JP2013534909A5 - - Google Patents
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- Publication number
- JP2013534909A5 JP2013534909A5 JP2013512082A JP2013512082A JP2013534909A5 JP 2013534909 A5 JP2013534909 A5 JP 2013534909A5 JP 2013512082 A JP2013512082 A JP 2013512082A JP 2013512082 A JP2013512082 A JP 2013512082A JP 2013534909 A5 JP2013534909 A5 JP 2013534909A5
- Authority
- JP
- Japan
- Prior art keywords
- zwitterion
- containing compound
- compound according
- group
- heteroatoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 229920002521 macromolecule Polymers 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 150000001412 amines Chemical group 0.000 claims 2
- 150000007942 carboxylates Chemical class 0.000 claims 2
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 150000001450 anions Chemical group 0.000 claims 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 claims 1
- 125000000837 carbohydrate group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 150000003573 thiols Chemical group 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 0 C(C1)C11[C@](CC2)[C@@]2*C1 Chemical compound C(C1)C11[C@](CC2)[C@@]2*C1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34692610P | 2010-05-21 | 2010-05-21 | |
| US61/346,926 | 2010-05-21 | ||
| PCT/US2011/036971 WO2011146595A2 (en) | 2010-05-21 | 2011-05-18 | Zwitterionic reagents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018000502A Division JP6524272B2 (ja) | 2010-05-21 | 2018-01-05 | 両性イオン性試薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013534909A JP2013534909A (ja) | 2013-09-09 |
| JP2013534909A5 true JP2013534909A5 (enExample) | 2014-07-03 |
Family
ID=44992311
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013512082A Pending JP2013534909A (ja) | 2010-05-21 | 2011-05-18 | 両性イオン性試薬 |
| JP2018000502A Active JP6524272B2 (ja) | 2010-05-21 | 2018-01-05 | 両性イオン性試薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018000502A Active JP6524272B2 (ja) | 2010-05-21 | 2018-01-05 | 両性イオン性試薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9487480B2 (enExample) |
| EP (2) | EP4183773B1 (enExample) |
| JP (2) | JP2013534909A (enExample) |
| CN (1) | CN102905690B (enExample) |
| ES (1) | ES2941663T3 (enExample) |
| WO (1) | WO2011146595A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008019381A1 (en) | 2006-08-07 | 2008-02-14 | University Of Washington | Mixed charge copolymers and hydrogels |
| WO2011146595A2 (en) * | 2010-05-21 | 2011-11-24 | Siemens Healthcare Diagnostics Inc. | Zwitterionic reagents |
| WO2016025752A1 (en) * | 2014-08-14 | 2016-02-18 | Prolynx Llc | Reagents for thiol conjugation and conjugates formed therefrom |
| US9533951B2 (en) | 2014-10-20 | 2017-01-03 | Eastman Chemical Company | Heterocyclic amphoteric compounds |
| US9943816B2 (en) | 2014-10-20 | 2018-04-17 | Eastman Chemical Company | Amphoteric ester sulfonates |
| US9381147B2 (en) | 2014-10-20 | 2016-07-05 | Johnson & Johnson Consumer Inc. | Compositions comprising zwitterionic ester ammonioalkanoates |
| EP3288932A4 (en) * | 2015-04-29 | 2018-12-05 | Sanford-Burnham Medical Research Institute | Novel epha4 inhibitors targeting its ligand binding domain |
| US9993408B2 (en) | 2015-09-17 | 2018-06-12 | Johnson & Johnson Consumer Inc. | Compositions comprising zwitterionic alkyl-alkanoylamides and/or alkyl alkanoates |
| US11414380B2 (en) | 2015-09-17 | 2022-08-16 | Eastman Chemical Company | Amphoteric compounds |
