UY32894A - Derivados de 5-fenil-pirazolopiridina, su preparación y su aplicación en terapéutica - Google Patents
Derivados de 5-fenil-pirazolopiridina, su preparación y su aplicación en terapéuticaInfo
- Publication number
- UY32894A UY32894A UY0001032894A UY32894A UY32894A UY 32894 A UY32894 A UY 32894A UY 0001032894 A UY0001032894 A UY 0001032894A UY 32894 A UY32894 A UY 32894A UY 32894 A UY32894 A UY 32894A
- Authority
- UY
- Uruguay
- Prior art keywords
- therapeutics
- phenyl
- preparation
- application
- derivatives
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 101001109698 Homo sapiens Nuclear receptor subfamily 4 group A member 2 Proteins 0.000 abstract 2
- 102100022676 Nuclear receptor subfamily 4 group A member 2 Human genes 0.000 abstract 2
- FXUDQKREGGIUQW-UHFFFAOYSA-N 5-phenyl-1h-pyrazolo[4,3-b]pyridine Chemical class N1=C2C=NNC2=CC=C1C1=CC=CC=C1 FXUDQKREGGIUQW-UHFFFAOYSA-N 0.000 abstract 1
- 101000785650 Homo sapiens Zinc finger protein 268 Proteins 0.000 abstract 1
- 108010093175 Member 2 Group A Nuclear Receptor Subfamily 4 Proteins 0.000 abstract 1
- 102000002559 Member 2 Group A Nuclear Receptor Subfamily 4 Human genes 0.000 abstract 1
- -1 NOT Proteins 0.000 abstract 1
- 101001109694 Rattus norvegicus Nuclear receptor subfamily 4 group A member 2 Proteins 0.000 abstract 1
- 102100026516 Zinc finger protein 268 Human genes 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Derivados de 5-fenil-pirazolopiridina de la fórmula (I) en el estado de base o de sal de adición a un ácido. La invención se refiere además a la preparación de los mismos y a la aplicación en terapéutica en el tratamiento o en la prevención de enfermedades que implican a los receptores nucleares Nurr-1, denominados también NR4A2, NOT, TINUR, RNR-1, y HZF3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0956444A FR2950344B1 (fr) | 2009-09-18 | 2009-09-18 | Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique. |
Publications (1)
Publication Number | Publication Date |
---|---|
UY32894A true UY32894A (es) | 2011-04-29 |
Family
ID=41572488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001032894A UY32894A (es) | 2009-09-18 | 2010-09-17 | Derivados de 5-fenil-pirazolopiridina, su preparación y su aplicación en terapéutica |
Country Status (16)
Country | Link |
---|---|
US (1) | US8618301B2 (es) |
EP (1) | EP2477990B1 (es) |
JP (1) | JP5616453B2 (es) |
AR (1) | AR078180A1 (es) |
CY (1) | CY1116581T1 (es) |
DK (1) | DK2477990T3 (es) |
ES (1) | ES2523505T3 (es) |
FR (1) | FR2950344B1 (es) |
HR (1) | HRP20141119T1 (es) |
JO (1) | JO3017B1 (es) |
PL (1) | PL2477990T3 (es) |
PT (1) | PT2477990E (es) |
SI (1) | SI2477990T1 (es) |
TW (1) | TWI464169B (es) |
UY (1) | UY32894A (es) |
WO (1) | WO2011033230A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2953520B1 (fr) * | 2009-12-04 | 2011-11-25 | Sanofi Aventis | Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique |
JP2024525791A (ja) * | 2021-07-16 | 2024-07-12 | サノフイ | 治療に使用するためのイミダゾ[1,2-b][1,2,4]トリアゾール誘導体 |
