JP2014518641A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014518641A5 JP2014518641A5 JP2014514835A JP2014514835A JP2014518641A5 JP 2014518641 A5 JP2014518641 A5 JP 2014518641A5 JP 2014514835 A JP2014514835 A JP 2014514835A JP 2014514835 A JP2014514835 A JP 2014514835A JP 2014518641 A5 JP2014518641 A5 JP 2014518641A5
- Authority
- JP
- Japan
- Prior art keywords
- double
- stranded rna
- sequence
- endoribonuclease
- main groove
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 78
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims description 78
- 102100030011 Endoribonuclease Human genes 0.000 claims description 37
- 108010093099 Endoribonucleases Proteins 0.000 claims description 37
- 239000000758 substrate Substances 0.000 claims description 18
- 238000003776 cleavage reaction Methods 0.000 claims description 11
- 230000007017 scission Effects 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 8
- 108091035707 Consensus sequence Proteins 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 230000035772 mutation Effects 0.000 claims 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 241000702217 Pseudomonas virus phi6 Species 0.000 description 1
- 230000007022 RNA scission Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494574P | 2011-06-08 | 2011-06-08 | |
| US61/494,574 | 2011-06-08 | ||
| PL395178A PL222511B1 (pl) | 2011-06-08 | 2011-06-08 | Endorybonukleazy dsRNA |
| PLP.395178 | 2011-06-08 | ||
| PCT/PL2012/050020 WO2012169917A1 (en) | 2011-06-08 | 2012-06-07 | Dsrna endoribonucleases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518641A JP2014518641A (ja) | 2014-08-07 |
| JP2014518641A5 true JP2014518641A5 (enExample) | 2016-03-17 |
| JP6075892B2 JP6075892B2 (ja) | 2017-02-08 |
Family
ID=47296271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014514835A Expired - Fee Related JP6075892B2 (ja) | 2011-06-08 | 2012-06-07 | 二本鎖ｒｎａエンドリボヌクレアーゼ |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9238805B2 (enExample) |
| EP (1) | EP2718431B1 (enExample) |
| JP (1) | JP6075892B2 (enExample) |
| KR (1) | KR20140045371A (enExample) |
| CN (1) | CN103764821B (enExample) |
| AU (1) | AU2012267271B2 (enExample) |
| CA (1) | CA2837143C (enExample) |
| DK (1) | DK2718431T3 (enExample) |
| ES (1) | ES2555661T3 (enExample) |
| PL (1) | PL222511B1 (enExample) |
| WO (1) | WO2012169917A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014531908A (ja) | 2011-10-14 | 2014-12-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 構造アッセンブリによる配列決定 |
| US10227639B2 (en) | 2011-12-22 | 2019-03-12 | President And Fellows Of Harvard College | Compositions and methods for analyte detection |
| ES2991004T3 (es) | 2011-12-22 | 2024-12-02 | Harvard College | Métodos para la detección de analitos |
| WO2013184754A2 (en) | 2012-06-05 | 2013-12-12 | President And Fellows Of Harvard College | Spatial sequencing of nucleic acids using dna origami probes |
| EP2971184B1 (en) | 2013-03-12 | 2019-04-17 | President and Fellows of Harvard College | Method of generating a three-dimensional nucleic acid containing matrix |
| AU2014274939B2 (en) | 2013-06-04 | 2020-03-19 | President And Fellows Of Harvard College | RNA-guideded transcriptional regulation |
| WO2016007839A1 (en) | 2014-07-11 | 2016-01-14 | President And Fellows Of Harvard College | Methods for high-throughput labelling and detection of biological features in situ using microscopy |
| CN104306989A (zh) * | 2014-09-27 | 2015-01-28 | 郭和友 | 一种利用切割酶治疗细菌方法 |
| GB2559526B (en) | 2015-11-03 | 2021-02-17 | Harvard College | Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix |
