JP2013533267A - ５位で置換されたべンゾフラン誘導体の調製方法 - Google Patents

５位で置換されたべンゾフラン誘導体の調製方法 Download PDF

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Publication number
JP2013533267A
JP2013533267A JP2013520191A JP2013520191A JP2013533267A JP 2013533267 A JP2013533267 A JP 2013533267A JP 2013520191 A JP2013520191 A JP 2013520191A JP 2013520191 A JP2013520191 A JP 2013520191A JP 2013533267 A JP2013533267 A JP 2013533267A
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formula
group
compound
alkyl group
branched
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JP2013520191A
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English (en)
Japanese (ja)
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JP2013533267A5 (enExample
Inventor
バイイ，フレデリク
ボン，グザビエ
バイロン，フイリツプ
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Sanofi SA
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Sanofi SA
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Publication of JP2013533267A publication Critical patent/JP2013533267A/ja
Publication of JP2013533267A5 publication Critical patent/JP2013533267A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/60—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
JP2013520191A 2010-07-21 2011-07-20 ５位で置換されたべンゾフラン誘導体の調製方法 Pending JP2013533267A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1055951A FR2963006B1 (fr) 2010-07-21 2010-07-21 Procede de preparation de derives de nitro-benzofurane
FR1055951 2010-07-21
PCT/FR2011/051751 WO2012010802A1 (fr) 2010-07-21 2011-07-20 Procede de preparation de derives de benzofurane substitues en position 5

Publications (2)

Publication Number Publication Date
JP2013533267A true JP2013533267A (ja) 2013-08-22
JP2013533267A5 JP2013533267A5 (enExample) 2014-07-10

Family

ID=42790926

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013520191A Pending JP2013533267A (ja) 2010-07-21 2011-07-20 ５位で置換されたべンゾフラン誘導体の調製方法

Country Status (13)

Country Link
US (1) US8748636B2 (enExample)
EP (1) EP2595977A1 (enExample)
JP (1) JP2013533267A (enExample)
KR (1) KR20130094305A (enExample)
CN (1) CN103221401A (enExample)
AU (1) AU2011281435A1 (enExample)
BR (1) BR112013001365A2 (enExample)
CA (1) CA2805868A1 (enExample)
FR (1) FR2963006B1 (enExample)
MX (1) MX2013000845A (enExample)
RU (1) RU2013107600A (enExample)
SG (1) SG187565A1 (enExample)
WO (1) WO2012010802A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
WO2013121235A2 (en) 2012-02-13 2013-08-22 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
WO2013121234A1 (en) 2012-02-14 2013-08-22 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction
CN109384754B (zh) * 2017-08-14 2020-06-09 新发药业有限公司 一种盐酸决奈达隆的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009044143A2 (en) * 2007-10-02 2009-04-09 Cambrex Karlskoga Ab Process for preparing benzofurans
WO2010038029A1 (en) * 2008-10-02 2010-04-08 Cambrex Karlskoga Ab New process for preparing diketones and medicaments
WO2010040261A1 (en) * 2008-10-10 2010-04-15 Lonza Ltd Process for preparing 2-alkyl-3-aroyl-5-nitro-benzofurans
JP2013521264A (ja) * 2010-03-02 2013-06-10 サノフイ ケトベンゾフラン誘導体、その合成方法および中間体

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2337396A1 (de) * 1973-07-23 1975-02-13 Hoechst Ag Verfahren zur herstellung aromatischer 1,3-diketone
FR2665444B1 (fr) 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
IT1275997B1 (it) * 1995-03-31 1997-10-24 Great Lakes Chemical Italia Enammine come accelleranti di vulcanizzazione per gomme naturali o sintetiche
FR2813306B1 (fr) 2000-08-23 2005-10-21 Sanofi Synthelabo Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
FR2813308B1 (fr) * 2000-08-23 2005-07-01 Sanofi Synthelabo Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant
FR2817864B1 (fr) 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
FR2817865B1 (fr) 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
EP1644371B1 (en) * 2003-07-03 2008-02-13 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivatives as kinase inhibitors
UY32657A (es) 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para la fabricación de productos intermedios de dronedarona
TW201107303A (en) 2009-05-27 2011-03-01 Sanofi Aventis Process for the production of benzofurans
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
FR2973027A1 (fr) 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100166A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009044143A2 (en) * 2007-10-02 2009-04-09 Cambrex Karlskoga Ab Process for preparing benzofurans
WO2010038029A1 (en) * 2008-10-02 2010-04-08 Cambrex Karlskoga Ab New process for preparing diketones and medicaments
WO2010040261A1 (en) * 2008-10-10 2010-04-15 Lonza Ltd Process for preparing 2-alkyl-3-aroyl-5-nitro-benzofurans
JP2013521264A (ja) * 2010-03-02 2013-06-10 サノフイ ケトベンゾフラン誘導体、その合成方法および中間体

Also Published As

Publication number Publication date
KR20130094305A (ko) 2013-08-23
US8748636B2 (en) 2014-06-10
CN103221401A (zh) 2013-07-24
FR2963006A1 (fr) 2012-01-27
MX2013000845A (es) 2013-02-11
US20130165674A1 (en) 2013-06-27
EP2595977A1 (fr) 2013-05-29
AU2011281435A1 (en) 2013-02-07
SG187565A1 (en) 2013-03-28
BR112013001365A2 (pt) 2016-05-17
WO2012010802A1 (fr) 2012-01-26
CA2805868A1 (fr) 2012-01-26
FR2963006B1 (fr) 2013-03-15
RU2013107600A (ru) 2014-08-27

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