JP2013523694A5 - - Google Patents
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- JP2013523694A5 JP2013523694A5 JP2013501854A JP2013501854A JP2013523694A5 JP 2013523694 A5 JP2013523694 A5 JP 2013523694A5 JP 2013501854 A JP2013501854 A JP 2013501854A JP 2013501854 A JP2013501854 A JP 2013501854A JP 2013523694 A5 JP2013523694 A5 JP 2013523694A5
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- JP
- Japan
- Prior art keywords
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- composition
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- amount
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 21
- 239000002904 solvent Substances 0.000 claims 5
- 239000003589 local anesthetic agent Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 150000004671 saturated fatty acids Chemical class 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims 3
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 3
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims 2
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- 206010000210 abortion Diseases 0.000 claims 2
- 231100000176 abortion Toxicity 0.000 claims 2
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 150000004668 long chain fatty acids Chemical class 0.000 claims 2
- 235000021281 monounsaturated fatty acids Nutrition 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 claims 2
- 229960003656 ricinoleic acid Drugs 0.000 claims 2
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 claims 2
- 229960001549 ropivacaine Drugs 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 235000003441 saturated fatty acids Nutrition 0.000 claims 2
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- 206010000234 Abortion spontaneous Diseases 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004720 fertilization Effects 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 229960004288 levobupivacaine Drugs 0.000 claims 1
- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 claims 1
- 229960005015 local anesthetics Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000012074 organic phase Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 208000000995 spontaneous abortion Diseases 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1050322 | 2010-04-01 | ||
| SE1050322-5 | 2010-04-01 | ||
| US32542510P | 2010-04-19 | 2010-04-19 | |
| US61/325,425 | 2010-04-19 | ||
| PCT/EP2011/055025 WO2011121082A1 (en) | 2010-04-01 | 2011-03-31 | Bioadhesive compositions of local anaesthetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013523694A JP2013523694A (ja) | 2013-06-17 |
| JP2013523694A5 true JP2013523694A5 (https=) | 2014-05-22 |
Family
ID=44278867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013501854A Pending JP2013523694A (ja) | 2010-04-01 | 2011-03-31 | 局所麻酔薬の生体接着性組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20130079371A1 (https=) |
| EP (1) | EP2552409A1 (https=) |
| JP (1) | JP2013523694A (https=) |
| KR (1) | KR20130080435A (https=) |
| CN (1) | CN102869344A (https=) |
| AU (1) | AU2011234415C1 (https=) |
| BR (1) | BR112012024885A2 (https=) |
| CA (1) | CA2794280A1 (https=) |
| CL (1) | CL2012002705A1 (https=) |
| EA (1) | EA201290790A1 (https=) |
| IL (1) | IL222225A0 (https=) |
| MX (1) | MX2012011261A (https=) |
| NZ (1) | NZ602540A (https=) |
| PH (1) | PH12012501887A1 (https=) |
| SG (1) | SG184072A1 (https=) |
| WO (1) | WO2011121082A1 (https=) |
| ZA (1) | ZA201206989B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9642912B2 (en) | 2006-03-06 | 2017-05-09 | Crescita Therapeutics Inc. | Topical formulations for treating skin conditions |
| US9308181B2 (en) | 2006-03-06 | 2016-04-12 | Nuvo Research Inc. | Topical formulations, systems and methods |
| WO2010033726A2 (en) | 2008-09-17 | 2010-03-25 | The Brigham And Women's Hospital, Inc. | Drug delivery composition comprising a self-assembled gelator |
| BR112013008697A2 (pt) | 2010-09-24 | 2016-06-21 | Massachusetts Inst Technology | géis nanoestruturados capazes de liberação controlada de agentes encapsulados |
| CN105120839B (zh) * | 2013-02-28 | 2020-07-28 | 湖州惠中济世生物科技有限公司 | 可注射长效局麻药半固体制剂及其组成成分 |
| US10220093B2 (en) * | 2013-02-28 | 2019-03-05 | Mira Pharma Corporation | Long-acting semi-solid lipid formulations |
