ATE385253T1 - Nhibitor-resistente hcv ns3 protease - Google Patents

Nhibitor-resistente hcv ns3 protease

Info

Publication number
ATE385253T1
ATE385253T1 AT03770808T AT03770808T ATE385253T1 AT E385253 T1 ATE385253 T1 AT E385253T1 AT 03770808 T AT03770808 T AT 03770808T AT 03770808 T AT03770808 T AT 03770808T AT E385253 T1 ATE385253 T1 AT E385253T1
Authority
AT
Austria
Prior art keywords
protease
resistant
inhibitor
hcv
nhibitor
Prior art date
Application number
AT03770808T
Other languages
English (en)
Inventor
George Kukolj
Lisette Lagace
Martin Marquis
Daniel Lamarre
Arnim Pause
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of ATE385253T1 publication Critical patent/ATE385253T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Materials For Photolithography (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • External Artificial Organs (AREA)
AT03770808T 2002-10-29 2003-10-24 Nhibitor-resistente hcv ns3 protease ATE385253T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42194302P 2002-10-29 2002-10-29

Publications (1)

Publication Number Publication Date
ATE385253T1 true ATE385253T1 (de) 2008-02-15

Family

ID=32230287

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03770808T ATE385253T1 (de) 2002-10-29 2003-10-24 Nhibitor-resistente hcv ns3 protease

Country Status (13)

Country Link
US (1) US7208309B2 (de)
EP (1) EP1558730B1 (de)
JP (1) JP4295222B2 (de)
AT (1) ATE385253T1 (de)
AU (1) AU2003280239B2 (de)
CA (1) CA2498653C (de)
DE (1) DE60318954T2 (de)
DK (1) DK1558730T3 (de)
ES (1) ES2298585T3 (de)
IL (1) IL168254A (de)
MX (1) MXPA05004276A (de)
NZ (1) NZ540292A (de)
WO (1) WO2004039970A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005000308A2 (en) * 2003-05-15 2005-01-06 Rigel Pharmaceuticals, Inc. Methods of identifying hcv ns5b polymerase inhibitors and use against hepatitis c
CN1894276B (zh) * 2003-10-27 2010-06-16 威特克斯医药股份有限公司 Hcv ns3-ns4a蛋白酶抗药性突变体
ES2336009T3 (es) 2004-01-30 2010-04-07 Medivir Ab Inhibidores de la ns-3 serina proteasa del vhc.
US20090081636A1 (en) * 2005-04-11 2009-03-26 Mingjun Huang Pharmaceutical compositions for and methods of inhibiting HCV replication
US7465537B2 (en) * 2005-05-01 2008-12-16 The Board Of Trustees Of The University Of Arkansas Compounds and methods for inhibiting hepatitis C virus replication
US20070128625A1 (en) * 2005-07-25 2007-06-07 Gilead Sciences, Llc Drug-resistant mutants of hepatitis C virus
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
US7705138B2 (en) 2005-11-11 2010-04-27 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants
EP1951748B1 (de) 2005-11-11 2013-07-24 Vertex Pharmaceuticals, Inc. Varianten des hepatitis-c-virus
EP2527474A1 (de) 2006-10-20 2012-11-28 Innogenetics N.V. Verfahren zur Analyse von Sequenzvariationen innerhalb des HCV-NS3/4A-Genombereichs
US20100143886A1 (en) * 2007-03-09 2010-06-10 Ludmerer Steven W In vivo hcv resistance to anti-viral inhibitors
US8298541B2 (en) * 2007-03-29 2012-10-30 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Live attenuated virus vaccines for La Crosse virus and other Bunyaviridae
EP3199630B1 (de) 2008-09-05 2019-05-08 President and Fellows of Harvard College Kontinuierliche gerichtete evolution von proteinen und nukleinsäuren
EP2655614B1 (de) 2010-12-22 2017-03-15 President and Fellows of Harvard College Kontinuierliche gerichtete evolution
WO2013006722A1 (en) * 2011-07-06 2013-01-10 Gilead Sciences, Inc. Hcv genotype 3 replicons
WO2013006721A1 (en) 2011-07-06 2013-01-10 Gilead Sciences, Inc. Hcv genotype 4 replicons
EP3097196B1 (de) 2014-01-20 2019-09-11 President and Fellows of Harvard College Negativauswahl und stringenzmodulation in systemen der kontinuierlichen evolution
WO2016077052A2 (en) 2014-10-22 2016-05-19 President And Fellows Of Harvard College Evolution of proteases
WO2016168631A1 (en) 2015-04-17 2016-10-20 President And Fellows Of Harvard College Vector-based mutagenesis system
WO2017015545A1 (en) 2015-07-22 2017-01-26 President And Fellows Of Harvard College Evolution of site-specific recombinases
US11524983B2 (en) 2015-07-23 2022-12-13 President And Fellows Of Harvard College Evolution of Bt toxins
US10612011B2 (en) 2015-07-30 2020-04-07 President And Fellows Of Harvard College Evolution of TALENs
US11447809B2 (en) 2017-07-06 2022-09-20 President And Fellows Of Harvard College Evolution of tRNA synthetases
US11624130B2 (en) 2017-09-18 2023-04-11 President And Fellows Of Harvard College Continuous evolution for stabilized proteins
WO2019241649A1 (en) 2018-06-14 2019-12-19 President And Fellows Of Harvard College Evolution of cytidine deaminases
CA3135428A1 (en) 2019-03-29 2020-10-08 Trustees Of Boston University Chimeric antigen receptor (car) modulation
WO2022020431A2 (en) 2020-07-21 2022-01-27 Trustees Of Boston University Inducible control of gene expression

