JP2014500286A5 - - Google Patents

Download PDF

Info

Publication number
JP2014500286A5
JP2014500286A5 JP2013545217A JP2013545217A JP2014500286A5 JP 2014500286 A5 JP2014500286 A5 JP 2014500286A5 JP 2013545217 A JP2013545217 A JP 2013545217A JP 2013545217 A JP2013545217 A JP 2013545217A JP 2014500286 A5 JP2014500286 A5 JP 2014500286A5
Authority
JP
Japan
Prior art keywords
alkyl
het
hal
cycloalkyl
conh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013545217A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014500286A (ja
JP6007189B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2011/073015 external-priority patent/WO2012084704A1/en
Publication of JP2014500286A publication Critical patent/JP2014500286A/ja
Publication of JP2014500286A5 publication Critical patent/JP2014500286A5/ja
Application granted granted Critical
Publication of JP6007189B2 publication Critical patent/JP6007189B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013545217A 2010-12-20 2011-12-16 Irak阻害剤としてのインダゾリルトリアゾール誘導体 Expired - Fee Related JP6007189B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201061424890P 2010-12-20 2010-12-20
US61/424,890 2010-12-20
EP10195867 2010-12-20
EP10195867.6 2010-12-20
PCT/EP2011/073015 WO2012084704A1 (en) 2010-12-20 2011-12-16 Indazolyl triazole derivatives as irak inhibitors

Publications (3)

Publication Number Publication Date
JP2014500286A JP2014500286A (ja) 2014-01-09
JP2014500286A5 true JP2014500286A5 (OSRAM) 2016-04-28
JP6007189B2 JP6007189B2 (ja) 2016-10-12

Family

ID=43838132

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013545217A Expired - Fee Related JP6007189B2 (ja) 2010-12-20 2011-12-16 Irak阻害剤としてのインダゾリルトリアゾール誘導体

Country Status (23)

