JP2013541339A5 - - Google Patents
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- JP2013541339A5 JP2013541339A5 JP2013532235A JP2013532235A JP2013541339A5 JP 2013541339 A5 JP2013541339 A5 JP 2013541339A5 JP 2013532235 A JP2013532235 A JP 2013532235A JP 2013532235 A JP2013532235 A JP 2013532235A JP 2013541339 A5 JP2013541339 A5 JP 2013541339A5
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- JP
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- Prior art keywords
- expression level
- maf
- gene
- metastasis
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 44
- 102100039189 Transcription factor Maf Human genes 0.000 claims description 41
- 230000014509 gene expression Effects 0.000 claims description 39
- 206010027476 Metastases Diseases 0.000 claims description 37
- 230000009401 metastasis Effects 0.000 claims description 36
- 108090000623 proteins and genes Proteins 0.000 claims description 34
- 206010006187 Breast cancer Diseases 0.000 claims description 18
- 208000026310 Breast neoplasm Diseases 0.000 claims description 18
- 239000013068 control sample Substances 0.000 claims description 17
- 102000014128 RANK Ligand Human genes 0.000 claims description 16
- 108010025832 RANK Ligand Proteins 0.000 claims description 16
- 210000000988 bone and bone Anatomy 0.000 claims description 16
- 239000000523 sample Substances 0.000 claims description 14
- 210000001519 tissue Anatomy 0.000 claims description 13
- 239000003112 inhibitor Substances 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 206010028980 Neoplasm Diseases 0.000 claims description 9
- 230000003321 amplification Effects 0.000 claims description 9
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 9
- 229940122361 Bisphosphonate Drugs 0.000 claims description 8
- 150000004663 bisphosphonates Chemical class 0.000 claims description 8
- 238000000338 in vitro Methods 0.000 claims description 8
- 238000011282 treatment Methods 0.000 claims description 7
- 108020004635 Complementary DNA Proteins 0.000 claims description 6
- 206010027452 Metastases to bone Diseases 0.000 claims description 6
- 238000010804 cDNA synthesis Methods 0.000 claims description 6
- 239000002299 complementary DNA Substances 0.000 claims description 6
- 201000007281 estrogen-receptor positive breast cancer Diseases 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 108020004999 messenger RNA Proteins 0.000 claims description 6
- 230000015556 catabolic process Effects 0.000 claims description 5
- 238000006731 degradation reaction Methods 0.000 claims description 5
- 230000000010 osteolytic effect Effects 0.000 claims description 5
- 102000055006 Calcitonin Human genes 0.000 claims description 4
- 108060001064 Calcitonin Proteins 0.000 claims description 4
- 102000004171 Cathepsin K Human genes 0.000 claims description 4
- 108090000625 Cathepsin K Proteins 0.000 claims description 4
- 208000003076 Osteolysis Diseases 0.000 claims description 4
- 102000008108 Osteoprotegerin Human genes 0.000 claims description 4
- 108010035042 Osteoprotegerin Proteins 0.000 claims description 4
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims description 4
- 229960004015 calcitonin Drugs 0.000 claims description 4
- 229960001251 denosumab Drugs 0.000 claims description 4
- 239000002834 estrogen receptor modulator Substances 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 208000029791 lytic metastatic bone lesion Diseases 0.000 claims description 4
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 4
- XXUPLYBCNPLTIW-UHFFFAOYSA-N octadec-7-ynoic acid Chemical compound CCCCCCCCCCC#CCCCCCC(O)=O XXUPLYBCNPLTIW-UHFFFAOYSA-N 0.000 claims description 4
- 238000003752 polymerase chain reaction Methods 0.000 claims description 4
