JP2013535210A5 - - Google Patents

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JP2013535210A5
JP2013535210A5 JP2013522292A JP2013522292A JP2013535210A5 JP 2013535210 A5 JP2013535210 A5 JP 2013535210A5 JP 2013522292 A JP2013522292 A JP 2013522292A JP 2013522292 A JP2013522292 A JP 2013522292A JP 2013535210 A5 JP2013535210 A5 JP 2013535210A5
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JP
Japan
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seq
dna
primer
sequence
amplification
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JP2013522292A
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English (en)
Japanese (ja)
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JP2013535210A (ja
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Priority claimed from GBGB1013153.0A external-priority patent/GB201013153D0/en
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Publication of JP2013535210A publication Critical patent/JP2013535210A/ja
Publication of JP2013535210A5 publication Critical patent/JP2013535210A5/ja
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JP2013522292A 2010-08-04 2011-08-04 パリンドローム配列を用いた閉鎖型直鎖状ｄｎａの生成 Pending JP2013535210A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1013153.0 2010-08-04
GBGB1013153.0A GB201013153D0 (en) 2010-08-04 2010-08-04 Primer for production of closed linear DNA
PCT/GB2011/001175 WO2012017210A1 (en) 2010-08-04 2011-08-04 Production of closed linear dna using a palindromic sequence

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016202277A Division JP6689726B2 (ja) 2010-08-04 2016-10-14 パリンドローム配列を用いた閉鎖型直鎖状ｄｎａの生成

Publications (2)

Publication Number Publication Date
JP2013535210A JP2013535210A (ja) 2013-09-12
JP2013535210A5 true JP2013535210A5 (enExample) 2014-09-18

Family

ID=42931209

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JP2013522292A Pending JP2013535210A (ja) 2010-08-04 2011-08-04 パリンドローム配列を用いた閉鎖型直鎖状ｄｎａの生成
JP2016202277A Active JP6689726B2 (ja) 2010-08-04 2016-10-14 パリンドローム配列を用いた閉鎖型直鎖状ｄｎａの生成

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JP2016202277A Active JP6689726B2 (ja) 2010-08-04 2016-10-14 パリンドローム配列を用いた閉鎖型直鎖状ｄｎａの生成

Country Status (6)