Country Link
US (1) US9073892B2 (OSRAM)
EP (1) EP2655357B1 (OSRAM)
JP (1) JP6007189B2 (OSRAM)
KR (1) KR101842098B1 (OSRAM)
CN (1) CN103429585B (OSRAM)
AR (1) AR084507A1 (OSRAM)
AU (1) AU2011347711B2 (OSRAM)
BR (2) BR122021014375B1 (OSRAM)
CA (1) CA2822166C (OSRAM)
EA (1) EA023544B1 (OSRAM)
ES (1) ES2592713T3 (OSRAM)
HR (1) HRP20161127T1 (OSRAM)
HU (1) HUE029617T2 (OSRAM)
IL (1) IL226912A (OSRAM)
LT (1) LT2655357T (OSRAM)
MX (1) MX2013007149A (OSRAM)
PL (1) PL2655357T3 (OSRAM)
PT (1) PT2655357T (OSRAM)
RS (1) RS55165B1 (OSRAM)
SG (1) SG191205A1 (OSRAM)
SI (1) SI2655357T1 (OSRAM)
WO (1) WO2012084704A1 (OSRAM)
ZA (1) ZA201305483B (OSRAM)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR045563A1 (es) 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
US9351965B2 (en) 2010-12-21 2016-05-31 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
ES2984771T3 (es) 2012-06-13 2024-10-31 Incyte Holdings Corp Compuestos tricíclicos sustituidos como inhibidores de FGFR
US9765057B2 (en) 2012-12-20 2017-09-19 Merck Sharp & Dohme Corp. 3-ester-4 substituted orexin receptor antagonists
EP2934517A4 (en) 2012-12-20 2016-05-25 Merck Sharp & Dohme 2-PYRIDYLOXY-3-NITRIL-4-SUBSTITUTED OREXINE RECEPTOR ANTAGONISTS
LT2953952T (lt) * 2013-02-07 2017-08-25 Merck Patent Gmbh Makrocikliniai piridazinono dariniai
RS56331B1 (sr) * 2013-02-07 2017-12-29 Merck Patent Gmbh Derivati piridazinon-amida
EA035095B1 (ru) 2013-04-19 2020-04-27 Инсайт Холдингс Корпорейшн Бициклические гетероциклы в качестве ингибиторов fgfr
TWI667233B (zh) * 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺,其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
JP2017505337A (ja) 2014-01-10 2017-02-16 アウリジーン ディスカバリー テクノロジーズ リミテッド Irak4阻害剤としてのインダゾール化合物
PL3805233T3 (pl) 2014-01-13 2024-06-10 Aurigene Oncology Limited ENANCJOMERY (R) I (S) (S)-N-(5-(3-hydroksypirolidyn-1-ylo)-2-morfolinooksazolo[4,5-b]pirydyn-6-ylo)-2-(2-metylopirydyn-4-ylo)oksazolo-4-karboksyamidu jako inhibitory IRAK4 do leczenia nowotworu złośliwego
EP3200788B1 (en) 2014-09-30 2019-09-18 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
EP3200789B1 (en) * 2014-09-30 2019-11-06 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
US9943516B2 (en) 2014-09-30 2018-04-17 Merck Sharp & Dohme Corp. Inhibitors of IRAK4 activity
US9969749B2 (en) 2014-09-30 2018-05-15 Merck Sharp & Dohme Corp. Inhibitors of IRAK4 activity
JO3705B1 (ar) * 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
EP3233840B1 (en) 2014-12-16 2018-11-21 Eudendron S.r.l. Heterocyclic derivatives modulating activity of certain protein kinases
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
ES2861351T3 (es) 2015-04-22 2021-10-06 Rigel Pharmaceuticals Inc Compuestos de pirazol y método para fabricar y usar los compuestos
EP3288558B1 (en) 2015-04-30 2022-05-11 Bayer Pharma Aktiengesellschaft Combinations of inhibitors of irak4 with inhibitors of btk
EP3195865A1 (de) 2016-01-25 2017-07-26 Bayer Pharma Aktiengesellschaft Kombinationen von irak4 inhibitoren und btk inhibitoren
US10435396B2 (en) 2016-03-03 2019-10-08 Bayer Pharma Aktiegesellschaft 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs
EP3219329A1 (en) 2016-03-17 2017-09-20 Bayer Pharma Aktiengesellschaft Combinations of copanlisib
SI3448848T1 (sl) 2016-04-29 2024-01-31 Bayer Pharma Aktiengesellschaft Polimorfna oblika N-(6-(2-hidroksipropan-2-il)-2-(2-(metilsulfonil)etil)-2H-indazol-5-il) -6-(trifluormetil)piridin-2-karboksamida
PE20240651A1 (es) 2016-04-29 2024-04-04 Bayer Pharma AG Sintesis de indazoles
EP3464266B1 (en) 2016-06-01 2021-10-20 Bayer Animal Health GmbH Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseases in animals
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
CN120267671A (zh) 2017-03-31 2025-07-08 奥锐金肿瘤有限公司 用于治疗血液病的化合物和组合物
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CA3076613A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES THEREOF
KR20200073216A (ko) 2017-10-19 2020-06-23 바이엘 애니멀 헬스 게엠베하 동물에서의 질환의 치료 및 방지를 위한 융합된 헤테로방향족 피롤리돈의 용도
JP7241747B2 (ja) 2017-10-31 2023-03-17 キュリス,インコーポレイテッド 血液学的障害を治療するための化合物および組成物
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
EP3737675A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
GB201801226D0 (en) 2018-01-25 2018-03-14 Redx Pharma Plc Modulators of Rho-associated protein kinase
US11174257B2 (en) 2018-05-04 2021-11-16 Incyte Corporation Salts of an FGFR inhibitor
RS66310B1 (sr) 2018-05-04 2025-01-31 Incyte Corp Čvrsti oblici inhibitora fgfr i procesi za njegovu pripremu
WO2020010227A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US11292792B2 (en) 2018-07-06 2022-04-05 Kymera Therapeutics, Inc. Tricyclic CRBN ligands and uses thereof
TWI842978B (zh) 2018-07-13 2024-05-21 美商基利科學股份有限公司 衍生物
JP7623943B2 (ja) 2018-11-30 2025-01-29 カイメラ セラピューティクス, インコーポレイテッド Irak分解剤およびそれらの使用
CA3129601A1 (en) 2019-02-11 2020-08-20 Merck Patent Gmbh Indazolyl-isoxazole derivatives for the treatment of diseases such as cancer
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
CA3145043A1 (en) * 2019-06-27 2020-12-30 Biogen Ma Inc. 2h-indazole derivatives and their use in the treatment of disease
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN114364674B (zh) 2019-08-30 2025-10-03 里格尔药品股份有限公司 吡唑化合物,其配制品以及使用所述化合物和/或配制品的方法
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
AU2020360000B2 (en) 2019-10-02 2023-04-20 Kainos Medicine, Inc. N-(1H-imidazol-2-yl)benzamide compound and pharmaceutical composition comprising the same as active ingredient
PH12022550892A1 (en) 2019-10-14 2023-05-03 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
EP4051387B1 (en) 2019-10-31 2025-02-19 F. Hoffmann-La Roche AG Hydropyrazino[1,2-d][1,4]diazepine compounds for the treatment of autoimmune disease
US12486273B2 (en) 2019-11-19 2025-12-02 Hoffmann-La Roche Inc. Hydro-1H-pyrrolo[1,2-a]pyrazine compounds for the treatment of autoimmune disease
EP4069693B1 (en) 2019-12-03 2024-03-20 F. Hoffmann-La Roche AG Hydropyrido[1,2-alpha]pyrazine compounds for the treatment of autoimmune diseases
AU2020395185A1 (en) 2019-12-04 2022-06-02 Incyte Corporation Derivatives of an FGFR inhibitor
EP4069696A1 (en) 2019-12-04 2022-10-12 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
US11591332B2 (en) 2019-12-17 2023-02-28 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
KR20220145325A (ko) 2019-12-17 2022-10-28 카이메라 쎄라퓨틱스 인코포레이티드 Irak 분해제 및 이의 용도
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
US11866405B2 (en) 2020-12-10 2024-01-09 Astrazeneca Ab Substituted indazoles as IRAK4 inhibitors
AR124547A1 (es) 2020-12-30 2023-04-05 Kymera Therapeutics Inc Degradadores de irak y sus usos
MX2023009527A (es) 2021-02-15 2023-08-24 Kymera Therapeutics Inc Degradadores de la cinasa 4 asociada al receptor de interleucina 1 (irak4) y usos de los mismos.
WO2022187303A1 (en) 2021-03-03 2022-09-09 Rigel Pharmaceuticals, Inc. A method for treating a disease or condition using a pyrazole compound or formulation thereof
CN117120054A (zh) 2021-04-08 2023-11-24 柯里斯公司 治疗癌症的组合疗法
JP2024513575A (ja) 2021-04-12 2024-03-26 インサイト・コーポレイション Fgfr阻害剤及びネクチン-4標的化剤を含む併用療法
AR125798A1 (es) 2021-05-07 2023-08-16 Kymera Therapeutics Inc Degradadores cdk2 y usos de los mismos
TW202313610A (zh) 2021-06-09 2023-04-01 美商英塞特公司 作為fgfr抑制劑之三環雜環
WO2022261160A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
CA3223447A1 (en) 2021-06-25 2022-12-29 Korea Research Institute Of Chemical Technology Novel bifunctional heterocyclic compound having btk degradation function via ubiquitin proteasome pathway, and use thereof
EP4422635A4 (en) 2021-10-29 2025-11-26 Kymera Therapeutics Inc IRAQ4 DEGRADATION AGENTS AND THEIR SYNTHESIS
CA3243560A1 (en) 2022-01-31 2023-08-03 Kymera Therapeutics, Inc. Iraqi Degradation Agents and Their Uses
IL315677A (en) 2022-03-23 2024-11-01 Rigel Pharmaceuticals Inc Pyrimid-2-yl-pyrazole compounds as irak inhibitors
KR102607237B1 (ko) * 2023-06-07 2023-11-30 주식회사 젠센 신규한 트리아졸이 치환된 인다졸 유도체 및 이의 용도
WO2025036285A1 (zh) * 2023-08-11 2025-02-20 深圳众格生物科技有限公司 一种降解irak4的蛋白降解靶向嵌合体化合物及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1732004A (zh) * 2002-10-24 2006-02-08 细胞基因公司 用jnk抑制剂治疗疼痛
US20040087642A1 (en) 2002-10-24 2004-05-06 Zeldis Jerome B. Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
US20050090529A1 (en) * 2003-07-31 2005-04-28 Pfizer Inc 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
US6984652B2 (en) * 2003-09-05 2006-01-10 Warner-Lambert Company Llc Gyrase inhibitors
AU2006252938A1 (en) * 2005-04-29 2006-12-07 Celgene Corporation Solid forms of 1-( 5-(IH-I , 2 , 4 -triazol- 5 -yl)(1H-indazol-3-yl))-3-(2-piperidylethoxy)benzene
SG182187A1 (en) * 2007-06-08 2012-07-30 Abbott Gmbh & Co Kg 5-heteroaryl substituted indazoles as kinase inhibitors

