CN103221401A - 制备5位被取代的苯并呋喃衍生物的方法 - Google Patents

制备5位被取代的苯并呋喃衍生物的方法 Download PDF

Info

Publication number
CN103221401A
CN103221401A CN2011800454136A CN201180045413A CN103221401A CN 103221401 A CN103221401 A CN 103221401A CN 2011800454136 A CN2011800454136 A CN 2011800454136A CN 201180045413 A CN201180045413 A CN 201180045413A CN 103221401 A CN103221401 A CN 103221401A
Authority
CN
China
Prior art keywords
formula
compound
alkyl
group
mean
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800454136A
Other languages
English (en)
Chinese (zh)
Inventor
F.贝利
X.邦
P.维隆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of CN103221401A publication Critical patent/CN103221401A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
    • C07C251/60—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
CN2011800454136A 2010-07-21 2011-07-20 制备5位被取代的苯并呋喃衍生物的方法 Pending CN103221401A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1055951A FR2963006B1 (fr) 2010-07-21 2010-07-21 Procede de preparation de derives de nitro-benzofurane
FR1055951 2010-07-21
PCT/FR2011/051751 WO2012010802A1 (fr) 2010-07-21 2011-07-20 Procede de preparation de derives de benzofurane substitues en position 5

Publications (1)

Publication Number Publication Date
CN103221401A true CN103221401A (zh) 2013-07-24

Family

ID=42790926

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800454136A Pending CN103221401A (zh) 2010-07-21 2011-07-20 制备5位被取代的苯并呋喃衍生物的方法

Country Status (13)

Country Link
US (1) US8748636B2 (enExample)
EP (1) EP2595977A1 (enExample)
JP (1) JP2013533267A (enExample)
KR (1) KR20130094305A (enExample)
CN (1) CN103221401A (enExample)
AU (1) AU2011281435A1 (enExample)
BR (1) BR112013001365A2 (enExample)
CA (1) CA2805868A1 (enExample)
FR (1) FR2963006B1 (enExample)
MX (1) MX2013000845A (enExample)
RU (1) RU2013107600A (enExample)
SG (1) SG187565A1 (enExample)
WO (1) WO2012010802A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109384754A (zh) * 2017-08-14 2019-02-26 新发药业有限公司 一种盐酸决奈达隆的制备方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
WO2013121234A1 (en) 2012-02-14 2013-08-22 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2238696A1 (enExample) * 1973-07-23 1975-02-21 Hoechst Ag
EP0735083A1 (en) * 1995-03-31 1996-10-02 GREAT LAKES CHEMICAL ITALIA S.r.l. Enamines as vulcanization accelerators for natural or synthetic rubbers
WO2002016340A1 (fr) * 2000-08-23 2002-02-28 Sanofi-Synthelabo Aminoalkoxybenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant
WO2005012301A1 (en) * 2003-07-03 2005-02-10 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivatives as kinase inhibitors
WO2009044143A2 (en) * 2007-10-02 2009-04-09 Cambrex Karlskoga Ab Process for preparing benzofurans
WO2010038029A1 (en) * 2008-10-02 2010-04-08 Cambrex Karlskoga Ab New process for preparing diketones and medicaments
WO2010040261A1 (en) * 2008-10-10 2010-04-15 Lonza Ltd Process for preparing 2-alkyl-3-aroyl-5-nitro-benzofurans

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665444B1 (fr) 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
FR2813306B1 (fr) 2000-08-23 2005-10-21 Sanofi Synthelabo Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
FR2817865B1 (fr) 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
FR2817864B1 (fr) 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
TW201107303A (en) 2009-05-27 2011-03-01 Sanofi Aventis Process for the production of benzofurans
UY32657A (es) 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para la fabricación de productos intermedios de dronedarona
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2957079B1 (fr) 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
FR2973027A1 (fr) 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100166A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2238696A1 (enExample) * 1973-07-23 1975-02-21 Hoechst Ag
EP0735083A1 (en) * 1995-03-31 1996-10-02 GREAT LAKES CHEMICAL ITALIA S.r.l. Enamines as vulcanization accelerators for natural or synthetic rubbers
WO2002016340A1 (fr) * 2000-08-23 2002-02-28 Sanofi-Synthelabo Aminoalkoxybenzoyl-benzofuranes ou benzothiophenes, leur procede de preparation et les compositions les contenant
WO2005012301A1 (en) * 2003-07-03 2005-02-10 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivatives as kinase inhibitors
WO2009044143A2 (en) * 2007-10-02 2009-04-09 Cambrex Karlskoga Ab Process for preparing benzofurans
WO2010038029A1 (en) * 2008-10-02 2010-04-08 Cambrex Karlskoga Ab New process for preparing diketones and medicaments
WO2010040261A1 (en) * 2008-10-10 2010-04-15 Lonza Ltd Process for preparing 2-alkyl-3-aroyl-5-nitro-benzofurans

