JP2012522756A5 - - Google Patents
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- Publication number
- JP2012522756A5 JP2012522756A5 JP2012502710A JP2012502710A JP2012522756A5 JP 2012522756 A5 JP2012522756 A5 JP 2012522756A5 JP 2012502710 A JP2012502710 A JP 2012502710A JP 2012502710 A JP2012502710 A JP 2012502710A JP 2012522756 A5 JP2012522756 A5 JP 2012522756A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- lif
- inhibitor
- gene
- glioma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims 27
- 206010028980 Neoplasm Diseases 0.000 claims 22
- 102100032352 Leukemia inhibitory factor Human genes 0.000 claims 19
- 201000011510 cancer Diseases 0.000 claims 19
- 239000003112 inhibitor Substances 0.000 claims 17
- 238000000034 method Methods 0.000 claims 16
- 208000032612 Glial tumor Diseases 0.000 claims 10
- 206010018338 Glioma Diseases 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 5
- 239000012472 biological sample Substances 0.000 claims 4
- 108020004635 Complementary DNA Proteins 0.000 claims 3
- 230000004163 JAK-STAT signaling pathway Effects 0.000 claims 3
- 102100021747 Leukemia inhibitory factor receptor Human genes 0.000 claims 3
- 101710142062 Leukemia inhibitory factor receptor Proteins 0.000 claims 3
- 238000010804 cDNA synthesis Methods 0.000 claims 3
- 239000002299 complementary DNA Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000013068 control sample Substances 0.000 claims 3
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 208000025324 B-cell acute lymphoblastic leukemia Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 238000011002 quantification Methods 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 108700026220 vif Genes Proteins 0.000 claims 2
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- -1 antibodies Proteins 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 102000003675 cytokine receptors Human genes 0.000 claims 1
- 108010057085 cytokine receptors Proteins 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 238000002991 immunohistochemical analysis Methods 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000003752 polymerase chain reaction Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 238000003753 real-time PCR Methods 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 210000001541 thymus gland Anatomy 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP200900928 | 2009-04-03 | ||
| ES200900928A ES2363358B1 (es) | 2009-04-03 | 2009-04-03 | Agentes terapéuticos para el tratamiento de enfermedades asociadas con una proliferación celular indeseable. |
| PCT/EP2010/054499 WO2010115868A2 (en) | 2009-04-03 | 2010-04-06 | Therapeutic agents for the treatment of diseases associated with undesired cell proliferation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015178986A Division JP2016040255A (ja) | 2009-04-03 | 2015-09-11 | 望ましくない細胞増殖と関連する疾患の治療のための治療剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012522756A JP2012522756A (ja) | 2012-09-27 |
| JP2012522756A5 true JP2012522756A5 (enExample) | 2013-05-23 |
| JP6207836B2 JP6207836B2 (ja) | 2017-10-04 |
Family
ID=42342718
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502710A Active JP6207836B2 (ja) | 2009-04-03 | 2010-04-06 | 望ましくない細胞増殖と関連する疾患の治療のための治療剤 |
| JP2015178986A Pending JP2016040255A (ja) | 2009-04-03 | 2015-09-11 | 望ましくない細胞増殖と関連する疾患の治療のための治療剤 |
| JP2018152551A Pending JP2019006784A (ja) | 2009-04-03 | 2018-08-14 | 望ましくない細胞増殖と関連する疾患の治療のための治療剤 |