CN118234727A (zh) * | 2021-07-16 | 2024-06-21 | 赛诺菲 | 用于疗法的6H-咪唑并[1,2-a]吡咯并[2,3-e]吡啶衍生物 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ301491B6 (cs) * | 2001-04-27 | 2010-03-24 | Eisai R&D Management Co., Ltd. | Pyrazolo[1,5-a]pyridiny a léciva s jejich obsahem |
BR0308391A (pt) * | 2002-03-13 | 2005-01-11 | Pharmacia & Upjohn Co Llc | Derivados de pirazolo(1,5-a)piridina como moduladores neurotransmissores |
JP4890439B2 (ja) * | 2005-03-07 | 2012-03-07 | 杏林製薬株式会社 | ピラゾロピリジン−4−イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするpde阻害剤 |
FR2906250B1 (fr) * | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
US8513276B2 (en) * | 2006-12-22 | 2013-08-20 | Astex Therapeutics Limited | Imidazo[1,2-a]pyridine compounds for use in treating cancer |
US8895745B2 (en) * | 2006-12-22 | 2014-11-25 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as FGFR inhibitors |
FR2925900B1 (fr) * | 2008-01-02 | 2011-03-04 | Sanofi Aventis | DERIVES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
FR2928922B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique |
FR2953520B1 (fr) * | 2009-12-04 | 2011-11-25 | Sanofi Aventis | Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique |
-
2009
- 2009-09-18 FR FR0956444A patent/FR2950344B1/fr not_active Expired - Fee Related
-
2010
- 2010-09-16 JO JOP/2010/0315A patent/JO3017B1/ar active
- 2010-09-16 AR ARP100103375A patent/AR078180A1/es unknown
- 2010-09-17 EP EP10771159.0A patent/EP2477990B1/fr not_active Not-in-force
- 2010-09-17 PT PT107711590T patent/PT2477990E/pt unknown
- 2010-09-17 PL PL10771159T patent/PL2477990T3/pl unknown
- 2010-09-17 US US13/496,118 patent/US8618301B2/en not_active Expired - Fee Related
- 2010-09-17 SI SI201030792T patent/SI2477990T1/sl unknown
- 2010-09-17 ES ES10771159.0T patent/ES2523505T3/es active Active
- 2010-09-17 WO PCT/FR2010/051932 patent/WO2011033230A1/fr active Application Filing
- 2010-09-17 JP JP2012529329A patent/JP5616453B2/ja not_active Expired - Fee Related
- 2010-09-17 TW TW099131736A patent/TWI464169B/zh not_active IP Right Cessation
- 2010-09-17 UY UY0001032894A patent/UY32894A/es not_active Application Discontinuation
- 2010-09-17 DK DK10771159.0T patent/DK2477990T3/en active
-
2014
- 2014-11-19 HR HRP20141119AT patent/HRP20141119T1/hr unknown
- 2014-11-20 CY CY20141100967T patent/CY1116581T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
FR2950344B1 (fr) | 2011-11-25 |
HRP20141119T1 (hr) | 2015-01-30 |
PL2477990T3 (pl) | 2015-02-27 |
EP2477990B1 (fr) | 2014-08-20 |
TW201118093A (en) | 2011-06-01 |
WO2011033230A1 (fr) | 2011-03-24 |
TWI464169B (zh) | 2014-12-11 |
JP2013505227A (ja) | 2013-02-14 |
FR2950344A1 (fr) | 2011-03-25 |
PT2477990E (pt) | 2014-11-27 |
DK2477990T3 (en) | 2014-12-01 |
AR078180A1 (es) | 2011-10-19 |
JP5616453B2 (ja) | 2014-10-29 |
US20130023554A1 (en) | 2013-01-24 |
EP2477990A1 (fr) | 2012-07-25 |
US8618301B2 (en) | 2013-12-31 |
ES2523505T3 (es) | 2014-11-26 |
JO3017B1 (ar) | 2016-09-05 |
SI2477990T1 (sl) | 2014-12-31 |
CY1116581T1 (el) | 2018-03-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20190222 |