CL2012002705A1 - Composicion farmaceutica que comprende: a) 0,1-20% de ropivacaina,bupivacaina o levobupivacaina, b) 15 a 70% en peso de un monoglicerido de acido graso de cadena larga o sus mezclas, c) 5 a 60% de un acido graso libre saturado o instaurado de cadena larga y d)menos de 30% de agua; uso para reducir el dolor. - Google Patents
Composicion farmaceutica que comprende: a) 0,1-20% de ropivacaina,bupivacaina o levobupivacaina, b) 15 a 70% en peso de un monoglicerido de acido graso de cadena larga o sus mezclas, c) 5 a 60% de un acido graso libre saturado o instaurado de cadena larga y d)menos de 30% de agua; uso para reducir el dolor.Info
- Publication number
- CL2012002705A1 CL2012002705A1 CL2012002705A CL2012002705A CL2012002705A1 CL 2012002705 A1 CL2012002705 A1 CL 2012002705A1 CL 2012002705 A CL2012002705 A CL 2012002705A CL 2012002705 A CL2012002705 A CL 2012002705A CL 2012002705 A1 CL2012002705 A1 CL 2012002705A1
- Authority
- CL
- Chile
- Prior art keywords
- long chain
- weight
- saturated
- fatty acid
- mixtures
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Anesthesiology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Composición farmacéutica acuosa, gelificante, bioadhesiva y estabilizada que comprende A) Al menos un anestésico local, b) 15 a 70 % en peso de un monoglicérido o un diglicérido, o sus mezclas, de un ácido graso de cadena larga, y C) 5 a 60 % en peso de un ácido graso libre saturado o insaturado de cadena larga; y su método de preparación.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1050322 | 2010-04-01 | ||
| US32542510P | 2010-04-19 | 2010-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2012002705A1 true CL2012002705A1 (es) | 2013-02-01 |
Family
ID=44278867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012002705A CL2012002705A1 (es) | 2010-04-01 | 2012-09-27 | Composicion farmaceutica que comprende: a) 0,1-20% de ropivacaina,bupivacaina o levobupivacaina, b) 15 a 70% en peso de un monoglicerido de acido graso de cadena larga o sus mezclas, c) 5 a 60% de un acido graso libre saturado o instaurado de cadena larga y d)menos de 30% de agua; uso para reducir el dolor. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20130079371A1 (es) |
| EP (1) | EP2552409A1 (es) |
| JP (1) | JP2013523694A (es) |
| KR (1) | KR20130080435A (es) |
| CN (1) | CN102869344A (es) |
| AU (1) | AU2011234415C1 (es) |
| BR (1) | BR112012024885A2 (es) |
| CA (1) | CA2794280A1 (es) |
| CL (1) | CL2012002705A1 (es) |
| EA (1) | EA201290790A1 (es) |
| IL (1) | IL222225A0 (es) |
| MX (1) | MX2012011261A (es) |
| NZ (1) | NZ602540A (es) |
| SG (1) | SG184072A1 (es) |
| WO (1) | WO2011121082A1 (es) |
| ZA (1) | ZA201206989B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9308181B2 (en) | 2006-03-06 | 2016-04-12 | Nuvo Research Inc. | Topical formulations, systems and methods |
| US9642912B2 (en) | 2006-03-06 | 2017-05-09 | Crescita Therapeutics Inc. | Topical formulations for treating skin conditions |
| WO2010033726A2 (en) | 2008-09-17 | 2010-03-25 | The Brigham And Women's Hospital, Inc. | Drug delivery composition comprising a self-assembled gelator |
| EP2618821A4 (en) | 2010-09-24 | 2014-08-13 | Brigham & Womens Hospital | NANOSTRUCTURED GELS FOR CONTROLLED RELEASE OF CAPSUED MEDIUM |
| US10220093B2 (en) | 2013-02-28 | 2019-03-05 | Mira Pharma Corporation | Long-acting semi-solid lipid formulations |
| JP6363115B2 (ja) * | 2013-02-28 | 2018-07-25 | ミラ ファーマ コーポレイション | 注射可能局所麻酔半固体製剤およびその組成物 |
| GB201317718D0 (en) * | 2013-10-07 | 2013-11-20 | Buzzz Pharmaceuticals Ltd | Novel formulation |
| AU2016237984B2 (en) | 2015-03-25 | 2019-01-31 | Terumo Kabushiki Kaisha | Gel type local anesthetic agent and gel type local anesthetic preparation using same |
| EP3375456B1 (en) | 2015-11-12 | 2023-05-03 | Terumo Kabushiki Kaisha | Sustained-release topically administered agent |
| US11020410B2 (en) | 2017-02-03 | 2021-06-01 | The Brigham And Women's Hospital, Inc. | Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof |
| CA3061480A1 (en) * | 2017-05-08 | 2018-11-15 | Alivio Therapeutics, Inc. | Formulation of nanostructured gels for increased agent loading and adhesion |