| GB201317718D0 (en) | 2013-10-07 | 2013-11-20 | Buzzz Pharmaceuticals Ltd | Novel formulation |
| JP6678946B2 (ja) | 2015-03-25 | 2020-04-15 | テルモ株式会社 | ゲル状局所麻酔剤およびそれを用いたゲル状局所麻酔製剤 |
| EP3375456B1 (en) | 2015-11-12 | 2023-05-03 | Terumo Kabushiki Kaisha | Sustained-release topically administered agent |
| US11020410B2 (en) | 2017-02-03 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof |
| US10881745B2 (en) * | 2017-05-08 | 2021-01-05 | Alivio Therapeutics, Inc. | Formulation of nanostructured gels for increased agent loading and adhesion |
| JP7046396B2 (ja) | 2017-12-06 | 2022-04-04 | 湖州惠中濟世生物科技有限公司 | 注射可能な長時間作用性局所麻酔薬半固形製剤 |
| US10561606B2 (en) | 2017-12-06 | 2020-02-18 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid gel formulations |
| US11426418B2 (en) | 2017-12-06 | 2022-08-30 | Mira Pharma Corporation | Injectable long-acting semi-solid gel formulations |
| CA3113948A1 (en) | 2018-10-11 | 2020-04-16 | Alivio Therapeutics, Inc. | Non-injectable hydrogel formulations for smart release |
| JP2024505227A (ja) * | 2021-01-29 | 2024-02-05 | インシツ バイオロジクス、インク． | 疼痛の持続的治療のための組成物および方法 |
| CN118697692B (zh) * | 2024-06-27 | 2024-11-26 | 山东中医药大学附属医院 | 一种防苦麻醉胶浆剂、方法及应用 |
| CN119587525B (zh) * | 2024-11-07 | 2025-09-05 | 海南三帝制药有限公司 | 一种二甲卡因复合制剂及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5045553A (en) * | 1987-06-24 | 1991-09-03 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter |
| ATE180971T1 (de) * | 1994-03-30 | 1999-06-15 | Gs Dev Ab | Verwendung von fettsäureester als bioklebstoffe |
| SE9601421D0 (sv) | 1996-04-12 | 1996-04-12 | Astra Ab | New composition |
| BR9711911A (pt) * | 1996-10-14 | 2000-01-18 | Kowa Co | Anestésico lopcal para uso externo. |
| US20040001889A1 (en) * | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| EP1594484A2 (en) * | 2003-02-17 | 2005-11-16 | Cipla Ltd. | Pharmaceutical patch |
| US20050084508A1 (en) | 2003-07-22 | 2005-04-21 | Vancaillie Thierry G. | Topical anesthesia formulation for bodily cavities |
| US9757461B2 (en) * | 2005-01-14 | 2017-09-12 | Camurus Ab | GnRH analogue formulations |
| JP4931369B2 (ja) | 2005-05-31 | 2012-05-16 | ポーラ化成工業株式会社 | リポソームおよびそれを含む処置用の組成物 |
| AU2006341116C1 (en) * | 2005-09-27 | 2013-05-23 | Efrat Biopolymers Ltd. | Gelling hydrophobic injectable polymer compositions |
| GB0524958D0 (en) * | 2005-12-07 | 2006-01-18 | Pharmakodex Ltd | Transdermal administration of active agents |
| US20070280972A1 (en) * | 2006-04-25 | 2007-12-06 | Zars, Inc. | Adhesive solid gel-forming formulations for dermal drug delivery |
| US20070269386A1 (en) * | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
| JP5181320B2 (ja) * | 2006-10-18 | 2013-04-10 | ニチバン株式会社 | 皮膚刺激の少ない経皮吸収型製剤 |
| US9918934B2 (en) | 2006-12-12 | 2018-03-20 | Edgar Joel Acosta-Zara | Linker-based lecithin microemulsion delivery vehicles |
| US20090247494A1 (en) | 2008-04-01 | 2009-10-01 | Phillip Mark Kofsky | Omega-3 essential fatty acid composition and method for treatment of anal and colon-rectal disorders |
-
2011
- 2011-03-31 KR KR1020127028642A patent/KR20130080435A/ko not_active Withdrawn
- 2011-03-31 BR BR112012024885A patent/BR112012024885A2/pt not_active IP Right Cessation
- 2011-03-31 NZ NZ602540A patent/NZ602540A/en not_active IP Right Cessation
- 2011-03-31 MX MX2012011261A patent/MX2012011261A/es not_active Application Discontinuation
- 2011-03-31 WO PCT/EP2011/055025 patent/WO2011121082A1/en not_active Ceased
- 2011-03-31 CA CA2794280A patent/CA2794280A1/en not_active Abandoned
- 2011-03-31 AU AU2011234415A patent/AU2011234415C1/en not_active Ceased
- 2011-03-31 US US13/638,519 patent/US20130079371A1/en not_active Abandoned
- 2011-03-31 JP JP2013501854A patent/JP2013523694A/ja active Pending
- 2011-03-31 CN CN2011800166567A patent/CN102869344A/zh active Pending
- 2011-03-31 EP EP11711566A patent/EP2552409A1/en not_active Withdrawn
- 2011-03-31 EA EA201290790A patent/EA201290790A1/ru unknown
- 2011-03-31 SG SG2012068250A patent/SG184072A1/en unknown
- 2011-03-31 PH PH1/2012/501887A patent/PH12012501887A1/en unknown
-
2012
- 2012-09-18 ZA ZA2012/06989A patent/ZA201206989B/en unknown
- 2012-09-27 IL IL222225A patent/IL222225A0/en unknown
- 2012-09-27 CL CL2012002705A patent/CL2012002705A1/es unknown
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