JP2013524777A5 - - Google Patents
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- JP2013524777A5 JP2013524777A5 JP2012557290A JP2012557290A JP2013524777A5 JP 2013524777 A5 JP2013524777 A5 JP 2013524777A5 JP 2012557290 A JP2012557290 A JP 2012557290A JP 2012557290 A JP2012557290 A JP 2012557290A JP 2013524777 A5 JP2013524777 A5 JP 2013524777A5
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- Prior art keywords
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- antibody
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- antigen
- Prior art date
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- 229920001184 polypeptide Polymers 0.000 claims description 81
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 81
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 81
- 239000012634 fragment Substances 0.000 claims description 67
- 239000000427 antigen Substances 0.000 claims description 63
- 102000036639 antigens Human genes 0.000 claims description 63
- 108091007433 antigens Proteins 0.000 claims description 63
- 229940127121 immunoconjugate Drugs 0.000 claims description 35
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 claims description 22
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 claims description 20
- 210000004027 cell Anatomy 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 206010025323 Lymphomas Diseases 0.000 claims description 9
- 229940127089 cytotoxic agent Drugs 0.000 claims description 9
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims description 8
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims description 8
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 8
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 8
- 230000004540 complement-dependent cytotoxicity Effects 0.000 claims description 8
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims description 8
- 208000021937 marginal zone lymphoma Diseases 0.000 claims description 8
- 239000002254 cytotoxic agent Substances 0.000 claims description 7
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 7
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 6
- 239000002246 antineoplastic agent Substances 0.000 claims description 6
- 201000003444 follicular lymphoma Diseases 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- -1 taxoid Chemical compound 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- JSHOVKSMJRQOGY-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(pyridin-2-yldisulfanyl)butanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCSSC1=CC=CC=N1 JSHOVKSMJRQOGY-UHFFFAOYSA-N 0.000 claims description 4
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims description 4
- 208000008691 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims description 4
- 230000006907 apoptotic process Effects 0.000 claims description 4
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims description 4
- AMRJKAQTDDKMCE-UHFFFAOYSA-N dolastatin Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)C)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 AMRJKAQTDDKMCE-UHFFFAOYSA-N 0.000 claims description 4
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- UOWVMDUEMSNCAV-WYENRQIDSA-N rachelmycin Chemical compound C1([C@]23C[C@@H]2CN1C(=O)C=1NC=2C(OC)=C(O)C4=C(C=2C=1)CCN4C(=O)C1=CC=2C=4CCN(C=4C(O)=C(C=2N1)OC)C(N)=O)=CC(=O)C1=C3C(C)=CN1 UOWVMDUEMSNCAV-WYENRQIDSA-N 0.000 claims description 4
- GTBCXYYVWHFQRS-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(pyridin-2-yldisulfanyl)pentanoate Chemical compound C=1C=CC=NC=1SSC(C)CCC(=O)ON1C(=O)CCC1=O GTBCXYYVWHFQRS-UHFFFAOYSA-N 0.000 claims description 3
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims description 3