- 238000004393 prognosis Methods 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 229940079488 strontium ranelate Drugs 0.000 claims description 4
- XXUZFRDUEGQHOV-UHFFFAOYSA-J strontium ranelate Chemical compound [Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N XXUZFRDUEGQHOV-UHFFFAOYSA-J 0.000 claims description 4
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical group OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims description 4
- 229960004276 zoledronic acid Drugs 0.000 claims description 4
- 238000003745 diagnosis Methods 0.000 claims description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 2
- 102000053642 Catalytic RNA Human genes 0.000 claims description 2
- 108090000994 Catalytic RNA Proteins 0.000 claims description 2
- 108020004414 DNA Proteins 0.000 claims description 2
- 238000002965 ELISA Methods 0.000 claims description 2
- 108091034117 Oligonucleotide Proteins 0.000 claims description 2
- 108020004459 Small interfering RNA Proteins 0.000 claims description 2
- 239000000074 antisense oligonucleotide Substances 0.000 claims description 2
- 238000012230 antisense oligonucleotides Methods 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000007901 in situ hybridization Methods 0.000 claims description 2
- 238000003498 protein array Methods 0.000 claims description 2
- 238000003753 real-time PCR Methods 0.000 claims description 2
- 108091092562 ribozyme Proteins 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 238000001262 western blot Methods 0.000 claims description 2
- 241000287463 Phalacrocorax Species 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 description 3
- 239000013543 active substance Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201031478A ES2379918B1 (es) | 2010-10-06 | 2010-10-06 | Método para el diagnóstico, pronóstico y tratamiento de la metástasis de cáncer de mama. |
| ESP201031478 | 2010-10-06 | ||
| ES201131073 | 2011-06-27 | ||
| ESP201131073 | 2011-06-27 | ||
| PCT/ES2011/070693 WO2012045905A2 (es) | 2010-10-06 | 2011-10-05 | Método para el diagnóstico, pronóstico y tratamiento de la metástasis de cáncer de mama |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017011967A Division JP6571698B2 (ja) | 2010-10-06 | 2017-01-26 | 乳がん転移の診断、予後診断、および処置のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013541339A JP2013541339A (ja) | 2013-11-14 |
| JP2013541339A5 true JP2013541339A5 (enExample) | 2014-11-27 |
| JP6159254B2 JP6159254B2 (ja) | 2017-07-12 |
Family
ID=45099129
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013532235A Active JP6159254B2 (ja) | 2010-10-06 | 2011-10-05 | 乳がん転移の診断、予後診断、および処置のための方法 |
| JP2017011967A Active JP6571698B2 (ja) | 2010-10-06 | 2017-01-26 | 乳がん転移の診断、予後診断、および処置のための方法 |
| JP2018054132A Pending JP2018099132A (ja) | 2010-10-06 | 2018-03-22 | 乳がん転移の診断、予後診断、および処置のための方法 |
| JP2019146185A Active JP6946385B2 (ja) | 2010-10-06 | 2019-08-08 | 乳がん転移の診断、予後診断、および処置のための方法 |
| JP2021150170A Pending JP2021192636A (ja) | 2010-10-06 | 2021-09-15 | 乳がん転移の診断、予後診断、および処置のための方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017011967A Active JP6571698B2 (ja) | 2010-10-06 | 2017-01-26 | 乳がん転移の診断、予後診断、および処置のための方法 |
| JP2018054132A Pending JP2018099132A (ja) | 2010-10-06 | 2018-03-22 | 乳がん転移の診断、予後診断、および処置のための方法 |
| JP2019146185A Active JP6946385B2 (ja) | 2010-10-06 | 2019-08-08 | 乳がん転移の診断、予後診断、および処置のための方法 |
| JP2021150170A Pending JP2021192636A (ja) | 2010-10-06 | 2021-09-15 | 乳がん転移の診断、予後診断、および処置のための方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10047398B2 (enExample) |
| EP (3) | EP2626431B1 (enExample) |
| JP (5) | JP6159254B2 (enExample) |
| KR (2) | KR101944555B1 (enExample) |
| CN (2) | CN103339265B (enExample) |
| AR (1) | AR083357A1 (enExample) |
| AU (4) | AU2011311452B2 (enExample) |
| BR (1) | BR112013008505B1 (enExample) |
| CA (1) | CA2813674C (enExample) |
| DK (2) | DK3091085T3 (enExample) |