Country Link
US (1) US9499847B2 (enExample)
EP (1) EP2601312B1 (enExample)
JP (2) JP2013535210A (enExample)
CN (1) CN103080337B (enExample)
GB (1) GB201013153D0 (enExample)
WO (1) WO2012017210A1 (enExample)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0901593D0 (en) * 2009-01-30 2009-03-11 Touchlight Genetics Ltd Production of closed linear DNA
EP2692870A1 (en) * 2012-08-03 2014-02-05 Alacris Theranostics GmbH Method for nucleic acid amplification
WO2014145291A1 (en) 2013-03-15 2014-09-18 Theranos, Inc. Nucleic acid amplification
BR112015023398A8 (pt) 2013-03-15 2022-08-23 Theranos Inc Métodos para amplificar ácidos nucléicos
US9290800B2 (en) 2013-03-15 2016-03-22 Pacific Biosciences Of California, Inc. Targeted rolling circle amplification
US10450595B2 (en) 2013-03-15 2019-10-22 Theranos Ip Company, Llc Nucleic acid amplification
EP2970960B1 (en) 2013-03-15 2019-03-13 Theranos IP Company, LLC Nucleic acid amplification
CN111378568A (zh) 2013-09-06 2020-07-07 赛拉诺斯知识产权有限责任公司 用于检测感染性疾病的系统和方法
WO2015134812A1 (en) 2014-03-05 2015-09-11 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating usher syndrome and retinitis pigmentosa
US11339437B2 (en) 2014-03-10 2022-05-24 Editas Medicine, Inc. Compositions and methods for treating CEP290-associated disease
US11141493B2 (en) 2014-03-10 2021-10-12 Editas Medicine, Inc. Compositions and methods for treating CEP290-associated disease
DK3116997T3 (da) 2014-03-10 2019-08-19 Editas Medicine Inc Crispr/cas-relaterede fremgangsmåder og sammensætninger til behandling af lebers kongenitale amaurose 10 (lca10)
EP3981876A1 (en) 2014-03-26 2022-04-13 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating sickle cell disease
EP3126495A1 (en) 2014-04-02 2017-02-08 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating primary open angle glaucoma
GB201415789D0 (en) * 2014-09-05 2014-10-22 Touchlight Genetics Ltd Synthesis of DNA
GB201502645D0 (en) 2015-02-17 2015-04-01 Touchlight Genetics Ltd Method
US11180793B2 (en) 2015-04-24 2021-11-23 Editas Medicine, Inc. Evaluation of Cas9 molecule/guide RNA molecule complexes
FR3042121A1 (fr) * 2015-10-08 2017-04-14 Jean-Marc Limacher Composition anti-tumorale
WO2017165862A1 (en) 2016-03-25 2017-09-28 Editas Medicine, Inc. Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
JP7004651B2 (ja) * 2016-07-19 2022-02-04 株式会社バイオダイナミクス研究所 長鎖一本鎖ｄｎａを調製する方法
BR112019001887A2 (pt) 2016-08-02 2019-07-09 Editas Medicine Inc composições e métodos para o tratamento de doença associada a cep290
LT3500682T (lt) * 2016-08-16 2020-10-26 Touchlight IP Limited Uždarytos linijinės dnr gamyba
WO2018170184A1 (en) 2017-03-14 2018-09-20 Editas Medicine, Inc. Systems and methods for the treatment of hemoglobinopathies
WO2018209158A2 (en) 2017-05-10 2018-11-15 Editas Medicine, Inc. Crispr/rna-guided nuclease systems and methods
EP3652312A1 (en) 2017-07-14 2020-05-20 Editas Medicine, Inc. Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
