JP2016522172A5 - - Google Patents
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- JP2016522172A5 JP2016522172A5 JP2016507703A JP2016507703A JP2016522172A5 JP 2016522172 A5 JP2016522172 A5 JP 2016522172A5 JP 2016507703 A JP2016507703 A JP 2016507703A JP 2016507703 A JP2016507703 A JP 2016507703A JP 2016522172 A5 JP2016522172 A5 JP 2016522172A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- deuterium
- compound
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229910052739 hydrogen Inorganic materials 0.000 claims 22
- 239000001257 hydrogen Substances 0.000 claims 22
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 20
- 229910052805 deuterium Inorganic materials 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 150000002431 hydrogen Chemical class 0.000 claims 16
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 11
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 9
- 125000005282 allenyl group Chemical group 0.000 claims 9
- 125000004438 haloalkoxy group Chemical group 0.000 claims 8
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- -1 alkyl carbamate Chemical compound 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 230000009385 viral infection Effects 0.000 claims 3
- 241000710781 Flaviviridae Species 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- UCDBLYHPJMMFMY-UHFFFAOYSA-N 8-bromoquinoline-4-carbonitrile Chemical compound C1=CN=C2C(Br)=CC=CC2=C1C#N UCDBLYHPJMMFMY-UHFFFAOYSA-N 0.000 claims 1
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 claims 1
- 208000001490 Dengue Diseases 0.000 claims 1
- 206010012310 Dengue fever Diseases 0.000 claims 1
- 208000005176 Hepatitis C Diseases 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 206010057293 West Nile viral infection Diseases 0.000 claims 1
- 208000003152 Yellow Fever Diseases 0.000 claims 1
- 241000710772 Yellow fever virus Species 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 208000025729 dengue disease Diseases 0.000 claims 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 0 CC(C(N1)=O)=C(*)NC1=O Chemical compound CC(C(N1)=O)=C(*)NC1=O 0.000 description 18
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361811464P | 2013-04-12 | 2013-04-12 | |
| US61/811,464 | 2013-04-12 | ||
| PCT/US2014/034021 WO2014169280A2 (en) | 2013-04-12 | 2014-04-14 | Deuterated nucleoside prodrugs useful for treating hcv |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016522172A JP2016522172A (ja) | 2016-07-28 |
| JP2016522172A5 true JP2016522172A5 (OSRAM) | 2017-06-01 |
Family
ID=50686233
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016507702A Ceased JP2016518359A (ja) | 2013-04-12 | 2014-04-14 | Ｈｃｖを治療するための高活性のヌクレオシド誘導体 |
| JP2016507703A Pending JP2016522172A (ja) | 2013-04-12 | 2014-04-14 | Ｈｃｖを治療するのに有用な重水素化されたヌクレオシドプロドラッグ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016507702A Ceased JP2016518359A (ja) | 2013-04-12 | 2014-04-14 | Ｈｃｖを治療するための高活性のヌクレオシド誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9447132B2 (OSRAM) |
| EP (2) | EP2984097B1 (OSRAM) |
| JP (2) | JP2016518359A (OSRAM) |
| KR (2) | KR20160002896A (OSRAM) |
| CN (2) | CN105705511A (OSRAM) |
| AU (2) | AU2014250762A1 (OSRAM) |
| BR (2) | BR112015025716A2 (OSRAM) |
| CA (2) | CA2909273A1 (OSRAM) |
| ES (1) | ES2623287T3 (OSRAM) |
| RU (2) | RU2015148010A (OSRAM) |
| WO (2) | WO2014169278A1 (OSRAM) |
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-
2014
- 2014-04-14 CN CN201480033500.3A patent/CN105705511A/zh active Pending
- 2014-04-14 RU RU2015148010A patent/RU2015148010A/ru not_active Application Discontinuation
- 2014-04-14 RU RU2015148006A patent/RU2015148006A/ru not_active Application Discontinuation
- 2014-04-14 AU AU2014250762A patent/AU2014250762A1/en not_active Abandoned
- 2014-04-14 KR KR1020157032206A patent/KR20160002896A/ko not_active Withdrawn
- 2014-04-14 EP EP14722955.3A patent/EP2984097B1/en active Active
- 2014-04-14 AU AU2014250764A patent/AU2014250764A1/en not_active Abandoned
- 2014-04-14 WO PCT/US2014/034018 patent/WO2014169278A1/en not_active Ceased
- 2014-04-14 BR BR112015025716A patent/BR112015025716A2/pt not_active IP Right Cessation
- 2014-04-14 BR BR112015025766A patent/BR112015025766A2/pt not_active Application Discontinuation
- 2014-04-14 EP EP14724944.5A patent/EP2984098A2/en not_active Withdrawn
- 2014-04-14 CN CN201480033503.7A patent/CN105377868A/zh active Pending
- 2014-04-14 CA CA2909273A patent/CA2909273A1/en not_active Abandoned
- 2014-04-14 ES ES14722955.3T patent/ES2623287T3/es active Active
- 2014-04-14 JP JP2016507702A patent/JP2016518359A/ja not_active Ceased
- 2014-04-14 KR KR1020157032200A patent/KR20160003700A/ko not_active Withdrawn
- 2014-04-14 CA CA2909270A patent/CA2909270A1/en not_active Abandoned
- 2014-04-14 JP JP2016507703A patent/JP2016522172A/ja active Pending
- 2014-04-14 WO PCT/US2014/034021 patent/WO2014169280A2/en not_active Ceased
- 2014-04-14 US US14/252,290 patent/US9447132B2/en not_active Expired - Fee Related
- 2014-04-14 US US14/252,494 patent/US20140309164A1/en not_active Abandoned
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