JP2014055161A5 - - Google Patents
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- Publication number
- JP2014055161A5 JP2014055161A5 JP2013234011A JP2013234011A JP2014055161A5 JP 2014055161 A5 JP2014055161 A5 JP 2014055161A5 JP 2013234011 A JP2013234011 A JP 2013234011A JP 2013234011 A JP2013234011 A JP 2013234011A JP 2014055161 A5 JP2014055161 A5 JP 2014055161A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- substituted
- amide
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 21
- 239000003795 chemical substances by application Substances 0.000 claims 17
- -1 cyano, carboxy Chemical group 0.000 claims 16
- 150000001408 amides Chemical class 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000001475 halogen functional group Chemical group 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 229910003827 NRaRb Inorganic materials 0.000 claims 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000003226 pyrazolyl group Chemical group 0.000 claims 4
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 2
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 2
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 2
- 150000002825 nitriles Chemical class 0.000 claims 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- ICCBZGUDUOMNOF-UHFFFAOYSA-N azidoamine Chemical compound NN=[N+]=[N-] ICCBZGUDUOMNOF-UHFFFAOYSA-N 0.000 claims 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0400199A SE0400199D0 (sv) | 2004-01-30 | 2004-01-30 | HCV Protease inhbitors |
| SE0400199-6 | 2004-01-30 | ||
| SE0401288A SE0401288D0 (sv) | 2004-05-19 | 2004-05-19 | HCV NS-3 Serine Protease Inhbitors |
| SE0401288-6 | 2004-05-19 | ||
| SE0402562-3 | 2004-10-22 | ||
| SE0402562A SE0402562D0 (sv) | 2004-10-22 | 2004-10-22 | HCV Protease Inhbitors |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010279178A Division JP2011140488A (ja) | 2004-01-30 | 2010-12-15 | Ｈｃｖｎｓ−３セリンプロテアーゼインヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014055161A JP2014055161A (ja) | 2014-03-27 |
| JP2014055161A5 true JP2014055161A5 (OSRAM) | 2015-02-26 |
| JP5795619B2 JP5795619B2 (ja) | 2015-10-14 |
Family
ID=34831013
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551000A Expired - Fee Related JP5248783B2 (ja) | 2004-01-30 | 2005-01-28 | Ｈｃｖｎｓ−３セリンプロテアーゼインヒビター |
| JP2006551001A Expired - Fee Related JP4902361B2 (ja) | 2004-01-30 | 2005-01-28 | Ｈｃｖｎｓ−３セリンプロテアーゼインヒビター |
| JP2010279178A Pending JP2011140488A (ja) | 2004-01-30 | 2010-12-15 | Ｈｃｖｎｓ−３セリンプロテアーゼインヒビター |
| JP2013234011A Expired - Fee Related JP5795619B2 (ja) | 2004-01-30 | 2013-11-12 | Ｈｃｖｎｓ−３セリンプロテアーゼインヒビター |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006551000A Expired - Fee Related JP5248783B2 (ja) | 2004-01-30 | 2005-01-28 | Ｈｃｖｎｓ−３セリンプロテアーゼインヒビター |
| JP2006551001A Expired - Fee Related JP4902361B2 (ja) | 2004-01-30 | 2005-01-28 | Ｈｃｖｎｓ−３セリンプロテアーゼインヒビター |
| JP2010279178A Pending JP2011140488A (ja) | 2004-01-30 | 2010-12-15 | Ｈｃｖｎｓ−３セリンプロテアーゼインヒビター |
Country Status (32)
| Country | Link |
|---|---|
| US (5) | US7608590B2 (OSRAM) |
| EP (2) | EP1713822B1 (OSRAM) |
| JP (4) | JP5248783B2 (OSRAM) |
| KR (3) | KR20120090077A (OSRAM) |
| AR (2) | AR047793A1 (OSRAM) |
| AT (2) | ATE448243T1 (OSRAM) |
| AU (2) | AU2005207816C1 (OSRAM) |
| BR (2) | BRPI0506945A (OSRAM) |
| CA (2) | CA2552319C (OSRAM) |
| CR (2) | CR8540A (OSRAM) |
| CY (1) | CY1109779T1 (OSRAM) |
| DE (2) | DE602005019979D1 (OSRAM) |
| DK (2) | DK1713823T3 (OSRAM) |
| EA (2) | EA012410B1 (OSRAM) |
| EC (2) | ECSP066725A (OSRAM) |
| ES (2) | ES2336009T3 (OSRAM) |
| HR (1) | HRP20100048T1 (OSRAM) |
| IL (2) | IL176848A (OSRAM) |
| LU (1) | LU92595I2 (OSRAM) |
| MY (2) | MY146349A (OSRAM) |
| NI (1) | NI200600168A (OSRAM) |
| NL (1) | NL300703I2 (OSRAM) |
| NO (1) | NO341392B1 (OSRAM) |
| NZ (2) | NZ548739A (OSRAM) |
| PL (2) | PL1713822T3 (OSRAM) |
| PT (1) | PT1713823E (OSRAM) |
| RS (1) | RS51243B (OSRAM) |
| SI (1) | SI1713823T1 (OSRAM) |
| TW (2) | TWI367211B (OSRAM) |
| UA (2) | UA84189C2 (OSRAM) |
| WO (2) | WO2005073195A2 (OSRAM) |
| ZA (1) | ZA200607214B (OSRAM) |
Families Citing this family (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| US7176208B2 (en) | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
| CL2004001161A1 (es) * | 2003-05-21 | 2005-04-08 | Boehringer Ingelheim Int | Compuestos describe compuestos derivados de quinolina; composicion farmaceutica; y su uso para tratar una enfermedad causada por el virus de la hepatitis c. |
