JP2013529183A5 - - Google Patents

Info

Publication number

JP2013529183A5

JP2013529183A5 JP2013502691A JP2013502691A JP2013529183A5 JP 2013529183 A5 JP2013529183 A5 JP 2013529183A5 JP 2013502691 A JP2013502691 A JP 2013502691A JP 2013502691 A JP2013502691 A JP 2013502691A JP 2013529183 A5 JP2013529183 A5 JP 2013529183A5

Authority

JP

Japan

Prior art keywords

cancer

seq

antibody

sequence

fragment

Prior art date

2011-03-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 206010028980 Neoplasm Diseases 0.000 claims 7
• 201000011510 cancer Diseases 0.000 claims 7
• 125000003275 alpha amino acid group Chemical group 0.000 claims 6
• 239000012634 fragment Substances 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims 3
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
• 206010014733 Endometrial cancer Diseases 0.000 claims 2
• 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
• 206010060862 Prostate cancer Diseases 0.000 claims 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
• 238000011394 anticancer treatment Methods 0.000 claims 2
• 208000032839 leukemia Diseases 0.000 claims 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 208000017604 Hodgkin disease Diseases 0.000 claims 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
• 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 208000034578 Multiple myelomas Diseases 0.000 claims 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
• 206010038389 Renal cancer Diseases 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 229960003668 docetaxel Drugs 0.000 claims 1
• 229960004679 doxorubicin Drugs 0.000 claims 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
• 229940022353 herceptin Drugs 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 230000000977 initiatory effect Effects 0.000 claims 1
• 201000010982 kidney cancer Diseases 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 210000002381 plasma Anatomy 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• 238000011282 treatment Methods 0.000 claims 1
• 238000011269 treatment regimen Methods 0.000 claims 1
• 210000004881 tumor cell Anatomy 0.000 claims 1