JP2014101382A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014101382A5 JP2014101382A5 JP2014043564A JP2014043564A JP2014101382A5 JP 2014101382 A5 JP2014101382 A5 JP 2014101382A5 JP 2014043564 A JP2014043564 A JP 2014043564A JP 2014043564 A JP2014043564 A JP 2014043564A JP 2014101382 A5 JP2014101382 A5 JP 2014101382A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- nanoparticles
- liposome
- formulation according
- liposomal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002105 nanoparticle Substances 0.000 claims 36
- 239000008194 pharmaceutical composition Substances 0.000 claims 33
- 238000000034 method Methods 0.000 claims 20
- 239000002502 liposome Substances 0.000 claims 19
- 150000004625 docetaxel anhydrous derivatives Chemical class 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 13
- 229920001427 mPEG Polymers 0.000 claims 10
- 229920001223 polyethylene glycol Polymers 0.000 claims 8
- 239000004698 Polyethylene Substances 0.000 claims 7
- 239000002202 Polyethylene glycol Substances 0.000 claims 7
- 238000009472 formulation Methods 0.000 claims 7
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 7
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 6
- 229930182558 Sterol Natural products 0.000 claims 6
- 150000002632 lipids Chemical class 0.000 claims 6
- 150000003432 sterols Chemical class 0.000 claims 6
- 235000003702 sterols Nutrition 0.000 claims 6
- 239000000725 suspension Substances 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 239000007864 aqueous solution Substances 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims 3
- 229940106189 ceramide Drugs 0.000 claims 3
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims 3
- 239000007979 citrate buffer Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 3
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 239000006174 pH buffer Substances 0.000 claims 2
- -1 phosphatidylcholine lipid Chemical class 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- CFWRDBDJAOHXSH-UHFFFAOYSA-N 2-azaniumylethyl 2,3-diacetyloxypropyl phosphate Chemical compound CC(=O)OCC(OC(C)=O)COP(O)(=O)OCCN CFWRDBDJAOHXSH-UHFFFAOYSA-N 0.000 claims 1
- HIYAVKIYRIFSCZ-CYEMHPAKSA-N 5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid Chemical compound O=C([C@@H](C)[C@H]1O[C@@]2([C@@H](C[C@H]1C)C)O[C@@H]([C@@H](CC2)C)CC=1OC2=CC=C(C(=C2N=1)C(O)=O)NC)C1=CC=CN1 HIYAVKIYRIFSCZ-CYEMHPAKSA-N 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims 1
- 235000011130 ammonium sulphate Nutrition 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- DANUORFCFTYTSZ-UHFFFAOYSA-N epinigericin Natural products O1C2(C(CC(C)(O2)C2OC(C)(CC2)C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)C)C(C)C(OC)CC1CC1CCC(C)C(C(C)C(O)=O)O1 DANUORFCFTYTSZ-UHFFFAOYSA-N 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 239000002555 ionophore Substances 0.000 claims 1
- 230000000236 ionophoric effect Effects 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- DANUORFCFTYTSZ-BIBFWWMMSA-N nigericin Chemical compound C([C@@H]1C[C@H]([C@H]([C@]2([C@@H](C[C@](C)(O2)C2O[C@@](C)(CC2)C2[C@H](CC(O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C)O1)C)OC)[C@H]1CC[C@H](C)C([C@@H](C)C(O)=O)O1 DANUORFCFTYTSZ-BIBFWWMMSA-N 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 238000012856 packing Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5592908P | 2008-05-23 | 2008-05-23 | |
| US61/055,929 | 2008-05-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510067A Division JP5542804B2 (ja) | 2008-05-23 | 2009-05-26 | リポソームナノ粒子中で使用するための修飾薬物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014146559A Division JP5992019B2 (ja) | 2008-05-23 | 2014-07-17 | リポソームナノ粒子中で使用するための修飾薬物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014101382A JP2014101382A (ja) | 2014-06-05 |