| ES (3) | ES2562274T3 (enExample) |
| MX (2) | MX382266B (enExample) |
| WO (1) | WO2012045905A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2562274T3 (es) | 2010-10-06 | 2016-03-03 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Procedimiento para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de mama |
| EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
| EP3467124A1 (en) * | 2012-06-06 | 2019-04-10 | Fundació Institut de Recerca Biomèdica IRB (Barcelona) | Method for the diagnosis, prognosis and treatment of lung cancer metastasis |
| US10119171B2 (en) | 2012-10-12 | 2018-11-06 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
| CA2888122A1 (en) * | 2012-10-12 | 2014-04-17 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis using c-maf |
| US20160032399A1 (en) * | 2013-03-15 | 2016-02-04 | Inbiomotion S.L. | Method for the Prognosis and Treatment of Renal Cell Carcinoma Metastasis |
| KR20150122786A (ko) * | 2013-03-15 | 2015-11-02 | 펀다시오 인스티튜트 드 르세르카 바이오메디카 (아이알비 바르셀로나) | 암 전이의 진단, 예후 및 치료를 위한 방법 |
| US20160032400A1 (en) * | 2013-03-15 | 2016-02-04 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Method for the prognosis and treatment of cancer metastasis |
| EP3524698A1 (en) * | 2013-10-09 | 2019-08-14 | Fundació Institut de Recerca Biomèdica IRB (Barcelona) | Method for the prognosis and treatment of cancer metastasis |
| EP2933639A1 (en) * | 2014-04-16 | 2015-10-21 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | S100p and Hyaluronic acid as biomarkers for metastatic breast cancer |
| CN104398506A (zh) * | 2014-12-09 | 2015-03-11 | 厦门大学 | 雷奈酸锶在制备预防和治疗腺癌药物中的新用途 |
| KR20170093182A (ko) | 2014-12-11 | 2017-08-14 | 인바이오모션 에스.엘. | 인간 c-maf에 대한 결합 구성원 |
| CA3025264A1 (en) * | 2016-05-25 | 2017-11-30 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-maf status |
| KR101896558B1 (ko) | 2016-11-21 | 2018-09-07 | 주식회사 젠큐릭스 | 유방암 환자의 예후 예측 방법 |
| CN107699619B (zh) * | 2017-11-17 | 2019-02-22 | 柳超 | lncRNA组合物及制备诊断预示Luminal B型乳腺癌骨转移基因诊断试剂盒的用途 |
| CA3082728A1 (en) | 2017-11-22 | 2019-05-31 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-maf status |
| JP2023079997A (ja) | 2021-11-29 | 2023-06-08 | 東洋インキＳｃホールディングス株式会社 | 活性エネルギー線硬化型インクジェットインキ及び印刷物 |
| CN114574577A (zh) * | 2022-01-04 | 2022-06-03 | 中山大学孙逸仙纪念医院 | Mettl16基因及其用途 |
| CN119614707A (zh) * | 2025-01-13 | 2025-03-14 | 中山大学 | ERα生物标志物在ER+乳腺癌骨转移诊断、治疗和预后中的应用 |
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| EP3467124A1 (en) | 2012-06-06 | 2019-04-10 | Fundació Institut de Recerca Biomèdica IRB (Barcelona) | Method for the diagnosis, prognosis and treatment of lung cancer metastasis |
| CA2888122A1 (en) | 2012-10-12 | 2014-04-17 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis using c-maf |
| US10119171B2 (en) | 2012-10-12 | 2018-11-06 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
| US20160032400A1 (en) | 2013-03-15 | 2016-02-04 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Method for the prognosis and treatment of cancer metastasis |
| KR20150122786A (ko) | 2013-03-15 | 2015-11-02 | 펀다시오 인스티튜트 드 르세르카 바이오메디카 (아이알비 바르셀로나) | 암 전이의 진단, 예후 및 치료를 위한 방법 |
| US20160032399A1 (en) | 2013-03-15 | 2016-02-04 | Inbiomotion S.L. | Method for the Prognosis and Treatment of Renal Cell Carcinoma Metastasis |
| EP3524698A1 (en) | 2013-10-09 | 2019-08-14 | Fundació Institut de Recerca Biomèdica IRB (Barcelona) | Method for the prognosis and treatment of cancer metastasis |
| KR20170093182A (ko) | 2014-12-11 | 2017-08-14 | 인바이오모션 에스.엘. | 인간 c-maf에 대한 결합 구성원 |
| CA3025264A1 (en) | 2016-05-25 | 2017-11-30 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-maf status |
| CA3082728A1 (en) | 2017-11-22 | 2019-05-31 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-maf status |
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