Similar Documents

Publication Publication Date Title
JP2014500286A5 (OSRAM)
AR068846A1 (es) Compuestos derivados de pirrolo (2,3d)-pirimidina inhibidores de la actividad de pkb, composiciones farmaceuticas que los contienen, proceso de preparacion y uso de los mismos como agentes anticancer
RU2451018C2 (ru) Модуляторы атф-связывающих кассетных транспортеров
JP2011137006A5 (OSRAM)
JP2015503625A5 (OSRAM)
AR113826A1 (es) Indol-2-carboxamidas sustituidas con amino-tiazol activas contra el virus de la hepatitis b (vhb)
RU2019119893A (ru) Ингибиторы jak2 и alk2 и способы их использования
JP2006522035A5 (OSRAM)
AR084507A1 (es) Derivados de indazoliltriazol
AR095427A1 (es) Compuestos aromáticos sustituidos para el tratamiento de la fibrosis pulmonar, la fibrosis hepática, la fibrosis de la piel y la fibrosis cardíaca
JP2009523165A5 (OSRAM)
JP2012529535A5 (OSRAM)
ES2644758T3 (es) Moduladores de PKM2 y métodos para su uso
JP2018536648A5 (OSRAM)
PE20180799A1 (es) Reguladores de nrf2
RU2014145819A (ru) Бициклическое соединение
RU2017123619A (ru) Соединения пиколинамида с фунгицидной активностью
AR111466A1 (es) Inhibidores de hdac6 selectivos
RU2016103139A (ru) Новые композиции для предупреждения и/или лечения лизосомных болезней накопления
ME02367B (me) Analozi buprenorfina kao agonisti i/ili antagonisti opioidnog receptora
JP2016540742A5 (OSRAM)
AR090867A1 (es) Compuestos y composiciones plaguicidas y procesos relacionados
AR067506A1 (es) Derivados de quinazolinamida
AR103833A1 (es) Compuestos bicíclicos de sulfonamida cetona
JP2011504903A5 (OSRAM)