| JP2014101382A5 true JP2014101382A5 (OSRAM) | 2014-09-04 |
| JP5744267B2 JP5744267B2 (ja) | 2015-07-08 |
Family
ID=41340622
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510067A Expired - Fee Related JP5542804B2 (ja) | 2008-05-23 | 2009-05-26 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2014043564A Expired - Fee Related JP5744267B2 (ja) | 2008-05-23 | 2014-03-06 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2014146559A Expired - Fee Related JP5992019B2 (ja) | 2008-05-23 | 2014-07-17 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2016159491A Expired - Fee Related JP6437968B2 (ja) | 2008-05-23 | 2016-08-16 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2018214441A Pending JP2019048851A (ja) | 2008-05-23 | 2018-11-15 | リポソームナノ粒子中で使用するための修飾薬物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510067A Expired - Fee Related JP5542804B2 (ja) | 2008-05-23 | 2009-05-26 | リポソームナノ粒子中で使用するための修飾薬物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014146559A Expired - Fee Related JP5992019B2 (ja) | 2008-05-23 | 2014-07-17 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2016159491A Expired - Fee Related JP6437968B2 (ja) | 2008-05-23 | 2016-08-16 | リポソームナノ粒子中で使用するための修飾薬物 |
| JP2018214441A Pending JP2019048851A (ja) | 2008-05-23 | 2018-11-15 | リポソームナノ粒子中で使用するための修飾薬物 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US8790691B2 (OSRAM) |
| EP (2) | EP2282724B1 (OSRAM) |
| JP (5) | JP5542804B2 (OSRAM) |
| KR (5) | KR20190049930A (OSRAM) |
| CN (2) | CN102105135B (OSRAM) |
| CA (3) | CA2989616A1 (OSRAM) |
| ES (1) | ES2694481T3 (OSRAM) |
| IL (2) | IL209419A (OSRAM) |
| WO (1) | WO2009141738A2 (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2282724B1 (en) * | 2008-05-23 | 2018-09-05 | The University Of British Columbia | Modified drugs for use in liposomal nanoparticles |
| CN102018672B (zh) * | 2010-11-29 | 2013-09-18 | 广州朗圣药业有限公司 | 一种水溶性药物的脂质体冻干组合物及其制备方法 |
| CN102617517B (zh) * | 2011-01-27 | 2015-11-18 | 李勤耕 | 一类新的7,10-o,o-二甲多西紫杉醇衍生物及其应用 |
| CN108210463A (zh) * | 2011-01-28 | 2018-06-29 | 皇家飞利浦电子股份有限公司 | 用于局部释放亲水性前药的载体 |
| WO2012166949A1 (en) * | 2011-05-31 | 2012-12-06 | Regents Of The University Of Minnesota | Silicate prodrugs and nanoparticles |
| WO2014058729A1 (en) * | 2012-10-09 | 2014-04-17 | California Institute Of Technology | In vivo and in vitro carbene insertion and nitrene transfer reactions catalyzed by heme enzymes |
| EP2906518A4 (en) | 2012-10-09 | 2016-07-27 | California Inst Of Techn | CYCLES CATALYZED IN VIVO AND IN VITRO OLEFINCYCLOPROPANATION |
| BR112015022819A8 (pt) * | 2013-03-13 | 2019-11-26 | Mallinckrodt Llc | método para a preparação de um taxano lipossomal, composição compreendendo um lipossoma e taxano lipossomal |
| GB201315321D0 (en) * | 2013-08-28 | 2013-10-09 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction Buffer |
| EP3052508A1 (en) | 2013-09-30 | 2016-08-10 | Danmarks Tekniske Universitet | Silicone chain extender |
| US9399762B2 (en) | 2014-02-18 | 2016-07-26 | California Institute Of Technology | Methods and systems for sulfimidation or sulfoximidation of organic molecules |
| CN105085437B (zh) * | 2014-05-23 | 2018-07-03 | 上海交通大学 | 3-(1-叔丁氧羰酰哌嗪-4-yl)丙酸的两亲性衍生物及其用途 |
| CN104368011B (zh) * | 2014-11-27 | 2017-05-10 | 东南大学 | 一种药物甜菜碱缀合物、其药物组合物及应用 |
| EP3258913A1 (en) * | 2015-02-17 | 2017-12-27 | Mallinckrodt Nuclear Medicine LLC | Modified docetaxel liposome formulations and uses thereof |