| JP2020016672A Pending JP2020090522A (ja) | 2009-04-03 | 2020-02-04 | 望ましくない細胞増殖と関連する疾患の治療のための治療剤 |
| JP2021186785A Active JP7197665B2 (ja) | 2009-04-03 | 2021-11-17 | 望ましくない細胞増殖と関連する疾患の治療のための治療剤 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015178986A Pending JP2016040255A (ja) | 2009-04-03 | 2015-09-11 | 望ましくない細胞増殖と関連する疾患の治療のための治療剤 |
| JP2018152551A Pending JP2019006784A (ja) | 2009-04-03 | 2018-08-14 | 望ましくない細胞増殖と関連する疾患の治療のための治療剤 |
| JP2020016672A Pending JP2020090522A (ja) | 2009-04-03 | 2020-02-04 | 望ましくない細胞増殖と関連する疾患の治療のための治療剤 |
| JP2021186785A Active JP7197665B2 (ja) | 2009-04-03 | 2021-11-17 | 望ましくない細胞増殖と関連する疾患の治療のための治療剤 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US10100112B2 (enExample) |
| EP (2) | EP3045474B1 (enExample) |
| JP (5) | JP6207836B2 (enExample) |
| KR (6) | KR102373754B1 (enExample) |
| CN (2) | CN107964043A (enExample) |
| AU (1) | AU2010233791B2 (enExample) |
| BR (1) | BRPI1015369A2 (enExample) |
| CA (1) | CA2757680C (enExample) |
| CY (1) | CY1124148T1 (enExample) |
| DK (1) | DK3045474T3 (enExample) |
| EA (1) | EA201101450A1 (enExample) |
| ES (2) | ES2363358B1 (enExample) |
| HR (1) | HRP20210352T1 (enExample) |
| HU (1) | HUE054196T2 (enExample) |
| IL (1) | IL215467A (enExample) |
| LT (1) | LT3045474T (enExample) |
| MX (1) | MX336903B (enExample) |
| PL (1) | PL3045474T3 (enExample) |
| PT (1) | PT3045474T (enExample) |
| SG (2) | SG10202010568RA (enExample) |
| SI (1) | SI3045474T1 (enExample) |
| SM (1) | SMT202100153T1 (enExample) |
| WO (1) | WO2010115868A2 (enExample) |
| ZA (1) | ZA201107215B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2790675C (en) * | 2005-07-19 | 2016-12-20 | Stemgen S.P.A. | Inhibition of the tumorigenic potential of tumor stem cells by lif and bmps |
| EP2371860A1 (en) | 2010-04-05 | 2011-10-05 | Fundació Privada Institut d'Investigació Oncològica de Vall d'Hebron | Antibody recognising human leukemia inhibitory factor (LIF) and use of anti-LIF antibodies in the treatment of diseases associated with unwanted cell proliferation |
| JP2015071566A (ja) * | 2013-10-03 | 2015-04-16 | 住友ベークライト株式会社 | Ｆｇｆ４遺伝子増幅腫瘍の医薬組成物 |
| WO2015136557A2 (en) * | 2014-03-11 | 2015-09-17 | Godavari Biorefineries Limited | Cancer stem cell targeting compounds |
| JP6842926B2 (ja) * | 2014-06-30 | 2021-03-17 | アルター・バイオサイエンス・コーポレーション | Ｉｌ−１５ベース分子及びその使用方法 |
| EP3191129A4 (en) * | 2014-09-10 | 2018-03-14 | The Regents of The University of California | TARGETING K-RAS-MEDIATED SIGNALING PATHWAYS AND MALIGNANCY BY ANTI-hLIF ANTIBODIES |
| EP3067422B1 (en) * | 2015-03-13 | 2024-07-31 | Sabanci Üniversitesi | Ct-1 inhibitors |
| WO2016154203A1 (en) | 2015-03-23 | 2016-09-29 | Evestra, Inc. | Novel cytotoxic agents that preferentially target leukemia inhibitory factor (lif) for the treatment of malignancies and as new contraceptive agents |
| EP3173483A1 (en) | 2015-11-27 | 2017-05-31 | Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron | Agents for the treatment of diseases associated with undesired cell proliferation |
| WO2018115960A1 (en) | 2016-12-19 | 2018-06-28 | Mosaic Biomedicals, S.L. | Antibodies against lif and uses thereof |
| SI3555132T1 (sl) * | 2016-12-19 | 2024-04-30 | Medimmune Limited | Protitelesa proti LIF in njihove uporabe |
| SG11202011170YA (en) * | 2018-05-14 | 2020-12-30 | Medimmune Ltd | Antibodies against lif and dosage forms thereof |