| US10561606B2 (en) | 2017-12-06 | 2020-02-18 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid gel formulations |
| US11426418B2 (en) | 2017-12-06 | 2022-08-30 | Mira Pharma Corporation | Injectable long-acting semi-solid gel formulations |
| EP3720420A1 (en) | 2017-12-06 | 2020-10-14 | Huzhou Hui Zhong Ji Shi Biotechnology Co., Ltd. | Injectable long-acting local anesthetic semi-solid gel formulations |
| CN113825495A (zh) | 2018-10-11 | 2021-12-21 | 阿利维奥治疗学股份有限公司 | 用于智能释放的不可注射水凝胶调配物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5045553A (en) * | 1987-06-24 | 1991-09-03 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter |
| JP4137179B2 (ja) * | 1994-03-30 | 2008-08-20 | ジーエス ディベロップメント エービー | 生物付着性物質としての脂肪酸エステルの使用 |
| SE9601421D0 (sv) * | 1996-04-12 | 1996-04-12 | Astra Ab | New composition |
| YU19399A (sh) * | 1996-10-14 | 2001-09-28 | Kowa Company Ltd. | Lokalni anestetik za spoljnu upotrebu |
| US20040001889A1 (en) * | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| WO2004071398A2 (en) * | 2003-02-17 | 2004-08-26 | Cipla Ltd | Pharmaceutical patch |
| US20050084508A1 (en) | 2003-07-22 | 2005-04-21 | Vancaillie Thierry G. | Topical anesthesia formulation for bodily cavities |
| PL1848403T3 (pl) * | 2005-01-14 | 2010-09-30 | Camurus Ab | Preparaty bioadhezyjne o działaniu miejscowym |
| JP4931369B2 (ja) | 2005-05-31 | 2012-05-16 | ポーラ化成工業株式会社 | リポソームおよびそれを含む処置用の組成物 |
| EP1931308A2 (en) * | 2005-09-27 | 2008-06-18 | Efrat Biopolymers Ltd. | Gelling hydrophobic injectable polymer compositions |
| GB0524958D0 (en) * | 2005-12-07 | 2006-01-18 | Pharmakodex Ltd | Transdermal administration of active agents |
| US20070280972A1 (en) * | 2006-04-25 | 2007-12-06 | Zars, Inc. | Adhesive solid gel-forming formulations for dermal drug delivery |
| US20070269386A1 (en) * | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
| JP5181320B2 (ja) * | 2006-10-18 | 2013-04-10 | ニチバン株式会社 | 皮膚刺激の少ない経皮吸収型製剤 |
| US9918934B2 (en) | 2006-12-12 | 2018-03-20 | Edgar Joel Acosta-Zara | Linker-based lecithin microemulsion delivery vehicles |
| US20090247494A1 (en) | 2008-04-01 | 2009-10-01 | Phillip Mark Kofsky | Omega-3 essential fatty acid composition and method for treatment of anal and colon-rectal disorders |
-
2011
- 2011-03-31 US US13/638,519 patent/US20130079371A1/en not_active Abandoned
- 2011-03-31 CA CA2794280A patent/CA2794280A1/en not_active Abandoned
- 2011-03-31 AU AU2011234415A patent/AU2011234415C1/en not_active Ceased
- 2011-03-31 NZ NZ602540A patent/NZ602540A/en not_active IP Right Cessation
- 2011-03-31 EA EA201290790A patent/EA201290790A1/ru unknown
- 2011-03-31 SG SG2012068250A patent/SG184072A1/en unknown
- 2011-03-31 WO PCT/EP2011/055025 patent/WO2011121082A1/en active Application Filing
- 2011-03-31 KR KR1020127028642A patent/KR20130080435A/ko not_active Application Discontinuation
- 2011-03-31 JP JP2013501854A patent/JP2013523694A/ja active Pending
- 2011-03-31 BR BR112012024885A patent/BR112012024885A2/pt not_active IP Right Cessation
- 2011-03-31 EP EP11711566A patent/EP2552409A1/en not_active Withdrawn
- 2011-03-31 MX MX2012011261A patent/MX2012011261A/es not_active Application Discontinuation
- 2011-03-31 CN CN2011800166567A patent/CN102869344A/zh active Pending
-
2012
- 2012-09-18 ZA ZA2012/06989A patent/ZA201206989B/en unknown
- 2012-09-27 IL IL222225A patent/IL222225A0/en unknown
- 2012-09-27 CL CL2012002705A patent/CL2012002705A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102869344A (zh) | 2013-01-09 |
| CA2794280A1 (en) | 2011-10-06 |
| EP2552409A1 (en) | 2013-02-06 |
| EA201290790A1 (ru) | 2013-04-30 |
| BR112012024885A2 (pt) | 2016-06-21 |
| MX2012011261A (es) | 2012-12-05 |
| US20130079371A1 (en) | 2013-03-28 |
| NZ602540A (en) | 2014-05-30 |
| AU2011234415A1 (en) | 2012-10-18 |
| SG184072A1 (en) | 2012-10-30 |
| WO2011121082A1 (en) | 2011-10-06 |
| AU2011234415C1 (en) | 2014-07-10 |
| AU2011234415B2 (en) | 2014-04-10 |
| IL222225A0 (en) | 2012-12-31 |
| ZA201206989B (en) | 2014-04-30 |
| JP2013523694A (ja) | 2013-06-17 |
| KR20130080435A (ko) | 2013-07-12 |
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