| TWI678213B (zh) * | 2015-07-22 | 2019-12-01 | 美商史倍壯製藥公司 | 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物 |
| EP3352733A1 (en) * | 2015-09-21 | 2018-08-01 | Mallinckrodt LLC | Improved stability of liposome formulations and uses thereof |
| GB201521101D0 (en) | 2015-11-30 | 2016-01-13 | Koninklijke Nederlandse Akademie Van Wetenschappen | Transduction buffer |
| US10780174B2 (en) * | 2015-12-23 | 2020-09-22 | The University Of British Columbia | Lipid-linked prodrugs |
| WO2018160794A1 (en) | 2017-03-01 | 2018-09-07 | Merrimack Pharmaceuticals, Inc. | Epha2-targeted docetaxel -generating liposomes in combination with an agent that impedes regulatory t cell activity for treating cancer |
| CN109422759B (zh) * | 2017-08-22 | 2021-05-04 | 复旦大学 | 小分子修饰的紫杉烷类水溶性前药及其药用用途 |
| CN111004195B (zh) * | 2019-12-03 | 2022-01-28 | 沈阳药科大学 | 卡巴他赛弱碱性衍生物及其制剂 |
| WO2024010886A2 (en) * | 2022-07-07 | 2024-01-11 | Nanostar Pharmaceuticals Ltd. | Multilamellar vesicle drug formulation |
| CN117024381B (zh) * | 2023-08-14 | 2025-08-12 | 沈阳药科大学 | 卡巴他赛衍生物及其脂质体制剂 |
| CN118324842B (zh) * | 2024-04-10 | 2025-05-02 | 沈阳药科大学 | 地塞米松弱碱性衍生物及其制剂的制备及应用 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2979518A (en) * | 1956-08-14 | 1961-04-11 | Organon | New steroid alaninates |
| GB1272841A (en) * | 1969-01-23 | 1972-05-03 | Leo Ab | New corticoid steroid compounds of cytostatic interest |
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4443440A (en) * | 1982-08-30 | 1984-04-17 | The Upjohn Company | Amine containing ester prodrugs of corticosteroids |
| US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| AU589917B2 (en) * | 1984-10-04 | 1989-10-26 | Novartis Ag | Monoclonal antibodies to cyclosporins |
| US4975282A (en) * | 1985-06-26 | 1990-12-04 | The Liposome Company, Inc. | Multilamellar liposomes having improved trapping efficiencies |
| US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| JPH01117885A (ja) * | 1987-10-30 | 1989-05-10 | Dai Ichi Seiyaku Co Ltd | 新規ボドフィロトキシン誘導体及びその製造法 |
| ZA886810B (en) * | 1987-12-18 | 1989-08-30 | Bristol Myers Co | Epipodophyllotoxin glucoside 4'-acyl derivatives |
| US4942184A (en) * | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
| IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5534632A (en) * | 1991-09-05 | 1996-07-09 | Abbott Laboratories | Macrocyclic carbamate immunomodulators |
| US5457111A (en) * | 1991-09-05 | 1995-10-10 | Abbott Laboratories | Macrocyclic immunomodulators |
| US5563172A (en) * | 1991-09-05 | 1996-10-08 | Abbott Laboratories | Macrocyclic amide and urea immunomodulators |
| JPH069600A (ja) | 1992-05-06 | 1994-01-18 | Bristol Myers Squibb Co | タクソールのベンゾエート誘導体 |
| US5547981A (en) * | 1993-03-09 | 1996-08-20 | Enzon, Inc. | Taxol-7-carbazates |
| US5475011A (en) * | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| EP0727992A4 (en) * | 1993-10-20 | 2001-01-31 | Enzon Inc | SUBSTITUTED TAXOID SUBSTANCES IN 2 'AND / OR 7' POSITION |
| US5489589A (en) * | 1994-12-07 | 1996-02-06 | Bristol-Myers Squibb Company | Amino acid derivatives of paclitaxel |
| JPH09110865A (ja) * | 1995-08-15 | 1997-04-28 | Masao Oguro | タキソール誘導体 |
| US6107332A (en) | 1995-09-12 | 2000-08-22 | The Liposome Company, Inc. | Hydrolysis-promoting hydrophobic taxane derivatives |
| EP0929293B1 (en) * | 1996-08-23 | 2003-10-22 | Sequus Pharmaceuticals, Inc. | Liposomes containing a cisplatin compound |
| GB9814527D0 (en) * | 1998-07-03 | 1998-09-02 | Cyclacel Ltd | Delivery system |
| US6342244B1 (en) * | 1999-04-23 | 2002-01-29 | Alza Corporation | Releasable linkage and compositions containing same |
