JP2008536480A5 - - Google Patents
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- JP2008536480A5 JP2008536480A5 JP2007556309A JP2007556309A JP2008536480A5 JP 2008536480 A5 JP2008536480 A5 JP 2008536480A5 JP 2007556309 A JP2007556309 A JP 2007556309A JP 2007556309 A JP2007556309 A JP 2007556309A JP 2008536480 A5 JP2008536480 A5 JP 2008536480A5
- Authority
- JP
- Japan
- Prior art keywords
- marker
- cancer
- subject
- sample
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003550 marker Substances 0.000 claims 45
- 206010028980 Neoplasm Diseases 0.000 claims 36
- 201000011510 cancer Diseases 0.000 claims 36
- 239000000523 sample Substances 0.000 claims 28
- 238000000034 method Methods 0.000 claims 27
- 230000000694 effects Effects 0.000 claims 23
- 108090000623 proteins and genes Proteins 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 2
- 238000010171 animal model Methods 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000009368 gene silencing by RNA Effects 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000003753 real-time PCR Methods 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 108091023037 Aptamer Proteins 0.000 claims 1
- 102100026596 Bcl-2-like protein 1 Human genes 0.000 claims 1
- 101150008012 Bcl2l1 gene Proteins 0.000 claims 1
- 101000830894 Homo sapiens Targeting protein for Xklp2 Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 claims 1
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 claims 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 102100024813 Targeting protein for Xklp2 Human genes 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 108700000711 bcl-X Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 230000000052 comparative effect Effects 0.000 claims 1
- -1 comparing Chemical class 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000007901 in situ hybridization Methods 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 238000006452 multicomponent reaction Methods 0.000 claims 1
- 239000002853 nucleic acid probe Substances 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65422705P | 2005-02-17 | 2005-02-17 | |
| US69006405P | 2005-06-13 | 2005-06-13 | |
| PCT/US2006/005584 WO2006089087A2 (en) | 2005-02-17 | 2006-02-17 | Compositions, kits and methods for identification, assessment, prevention and therapy of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008536480A JP2008536480A (ja) | 2008-09-11 |
| JP2008536480A5 true JP2008536480A5 (enExample) | 2009-03-26 |
Family
ID=36917075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007556309A Pending JP2008536480A (ja) | 2005-02-17 | 2006-02-17 | 癌の同定、評価、予防、および治療用組成物、キット、および方法、ならびに癌の治療法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8168602B2 (enExample) |
| EP (1) | EP1855727A2 (enExample) |
| JP (1) | JP2008536480A (enExample) |
| CA (1) | CA2595699A1 (enExample) |
| WO (1) | WO2006089087A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007095186A2 (en) * | 2006-02-14 | 2007-08-23 | Dana-Farber Cancer Institute, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer |
| WO2008016996A2 (en) * | 2006-08-01 | 2008-02-07 | Joslin Diabetes Center, Inc. | Methods of modulating metabolic memory |
| WO2008033782A2 (en) * | 2006-09-12 | 2008-03-20 | Genentech, Inc. | Methods and compositions for the diagnosis and treatment of lung cancer using pdgfra, kit or kdr gene as genetic marker |
| WO2008144724A1 (en) * | 2007-05-21 | 2008-11-27 | Dana-Farber Cancer Institute, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer |
