JP2012516147A5 - - Google Patents
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- Publication number
- JP2012516147A5 JP2012516147A5 JP2011546955A JP2011546955A JP2012516147A5 JP 2012516147 A5 JP2012516147 A5 JP 2012516147A5 JP 2011546955 A JP2011546955 A JP 2011546955A JP 2011546955 A JP2011546955 A JP 2011546955A JP 2012516147 A5 JP2012516147 A5 JP 2012516147A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- protelomerase
- template
- sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 19
- 108020004414 DNA Proteins 0.000 claims 18
- 102000053602 DNA Human genes 0.000 claims 18
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 5
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 5
- 108091026890 Coding region Proteins 0.000 claims 4
- 230000003321 amplification Effects 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108020004638 Circular DNA Proteins 0.000 claims 2
- 238000006073 displacement reaction Methods 0.000 claims 2
- 108700028149 Bacteriophage N15 protelomerase Proteins 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000003362 replicative effect Effects 0.000 claims 1
- 238000005096 rolling process Methods 0.000 claims 1
- 230000005030 transcription termination Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0901593.4A GB0901593D0 (en) | 2009-01-30 | 2009-01-30 | Production of closed linear DNA |
| GB0901593.4 | 2009-01-30 | ||
| PCT/GB2010/000165 WO2010086626A1 (en) | 2009-01-30 | 2010-02-01 | Production of closed linear dna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015175262A Division JP6454243B2 (ja) | 2009-01-30 | 2015-09-07 | 閉鎖型直鎖状ｄｎａの製造 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012516147A JP2012516147A (ja) | 2012-07-19 |
| JP2012516147A5 true JP2012516147A5 (enExample) | 2013-03-21 |
Family
ID=40469378
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011546955A Pending JP2012516147A (ja) | 2009-01-30 | 2010-02-01 | 閉鎖型直鎖状ｄｎａの製造 |
| JP2015175262A Active JP6454243B2 (ja) | 2009-01-30 | 2015-09-07 | 閉鎖型直鎖状ｄｎａの製造 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015175262A Active JP6454243B2 (ja) | 2009-01-30 | 2015-09-07 | 閉鎖型直鎖状ｄｎａの製造 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9109250B2 (enExample) |
| EP (3) | EP2612925B1 (enExample) |
| JP (2) | JP2012516147A (enExample) |
| KR (1) | KR101926662B1 (enExample) |
| CN (2) | CN104911177A (enExample) |
| AU (1) | AU2010209532B2 (enExample) |
| BR (1) | BRPI1005683B1 (enExample) |
| CA (1) | CA2751130C (enExample) |
| DK (2) | DK3150722T3 (enExample) |
| EA (1) | EA021069B1 (enExample) |
| ES (2) | ES2749629T3 (enExample) |
| GB (1) | GB0901593D0 (enExample) |
| IL (1) | IL213930A (enExample) |
| LT (1) | LT3150722T (enExample) |
| MX (1) | MX2011007937A (enExample) |
| NZ (1) | NZ594004A (enExample) |
| SG (1) | SG173102A1 (enExample) |
| WO (1) | WO2010086626A1 (enExample) |
| ZA (1) | ZA201105013B (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2351294B8 (es) * | 2009-07-02 | 2012-06-06 | Consejo Superior De Investigaciones Científicas (Csic) | Metodo para la replicación, amplificación, o secuenciación de un adn molde. |
| GB201013153D0 (en) * | 2010-08-04 | 2010-09-22 | Touchlight Genetics Ltd | Primer for production of closed linear DNA |
| US9290800B2 (en) | 2013-03-15 | 2016-03-22 | Pacific Biosciences Of California, Inc. | Targeted rolling circle amplification |
| GB201502645D0 (en) | 2015-02-17 | 2015-04-01 | Touchlight Genetics Ltd | Method |
| FR3042121A1 (fr) * | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| JP6949845B2 (ja) | 2015-12-22 | 2021-10-13 | キュアバック アーゲー | Ｒｎａ分子組成物の作製方法 |