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M.J.HADDADIN: "Reaction of benzofurazan oxide with unsymmetrical 1,3-diketones;steric and polar effects", 《TETRAHEDRON》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109384754A (zh) * 2017-08-14 2019-02-26 新发药业有限公司 一种盐酸决奈达隆的制备方法
CN109384754B (zh) * 2017-08-14 2020-06-09 新发药业有限公司 一种盐酸决奈达隆的制备方法

Also Published As

Publication number Publication date
JP2013533267A (ja) 2013-08-22
FR2963006A1 (fr) 2012-01-27
EP2595977A1 (fr) 2013-05-29
US8748636B2 (en) 2014-06-10
MX2013000845A (es) 2013-02-11
CA2805868A1 (fr) 2012-01-26
RU2013107600A (ru) 2014-08-27
KR20130094305A (ko) 2013-08-23
BR112013001365A2 (pt) 2016-05-17
US20130165674A1 (en) 2013-06-27
FR2963006B1 (fr) 2013-03-15
AU2011281435A1 (en) 2013-02-07
WO2012010802A1 (fr) 2012-01-26
SG187565A1 (en) 2013-03-28

Similar Documents

Publication Publication Date Title
CN103221401A (zh) 制备5位被取代的苯并呋喃衍生物的方法
JPH0753725B2 (ja) ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
TWI732808B (zh) 1,3－苯并二氧雜環戊烯雜環化合物之製備方法
TWI774791B (zh) 1,3-苯并二氧雜環戊烯雜環化合物之製備方法
WO2010136502A1 (en) Process for the production of dronedarone intermediates
JP5061138B2 (ja) ２−ヒドロキシアセトフェノンオキシム誘導体
KR20130021359A (ko) 아미노벤조푸란 유도체의 제조 방법
JP3763828B2 (ja) ベンゾピラン化合物の前駆体合成のための中間体の製造方法
CN105218329B (zh) 一种列净类似物中间体及其制备方法
NO178396B (no) Forbedret fremgangsmåte for fremstilling av substituerte indolonderivater og mellomprodukter i fremstillingen derav
TWI316939B (en) Process for the preparation of organic compounds
JP4131337B2 (ja) ３―（イソオキサゾール―５―イル）置換安息香酸誘導体およびその製造法
JPWO1997035850A1 (ja) ３−（イソオキサゾール−５−イル）置換安息香酸誘導体およびその製造法
CN101410386B (zh) 2-链烯基-3-氨基噻吩衍生物及其制备方法
KR20040039430A (ko) (2-니트로페닐)아세토니트릴 유도체의 제조방법 및 그합성중간체
SU620209A3 (ru) Способ получени производных арилалкиламина ил их солей
JP2008546818A (ja) １−［シアノ（４−ヒドロキシフェニル）メチル］シクロヘキサノール化合物の製造方法
JPH06128205A (ja) ピリジン及びキノリン誘導体の製造方法
AU2005305795B2 (en) Novel method for preparing 3-[5'-(3,4-bis-hydroxymethyl-benzyloxy)-2'- ethyl-2-propyl-biphenyl-4-yl]-penta-3-ol
JP4194984B2 (ja) フェニルナフチルイミダゾール化合物
US4798893A (en) Process for producing 1-(5-substituted-2-ethynylphenyl)-2-propanones
CN114761384A (zh) 用于合成2-硫代烷基嘧啶的方法
KR101219504B1 (ko) 디벤조티에핀 유도체의 제조방법
CS227020B2 (en) Method of preparing 5,6,7,7a-tetrahydro-4h-thiano (3,2-c) pyridin -2-one derivatives
JP2025165745A (ja) ハロゲノ－２，４－置換安息香酸誘導体、ベンゾフェノン誘導体、及びハロゲノベンゼン誘導体の製造方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20130724