JP2013542436A5 - - Google Patents
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- JP2013542436A5 JP2013542436A5 JP2013535387A JP2013535387A JP2013542436A5 JP 2013542436 A5 JP2013542436 A5 JP 2013542436A5 JP 2013535387 A JP2013535387 A JP 2013535387A JP 2013535387 A JP2013535387 A JP 2013535387A JP 2013542436 A5 JP2013542436 A5 JP 2013542436A5
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- JP
- Japan
- Prior art keywords
- reagent composition
- group
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- formula
- ecl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000003153 chemical reaction reagent Substances 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 9
- 239000012491 analyte Substances 0.000 claims 5
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 5
- 238000001514 detection method Methods 0.000 claims 5
- 238000005259 measurement Methods 0.000 claims 4
- 239000003755 preservative agent Substances 0.000 claims 4
- 230000002335 preservative effect Effects 0.000 claims 4
- 239000000376 reactant Substances 0.000 claims 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 2
- 239000004327 boric acid Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000001378 electrochemiluminescence detection Methods 0.000 claims 2
- 150000003512 tertiary amines Chemical class 0.000 claims 2
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical group CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 claims 2
- VJIOSCMTZVXQQU-UHFFFAOYSA-N 2-chlorobutanamide Chemical compound CCC(Cl)C(N)=O VJIOSCMTZVXQQU-UHFFFAOYSA-N 0.000 claims 1
- OEZPDHRXGCLGKB-UHFFFAOYSA-N 2-chloropropanamide Chemical compound CC(Cl)C(N)=O OEZPDHRXGCLGKB-UHFFFAOYSA-N 0.000 claims 1
- FVTWJXMFYOXOKK-UHFFFAOYSA-N 2-fluoroacetamide Chemical compound NC(=O)CF FVTWJXMFYOXOKK-UHFFFAOYSA-N 0.000 claims 1
- JQDXZJYAUSVHDH-UHFFFAOYSA-N 3-chloropropanamide Chemical compound NC(=O)CCCl JQDXZJYAUSVHDH-UHFFFAOYSA-N 0.000 claims 1
- LKJPYSCBVHEWIU-UHFFFAOYSA-N N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide Chemical compound C=1C=C(C#N)C(C(F)(F)F)=CC=1NC(=O)C(O)(C)CS(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-UHFFFAOYSA-N 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- 239000002518 antifoaming agent Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 claims 1
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 claims 1
- 238000004020 luminiscence type Methods 0.000 claims 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N O=C1NCCC1 Chemical compound O=C1NCCC1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10188716.4 | 2010-10-25 | ||
| EP10188716 | 2010-10-25 | ||
| EP10192106 | 2010-11-22 | ||
| EP10192106.2 | 2010-11-22 | ||
| PCT/EP2011/068540 WO2012055815A1 (en) | 2010-10-25 | 2011-10-24 | Use of signal enhancing compounds in electrochemiluminescence detection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013542436A JP2013542436A (ja) | 2013-11-21 |
| JP2013542436A5 true JP2013542436A5 (enExample) | 2014-07-03 |
| JP5824523B2 JP5824523B2 (ja) | 2015-11-25 |
Family
ID=44860372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013535387A Active JP5824523B2 (ja) | 2010-10-25 | 2011-10-24 | 電気化学ルミネセンス検出における信号増強化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9341575B2 (enExample) |
| EP (1) | EP2633289B1 (enExample) |
| JP (1) | JP5824523B2 (enExample) |
| KR (1) | KR101789356B1 (enExample) |
| CN (1) | CN103443614B (enExample) |
| AU (1) | AU2011322704B2 (enExample) |
| BR (1) | BR112013007614B1 (enExample) |
| CA (1) | CA2813089C (enExample) |
| DK (1) | DK2633289T3 (enExample) |
| ES (1) | ES2581553T3 (enExample) |
| HU (1) | HUE029030T2 (enExample) |
| MX (1) | MX336940B (enExample) |
| PL (1) | PL2633289T3 (enExample) |