US10350307B2 (en) * 2017-09-18 2019-07-16 General Electric Company In vivo RNA or protein expression using double-stranded concatemeric DNA including phosphorothioated nucleotides
US12214055B2 (en) 2017-10-24 2025-02-04 Editas Medicine, Inc. Systems and methods for treating hyper-igm syndrome
EP3707266A1 (en) 2017-11-07 2020-09-16 Editas Medicine, Inc. Targeted integration systems and methods for the treatment of hemoglobinopathies
AU2018383712B2 (en) 2017-12-11 2025-09-04 Editas Medicine, Inc. Cpf1-related methods and compositions for gene editing
WO2019118806A1 (en) * 2017-12-14 2019-06-20 Solid Biosciences Inc. Non-viral production and delivery of genes
WO2019178426A1 (en) 2018-03-14 2019-09-19 Editas Medicine, Inc. Systems and methods for the treatment of hemoglobinopathies
CN108531496B (zh) * 2018-04-04 2020-11-06 江南大学 一种提高外源基因mRNA数量的DNA及其应用
GB201805683D0 (en) 2018-04-05 2018-05-23 Touchlight Ip Ltd Reprogramming vectors
EP3810782A2 (en) * 2018-06-22 2021-04-28 Asklepios Biopharmaceutical, Inc. Vectors for gene delivery that persist within cells
JP2022536945A (ja) 2019-06-18 2022-08-22 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Ｂ型肝炎ウイルス（ＨＢＶ）ワクチンおよびＨＢＶを標的化するＲＮＡｉの組合せ
WO2020255010A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines
US20220305107A1 (en) 2019-06-18 2022-09-29 Janssen Sciences Ireland Unlimited Company COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi
MA56520A (fr) 2019-06-18 2022-04-27 Janssen Sciences Ireland Unlimited Co Construction de l'interleukine 12 recombinante et ses utilisations
WO2020255009A2 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 antibody
WO2020254876A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Virus-like particle delivery of hepatitis b virus (hbv) vaccines
CA3143680A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 or anti-pd-l1 antibody
AU2020297019A1 (en) 2019-06-20 2022-02-17 Janssen Sciences Ireland Unlimited Company Carbohydrate nanocarrier delivery of hepatitis B virus (HBV) vaccines
TW202114732A (zh) 2019-06-20 2021-04-16 愛爾蘭商健生科學愛爾蘭無限公司 遞送b型肝炎病毒(hbv)疫苗之脂質奈米顆粒或脂質體
EP3792367A1 (en) 2019-09-11 2021-03-17 Universität Bielefeld Method for the production of raav and method for the in vitro generation of genetically engineered, linear, single-stranded nucleic acid fragments containing itr sequences flanking a gene of interest
CA3151464A1 (en) 2019-09-18 2021-03-25 Bruce C. SCHNEPP Synthetic dna vectors and methods of use
GB201915163D0 (en) 2019-10-18 2019-12-04 Univ Southampton Cancer vaccine
JP7771066B2 (ja) * 2020-01-31 2025-11-17 ティリス セラピューティクス，エセ．エレ． 閉じた直鎖ｄｎａを作製するためのプロセス
GB202007428D0 (en) 2020-05-19 2020-07-01 Fabricnano Ltd Polynucleotide synthesis
CN116133668A (zh) * 2020-06-12 2023-05-16 罗切斯特大学 ACE-tRNA的编码和表达
CN112111544B (zh) * 2020-09-23 2022-04-01 复旦大学附属肿瘤医院 提高单链dna连接效率的方法
JP2024504355A (ja) * 2021-01-22 2024-01-31 ナンジン、ジェンスクリプト、バイオテック、カンパニー、リミテッド 標的ｄｎａ配列及びクローニングベクターを作製するための方法
ES2960777T3 (es) * 2021-03-18 2024-03-06 Genomill Health Oy Métodos para la cuantificación paralela precisa de ácidos nucleicos en muestras diluidas o no purificadas