| FR2810321B1 (fr) * | 2000-06-20 | 2002-07-26 | Adir | Nouveaux derives de podophyllotoxine carbamate et thiocarbamate, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2001294185B2 (en) * | 2000-10-04 | 2006-12-21 | Kyowa Hakko Kirin Co., Ltd. | Method of coating fine particles with lipid membrane |
| US6855720B2 (en) * | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| US6403604B1 (en) * | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| US8552054B2 (en) * | 2001-03-23 | 2013-10-08 | Luitpold Pharmaceuticals, Inc. | Fatty amine drug conjugates |
| DK1389089T3 (da) * | 2001-03-27 | 2009-12-21 | Phares Pharm Res Nv | Fremgangsmådeog sammensætning til solubilisering af en biologisk aktiv forbindelse med lav vandoplöselighed |
| GB0111279D0 (en) * | 2001-05-10 | 2001-06-27 | Nycomed Imaging As | Radiolabelled liposomes |
| ITMI20020148A1 (it) * | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
| US20050152962A1 (en) * | 2002-06-12 | 2005-07-14 | Metselaar Josbert M. | Composition for treatment of inflammatory disorders |
| CA2505520C (en) * | 2002-11-06 | 2012-07-17 | Azaya Therapeutics, Inc. | Protein-stabilized liposomal formulations of pharmaceutical agents |
| US7342114B2 (en) * | 2003-07-01 | 2008-03-11 | California Pacific Medical Center | Podophyllotoxin derivatives |
| US8173840B2 (en) * | 2003-07-29 | 2012-05-08 | Signature R&D Holdings, Llc | Compounds with high therapeutic index |
| US20050095283A1 (en) | 2003-09-16 | 2005-05-05 | Aphios Corporation | Compositions and methods for topically treating diseases |
| WO2005030258A2 (en) * | 2003-09-22 | 2005-04-07 | Acidophil Llc | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
| EP1537858A1 (en) * | 2003-12-04 | 2005-06-08 | Vectron Therapeutics AG | Drug delivery vehicles and uses thereof |
| CA2551807A1 (en) * | 2004-01-14 | 2005-08-04 | Gilead Sciences, Inc. | Lipid-based dispersions useful for drug delivery |
| CN103948545B (zh) * | 2004-05-03 | 2017-10-03 | 益普生生物制药公司 | 用于药物输送的脂质体 |
| JP5355890B2 (ja) * | 2004-09-09 | 2013-11-27 | イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム | グルココルチコイドおよびグルココルチコイド誘導体のリポソーム性組成物 |
| MX2007005234A (es) * | 2004-10-29 | 2008-03-10 | Neopharm Inc | Proceso de fabricacion para preparaciones liposomales. |
| JP4504845B2 (ja) * | 2005-03-11 | 2010-07-14 | テスコ・エコライティング株式会社 | 照明器具用下部反射板の取り付け具 |
| EP1896007B1 (en) * | 2005-05-04 | 2014-03-19 | Medigene AG | Method of administering a cationic liposomal preparation comprising paclitexel |
| US20090220583A1 (en) * | 2005-06-09 | 2009-09-03 | Lena Pereswetoff-Morath | Method and composition for treating inflammatory disorders |
| BRPI0708299A2 (pt) * | 2006-02-27 | 2011-05-24 | Univ Leland Stanford Junior | composições e métodos para o transporte de moléculas com propriedades melhoradas de liberação através de barreiras biológicas |
| TW201509433A (zh) * | 2006-12-13 | 2015-03-16 | Cerulean Pharma Inc | 用於醫物傳遞之以環糊精為基之聚合物 |
| CN101029034B (zh) | 2007-03-30 | 2010-05-26 | 浙江大学 | 多烯紫杉醇水溶性衍生物及制备方法和用途 |
| EP2282724B1 (en) * | 2008-05-23 | 2018-09-05 | The University Of British Columbia | Modified drugs for use in liposomal nanoparticles |
-
2009
- 2009-05-26 EP EP09750195.1A patent/EP2282724B1/en not_active Not-in-force
- 2009-05-26 CN CN200980128975.XA patent/CN102105135B/zh not_active Expired - Fee Related
- 2009-05-26 CA CA2989616A patent/CA2989616A1/en not_active Abandoned
- 2009-05-26 EP EP18185021.5A patent/EP3415151A1/en not_active Withdrawn
- 2009-05-26 JP JP2011510067A patent/JP5542804B2/ja not_active Expired - Fee Related
- 2009-05-26 KR KR1020197012513A patent/KR20190049930A/ko not_active Ceased