| EP3759460B1 (en) * | 2018-02-26 | 2026-04-22 | Waters Technologies Corporation | Acid labile surfactants and method for performing protein solubilization or enzyme digestion |
| JP2025535270A (ja) | 2022-10-13 | 2025-10-24 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 縮合複素環を有するアクリジニウム化合物 |
| EP4638467A4 (en) * | 2022-12-21 | 2026-03-04 | Siemens Healthcare Diagnostics Inc | CYCLOSPORINE-ACRIDINIUM ESTERS AND THEIR PRODUCTION AND USE PROCESSES |
| WO2025011419A1 (zh) | 2023-07-07 | 2025-01-16 | 上海诗健生物科技有限公司 | 一种连接子-药物分子及抗体药物偶联物、其制备方法和应用 |
| AU2025208742A1 (en) | 2024-01-19 | 2026-07-23 | Foreseen Technology (Beijing) Co., Ltd. | An anti_itga2 antibody drug conjugate |
| WO2026145811A1 (zh) * | 2025-01-06 | 2026-07-09 | 上海诗健生物科技有限公司 | 一种抗体药物缀合物 |
| CN122342832A (zh) * | 2025-01-06 | 2026-07-07 | 上海诗健生物科技有限公司 | 一种抗体药物缀合物 |
| WO2026149944A1 (en) | 2025-01-07 | 2026-07-16 | SunRock Biopharma S.L. | Ccr9-targeted antibody-drug conjugates |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3871929A (en) | 1974-01-30 | 1975-03-18 | Allied Chem | Polymeric etch resist strippers and method of using same |
| ATE7898T1 (de) * | 1981-02-26 | 1984-06-15 | Ciba-Geigy Ag | Amphotere styrolderivate. |
| EP0061872B1 (en) | 1981-03-30 | 1985-08-07 | Takeda Chemical Industries, Ltd. | Ethyleneglycol derivatives, their production and use |
| JPS5839651A (ja) * | 1981-09-04 | 1983-03-08 | Ajinomoto Co Inc | 新規ジアミノモノカルボン酸誘導体及びこれを活性成分とする界面活性剤 |
| JPH0411075Y2 (enExample) | 1985-09-13 | 1992-03-18 | ||
| JPH0411073Y2 (enExample) | 1986-03-07 | 1992-03-18 | ||
| AU609824B2 (en) | 1987-06-15 | 1991-05-09 | Southern Cross Biotech Pty Ltd. | Production of proteins in active forms |
| JPH0434078Y2 (enExample) | 1987-08-21 | 1992-08-13 | ||
| JPH01225494A (ja) | 1988-03-07 | 1989-09-08 | Toukuri Lab:Kk | 水不溶性融合蛋白質の可溶化方法 |
| US5656426A (en) | 1988-08-01 | 1997-08-12 | Chiron Diagnostics Corporation | Functionaized hydrophilic acridinium esters |
| US4962024A (en) | 1988-08-11 | 1990-10-09 | Becton, Dickinson And Company | Signal enhancement in assay for an enzyme |
| JPH0434079Y2 (enExample) | 1989-08-14 | 1992-08-13 | ||
| EP0495841B1 (en) * | 1989-10-13 | 1995-10-18 | Biocompatibles Limited | Method of reducing protein deposition in sight correction devices |
| JPH043079A (ja) | 1990-04-20 | 1992-01-08 | Seiko Epson Corp | 電子写真装置 |
| JPH0434079A (ja) * | 1990-04-24 | 1992-02-05 | Nippon Shokubai Co Ltd | 羊毛及び羊毛製品のセット加工用剤 |
| JPH0434078A (ja) | 1990-04-25 | 1992-02-05 | Nippon Shokubai Co Ltd | 羊毛及び羊毛製品のセット加工用剤 |
| JP2724022B2 (ja) | 1990-04-26 | 1998-03-09 | 株式会社日本触媒 | 繊維及び繊維製品の柔軟加工用剤 |
| JP2724023B2 (ja) | 1990-04-27 | 1998-03-09 | 株式会社日本触媒 | 繊維及び繊維製品の抗菌加工用剤 |
| US6017895A (en) * | 1992-02-10 | 2000-01-25 | Genzyme Corporation | Oligonucleotides possessing zwitterionic moieties |
| US5760021A (en) | 1992-05-29 | 1998-06-02 | The Procter & Gamble Company | Phosphonocarboxylate compounds pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| AU4400593A (en) | 1992-06-05 | 1994-01-04 | Abbott Laboratories | Methods and reagents for the determination of immunosuppressive agents |
| US5656246A (en) | 1995-10-30 | 1997-08-12 | International Ecoscience, Inc. | Contaminant destruction by oxidation processing via enhanced ozonation |
| JPH10730A (ja) | 1996-06-17 | 1998-01-06 | Toyo Ink Mfg Co Ltd | 光反射フィルム |
| AU4892897A (en) | 1996-09-17 | 1998-04-14 | Amur Pharmaceuticals, Inc. | Phospholipid drug derivatives |
| JPH10158979A (ja) | 1996-11-20 | 1998-06-16 | Matsushita Electric Ind Co Ltd | 洗濯用仕上げ剤 |