| WO2019243898A2 (en) * | 2018-06-18 | 2019-12-26 | Mosaic Biomedicals Slu | Methods for improving response to anti-lif antibody treatment in individuals with cancer |
| CA3103369A1 (en) * | 2018-06-18 | 2019-12-26 | Medimmune Limited | Combination of lif inhibitors and platinum-based antineoplastic agents for use in treating cancer |
| WO2020056349A2 (en) * | 2018-09-13 | 2020-03-19 | Evestra, Inc. | Lif/lifr antagonist oncology and nonmalignant diseases |
| EP3957324A4 (en) * | 2019-04-17 | 2023-02-08 | Hiroshima University | THERAPEUTIC FOR UROLOGICAL ONCOLOGY CHARACTERIZED BY BEING ADMINISTRATED IN COMBINATION WITH IL-6 INHIBITOR AND CCR2 INHIBITOR |
| CN111020030A (zh) * | 2019-12-03 | 2020-04-17 | 中山大学 | 一种骨肉瘤干细胞标志物及其应用、试剂盒 |
| EP3988116A1 (en) * | 2020-10-23 | 2022-04-27 | Consejo Superior De Investigaciones Científicas (CSIC) | Methods and compositions for the treatment of hematologic malignancies |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| JP3046318B2 (ja) | 1987-12-15 | 2000-05-29 | ジーン・シアーズ・ピーティーワイ・リミテッド | リボザイム |
| US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5256775A (en) | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
| US5264564A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| GB9004890D0 (en) * | 1990-03-05 | 1990-05-02 | Heath John K | Leukaemia inhibitory factor |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| JPH05304986A (ja) * | 1992-04-28 | 1993-11-19 | Tosoh Corp | ｇｐ１３０蛋白質に対するモノクロ−ナル抗体 |
| AU4231393A (en) * | 1992-05-08 | 1993-12-13 | Genentech Inc. | Antibodies to leukemia inhibitory factor |
| GB9413316D0 (en) | 1994-07-01 | 1994-08-24 | Cancer Res Campaign Tech | Novel proteins |
| US6251588B1 (en) | 1998-02-10 | 2001-06-26 | Agilent Technologies, Inc. | Method for evaluating oligonucleotide probe sequences |
| US20050147609A1 (en) | 1998-05-15 | 2005-07-07 | Genentech, Inc. | Use of anti-IL-17 antibody for the treatment of cartilage damaged by osteoarthritis |
| KR20060067983A (ko) | 1999-01-15 | 2006-06-20 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
| KR100704140B1 (ko) * | 1999-02-12 | 2007-04-09 | 더 스크립스 리서치 인스티튜트 | 혈관형성 억제제 및 항-종양 면역요법제를 포함하는, 종양 및 전이를 치료하기 위한 약제학적 조성물 및 이를 포함하는 키트 |
| US6110462A (en) | 1999-03-03 | 2000-08-29 | The Scripps Research Institute | Enzymatic DNA molecules that contain modified nucleotides |
| US7084257B2 (en) | 2001-10-05 | 2006-08-01 | Amgen Inc. | Fully human antibody Fab fragments with human interferon-gamma neutralizing activity |
| CA2480052A1 (en) | 2002-04-01 | 2003-10-16 | Human Genome Sciences, Inc. | Antibodies that specifically bind to gmad |
| WO2004016758A2 (en) * | 2002-08-15 | 2004-02-26 | Genzyme Corporation | Brain endothelial cell expression patterns |
| US20060078533A1 (en) * | 2004-10-12 | 2006-04-13 | Omoigui Osemwota S | Method of prevention and treatment of aging and age-related disorders including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, arthritis, type 2 diabetes, dementia, alzheimer's disease and cancer |
| US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| WO2004067778A2 (en) * | 2003-01-28 | 2004-08-12 | University Of South Florida | Differentially expressed genes in large granular lymphocyte leukemia |
| WO2005030803A1 (en) * | 2003-09-29 | 2005-04-07 | The Walter And Eliza Hall Institute Of Medical Research | Therapeutic molecules |
| KR20070085113A (ko) * | 2004-05-11 | 2007-08-27 | 가부시키가이샤 알파젠 | Rna간섭을 생기게 하는 폴리뉴클레오티드, 및 이를 이용한유전자발현억제 방법 |