- 2009-05-26 WO PCT/IB2009/006532 patent/WO2009141738A2/en not_active Ceased
- 2009-05-26 CA CA2910133A patent/CA2910133C/en not_active Expired - Fee Related
- 2009-05-26 CN CN201410836670.7A patent/CN104622809B/zh not_active Expired - Fee Related
- 2009-05-26 KR KR1020187003893A patent/KR101919093B1/ko not_active Expired - Fee Related
- 2009-05-26 KR KR1020107028838A patent/KR101659457B1/ko not_active Expired - Fee Related
- 2009-05-26 CA CA2725535A patent/CA2725535C/en not_active Expired - Fee Related
- 2009-05-26 KR KR1020167025450A patent/KR101830018B1/ko not_active Expired - Fee Related
- 2009-05-26 KR KR1020187032439A patent/KR101975843B1/ko not_active Expired - Fee Related
- 2009-05-26 ES ES09750195.1T patent/ES2694481T3/es active Active
- 2009-05-26 US US12/993,482 patent/US8790691B2/en not_active Expired - Fee Related
-
2010
- 2010-11-18 IL IL209419A patent/IL209419A/en active IP Right Grant
-
2012
- 2012-05-08 US US13/467,021 patent/US8324410B2/en not_active Expired - Fee Related
-
2013
- 2013-04-19 US US13/866,873 patent/US8545876B1/en not_active Expired - Fee Related
- 2013-04-19 US US13/866,956 patent/US8545877B2/en not_active Expired - Fee Related
- 2013-04-19 US US13/866,913 patent/US8568772B2/en not_active Expired - Fee Related
- 2013-04-25 IL IL225961A patent/IL225961A/en active IP Right Grant
-
2014
- 2014-03-06 JP JP2014043564A patent/JP5744267B2/ja not_active Expired - Fee Related
- 2014-06-12 US US14/302,537 patent/US9968554B2/en not_active Expired - Fee Related
- 2014-07-17 JP JP2014146559A patent/JP5992019B2/ja not_active Expired - Fee Related
-
2016
- 2016-08-16 JP JP2016159491A patent/JP6437968B2/ja not_active Expired - Fee Related
-
2018
- 2018-04-09 US US15/948,716 patent/US20180221279A1/en not_active Abandoned
- 2018-11-15 JP JP2018214441A patent/JP2019048851A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014101382A5 (OSRAM) | ||
| JP6363320B2 (ja) | 薬剤を装填したポリマーナノ粒子及びその製造方法と使用方法 | |
| RU2734236C2 (ru) | Композиции бендамустина и циклополисахарида | |
| MX2012013909A (es) | Metodos de tratamiento de cancer de vejiga. | |
| WO2011066684A1 (zh) | 伊立替康或盐酸伊立替康脂质体及其制备方法 | |
| Li et al. | A macromolecular prodrug strategy for combinatorial drug delivery | |
| JP6263609B2 (ja) | リポソーム組成物及びその製造方法 | |
| JP5788982B2 (ja) | ベンダムスチンアニオン性−カチオン性シクロポリサッカライド組成物 | |
| CN103989624B (zh) | 一种盐酸伊立替康组合物及其制备方法 | |
| Liu et al. | PDLLA length on anti-breast cancer efficacy of acid-responsive self-assembling mPEG-PDLLA‒docetaxel conjugates | |
| RU2492865C2 (ru) | Комбинированное применение производных холестанола | |
| JP5466174B2 (ja) | 水溶性、カチオン性および両親媒性の薬学的に活性な物質を投与するためのドラッグ・デリバリー・システム | |
| CN102166189B (zh) | 靶向和荧光双功能的难溶性抗肿瘤药物纳米结构脂质载体 | |
| CN109419773B (zh) | 复合纳米脂质给药系统及其对妇科肿瘤的治疗作用 | |
| Lv et al. | Influence of unsaturated fatty acids on the antitumor activity of polymeric conjugates grafted with cabazitaxel against prostate cancer | |
| CN113307824B (zh) | 一种双亲性材料及其在制备脂质体中的应用 | |
| CN103417977A (zh) | 叶酸受体α亚型高效介导的靶向投药系统 | |
| Zou et al. | Nanoformulation-based drug delivery systems for the treatment of gastric cancer: recent developments and future prospects | |
| CN104840968A (zh) | 甲基聚乙二醇2000-b-聚D,L-乳酸1000-1500嵌段共聚物载多烯紫杉醇纳米胶束制剂 | |
| JP7229412B1 (ja) | 脂質ナノ粒子及びその製造方法 | |
| RU2519186C2 (ru) | Производное соединение холестанола для комбинированного применения | |
| TWI500430B (zh) | 伊立替康或鹽酸伊立替康脂質體及其製備方法 | |
| CZ2005796A3 (cs) | Farmaceutická kompozice obsahující derivát taxanuse zlepsenou terapeutickou úcinností | |
| CN121059622A (zh) | 一种用于治疗肝癌或逆转索拉非尼耐药性的药物、双药脂质体及应用 | |
| JP5480241B2 (ja) | コレスタノール誘導体の併用用途 |