JP2024520797A (ja) 2021-06-08 2024-05-24 タッチライト・アイピー・リミテッド レンチウイルスベクター
GB202108176D0 (en) 2021-06-08 2021-07-21 Touchlight Ip Ltd Vector
AU2022299552A1 (en) 2021-06-25 2024-01-04 Oxford Biomedica (Us) Llc Adeno-associated virus packaging systems
EP4370151A1 (en) 2021-07-13 2024-05-22 Stonehaven Incubate AG Composition and uses thereof
GB202114105D0 (en) 2021-10-01 2021-11-17 Fabricnano Ltd Nucleotide synthesis
IL312184A (en) 2021-10-18 2024-06-01 Flagship Pioneering Innovations Vii Llc Dna compositions and related methods
WO2023114901A2 (en) 2021-12-15 2023-06-22 Oxford Biomedica Solutions Llc Methods and compositions for the production of adeno-associated virus
US20250127873A1 (en) 2021-12-20 2025-04-24 Zoetis Services Llc Compositions and methods for prevention of piscine myocarditis
JP2025503470A (ja) 2021-12-20 2025-02-04 ゾエティス・サービシーズ・エルエルシー 細胞膜上に抗原を発現させるための組成物及び方法
AU2022419971A1 (en) 2021-12-20 2024-07-04 Zoetis Services Llc Use of interferon as an adjuvant in vaccines
CN114561372B (zh) * 2022-04-27 2022-07-26 南京巨匠生物科技有限公司 Bst DNA聚合酶突变体及其应用和产品、基因、重组质粒和基因工程菌
EP4293101A1 (en) 2022-06-14 2023-12-20 Asklepios Biopharmaceutical, Inc. Reactor with temperature control and method of using the same
CN119698477A (zh) * 2022-08-10 2025-03-25 镇江蓬勃生物科技有限公司 线性闭合dna的制备方法及该方法所用质粒
AU2023324649A1 (en) 2022-08-16 2025-02-20 Aldevron, L.L.C. Cell-free method of producing synthetic circular nucleic acid
EP4589008A1 (en) * 2022-09-12 2025-07-23 Kaneka Corporation Double stranded circular dna vector, method for producing linear covalently closed dna, and fusion polypeptide containing protelomerase and endonuclease
EP4587052A1 (en) 2022-09-12 2025-07-23 Zoetis Services LLC Method of administration of aquaculture vaccines
CN117778498A (zh) * 2022-09-26 2024-03-29 深圳瑞吉生物科技有限公司 一种无细胞制备mRNA转录模板的方法
WO2024069549A1 (en) 2022-09-29 2024-04-04 Touchlight Aquaculture Limited Vaccine construct and uses thereof
WO2024121354A1 (en) * 2022-12-08 2024-06-13 Keygene N.V. Duplex sequencing with covalently closed dna ends
DK202370610A1 (en) 2022-12-13 2024-07-12 Zoetis Services Llc Methods of vaccine administration to salmonids
WO2024197081A1 (en) 2023-03-20 2024-09-26 Hc Bioscience, Inc. Minimally-sized dna threads for trna therapy
CN116606834A (zh) * 2023-04-10 2023-08-18 天津中合基因科技有限公司 多种具有切割连接活性的原端酶及其应用
WO2024256842A1 (en) 2023-06-16 2024-12-19 Touchlight IP Limited Therapeutic transfection
US11981936B1 (en) 2023-09-29 2024-05-14 New England Biolabs, Inc. TelA variants, compositions, and methods
GB202319998D0 (en) 2023-12-22 2024-02-07 Touchlight Ip Ltd duplexing method
FR3160186A1 (fr) 2024-03-13 2025-09-19 Odimma Therapeutics Vecteur non-viral pour transcription augmentee
WO2025202929A1 (en) * 2024-03-29 2025-10-02 Pfizer Inc. Methods for producing nucleic acids
WO2025250742A1 (en) * 2024-05-30 2025-12-04 Aclarity Genomics, Inc. Amplification of macromolecules
WO2025264964A1 (en) 2024-06-20 2025-12-26 Zoetis Services Llc Vaccines against tenacibaculum finnmarkense