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843752A (en) * 1995-05-12 1998-12-01 Schering Corporation Soluble active hepatitis C virus protease
IT1277914B1 (it) * 1995-08-22 1997-11-12 Angeletti P Ist Richerche Bio Procedimento per produrre - in forma pura e in quantita' elevate - polipeptidi con l'attivita' proteolitica della proteasi ns3 di hcv, e
US5990276A (en) * 1996-05-10 1999-11-23 Schering Corporation Synthetic inhibitors of hepatitis C virus NS3 protease
US6608027B1 (en) * 1999-04-06 2003-08-19 Boehringer Ingelheim (Canada) Ltd Macrocyclic peptides active against the hepatitis C virus
UA74546C2 (en) * 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US6326137B1 (en) * 1999-06-25 2001-12-04 Schering Corporation Hepatitis C virus protease-dependent chimeric pestivirus
US6986892B1 (en) * 1999-11-24 2006-01-17 Chiron Corporation Immunogenic Hepatitis C virus non-structural polypeptides
US20050074465A1 (en) * 1999-11-24 2005-04-07 Michael Houghton HCV fusion proteins with modified NS3 domains
ATE364085T1 (de) * 2000-12-22 2007-06-15 Boehringer Ingelheim Ca Ltd Selbstreplizierendes rna-molekül aus hepatitis-c- virus
WO2002068933A2 (en) * 2001-02-28 2002-09-06 The Scripps Research Institute Small molecule design against drug resistant mutants using directed evolution
CN1894276B (zh) 2003-10-27 2010-06-16 威特克斯医药股份有限公司 Hcv ns3-ns4a蛋白酶抗药性突变体

Also Published As

Publication number Publication date
EP1558730A1 (de) 2005-08-03
WO2004039970A1 (en) 2004-05-13
DE60318954T2 (de) 2009-01-22
IL168254A (en) 2010-11-30
ES2298585T3 (es) 2008-05-16
JP2006503584A (ja) 2006-02-02
DE60318954D1 (de) 2008-03-20
US20050019753A1 (en) 2005-01-27
NZ540292A (en) 2006-09-29
EP1558730B1 (de) 2008-01-30
US7208309B2 (en) 2007-04-24
AU2003280239A1 (en) 2004-05-25
CA2498653A1 (en) 2004-05-13
CA2498653C (en) 2010-12-14
DK1558730T3 (da) 2008-05-26
AU2003280239B2 (en) 2009-03-12
MXPA05004276A (es) 2005-08-03
JP4295222B2 (ja) 2009-07-15

Similar Documents

Publication Publication Date Title
IL168254A (en) Inhibitor-resistant hcv ns3 protease
WO2004101602A3 (en) Hepatitis c inhibitor peptide analogs
TW200615275A (en) Hepatitis C inhibitor dipeptide analogs
HK1081196A1 (en) Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
WO2007016476A3 (en) Hepatitis c serine protease inhibitors and uses therefor
EP1771454A4 (de) Peptidanaloga als hepatitis c-hemmer
DE60332814D1 (de) Peptide als hemmer der serinprotease des hepatitis c virus
IL152022A0 (en) Compounds useful as protease inhibitors and pharmaceutical compositions containing the same
DE602005015834D1 (de) 3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus
RS67004A (en) Macrocyclic peptides active against the hepatitis c virus
DE122012000004I1 (de) Peptide als inhibitoren der NS3-Serinprotease des hepatitis c virus.
HK1090644A1 (en) Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
HK1098164A1 (en) Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
BR0211623A (pt) Agentes de contraste alvos multiméricos com base em peptìdeo
EA200400986A1 (ru) Гетероциклические трипептиды в качестве ингибиторов вируса гепатита c
HK1095594A1 (en) 2-amido-4-aryloxy-1-carbonylpyrrolidine derivatives as inhibitors of serine proteases, particularly hcv ns3-ns4a protease
WO2002048116A3 (en) Inhibitors of hepatitis c virus ns3 protease
IL176237A0 (en) Inhibitors of hepatitis c virus ns3/ns4a serine protease
WO2004014852A3 (en) Iminothiazolidinones as inhibitors of hcv replication
AU2003259155A1 (en) Pharmaceutical compositions comprising hepatitis c viral protease inhibitors
HRP20080014T3 (en) Hepatitis c inhibitor compounds
SE0201976D0 (sv) Novel compounds
IL156774A0 (en) Inhibitors of cruzipain and other cysteine proteases
Bennett et al. The identification of α-ketoamides as potent inhibitors of hepatitis c virus nS3-4a proteinase
BRPI0410861A (pt) métodos e composições para a produção de aminoácidos

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1558730

Country of ref document: EP