| SG (1) | SG189113A1 (enExample) |
| WO (1) | WO2012055815A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106153953A (zh) * | 2015-04-03 | 2016-11-23 | 盐城拜明生物技术有限公司 | 一种用于检测血清样品中叶酸含量的叶酸释放剂 |
| JP7039481B2 (ja) | 2016-03-11 | 2022-03-22 | エフ．ホフマン－ラ ロシュ アーゲー | 電気化学発光検出における分枝鎖アミン |
| CN106124753B (zh) * | 2016-07-08 | 2018-03-06 | 广州东林生物科技有限公司 | 电化学发光缓冲液及清洗液 |
| CN108375571B (zh) * | 2018-02-05 | 2019-11-26 | 苏州长光华医生物医学工程有限公司 | 一种用于化学发光免疫检测的磁颗粒试剂及试剂盒 |
| AU2019418498A1 (en) * | 2019-01-03 | 2021-07-15 | Meso Scale Technologies, Llc | Compositions and methods for carrying out assay measurements |
| EP4006529A4 (en) * | 2019-07-31 | 2023-01-18 | Hitachi High-Tech Corporation | METHOD AND DEVICE FOR THE ANALYSIS OF BIOMOLECULES |
| CN115518417B (zh) * | 2022-09-01 | 2024-09-06 | 天津鸿宇泰生物科技有限公司 | 用于化学发光检测试剂的消泡剂组合物、使用方法和应用 |
| CN115494232B (zh) * | 2022-10-31 | 2023-10-27 | 江苏三联生物工程股份有限公司 | 4,4-二甲基噁唑啉在制备含辣根过氧化物酶的试剂中的应用 |
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| NL178647C (nl) * | 1974-03-08 | 1986-05-01 | Duphar Int Res | Werkwijze ter bereiding van een de plantengroei bevorderende vloeibare samenstelling. |
| US4698302A (en) | 1983-05-12 | 1987-10-06 | Advanced Magnetics, Inc. | Enzymatic reactions using magnetic particles |
| US4628037A (en) | 1983-05-12 | 1986-12-09 | Advanced Magnetics, Inc. | Binding assays employing magnetic particles |
| US4554088A (en) | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4695393A (en) | 1983-05-12 | 1987-09-22 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US5310687A (en) | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5591581A (en) | 1986-04-30 | 1997-01-07 | Igen, Inc. | Electrochemiluminescent rhenium moieties and methods for their use |
| US6165729A (en) | 1986-04-30 | 2000-12-26 | Hyperion Catalysis International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| US6316607B1 (en) | 1986-04-30 | 2001-11-13 | Igen International, Inc. | Electrochemiluminescent assays |
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| US4965392A (en) | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
| US5935779A (en) | 1988-11-03 | 1999-08-10 | Igen International Inc. | Methods for improved particle electrochemiluminescence assay |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5308754A (en) | 1988-03-21 | 1994-05-03 | Kankare Jouko J | Electrogenerated luminescence in solution |
| US5093268A (en) | 1988-04-28 | 1992-03-03 | Igen, Inc. | Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena |
| US5705402A (en) | 1988-11-03 | 1998-01-06 | Igen International, Inc. | Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets |
| US5779976A (en) * | 1988-11-03 | 1998-07-14 | Igen International, Inc. | Apparatus for improved luminescence assays |
| CA2002083C (en) | 1988-11-03 | 2001-01-09 | Haresh P. Shah | Enhanced electrochemiluminescence |
| US5324457A (en) | 1989-10-02 | 1994-06-28 | Board Of Regents, The University Of Tx System | Devices and methods for generating electrogenerated chemiluminescence |
| JPH0534345A (ja) | 1991-02-19 | 1993-02-09 | Tdk Corp | 化学発光を利用する抗原・抗体の測定方法 |
| ZA929351B (en) | 1991-12-11 | 1993-06-04 | Igen Inc | Electrochemiluminescent label for DNA assays. |
| JP3541047B2 (ja) * | 1993-02-18 | 2004-07-07 | 日本化薬株式会社 | バイオリアクターの防腐剤および測定法 |
| CN1089899C (zh) * | 1993-05-03 | 2002-08-28 | 罗赫诊断器材股份有限公司 | 电致化学发光分析 |
| DE4401577A1 (de) * | 1993-05-03 | 1994-11-10 | Boehringer Mannheim Gmbh | Elektrochemilumineszenzverfahren |
| US5466416A (en) | 1993-05-14 | 1995-11-14 | Ghaed; Ali | Apparatus and methods for carrying out electrochemiluminescence test measurements |
| CN1046531C (zh) | 1994-07-25 | 1999-11-17 | 伯伦格·曼海姆有限公司 | 有带电连接基的金属配合物、轭合物及其用途和制备方法 |