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
JPH03236781A (ja) * 1990-02-13 1991-10-22 Takara Shuzo Co Ltd ランダムプライマーキット及びその使用方法
AU649066B2 (en) 1990-07-25 1994-05-12 Syngene, Inc. Circular extension for generating multiple nucleic acid complements
FR2675803B1 (fr) 1991-04-25 1996-09-06 Genset Sa Oligonucleotides fermes, antisens et sens et leurs applications.
US6953676B1 (en) 1992-05-01 2005-10-11 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US5714320A (en) 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
DE69429038T2 (de) 1993-07-28 2002-03-21 Pe Corporation (Ny), Norwalk Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
US5889159A (en) * 1993-10-29 1999-03-30 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies to tumor marker TC1 and methods for use of same
FR2732971B1 (fr) 1995-04-13 1997-07-04 Genset Sa Oligonucleotide sens inhibiteur de virus herpes simplex (hsv) a structure en haltere
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
ATE199572T1 (de) 1995-11-21 2001-03-15 Univ Yale Unimolekulare segmentamplifikation und bestimmung
DE19648625A1 (de) 1996-11-13 1998-05-14 Soft Gene Gmbh Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer
JPH10234399A (ja) * 1997-02-28 1998-09-08 Shinkinrui Kinou Kaihatsu Kenkyusho:Kk ピシウム属菌検出用の核酸配列
US6054274A (en) 1997-11-12 2000-04-25 Hewlett-Packard Company Method of amplifying the signal of target nucleic acid sequence analyte
EP1179585B1 (en) 1997-12-24 2008-07-09 Cepheid Device and method for lysis
DE69934088T2 (de) 1998-01-09 2007-06-21 University Of Utah Research Foundation, Salt Lake City Verfahren zur in vitro amplifikation zirkulärer dna
DE19826758C1 (de) 1998-06-15 1999-10-21 Soft Gene Gmbh Darstellung von linearen kovalent geschlossenen DNA-Molekülen als Expressionskonstrukte
JP2002525049A (ja) 1998-09-15 2002-08-13 イェール ユニバーシティ ローリングサークル増幅を用いる分子クローニング
ATE294857T1 (de) 1999-07-08 2005-05-15 Mologen Forschungs Entwicklung Impfstoff gegen infektionen mit lentiviren, wie dem felinen immunschwäche-virus der katze
EP1268856A2 (de) * 2000-04-07 2003-01-02 Epigenomics AG Detektion von snp's und cytosin-methylierungen
GB0018120D0 (en) 2000-07-24 2000-09-13 Fermentas Ab Nuclease
JP2002051784A (ja) * 2000-08-09 2002-02-19 Toyobo Co Ltd 核酸の増幅方法及び標識核酸の調製方法
US6977148B2 (en) 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
US20030077611A1 (en) 2001-10-24 2003-04-24 Sention Methods and systems for dynamic gene expression profiling
CA2412187A1 (en) * 2001-12-21 2003-06-21 University Of Western Ontario Assay for identifying modulators of borrelia telomere resolvase
US7081339B2 (en) 2002-04-12 2006-07-25 Primera Biosystems, Inc. Methods for variation detection
WO2004007684A2 (en) 2002-07-12 2004-01-22 Affymetrix, Inc. Synthetic tag genes
AU2003281917A1 (en) 2002-09-23 2004-04-19 Mologen Ag Vaccine against infections caused by oncoviruses such as the feline leucosis virus of cats
US7955795B2 (en) 2003-06-06 2011-06-07 Qiagen Gmbh Method of whole genome amplification with reduced artifact production
US7452699B2 (en) 2003-01-15 2008-11-18 Dana-Farber Cancer Institute, Inc. Amplification of DNA in a hairpin structure, and applications
EP1594987B1 (en) 2003-02-21 2009-05-27 GeneForm Technologies Limited Nucleic acid sequencing methods, kits and reagents
US20050244847A1 (en) 2003-11-26 2005-11-03 Eppendorf Ag Methods and compositions for in vitro amplification of extrachromosomal nucleic acid
JP3972106B2 (ja) * 2004-03-03 2007-09-05 大学共同利用機関法人情報・システム研究機構 ゲノムライブラリー作製方法、および同方法により作製されたゲノムライブラリー
JP2008522628A (ja) * 2004-12-11 2008-07-03 サイトジェニックス， インコーポレイテッド 高品質核酸のセルフリー生合成及びその使用
CN101103122A (zh) * 2004-12-11 2008-01-09 西托吉尼克斯公司 高质量核酸的无细胞生物合成及其用途
WO2006108423A2 (en) 2005-04-12 2006-10-19 In Situ Rcp A/S Under Founding Methods for production of oligonucleotides
EP1885880B1 (en) 2005-04-29 2010-07-21 Synthetic Genomics, Inc. Amplification and cloning of single dna molecules using rolling circle amplification
EP1974037B1 (en) 2006-01-12 2012-03-14 Lucigen Corporation Linear vectors, host cells and cloning methods
EP3527671A1 (en) 2006-10-06 2019-08-21 Applied DNA Sciences Inc. System for a continuous rapid thermal cycle system
US20080118917A1 (en) * 2006-11-21 2008-05-22 Applera Corporation Isothermal SNP Detection Method
US8921072B2 (en) 2008-09-02 2014-12-30 General Electric Compnay Methods to generate DNA mini-circles
GB0901593D0 (en) * 2009-01-30 2009-03-11 Touchlight Genetics Ltd Production of closed linear DNA
JP5182949B2 (ja) * 2009-03-31 2013-04-17 浜名部品工業株式会社 ヨークの製造方法及び製造装置
US9114399B2 (en) 2010-08-31 2015-08-25 Canon U.S. Life Sciences, Inc. System and method for serial processing of multiple nucleic acid assays
EP2692870A1 (en) 2012-08-03 2014-02-05 Alacris Theranostics GmbH Method for nucleic acid amplification
KR102014989B1 (ko) 2013-04-15 2019-08-27 삼성전자주식회사 폴리뉴클레오티드 및 그의 용도

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