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 claims description 3
- 241001529936 Murinae Species 0.000 claims description 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 3
- 239000003431 cross linking reagent Substances 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 208000032839 leukemia Diseases 0.000 claims description 3
- 238000006467 substitution reaction Methods 0.000 claims description 3
- UQVNRKBFAXNOGA-LWTNMJDUSA-N (E)-tomaymycin Chemical class CO[C@H]1NC2=CC(O)=C(OC)C=C2C(=O)N2C\C(=C\C)C[C@@H]12 UQVNRKBFAXNOGA-LWTNMJDUSA-N 0.000 claims description 2
- FUHCFUVCWLZEDQ-UHFFFAOYSA-N 1-(2,5-dioxopyrrolidin-1-yl)oxy-1-oxo-4-(pyridin-2-yldisulfanyl)butane-2-sulfonic acid Chemical compound O=C1CCC(=O)N1OC(=O)C(S(=O)(=O)O)CCSSC1=CC=CC=N1 FUHCFUVCWLZEDQ-UHFFFAOYSA-N 0.000 claims description 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims description 2
- YCTIVQHRJIAMKZ-UHFFFAOYSA-N 2-amino-4-(2-iodoacetyl)benzoic acid Chemical compound NC1=CC(C(=O)CI)=CC=C1C(O)=O YCTIVQHRJIAMKZ-UHFFFAOYSA-N 0.000 claims description 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims description 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims description 2
- 208000030289 Lymphoproliferative disease Diseases 0.000 claims description 2
- 241000282553 Macaca Species 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims description 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 208000033014 Plasma cell tumor Diseases 0.000 claims description 2
- 208000007452 Plasmacytoma Diseases 0.000 claims description 2
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 2
- 229940049706 benzodiazepine Drugs 0.000 claims description 2
- 229930195731 calicheamicin Natural products 0.000 claims description 2
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims description 2
- 229930188854 dolastatin Natural products 0.000 claims description 2
- 229960004679 doxorubicin Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 229960005501 duocarmycin Drugs 0.000 claims description 2
- 229930184221 duocarmycin Natural products 0.000 claims description 2
- 230000003325 follicular Effects 0.000 claims description 2
- 201000009277 hairy cell leukemia Diseases 0.000 claims description 2
- 102000048426 human CD37 Human genes 0.000 claims description 2
- 210000004408 hybridoma Anatomy 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 201000000638 mature B-cell neoplasm Diseases 0.000 claims description 2
- ZNALDVNNEBOGGN-UHFFFAOYSA-N n-(2,5-dioxopyrrol-1-yl)propanamide Chemical compound CCC(=O)NN1C(=O)C=CC1=O ZNALDVNNEBOGGN-UHFFFAOYSA-N 0.000 claims description 2
- 208000010915 neoplasm of mature B-cells Diseases 0.000 claims description 2
- 208000010626 plasma cell neoplasm Diseases 0.000 claims description 2
- 239000000651 prodrug Substances 0.000 claims description 2
- 229940002612 prodrug Drugs 0.000 claims description 2
- 230000003393 splenic effect Effects 0.000 claims description 2
- 238000002054 transplantation Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- NNPUPCNWEHWRPW-UHFFFAOYSA-N 4-(pyridin-2-yldisulfanyl)-2-sulfobutanoic acid Chemical compound OC(=O)C(S(O)(=O)=O)CCSSC1=CC=CC=N1 NNPUPCNWEHWRPW-UHFFFAOYSA-N 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 241000257303 Hymenoptera Species 0.000 claims 1
- 229930126263 Maytansine Natural products 0.000 claims 1
- LJFFDOBFKICLHN-IXWHRVGISA-N [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[methyl(4-sulfanylpentanoyl)amino]propanoate Chemical compound CO[C@@H]([C@@]1(O)C[C@H](OC(=O)N1)[C@@H](C)[C@@H]1O[C@@]1(C)[C@@H](OC(=O)[C@H](C)N(C)C(=O)CCC(C)S)CC(=O)N1C)\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 LJFFDOBFKICLHN-IXWHRVGISA-N 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 201000000564 macroglobulinemia Diseases 0.000 claims 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 description 11