| BRPI0912927A2 (pt) * | 2008-08-29 | 2019-10-01 | Genentech Inc | "método de detectar um tumor independente de vegf em um indivíduo e método de tratar um tumor independente de vegf em um indivíduo" |
| EP2371860A1 (en) * | 2010-04-05 | 2011-10-05 | Fundació Privada Institut d'Investigació Oncològica de Vall d'Hebron | Antibody recognising human leukemia inhibitory factor (LIF) and use of anti-LIF antibodies in the treatment of diseases associated with unwanted cell proliferation |
| WO2018115960A1 (en) * | 2016-12-19 | 2018-06-28 | Mosaic Biomedicals, S.L. | Antibodies against lif and uses thereof |
-
2009
- 2009-04-03 ES ES200900928A patent/ES2363358B1/es not_active Withdrawn - After Issue
-
2010
- 2010-04-06 PT PT161550090T patent/PT3045474T/pt unknown
- 2010-04-06 EP EP16155009.0A patent/EP3045474B1/en active Active
- 2010-04-06 HU HUE16155009A patent/HUE054196T2/hu unknown
- 2010-04-06 JP JP2012502710A patent/JP6207836B2/ja active Active
- 2010-04-06 KR KR1020207017470A patent/KR102373754B1/ko active Active
- 2010-04-06 CN CN201711070081.2A patent/CN107964043A/zh active Pending
- 2010-04-06 WO PCT/EP2010/054499 patent/WO2010115868A2/en not_active Ceased
- 2010-04-06 EP EP10713619A patent/EP2414394A2/en not_active Ceased
- 2010-04-06 LT LTEP16155009.0T patent/LT3045474T/lt unknown
- 2010-04-06 KR KR1020117026088A patent/KR20120100703A/ko not_active Ceased
- 2010-04-06 CN CN2010800246730A patent/CN102574918A/zh active Pending
- 2010-04-06 SM SM20210153T patent/SMT202100153T1/it unknown
- 2010-04-06 KR KR1020227007752A patent/KR20220035978A/ko not_active Ceased
- 2010-04-06 AU AU2010233791A patent/AU2010233791B2/en not_active Ceased
- 2010-04-06 KR KR1020197022597A patent/KR20190093691A/ko not_active Ceased
- 2010-04-06 ES ES16155009T patent/ES2864639T3/es active Active
- 2010-04-06 DK DK16155009.0T patent/DK3045474T3/da active
- 2010-04-06 KR KR1020187018827A patent/KR20180079470A/ko not_active Ceased
- 2010-04-06 PL PL16155009T patent/PL3045474T3/pl unknown
- 2010-04-06 SG SG10202010568RA patent/SG10202010568RA/en unknown
- 2010-04-06 US US13/138,804 patent/US10100112B2/en active Active
- 2010-04-06 SI SI201032059T patent/SI3045474T1/sl unknown
- 2010-04-06 KR KR1020177030504A patent/KR20170121319A/ko not_active Ceased
- 2010-04-06 CA CA2757680A patent/CA2757680C/en active Active
- 2010-04-06 SG SG2011071834A patent/SG175032A1/en unknown
- 2010-04-06 MX MX2011010425A patent/MX336903B/es active IP Right Grant
- 2010-04-06 BR BRPI1015369-1A patent/BRPI1015369A2/pt not_active Application Discontinuation
- 2010-04-06 EA EA201101450A patent/EA201101450A1/ru unknown
-
2011
- 2011-10-02 IL IL215467A patent/IL215467A/en active IP Right Grant
- 2011-10-03 ZA ZA2011/07215A patent/ZA201107215B/en unknown
-
2015
- 2015-09-11 JP JP2015178986A patent/JP2016040255A/ja active Pending
-
2018
- 2018-08-14 JP JP2018152551A patent/JP2019006784A/ja active Pending
- 2018-08-28 US US16/115,191 patent/US20190211095A1/en not_active Abandoned
-
2020
- 2020-02-04 JP JP2020016672A patent/JP2020090522A/ja active Pending
- 2020-08-24 US US17/001,530 patent/US11999782B2/en active Active
-
2021
- 2021-03-02 HR HRP20210352TT patent/HRP20210352T1/hr unknown
- 2021-03-18 CY CY20211100232T patent/CY1124148T1/el unknown
- 2021-11-17 JP JP2021186785A patent/JP7197665B2/ja active Active
-
2024
- 2024-05-01 US US18/652,603 patent/US20240400667A1/en active Pending
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