| PL415883A1 (pl) * | 2016-01-22 | 2017-07-31 | Międzynarodowy Instytut Biologii Molekularnej I Komórkowej | RNazy MiniIII, sposoby zmiany specyficzności cięcia sekwencji RNA przez RNazy MiniIII oraz ich zastosowania |
| AU2017257624B2 (en) | 2016-04-25 | 2023-05-25 | President And Fellows Of Harvard College | Hybridization chain reaction methods for in situ molecular detection |
| WO2018045186A1 (en) | 2016-08-31 | 2018-03-08 | President And Fellows Of Harvard College | Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing |
| CN109983125B (zh) | 2016-08-31 | 2024-06-04 | 哈佛学院董事及会员团体 | 生成用于通过荧光原位测序检测的核酸序列文库的方法 |
| WO2018134386A1 (en) * | 2017-01-23 | 2018-07-26 | Novozymes A/S | Host cells and methods for producing double-stranded rna |
| CN112770776B (zh) | 2018-07-30 | 2025-08-19 | 瑞德库尔有限责任公司 | 用于样品处理或分析的方法和系统 |
| WO2020076976A1 (en) | 2018-10-10 | 2020-04-16 | Readcoor, Inc. | Three-dimensional spatial molecular indexing |
| US20220049303A1 (en) | 2020-08-17 | 2022-02-17 | Readcoor, Llc | Methods and systems for spatial mapping of genetic variants |
| CN120098964B (zh) * | 2025-03-05 | 2026-01-02 | 江苏百时美生物科技有限公司 | 高效热稳定的核糖核酸酶SiRe_0902在特异性识别GG位点中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5459392A (en) | 1977-10-14 | 1979-05-12 | Rikagaku Kenkyusho | Novel nuclease and its preparation |
| US20060057590A1 (en) | 2004-09-14 | 2006-03-16 | Azeddine Si-Ammour | RNA probes |
-
2011
- 2011-06-08 PL PL395178A patent/PL222511B1/pl unknown
-
2012
- 2012-06-07 JP JP2014514835A patent/JP6075892B2/ja not_active Expired - Fee Related
- 2012-06-07 ES ES12735349.8T patent/ES2555661T3/es active Active
- 2012-06-07 CA CA2837143A patent/CA2837143C/en not_active Expired - Fee Related
- 2012-06-07 EP EP12735349.8A patent/EP2718431B1/en not_active Not-in-force
- 2012-06-07 WO PCT/PL2012/050020 patent/WO2012169917A1/en not_active Ceased
- 2012-06-07 AU AU2012267271A patent/AU2012267271B2/en not_active Ceased
- 2012-06-07 DK DK12735349.8T patent/DK2718431T3/en active
- 2012-06-07 KR KR1020137032364A patent/KR20140045371A/ko not_active Ceased
- 2012-06-07 CN CN201280027648.7A patent/CN103764821B/zh not_active Expired - Fee Related
-
2013
- 2013-11-25 US US14/088,934 patent/US9238805B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014518641A5 (enExample) | ||
| US11859217B2 (en) | Terminal deoxynucleotidyl transferase variants and uses thereof | |
| US11434478B2 (en) | Compositions and methods for genome engineering with Cas12a proteins | |
| CA3153624A1 (en) | Nucleobase editors and methods of using same | |
| JP2013528372A5 (enExample) | ||
| Ban et al. | Structure of a PLS-class pentatricopeptide repeat protein provides insights into mechanism of RNA recognition | |
| JP2010142241A5 (enExample) | ||
| JP2013530689A5 (enExample) | ||
| JP2019518476A (ja) | 等温核酸自己増幅法 | |
| US20230159903A1 (en) | Terminal Deoxynucleotidyl Transferase Variants and Uses Thereof | |
| CN106906190B (zh) | 一组亮氨酸脱氢酶及其编码基因和应用 | |
| CN110628742A (zh) | 转氨酶突变体及其应用 | |
| CN104531637A (zh) | 一种β-葡萄糖苷酶和β-葡萄糖苷酶突变体及应用 | |
| CN104745557A (zh) | 来源于嗜清洁细小杆菌卤醇脱卤酶突变体及其应用 | |
| CN1293194C (zh) | D－泛解酸内酯水解酶cDNA及其克隆、表达和应用 | |
| CN104560917B (zh) | 一种β-葡萄糖苷酶和β-葡萄糖苷酶突变体及应用 | |
| US20230092081A1 (en) | Single-strand binding protein | |
| CN1090327A (zh) | 编码氨甲酰磷酸合成酶ii的核苷酸序列 | |
| JP2006504426A5 (enExample) | ||
| KR102567576B1 (ko) | 표적 특이성이 향상된 신규한 Cas9 단백질 변이체 및 이의 용도 | |
| CN103614347B (zh) | 一种嗜热酮还原酶突变体、编码基因及其应用 | |
| KR101806601B1 (ko) | Mus81-Eme1-DNA 복합체의 3차원 결정구조 및 결정화 방법 | |
| Lima-Neto et al. | Detection of the TLR4 1196C> T polymorphism by mismatched-polymerase chain reaction using plasmid DNA as internal control in restriction fragment length polymorphism assays | |
| JP2010081848A5 (enExample) | ||
| WO2007071399A3 (en) | Promoter sequences |