- 108091033319 polynucleotide Proteins 0.000 description 11
- 239000002157 polynucleotide Substances 0.000 description 11
- 239000013598 vector Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000012216 imaging agent Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- YACHGFWEQXFSBS-RJXCBBHPSA-N leptomycin Chemical class OC(=O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)/C=C(\C)/C=C/C[C@@H](C)\C=C(/CC)\C=C\[C@@H]1OC(=O)C=C[C@@H]1C YACHGFWEQXFSBS-RJXCBBHPSA-N 0.000 description 1
- 201000001268 lymphoproliferative syndrome Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31362810P | 2010-03-12 | 2010-03-12 | |
| US61/313,628 | 2010-03-12 | ||
| US32731410P | 2010-04-23 | 2010-04-23 | |
| US61/327,314 | 2010-04-23 | ||
| US41264410P | 2010-11-11 | 2010-11-11 | |
| US61/412,644 | 2010-11-11 | ||
| PCT/US2011/028172 WO2011112978A1 (en) | 2010-03-12 | 2011-03-11 | Cd37-binding molecules and immunoconjugates thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015019939A Division JP6133340B2 (ja) | 2010-03-12 | 2015-02-04 | Ｃｄ３７結合分子及びそのイムノコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013524777A JP2013524777A (ja) | 2013-06-20 |
| JP2013524777A5 true JP2013524777A5 (https=) | 2013-08-15 |
| JP5932672B2 JP5932672B2 (ja) | 2016-06-08 |
Family
ID=44563875
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012557290A Active JP5932672B2 (ja) | 2010-03-12 | 2011-03-11 | Ｃｄ３７結合分子及びそのイムノコンジュゲート |
| JP2015019939A Active JP6133340B2 (ja) | 2010-03-12 | 2015-02-04 | Ｃｄ３７結合分子及びそのイムノコンジュゲート |
| JP2016077196A Withdrawn JP2016127867A (ja) | 2010-03-12 | 2016-04-07 | Ｃｄ３７結合分子及びそのイムノコンジュゲート |
| JP2018093171A Withdrawn JP2018138053A (ja) | 2010-03-12 | 2018-05-14 | Ｃｄ３７結合分子及びそのイムノコンジュゲート |
| JP2020088800A Pending JP2020141693A (ja) | 2010-03-12 | 2020-05-21 | Ｃｄ３７結合分子及びそのイムノコンジュゲート |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015019939A Active JP6133340B2 (ja) | 2010-03-12 | 2015-02-04 | Ｃｄ３７結合分子及びそのイムノコンジュゲート |
| JP2016077196A Withdrawn JP2016127867A (ja) | 2010-03-12 | 2016-04-07 | Ｃｄ３７結合分子及びそのイムノコンジュゲート |
| JP2018093171A Withdrawn JP2018138053A (ja) | 2010-03-12 | 2018-05-14 | Ｃｄ３７結合分子及びそのイムノコンジュゲート |
| JP2020088800A Pending JP2020141693A (ja) | 2010-03-12 | 2020-05-21 | Ｃｄ３７結合分子及びそのイムノコンジュゲート |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US8765917B2 (https=) |
| EP (2) | EP3620467A1 (https=) |
| JP (5) | JP5932672B2 (https=) |
| KR (2) | KR101764572B1 (https=) |
| CN (2) | CN106046159B (https=) |
| AR (1) | AR080513A1 (https=) |
| AU (3) | AU2011226672B2 (https=) |
| BR (1) | BR112012023010A8 (https=) |
| CA (2) | CA2792618C (https=) |
| CY (1) | CY1122091T1 (https=) |
| DK (1) | DK2544719T3 (https=) |
| ES (1) | ES2748347T3 (https=) |
| HR (1) | HRP20191688T1 (https=) |
| HU (1) | HUE046360T2 (https=) |
| IL (2) | IL221682A (https=) |
| LT (1) | LT2544719T (https=) |
| MX (2) | MX338932B (https=) |
| MY (2) | MY177062A (https=) |
| NZ (2) | NZ602176A (https=) |
| PL (1) | PL2544719T3 (https=) |
| PT (1) | PT2544719T (https=) |
| RS (1) | RS59389B1 (https=) |
| RU (2) | RU2610662C9 (https=) |
| SG (3) | SG183542A1 (https=) |
| SI (1) | SI2544719T1 (https=) |
| SM (1) | SMT201900549T1 (https=) |
| TW (2) | TWI638662B (https=) |
| WO (1) | WO2011112978A1 (https=) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0737792B2 (ja) | 1986-02-14 | 1995-04-26 | 株式会社日立製作所 | ポンプ運転台数の制御装置 |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| KR20200058590A (ko) * | 2008-04-30 | 2020-05-27 | 이뮤노젠 아이엔씨 | 가교제 및 그 용도 |