| US5786141A (en) | 1994-08-26 | 1998-07-28 | Bard; Allen J. | Electrogenerated chemiluminescence labels for analysis and/or referencing |
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| US5641623A (en) | 1995-01-04 | 1997-06-24 | Martin; Mark T. | Electrochemiluminescence assay |
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| US20010003647A1 (en) | 1995-06-07 | 2001-06-14 | Ji Sun | Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same |
| CA2213854C (en) | 1995-03-10 | 2010-08-10 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
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| GB9606850D0 (en) | 1996-04-01 | 1996-06-05 | Univ Liverpool | An assay system and novel labelled compounds for use therwith |
| FI970593A7 (fi) * | 1997-02-12 | 1998-08-13 | Ala Kleme Timo | Pinnoitettujen johteiden käyttö analyyttisiin tarkoituksiin |
| FR2764381A1 (fr) | 1997-06-09 | 1998-12-11 | Univ De Neuchatel | Detecteur electrochimioluminescent |
| US6413783B1 (en) | 1997-09-18 | 2002-07-02 | Meso Scale Technologies, Llc | Assay sonication apparatus and methodology |
| DE19803528A1 (de) | 1998-01-30 | 1999-08-05 | Roche Diagnostics Gmbh | Verfahren zur Analyse einer Probe mittels eines Elektrochemolumineszenz-Bindungsreaktion-Tests |
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| EP0962773A1 (en) | 1998-06-03 | 1999-12-08 | Mark Howard Jones | Electrochemical based assay processes instrument and labels |
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| EP1436598B1 (en) * | 2001-09-10 | 2013-11-27 | Meso Scale Technologies LLC | Assay buffer, compositions containing the same, and methods of using the same |
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| FI119894B (fi) * | 2005-03-30 | 2009-04-30 | Labmaster Oy | Elektrokemiluminesenssiin perustuva analyysimenetelmä ja siinä käytettävä laite |
| US20070116600A1 (en) * | 2005-06-23 | 2007-05-24 | Kochar Manish S | Detection device and methods associated therewith |
| KR101489804B1 (ko) | 2005-12-21 | 2015-02-05 | 메소 스케일 테크놀러지즈, 엘엘시 | 분석 시약을 갖는 분석 모듈 및 그것의 제조 및 사용 방법 |
| ATE530895T1 (de) | 2006-08-25 | 2011-11-15 | Hoffmann La Roche | Zelle zur durchführung elektrochemilumineszenter messungen |
| CN101246125A (zh) * | 2008-03-14 | 2008-08-20 | 华南师范大学 | 基于纳米/微米粒子放大信号的非pcr扩增的快速检测转基因产品的电化学发光方法 |
| JP2010237020A (ja) * | 2009-03-31 | 2010-10-21 | Japan Aerospace Exploration Agency | 生体分子検出装置及び生体分子検出方法 |
| FI20100246A7 (fi) * | 2010-06-11 | 2011-12-12 | Jarkko Eskola | Menetelmät ja laitteet luminesenssin tuottamiseksi integroiduista elektrodisiruista katodisten ja bipolaaristen pulssien avulla |
-
2011
- 2011-10-24 ES ES11774051.4T patent/ES2581553T3/es active Active
- 2011-10-24 CN CN201180062441.9A patent/CN103443614B/zh active Active
- 2011-10-24 WO PCT/EP2011/068540 patent/WO2012055815A1/en not_active Ceased
- 2011-10-24 CA CA2813089A patent/CA2813089C/en active Active
- 2011-10-24 MX MX2013004230A patent/MX336940B/es active IP Right Grant
- 2011-10-24 DK DK11774051.4T patent/DK2633289T3/en active
- 2011-10-24 SG SG2013022553A patent/SG189113A1/en unknown
- 2011-10-24 AU AU2011322704A patent/AU2011322704B2/en not_active Ceased
- 2011-10-24 BR BR112013007614-3A patent/BR112013007614B1/pt not_active IP Right Cessation
- 2011-10-24 HU HUE11774051A patent/HUE029030T2/en unknown
- 2011-10-24 JP JP2013535387A patent/JP5824523B2/ja active Active
- 2011-10-24 EP EP11774051.4A patent/EP2633289B1/en active Active
- 2011-10-24 KR KR1020137009849A patent/KR101789356B1/ko not_active Expired - Fee Related
- 2011-10-24 PL PL11774051.4T patent/PL2633289T3/pl unknown
-
2013
- 2013-03-15 US US13/844,778 patent/US9341575B2/en active Active
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