| US20090075266A1 (en) * | 2007-09-14 | 2009-03-19 | Predictive Biosciences Corporation | Multiple analyte diagnostic readout |
| JP2011001267A (ja) * | 2007-10-17 | 2011-01-06 | Univ Of Tokyo | 大腸癌治療薬 |
| JP5586164B2 (ja) * | 2009-04-06 | 2014-09-10 | 聡明 渡邉 | 潰瘍性大腸炎患者の癌化リスクを決定する方法 |
| WO2010121370A1 (en) * | 2009-04-20 | 2010-10-28 | University Health Network | Prognostic gene expression signature for squamous cell carcinoma of the lung |
| CN102906275A (zh) | 2010-02-10 | 2013-01-30 | 加利福尼亚大学董事会 | 肺癌检测的唾液生物标记 |
| EP2913405B1 (en) | 2010-07-27 | 2016-11-09 | Genomic Health, Inc. | Method for using gene expression to determine prognosis of prostate cancer |
| US8709718B1 (en) | 2011-02-12 | 2014-04-29 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Method of treating lung cancer |
| CA2852098C (en) * | 2011-10-21 | 2023-05-02 | Chronix Biomedical | Colorectal cancer associated circulating nucleic acid biomarkers |
| BR112014019168B1 (pt) | 2012-02-03 | 2021-10-05 | California Institute Of Technology | Método capaz de detectar de forma não degenerada presença ou ausência de analitos em um único volume de amostra e método de detecção da presença ou ausência de cada analito dentre uma pluralidade de analitos |
| CN109979526B (zh) * | 2014-03-25 | 2023-11-24 | 凡弗3基因组有限公司 | 用于功能证实癌症突变的rna分析的系统和方法 |
| HK1255541A1 (zh) | 2015-12-11 | 2019-08-23 | Immatics Biotechnologies Gmbh | 用於多种癌症免疫治疗的新型肽和肽组合物 |
| GB201521894D0 (en) | 2015-12-11 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various cancers |
| WO2017127537A1 (en) * | 2016-01-19 | 2017-07-27 | Thomas Blumenthal | Down syndrome biomarkers and uses thereof |
| EP3203413A1 (en) * | 2016-02-08 | 2017-08-09 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method for quantitative measurement of a biomarker by in situ immunofluorescence and uses thereof |
| EP3665308A1 (en) | 2017-08-07 | 2020-06-17 | The Johns Hopkins University | Methods and materials for assessing and treating cancer |
| CN109125729A (zh) * | 2018-09-06 | 2019-01-04 | 苏州吉玛基因股份有限公司 | 与非小细胞肺癌诊疗相关的基因BRD9及其siRNAs和应用 |
| JP7262736B2 (ja) * | 2018-10-31 | 2023-04-24 | 公立大学法人北九州市立大学 | 癌の診断を補助する方法、および癌を診断するシステム |
| US20220280544A1 (en) * | 2019-07-24 | 2022-09-08 | Tohoku University | Chimeric molecule, pharmaceutical composition, method for cleaving target nucleic acid, and kit for target nucleic acid cleavage or diagnosis |
| CN110317876A (zh) * | 2019-08-02 | 2019-10-11 | 苏州宏元生物科技有限公司 | 一组染色体不稳定变异在制备诊断多发性骨髓瘤、评估预后的试剂或试剂盒中的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6602713B1 (en) * | 2001-02-09 | 2003-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of protein phosphatase 2 catalytic subunit beta expression |
| US5783683A (en) * | 1995-01-10 | 1998-07-21 | Genta Inc. | Antisense oligonucleotides which reduce expression of the FGFRI gene |
| JP4658936B2 (ja) * | 2004-03-24 | 2011-03-23 | オンコセラピー・サイエンス株式会社 | 肺癌を治療するための組成物および方法 |
| JP2008512984A (ja) * | 2004-05-28 | 2008-05-01 | ダナ−ファーバー キャンサー インスティチュート，インコーポレイテッド | 癌の同定、評価、予防および治療のための組成物、キットおよび方法 |
-
2006
- 2006-02-17 US US11/816,601 patent/US8168602B2/en not_active Expired - Fee Related
- 2006-02-17 JP JP2007556309A patent/JP2008536480A/ja active Pending
- 2006-02-17 WO PCT/US2006/005584 patent/WO2006089087A2/en not_active Ceased
- 2006-02-17 CA CA002595699A patent/CA2595699A1/en not_active Abandoned
- 2006-02-17 EP EP06735309A patent/EP1855727A2/en not_active Withdrawn
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