| RU2616279C1 (ru) * | 2015-12-28 | 2017-04-13 | Федеральное государственное бюджетное учреждение науки Институт биохимии и генетики Уфимского научного центра Российской академии наук (ИБГ УНЦ РАН) | Способ получения маркерных лестниц для гель-электрофоретического определения размеров фрагментов нуклеиновых кислот |
| US10077459B2 (en) | 2016-05-04 | 2018-09-18 | General Electric Company | Cell-free protein expression using rolling circle amplification product |
| US11505821B2 (en) | 2016-08-16 | 2022-11-22 | Touchlight IP Limited | Closed linear DNA production |
| WO2019118806A1 (en) | 2017-12-14 | 2019-06-20 | Solid Biosciences Inc. | Non-viral production and delivery of genes |
| GB201721846D0 (en) * | 2017-12-22 | 2018-02-07 | Arecor Ltd | Novel composition |
| CN109971825B (zh) * | 2017-12-28 | 2020-11-10 | 南京金斯瑞生物科技有限公司 | 快速制备桑格测序模板的方法 |
| GB201805683D0 (en) * | 2018-04-05 | 2018-05-23 | Touchlight Ip Ltd | Reprogramming vectors |
| CA3104113A1 (en) * | 2018-06-22 | 2019-12-26 | Asklepios Biopharmaceutical, Inc. | Vectors for gene delivery that persist within cells |
| JP7481755B2 (ja) * | 2018-11-02 | 2024-05-13 | ナイキジェン，リミテッド | 組換えパルボウイルスベクターならびにその作製および使用方法 |
| GB201905651D0 (en) * | 2019-04-24 | 2019-06-05 | Lightbio Ltd | Nucleic acid constructs and methods for their manufacture |
| US12595501B2 (en) | 2019-06-13 | 2026-04-07 | Global Life Sciences Solutions Usa Llc | Expression of products from nucleic acid concatemers |
| WO2020255010A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines |
| KR20220041080A (ko) | 2019-06-18 | 2022-03-31 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | B형 간염 바이러스(hbv) 백신 및 항-pd-1 또는 항-pc-l1 항체의 조합 |
| WO2020255008A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi |
| AU2020296372A1 (en) | 2019-06-18 | 2022-02-17 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis B virus (HBV) vaccines and anti-PD-1 antibody |
| MA56520A (fr) | 2019-06-18 | 2022-04-27 | Janssen Sciences Ireland Unlimited Co | Construction de l'interleukine 12 recombinante et ses utilisations |
| US20220305117A1 (en) | 2019-06-18 | 2022-09-29 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai |
| WO2020254876A1 (en) | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Virus-like particle delivery of hepatitis b virus (hbv) vaccines |
| MA56534A (fr) | 2019-06-20 | 2022-04-27 | Janssen Sciences Ireland Unlimited Co | Administration par nanoporteurs glucidiques, de vaccins contre le virus de l'hépatite b (vhb) |
| AU2020295807A1 (en) | 2019-06-20 | 2022-02-17 | Janssen Sciences Ireland Unlimited Company | Lipid nanoparticle or liposome delivery of hepatitis B virus (HBV) vaccines |
| EP3792367A1 (en) | 2019-09-11 | 2021-03-17 | Universität Bielefeld | Method for the production of raav and method for the in vitro generation of genetically engineered, linear, single-stranded nucleic acid fragments containing itr sequences flanking a gene of interest |
| GB2606844B (en) | 2019-09-18 | 2025-08-06 | Aldevron Llc | Synthetic DNA vectors and methods of use |
| GB201915163D0 (en) | 2019-10-18 | 2019-12-04 | Univ Southampton | Cancer vaccine |
| EP4077661A1 (en) | 2019-12-20 | 2022-10-26 | Keygene N.V. | Ngs library preparation using covalently closed nucleic acid molecule ends |
| US20230048994A1 (en) * | 2020-01-17 | 2023-02-16 | Asklepios Biopharmaceutical, Inc. | Recombinant aav production |
| CN115023503A (zh) * | 2020-01-31 | 2022-09-06 | 泰瑞斯疗法公司 | 生产闭合线性dna的方法 |
| EP4114937A4 (en) | 2020-03-04 | 2024-09-04 | Flagship Pioneering Innovations VI, LLC | METHODS AND COMPOSITIONS FOR MODULATING A GENOME |
| GB202007428D0 (en) | 2020-05-19 | 2020-07-01 | Fabricnano Ltd | Polynucleotide synthesis |
| CA3181680A1 (en) | 2020-06-12 | 2021-12-16 | University Of Rochester | Encoding and expression of ace-trnas |