| US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| EP1713822B1 (en) * | 2004-01-30 | 2010-03-17 | Medivir AB | Hcv ns-3 serine protease inhibitors |
| GEP20104926B (en) * | 2004-03-30 | 2010-03-25 | Intermune Inc | Macrocyclic compounds as inhibitors of viral replication |
| US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7592336B2 (en) | 2005-05-10 | 2009-09-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7601686B2 (en) | 2005-07-11 | 2009-10-13 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN101263156A (zh) | 2005-07-25 | 2008-09-10 | 因特蒙公司 | C型肝炎病毒复制的新颖大环抑制剂 |
| CN101273030B (zh) | 2005-07-29 | 2012-07-18 | 泰博特克药品有限公司 | 丙型肝炎病毒的大环抑制剂 |
| JO2768B1 (en) | 2005-07-29 | 2014-03-15 | تيبوتيك فارماسيوتيكالز ليمتد | Large cyclic inhibitors of hepatitis C virus |
| AR055361A1 (es) * | 2005-07-29 | 2007-08-22 | Medivir Ab | Inhibidores macrociclicos del virus de la hepatitis c |
| MY141245A (en) * | 2005-07-29 | 2010-03-31 | Tibotec Pharm Ltd | Macrocylic inhibitors of hepatitis c virus |
| JP2009502845A (ja) | 2005-07-29 | 2009-01-29 | メディヴィル・アクチボラグ | Ｃ型肝炎ウイルスの大環状インヒビター |
| PE20070343A1 (es) * | 2005-07-29 | 2007-05-12 | Medivir Ab | Inhibidores macrociclicos del virus de la hepatitis c |
| PE20070210A1 (es) * | 2005-07-29 | 2007-04-16 | Tibotec Pharm Ltd | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
| PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
| BRPI0614696A2 (pt) | 2005-07-29 | 2011-04-12 | Tibotec Pharm Ltd | inibidores macrocìclicos de vìrus da hepatite c |
| DE602006019883D1 (de) * | 2005-07-29 | 2011-03-10 | Medivir Ab | Makrocyclische inhibitoren des hepatitis-c-virus |
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| JP5426164B2 (ja) | 2005-07-29 | 2014-02-26 | ヤンセン・アールアンドデイ・アイルランド | Ｃ型肝炎ウイルスの大環式インヒビター |
| AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| CN101415705B (zh) | 2005-10-11 | 2011-10-26 | 因特蒙公司 | 抑制丙型肝炎病毒复制的化合物和方法 |
| US7772183B2 (en) | 2005-10-12 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7655394B2 (en) * | 2005-10-28 | 2010-02-02 | Boehringer Ingelheim International Gmbh | Hepatitis C virus NS2/3 activity assay |
| US7741281B2 (en) | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| KR20090024834A (ko) * | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | Ｃ형 간염 바이러스 복제의 신규 억제제 |
| WO2008008776A2 (en) | 2006-07-11 | 2008-01-17 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| BRPI0714343A2 (pt) | 2006-07-13 | 2013-03-19 | Achillion Pharmaceuticals Inc | peptÍdeos de 4-amino-4-oxobutanoil como inibidores de replicaÇço viral |
| EP1881001A1 (en) * | 2006-07-20 | 2008-01-23 | Tibotec Pharmaceuticals Ltd. | HCV NS-3 serine protease inhibitors |
| EP1881002A1 (en) * | 2006-07-20 | 2008-01-23 | Tibotec Pharmaceuticals Ltd. | HCV NS-3 serine protease inhibitors |
| EP2518494A3 (en) * | 2006-08-09 | 2013-11-20 | Sumitomo Bakelite Company, Ltd. | Sugar chain- capturing substance and use thereof |
| NZ575889A (en) | 2006-10-10 | 2011-09-30 | Medivir Ab | Hcv nucleoside inhibitor |
| US20120220520A1 (en) * | 2006-10-17 | 2012-08-30 | Van T Klooster Gerben Albert Eleutherius | Bioavailable combinations for hcv treatment |
| US8343477B2 (en) | 2006-11-01 | 2013-01-01 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
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| US8003604B2 (en) | 2006-11-16 | 2011-08-23 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7763584B2 (en) | 2006-11-16 | 2010-07-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7888464B2 (en) | 2006-11-16 | 2011-02-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| ES2470568T3 (es) | 2006-11-17 | 2014-06-24 | Janssen R&D Ireland | Inhibidores macroc�clicos del virus de la hepatitis C |
| US8034815B2 (en) | 2007-01-11 | 2011-10-11 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
| ES2547386T3 (es) * | 2007-01-26 | 2015-10-05 | Kaneq Pharma Inc. | Inhibidores de la PTP-1B aromáticos condensados |
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| CN102245599B (zh) | 2008-12-10 | 2014-05-14 | 艾其林医药公司 | 作为病毒复制抑制剂的新的4-氨基-4-氧代丁酰基肽 |
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| CN102356080B (zh) | 2009-02-27 | 2015-04-29 | 奥索-麦克尼尔-詹森药品公司 | Hcv大环抑制剂的无定形盐 |
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