (zh) * | 2014-12-11 | 2015-03-25 | 上海唐润医药科技有限公司 | 丙肝病毒蛋白酶抑制剂及其合成方法 |
| CN105859748B (zh) * | 2015-02-05 | 2018-06-08 | 爱博新药研发(上海)有限公司 | 多环化合物钠盐及其多晶型、制备方法及应用 |
| WO2016127859A1 (en) * | 2015-02-13 | 2016-08-18 | Sunshine Lake Pharma Co., Ltd. | Compounds as hepatitis c inhibitors and uses thereof in medicine |
| CN107074876B (zh) * | 2016-04-08 | 2019-12-20 | 上海长森药业有限公司 | 一类抑制丙肝病毒的大环状杂环化合物及其制备和用途 |
| CN107722109B (zh) * | 2016-08-11 | 2020-12-18 | 广东东阳光药业有限公司 | 作为丙型肝炎病毒抑制剂的晶型 |
| TW201805289A (zh) * | 2016-08-11 | 2018-02-16 | 廣東東陽光藥業有限公司 | 作為丙型肝炎病毒抑制劑的鹽 |
| WO2018222172A1 (en) * | 2017-05-30 | 2018-12-06 | Taigen Biotechnology Co., Ltd. | Solid dispersion formulation |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
| CN113337624A (zh) * | 2021-05-24 | 2021-09-03 | 温州医科大学 | 同时检测沙眼衣原体、淋病奈瑟氏球菌和解脲支原体的组合物及方法 |
| CN114773302B (zh) * | 2022-04-29 | 2024-04-02 | 中国药科大学 | 一种苯并呋喃衍生物及其医药用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4555508A (en) * | 1984-03-02 | 1985-11-26 | Usv Pharmaceutical Corp. | Antihypertensive spiro-cyclic compounds |
| US5876984A (en) * | 1996-09-25 | 1999-03-02 | Shionogi & Co., Ltd | Sequiterpene derivatives having antiviral activity |
| ZA9710927B (en) * | 1996-12-06 | 1998-06-15 | Fujisawa Pharmaceutical Co | Pharmaceutical composition. |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| IL159087A0 (en) * | 2001-07-11 | 2004-05-12 | Vertex Pharma | Bridged bicyclic compounds and pharmaceutical compositions containing the same |
| US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| CN100352819C (zh) * | 2002-01-23 | 2007-12-05 | 先灵公司 | 作为ns3－丝氨酸蛋白酶抑制剂的脯氨酸化合物用于制备治疗丙型肝炎病毒感染的药物 |
| US7119072B2 (en) * | 2002-01-30 | 2006-10-10 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis C virus |
| DE60324552D1 (en) * | 2002-05-20 | 2008-12-18 | Bristol Myers Squibb Co | Substituierte cycloalkyl p1' hepatitis c virus inhibitoren |
| MY140680A (en) * | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| ES2320771T3 (es) * | 2003-04-16 | 2009-05-28 | Bristol-Myers Squibb Company | Inhibidores peptidicos de isoquinolina macrociclicos del virus de la hepatitis c. |
| US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
| RS20060197A (sr) * | 2003-09-22 | 2008-09-29 | Boehringer Ingelheim International Gmbh., | Makrociklični peptidi koji su aktivni protiv hepatitisa c virusa |
| JP4525982B2 (ja) * | 2003-09-26 | 2010-08-18 | シェーリング コーポレイション | Ｃ型肝炎ウイルスのｎｓ３セリンプロテアーゼの大環状インヒビター |
| US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| JP2007532479A (ja) * | 2003-11-20 | 2007-11-15 | シェーリング コーポレイション | Ｃ型肝炎ウイルスｎｓ３プロテアーゼの脱ペプチド化インヒビター |
| BRPI0416902A (pt) * | 2003-12-11 | 2007-01-16 | Schering Corp | inibidores de ns3/ns4a serina protease do vìrus da hepatite c |
| EP1730167B1 (en) * | 2004-01-21 | 2011-01-12 | Boehringer Ingelheim International GmbH | Macrocyclic peptides active against the hepatitis c virus |
| US7375218B2 (en) * | 2004-09-17 | 2008-05-20 | Boehringer Ingelheim International Gmbh | Process for preparing macrocyclic HCV protease inhibitors |
| US20070207949A1 (en) * | 2005-06-02 | 2007-09-06 | Anima Ghosal | Medicaments and methods combining a HCV protease inhibitor and an AKR competitor |
| US20070237818A1 (en) * | 2005-06-02 | 2007-10-11 | Malcolm Bruce A | Controlled-release formulation of HCV protease inhibitor and methods using the same |
| US8012939B2 (en) * | 2005-07-29 | 2011-09-06 | Tibotec Pharmaceuticals Ltd. Co | Macrocyclic inhibitors of hepatitis C virus |
| US7605126B2 (en) * | 2006-08-11 | 2009-10-20 | Enanta Pharmaceuticals, Inc. | Acylaminoheteroaryl hepatitis C virus protease inhibitors |
| WO2008022006A2 (en) * | 2006-08-11 | 2008-02-21 | Enanta Pharmaceuticals, Inc. | Arylalkoxyl hepatitis c virus protease inhibitors |
| US20080267917A1 (en) * | 2007-04-26 | 2008-10-30 | Deqiang Niu | N-functionalized amides as hepatitis c serine protease inhibitors |
| US20090005387A1 (en) * | 2007-06-26 | 2009-01-01 | Deqiang Niu | Quinoxalinyl macrocyclic hepatitis c virus serine protease inhibitors |
| US20090111757A1 (en) * | 2007-10-25 | 2009-04-30 | Taigen Biotechnology Co., Ltd. | Hcv protease inhibitors |
-
2008
- 2008-10-28 CN CN2008101743025A patent/CN101580535B/zh active Active
- 2008-11-04 NZ NZ588189A patent/NZ588189A/xx not_active IP Right Cessation
- 2008-11-04 EA EA201071315A patent/EA020235B1/ru not_active IP Right Cessation
- 2008-11-04 EP EP08874317.4A patent/EP2274281B1/en not_active Not-in-force
- 2008-11-04 ES ES08874317.4T patent/ES2542880T3/es active Active
- 2008-11-04 AU AU2008356226A patent/AU2008356226B2/en not_active Ceased
- 2008-11-04 KR KR1020107027553A patent/KR20110011663A/ko not_active Ceased
- 2008-11-04 WO PCT/US2008/082329 patent/WO2009139792A1/en not_active Ceased
- 2008-11-04 DK DK08874317.4T patent/DK2274281T3/en active
- 2008-11-04 JP JP2011509462A patent/JP5586588B2/ja not_active Expired - Fee Related
- 2008-11-04 KR KR1020147005119A patent/KR20140048308A/ko not_active Withdrawn
- 2008-11-04 US US12/264,508 patent/US20090286814A1/en not_active Abandoned
- 2008-11-04 CA CA2722056A patent/CA2722056A1/en not_active Abandoned
- 2008-11-06 TW TW097142922A patent/TWI414306B/zh not_active IP Right Cessation
-
2010
- 2010-12-14 ZA ZA2010/08988A patent/ZA201008988B/en unknown
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