| WO2022043400A1 (en) | 2020-08-26 | 2022-03-03 | Scancell Limited | Nucleic acids encoding a polypeptide comprising a modified fc region of a human igg1 and at least one heterologous antigen |
| US20230407366A1 (en) | 2020-10-06 | 2023-12-21 | Keygene N.V. | Targeted sequence addition |
| US20240150793A1 (en) | 2021-03-29 | 2024-05-09 | Kaneka Corporation | Vector, linear covalently closed dna production method using vector, parvovirus vector production method, and parvovirus-vector-producing cell production method |
| GB202108176D0 (en) | 2021-06-08 | 2021-07-21 | Touchlight Ip Ltd | Vector |
| CA3222751A1 (en) | 2021-06-08 | 2022-12-15 | Touchlight IP Limited | Lentiviral vector |
| WO2022272297A1 (en) | 2021-06-25 | 2022-12-29 | Oxford Biomedica Solutions Llc | Adeno-associated virus packaging systems |
| WO2023285976A1 (en) | 2021-07-13 | 2023-01-19 | Stonehaven Incubate AG | Composition and uses thereof |
| EP4124660A1 (en) * | 2021-07-30 | 2023-02-01 | 4basebio, S.L.U. | Linear dna with enhanced resistance against exonucleases and methods for the production thereof |
| KR20260037664A (ko) | 2021-09-08 | 2026-03-18 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 게놈을 조절하기 위한 방법 및 조성물 |
| GB202114105D0 (en) | 2021-10-01 | 2021-11-17 | Fabricnano Ltd | Nucleotide synthesis |
| EP4419677A4 (en) | 2021-10-18 | 2025-09-24 | Flagship Pioneering Innovations Vii Llc | DNA COMPOSITIONS AND RELATED METHODS |
| US20230323395A1 (en) | 2021-12-15 | 2023-10-12 | Homology Medicines, Inc. | Methods and compositions for the production of adeno-associated virus |
| CN118489008A (zh) * | 2021-12-23 | 2024-08-13 | 世代生物公司 | 封闭端dna载体的可扩展且高纯度无细胞合成 |
| CN114561372B (zh) * | 2022-04-27 | 2022-07-26 | 南京巨匠生物科技有限公司 | Bst DNA聚合酶突变体及其应用和产品、基因、重组质粒和基因工程菌 |
| EP4293101A1 (en) | 2022-06-14 | 2023-12-20 | Asklepios Biopharmaceutical, Inc. | Reactor with temperature control and method of using the same |
| CN119698477A (zh) | 2022-08-10 | 2025-03-25 | 镇江蓬勃生物科技有限公司 | 线性闭合dna的制备方法及该方法所用质粒 |
| WO2024039652A1 (en) | 2022-08-16 | 2024-02-22 | Aldevron, L.L.C. | Cell-free method of producing synthetic circular nucleic acid |
| WO2024058155A1 (ja) | 2022-09-12 | 2024-03-21 | 株式会社カネカ | 二本鎖環状ｄｎａベクター、直鎖状共有結合閉鎖ｄｎａの作製方法、並びにプロテロメラーゼ及びエンドヌクレアーゼを含む融合ポリペプチド |
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| EP4365303A1 (en) | 2022-11-02 | 2024-05-08 | 4basebio, S.L.U. | Purification of linear dna products |
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| KR102753513B1 (ko) * | 2022-11-18 | 2025-01-13 | 최낙식 | Direct RNA 추출 버퍼 및 이의 용도 |
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| EP4410992B1 (en) | 2023-02-01 | 2025-12-17 | 4basebio UK Ltd | Linear dna with enhanced resistance against exonucleases and methods for the production thereof |
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-
2009
- 2009-01-30 GB GBGB0901593.4A patent/GB0901593D0/en not_active Ceased
-
2010
- 2010-02-01 EP EP13152077.7A patent/EP2612925B1/en active Active
- 2010-02-01 ES ES16195596T patent/ES2749629T3/es active Active
- 2010-02-01 DK DK16195596.8T patent/DK3150722T3/da active
- 2010-02-01 SG SG2011053014A patent/SG173102A1/en unknown
- 2010-02-01 KR KR1020117018730A patent/KR101926662B1/ko active Active
- 2010-02-01 LT LT16195596T patent/LT3150722T/lt unknown
- 2010-02-01 WO PCT/GB2010/000165 patent/WO2010086626A1/en not_active Ceased
- 2010-02-01 BR BRPI1005683-1A patent/BRPI1005683B1/pt active IP Right Grant
- 2010-02-01 EP EP10702726A patent/EP2391731B1/en active Active
- 2010-02-01 JP JP2011546955A patent/JP2012516147A/ja active Pending
- 2010-02-01 CN CN201510314041.2A patent/CN104911177A/zh active Pending
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