| JP5986745B2 (ja) | 2008-07-15 | 2016-09-06 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | Ｐｔｆｅ様のアルミニウム・コート・ガラススライド上のグリカンアレイおよび関連する方法 |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| SG183542A1 (en) | 2010-03-12 | 2012-10-30 | Immunogen Inc | Cd37-binding molecules and immunoconjugates thereof |
| US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| HUE027394T2 (en) | 2011-02-01 | 2016-10-28 | Huawei Tech Co Ltd | Energy saving procedure, access point device, and station device |
| WO2012135517A2 (en) | 2011-03-29 | 2012-10-04 | Immunogen, Inc. | Preparation of maytansinoid antibody conjugates by a one-step process |
| RS58367B1 (sr) | 2011-03-29 | 2019-03-29 | Immunogen Inc | Priprema konjugata antitela i majtanzinoida jednostepenim postupkom |
| EP2694105A4 (en) * | 2011-04-01 | 2015-04-29 | Immunogen Inc | CD37 BINDING MOLECULES AND IMMUNOCONJUGATES THEREOF |
| BR112014014258A2 (pt) * | 2011-12-13 | 2020-10-27 | Nordic Nanovector As. | molécula de anticorpo que se liga a cd37 humano; anticorpo; molécula de dna; vetor de expressão; célula hospedeira; método para produzir um anticorpo; composição farmacêutica; método de esgotamento de células b que expressam cd37 dentre uma população de células; radioimunoconjugado que se liga a cd37 humano; método de tratamento de uma malignidade de célula b; kit para a produção do radioimunoconjugado; e preparação injetável de anticorpo hh1 quimérico ou humanizado para uso no pré-tratamento de uma malignidade de célula b |
| CA2865415C (en) | 2012-02-24 | 2022-06-21 | Stem Centrx, Inc. | Anti sez6 antibodies and methods of use |
| HK1202156A1 (en) * | 2012-03-30 | 2015-09-18 | Immunogen, Inc. | Methods for increasing efficacy of cd37-based therapy |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| WO2014031498A1 (en) | 2012-08-18 | 2014-02-27 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| WO2014055877A1 (en) | 2012-10-04 | 2014-04-10 | Immunogen, Inc. | Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates |
| WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| BR112015023074A2 (pt) * | 2013-03-14 | 2017-11-21 | Oncomed Pharm Inc | agentes de ligação-met e uso dos mesmos |
| EP3013365B1 (en) | 2013-06-26 | 2019-06-05 | Academia Sinica | Rm2 antigens and use thereof |
| WO2014210564A1 (en) | 2013-06-27 | 2014-12-31 | Academia Sinica | Glycan conjugates and use thereof |
| JP6510518B2 (ja) | 2013-08-01 | 2019-05-08 | アジェンシス，インコーポレイテッド | Ｃｄ３７タンパク質に結合する抗体薬物結合体（ａｄｃ） |
| US9782476B2 (en) | 2013-09-06 | 2017-10-10 | Academia Sinica | Human iNKT cell activation using glycolipids with altered glycosyl groups |
| CN112043835B (zh) | 2013-12-06 | 2022-10-21 | 韩捷 | 用于含氮和羟基的药物的生物可逆引入基团 |
| CA2937123A1 (en) | 2014-01-16 | 2015-07-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| WO2015148915A1 (en) | 2014-03-27 | 2015-10-01 | Academia Sinica | Reactive labelling compounds and uses thereof |
| WO2015175533A2 (en) * | 2014-05-13 | 2015-11-19 | Immunogen, Inc. | Anti-cd37 immunoconjugate dosing regimens |
| CA2950423A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| KR102512592B1 (ko) | 2014-05-27 | 2023-03-21 | 아카데미아 시니카 | 항-ｈｅｒ2 글리코항체 및 이의 용도 |
| KR20170003720A (ko) | 2014-05-27 | 2017-01-09 | 아카데미아 시니카 | 항-ｃｄ20 글리코항체 및 이의 용도 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| CN106714829A (zh) | 2014-05-28 | 2017-05-24 | 中央研究院 | 抗TNF‑α醣抗体及其用途 |
| CN106999604B (zh) | 2014-09-02 | 2021-08-03 | 伊缪诺金公司 | 用于配制抗体药物缀合物组合物的方法 |
| EP3189057A1 (en) | 2014-09-03 | 2017-07-12 | ImmunoGen, Inc. | Cytotoxic benzodiazepine derivatives |
| ES2815353T3 (es) | 2014-09-03 | 2021-03-29 | Immunogen Inc | Derivados de benzodiazepina citotóxicos |
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