CY1119324T1 - Αντισωματα εναντιον csf-1r - Google Patents

Αντισωματα εναντιον csf-1r

Info

Publication number
CY1119324T1
CY1119324T1 CY20171100949T CY171100949T CY1119324T1 CY 1119324 T1 CY1119324 T1 CY 1119324T1 CY 20171100949 T CY20171100949 T CY 20171100949T CY 171100949 T CY171100949 T CY 171100949T CY 1119324 T1 CY1119324 T1 CY 1119324T1
Authority
CY
Cyprus
Prior art keywords
1r
csf
antibodies
inducing
invention
Prior art date
Application number
CY20171100949T
Other languages
English (en)
Inventor
Jacqueline Francoise Doody
Yanxia Li
Original Assignee
Imclone Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US31989610P priority Critical
Priority to PCT/US2011/030148 priority patent/WO2011123381A1/en
Application filed by Imclone Llc filed Critical Imclone Llc
Publication of CY1119324T1 publication Critical patent/CY1119324T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Η εφεύρεση παρέχει ανθρώπινο αντίσωμα που δεσμεύεται με ανθρώπινο CSF-1R με υψηλή συγγένεια. Τα αντισώματα της παρούσας εφεύρεσης έχουν σημαντικά πλεονεκτήματα συγκριτικά με τα αντισώματα που είναι γνωστά στην τεχνολογία όντας πολυλειτουργικά: αναστέλλοντας σηματοδότηση του CSF-1R, εσωτερικευόμενα και επάγοντας αποικοδόμηση CSF-1R και διεγείροντας ADCC σε κύτταρα που περιλαμβάνουν όγκους, μακροφάγα και μονοκύτταρα. Επιδεικνύεται επίσης ότι είναι αποτελεσματικά σε θεραπευτική αγωγή λευχαιμίας, καρκίνου μαστού, ενδομητρίου και προστάτη, μόνα τους ή σε συνδυασμό με δοκεταξέλη, πακλιταξέλη, Herceptin® ή δοξορουβικίνη.
CY20171100949T 2010-04-01 2017-09-07 Αντισωματα εναντιον csf-1r CY1119324T1 (el)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US31989610P true 2010-04-01 2010-04-01
PCT/US2011/030148 WO2011123381A1 (en) 2010-04-01 2011-03-28 Antibodies against csf-1r

Publications (1)

Publication Number Publication Date
CY1119324T1 true CY1119324T1 (el) 2018-02-14

Family

ID=44010222

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100949T CY1119324T1 (el) 2010-04-01 2017-09-07 Αντισωματα εναντιον csf-1r

Country Status (30)

Country Link
US (1) US8263079B2 (el)
EP (2) EP3156419A1 (el)
JP (1) JP5767310B2 (el)
KR (1) KR101439719B1 (el)
CN (1) CN102834414B (el)
AR (1) AR080698A1 (el)
AU (1) AU2011232850B2 (el)
BR (1) BR112012024564A2 (el)
CA (1) CA2795081C (el)
CY (1) CY1119324T1 (el)
DK (1) DK2552966T3 (el)
EA (1) EA021600B1 (el)
ES (1) ES2640909T3 (el)
HR (1) HRP20171153T1 (el)
HU (1) HUE036379T2 (el)
IL (1) IL222222A (el)
JO (1) JO3291B1 (el)
LT (1) LT2552966T (el)
ME (1) ME02806B (el)
MX (1) MX2012011234A (el)
NZ (1) NZ602621A (el)
PL (1) PL2552966T3 (el)
PT (1) PT2552966T (el)
RS (1) RS56219B1 (el)
SG (1) SG183829A1 (el)
SI (1) SI2552966T1 (el)
TW (1) TWI402078B (el)
UA (1) UA111818C2 (el)
WO (1) WO2011123381A1 (el)
ZA (1) ZA201206926B (el)

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Also Published As

Publication number Publication date
DK2552966T3 (en) 2017-08-14
KR101439719B1 (ko) 2014-09-12
TWI402078B (zh) 2013-07-21
JP5767310B2 (ja) 2015-08-19
KR20130001258A (ko) 2013-01-03
EP3156419A1 (en) 2017-04-19
TW201138824A (en) 2011-11-16
PT2552966T (pt) 2017-09-29
JO3291B1 (ar) 2018-09-16
MX2012011234A (es) 2012-11-30
ME02806B (me) 2018-01-20
EP2552966B1 (en) 2017-07-05
HRP20171153T1 (hr) 2017-10-06
CN102834414A (zh) 2012-12-19
RS56219B1 (sr) 2017-11-30
EA201270732A1 (ru) 2013-01-30
US8263079B2 (en) 2012-09-11
IL222222D0 (en) 2012-12-31
LT2552966T (lt) 2017-10-10
HUE036379T2 (hu) 2018-07-30
AU2011232850A1 (en) 2012-09-06
CN102834414B (zh) 2014-10-08
US20110243947A1 (en) 2011-10-06
SI2552966T1 (sl) 2017-08-31
CA2795081A1 (en) 2011-10-06
BR112012024564A2 (pt) 2016-11-29
ES2640909T3 (es) 2017-11-07
WO2011123381A1 (en) 2011-10-06
ZA201206926B (en) 2014-03-26
JP2013529183A (ja) 2013-07-18
EA021600B1 (ru) 2015-07-30
UA111818C2 (uk) 2016-06-24
NZ602621A (en) 2014-02-28
CA2795081C (en) 2017-12-05
AU2011232850B2 (en) 2014-06-19
SG183829A1 (en) 2012-10-30
EP2552966A1 (en) 2013-02-06
PL2552966T3 (pl) 2017-12-29
IL222222A (en) 2016-02-29
AR080698A1 (es) 2012-05-02

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