| US5830432A (en) | 1997-03-31 | 1998-11-03 | Amur Pharmacuticals, Inc. | Phospholipid drug derivatives |
| US20040146867A1 (en) | 2003-01-24 | 2004-07-29 | Slattum Paul M | Compounds and processes for single-pot attachment of a label to siRNA |
| SE9803838D0 (sv) * | 1998-11-09 | 1998-11-09 | Knut Irgum | A chromatography method and a column material useful in said method |
| JP3437517B2 (ja) | 1999-02-16 | 2003-08-18 | キヤノン株式会社 | 二次元位相型光学素子の作製方法 |
| JP3818001B2 (ja) | 1999-04-20 | 2006-09-06 | コニカミノルタホールディングス株式会社 | インクジェット記録用インク |
| JP2002052714A (ja) | 2000-05-30 | 2002-02-19 | Kyocera Corp | インクジェット記録ヘッド |
| JP4706816B2 (ja) | 2001-09-28 | 2011-06-22 | ライオン株式会社 | 液体柔軟剤組成物 |
| US8048408B2 (en) * | 2002-01-16 | 2011-11-01 | Biocompatibles Uk Limited | Polymer conjugates |
| AUPS298102A0 (en) * | 2002-06-13 | 2002-07-04 | Nucleics Pty Ltd | Method for performing chemical reactions |
| US7582260B2 (en) | 2002-07-18 | 2009-09-01 | Montana State University | Zwitterionic dyes for labeling in proteomic and other biological analyses |
| US7309615B2 (en) | 2002-09-27 | 2007-12-18 | Siemens Medical Solutions Diagnostic | High quantum yield acridinium compounds and their uses in improving assay sensitivity |
| US7005518B2 (en) | 2002-10-25 | 2006-02-28 | Li-Cor, Inc. | Phthalocyanine dyes |
| DE10304219B3 (de) | 2003-01-30 | 2004-08-19 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität |
| DE10307725B4 (de) * | 2003-02-24 | 2007-04-19 | Clariant Produkte (Deutschland) Gmbh | Korrosions-und Gashydratinhibitoren mit verbesserter Wasserlöslichkeit und erhöhter biologischer Abbaubarkeit |
| US7767834B2 (en) | 2004-08-13 | 2010-08-03 | Elitech Holding B.V. | Phosphonylated fluorescent dyes and conjugates |
| US20060183863A1 (en) * | 2005-02-14 | 2006-08-17 | Ciphergen Biosystems, Inc. | Zwitterionic polymers |
| DE102005051587A1 (de) | 2005-10-27 | 2007-05-03 | Consortium für elektrochemische Industrie GmbH | Zwitterionische Strukturelemente aufweisende Partikel |
| EP2007801A4 (en) | 2006-04-07 | 2010-08-04 | Modpro Ab | BINDER FOR C-REACTIVE PROTEIN |
| EP2074101B1 (en) | 2006-10-13 | 2012-08-08 | Siemens Healthcare Diagnostics Inc. | Stable acridinium esters with fast light emission |
| US8268865B2 (en) * | 2007-05-11 | 2012-09-18 | Rempex Pharmaceuticals, Inc. | Quaternary alkyl ammonium bacterial efflux pump inhibitors and therapeutic uses thereof |
| CN101918462B (zh) | 2007-11-19 | 2013-07-17 | 华盛顿大学 | 具有控制生物性能的两性离子甜菜碱的阳离子甜菜碱前体 |
| US7745670B2 (en) | 2008-06-27 | 2010-06-29 | Codman & Shurtleff, Inc. | Curcumin-Resveratrol hybrid molecule |
| CN105153115B (zh) * | 2009-11-16 | 2021-08-03 | 西门子医疗保健诊断公司 | 含两性离子的吖啶鎓化合物 |
| WO2011146595A2 (en) * | 2010-05-21 | 2011-11-24 | Siemens Healthcare Diagnostics Inc. | Zwitterionic reagents |
-
2011
- 2011-05-18 WO PCT/US2011/036971 patent/WO2011146595A2/en not_active Ceased
- 2011-05-18 CN CN201180025264.7A patent/CN102905690B/zh active Active
- 2011-05-18 ES ES11784156T patent/ES2941663T3/es active Active
- 2011-05-18 EP EP22209183.7A patent/EP4183773B1/en active Active
- 2011-05-18 US US13/699,435 patent/US9487480B2/en active Active
- 2011-05-18 JP JP2013512082A patent/JP2013534909A/ja active Pending
- 2011-05-18 EP EP11784156.9A patent/EP2571487B1/en active Active
-
2016
- 2016-05-28 US US15/168,018 patent/US10710962B2/en active Active
-
2018
- 2018-01-05 JP JP2018000502A patent/JP6524272B2/ja active Active
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